Clinical Trials: SEARCH[STUDY] TILT[STUDY:STUDY-FIRST-POSTED] ( Intense protocol [STUDY:TREATMENT] )
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NCTID/Status
Study
Last Changed
451
NCT00404430
Active, not recruiting
Active, not recruiting
Protocol Chronic Obstructive Pulmonary Disease
Conditions: Chronic Obstructive Pulmonary Disease; Acute Respiratory Failure
Conditions: Chronic Obstructive Pulmonary Disease; Acute Respiratory Failure
August 18, 2016
452
NCT02010567
Active, not recruiting
Active, not recruiting
Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer
Conditions: Rectal Cancer
Intervention: CRLX101, Capecitabine, Radiotherapy, Surgery
Conditions: Rectal Cancer
Intervention: CRLX101, Capecitabine, Radiotherapy, Surgery
January 4, 2019
453
NCT03979287
Not yet recruiting
Not yet recruiting
Interferential Current and Therapeutic Exercise Program in Chronic Neck Pain
Conditions: Neck Pain
Intervention: Interferential Current And Therapeutic Exercise Program, Therapeutic Exercise Program
Conditions: Neck Pain
Intervention: Interferential Current And Therapeutic Exercise Program, Therapeutic Exercise Program
June 5, 2019
454
NCT04042532
Not yet recruiting
Not yet recruiting
Theta-burst Stimulation on Cognitive Function in the Patients With Young-onset Alzheimer's Disease Dementia
Conditions: Alzheimer Disease, Early Onset
Intervention: Theta-burst Stimulation (TBS)
Conditions: Alzheimer Disease, Early Onset
Intervention: Theta-burst Stimulation (TBS)
July 31, 2019
455
NCT03840954
Not yet recruiting
Not yet recruiting
Effects of Neuromuscular Electrical Stimulation in Muscle Architecture and Functionality of Patients After Acute Stroke
Conditions: Stroke, Acute; Neuromuscular Electrical Stimulation
Intervention: Neuromuscular Electrical Stimulation
Conditions: Stroke, Acute; Neuromuscular Electrical Stimulation
Intervention: Neuromuscular Electrical Stimulation
June 27, 2019
456
NCT03418376
Completed
Completed
Carnosine Loading in MS and HC
Conditions: Multiple Sclerosis; Exercise Therapy; Dietary Supplement
Intervention: Beta-alanine Supplementation, Exercise Intervention
Conditions: Multiple Sclerosis; Exercise Therapy; Dietary Supplement
Intervention: Beta-alanine Supplementation, Exercise Intervention
January 9, 2019
457
NCT01840137
Completed
Completed
Trial of Prehabilitation in Vulnerable Patients Undergoing Cystectomy for Bladder Cancer
Conditions: Bladder Cancer
Intervention: Baseline Strength Test, Exercise
Conditions: Bladder Cancer
Intervention: Baseline Strength Test, Exercise
August 6, 2019
458
NCT01810952
Completed
Completed
The Management of Glucocorticoid-Induced Hyperglycemia in Hospitalized Patients
Conditions: Hyperglycemia; Diabetes Mellitus
Intervention: Glargine Insulin, Lispro Insulin, NPH Insulin
Conditions: Hyperglycemia; Diabetes Mellitus
Intervention: Glargine Insulin, Lispro Insulin, NPH Insulin
February 7, 2017
459
NCT02753829
Completed
Completed
Home-based Cardiovascular Rehabilitation, Maintenance Phase, in Subjects With Coronary Artery Disease
Conditions: Coronary Heart Disease; Acute Myocardial Infarction: Rehabilitation Phase
Intervention: Cardiovascular Rehabilitation Program Using Kinect Of Xbox, Cardiovascular Rehabilitation Program Using Paper Manual, Educational Component
Conditions: Coronary Heart Disease; Acute Myocardial Infarction: Rehabilitation Phase
Intervention: Cardiovascular Rehabilitation Program Using Kinect Of Xbox, Cardiovascular Rehabilitation Program Using Paper Manual, Educational Component
April 27, 2016
460
NCT02694185
Active, not recruiting
Active, not recruiting
Secondary Event Prevention Using Population Risk Management After PCI and for Anti-Rheumatic Medications
Conditions: Myocardial Ischemia; Rheumatic Diseases
Intervention: Caplan IVR
Conditions: Myocardial Ischemia; Rheumatic Diseases
Intervention: Caplan IVR
July 25, 2019
461
NCT00797732
Completed
Completed
A Pilot Study of Acupuncture Treatment for Dysphagia
Conditions: Carcinomas, Squamous Cell; Dysphagia
Intervention: Acupuncture
Conditions: Carcinomas, Squamous Cell; Dysphagia
Intervention: Acupuncture
January 16, 2018
462
NCT00296062
Terminated
Terminated
Dose Dense Therapy and Bevacizumab in Solid Tumors and Colorectal Cancer
Conditions: Colorectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Bevacizumab, Capecitabine, Irinotecan Hydrochloride, Oxaliplatin
Conditions: Colorectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Bevacizumab, Capecitabine, Irinotecan Hydrochloride, Oxaliplatin
January 13, 2012
463
NCT00140439
Completed
Completed
Improving Asthma Outcomes in an Urban Pediatric Population
Conditions: Asthma
Intervention: Emergency Department Based Asthma Follow-up Clinic
Conditions: Asthma
Intervention: Emergency Department Based Asthma Follow-up Clinic
August 21, 2015
464
NCT01231893
Unknown status
Unknown status
Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury
Conditions: Complete Spinal Cord Injuries
Intervention: Olfactory Mucosa Ensheathing Cell Grafting, Rehabilitation, Rehabilitation
Conditions: Complete Spinal Cord Injuries
Intervention: Olfactory Mucosa Ensheathing Cell Grafting, Rehabilitation, Rehabilitation
October 29, 2010
465
NCT02290457
Completed
Completed
Core Strength Training in Youth
Conditions: Exercise; Strength Training
Intervention: Core Strength Training
Conditions: Exercise; Strength Training
Intervention: Core Strength Training
November 13, 2014
466
NCT00111358
Completed
Completed
Study of Lifestyle Modification in HIV Lipodystrophy
Conditions: HIV; Metabolic Diseases
Intervention: Lifestyle Modification, No Lifestyle Modification
Conditions: HIV; Metabolic Diseases
Intervention: Lifestyle Modification, No Lifestyle Modification
April 15, 2011
467
NCT02458612
Unknown status
Unknown status
Effects of Mirror Therapy Combined With Progressive Strength Training in Unilateral Spastic Cerebral Palsy
Conditions: Spastic Hemiplegic Cerebral Palsy
Intervention: Control Group, Intervention Group
Conditions: Spastic Hemiplegic Cerebral Palsy
Intervention: Control Group, Intervention Group
February 18, 2016
468
NCT00650715
Completed
Completed
Effects of Whole-Body Vibration Exercise on Serum IGF-1 in Fibromyalgia
Conditions: Fibromyalgia; Hormonal Responses to Exercise in Patients With Fibromyalgia.
Intervention: Vibratory Platform, PowerPlate®, Badhoevendorp, Netherlands, Placebo Whole-body Vibration Exercise
Conditions: Fibromyalgia; Hormonal Responses to Exercise in Patients With Fibromyalgia.
Intervention: Vibratory Platform, PowerPlate®, Badhoevendorp, Netherlands, Placebo Whole-body Vibration Exercise
March 31, 2008
469
NCT03954730
Completed
Completed
Eccentric Training Versus Active Release Technique On Quadriceps In Patients With Dynamic Hip Screw
Conditions: Hip Surgery
Intervention: Eccentric Training, Active Release Technique
Conditions: Hip Surgery
Intervention: Eccentric Training, Active Release Technique
August 8, 2019
470
NCT02214485
Completed
Completed
Integrated Care and Lower Extremity Strength Training Among Community-Dwelling Frail Older Adults in Taiwan
Conditions: Frailty
Intervention: Integrated Care, Lower Extremity Strength Training
Conditions: Frailty
Intervention: Integrated Care, Lower Extremity Strength Training
August 10, 2014
471
NCT02542839
Recruiting
Recruiting
rTMS and Botulinum Toxin in Primary Cervical Dystonia
Conditions: Primary Cervical Dystonia; Dystonia
Intervention: NeuroStar TMS Therapy, Sham NeuroStar TMS Therapy, Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), Craniocervical Dystonia Questionnaire (CDQ-24), Cerebellar-brain Inhibition (CBI), Botulinum Toxin Injections
Conditions: Primary Cervical Dystonia; Dystonia
Intervention: NeuroStar TMS Therapy, Sham NeuroStar TMS Therapy, Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), Craniocervical Dystonia Questionnaire (CDQ-24), Cerebellar-brain Inhibition (CBI), Botulinum Toxin Injections
July 24, 2019
472
NCT02395874
Unknown status
Unknown status
tDCS and Speech Therapy to Improve Aphasia
Conditions: Aphasia, Global; Stroke; Transcranial Direct Current Stimulation; Speech Therapy
Intervention: TDCS + Speech Therapy
Conditions: Aphasia, Global; Stroke; Transcranial Direct Current Stimulation; Speech Therapy
Intervention: TDCS + Speech Therapy
September 12, 2016
473
NCT01257737
Completed
Completed
To Evaluate the Safety of Long-term Use of HPN-100 in the Management of Urea Cycle Disorders (UCDs)
Conditions: Urea Cycle Disorders
Intervention: HPN-100
Conditions: Urea Cycle Disorders
Intervention: HPN-100
April 4, 2018
474
NCT00479193
Withdrawn
Withdrawn
Polymem vs. Bacitracin/Xeroform in Treating Burn Wounds
Conditions: Burns
Intervention: Bacitracin/xeroform, Polymem
Conditions: Burns
Intervention: Bacitracin/xeroform, Polymem
September 7, 2017
475
NCT02205762
Recruiting
Recruiting
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
Conditions: Langerhans Cell Histiocytosis
Intervention: Prednisone, Vinblastine, Mercaptopurine, INDOMETHACIN, Methotrexate, Cytosine Arabinoside, 2-chlorodeoxyadenosine, Hematopoietic Stem Cell Transplantation (RIC-HSCT), Intravenous Immunoglobulin
Conditions: Langerhans Cell Histiocytosis
Intervention: Prednisone, Vinblastine, Mercaptopurine, INDOMETHACIN, Methotrexate, Cytosine Arabinoside, 2-chlorodeoxyadenosine, Hematopoietic Stem Cell Transplantation (RIC-HSCT), Intravenous Immunoglobulin
May 2, 2018
476
NCT01759992
Completed
Completed
Effects and Costs of Respiratory Muscle Training in Institutionalized Elderly People
Conditions: Muscle Weakness; Syndrome; Institutionalization; Respiratory Morbidity; Cardiovascular Morbidity
Intervention: Threshold® Inspiratory Muscle Trainer (treatment).
Conditions: Muscle Weakness; Syndrome; Institutionalization; Respiratory Morbidity; Cardiovascular Morbidity
Intervention: Threshold® Inspiratory Muscle Trainer (treatment).
March 18, 2014
477
NCT02961023
Unknown status
Unknown status
The Effect of Adding Exercise Training to Optimal Therapy in PAH
Conditions: Pulmonary Arterial Hypertension
Intervention: Exercise Therapy
Conditions: Pulmonary Arterial Hypertension
Intervention: Exercise Therapy
November 22, 2016
478
NCT03217929
Not yet recruiting
Not yet recruiting
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Food Craving in Obese Individuals.
Conditions: Obesity; Craving
Intervention: Active-taVNS, Sham-taVNS
Conditions: Obesity; Craving
Intervention: Active-taVNS, Sham-taVNS
July 12, 2017
479
NCT03171519
Recruiting
Recruiting
Effects of Exercise and Acupuncture on Chronic Insomnia
Conditions: Chronic Insomnia
Intervention: Exercise, Acupuncture
Conditions: Chronic Insomnia
Intervention: Exercise, Acupuncture
April 16, 2019
480
NCT02925845
Unknown status
Unknown status
Neuromuscular Electrostimulation in Radiocephalic Fistula
Conditions: Arteriovenous Fistula
Intervention: Neuromuscular Electrostimulation
Conditions: Arteriovenous Fistula
Intervention: Neuromuscular Electrostimulation
October 4, 2016
481
NCT01759498
Completed
Completed
The Effects of Hydrogen-rich Formulation for Treatment of Sport-related Soft Tissue Injuries
Conditions: Soft Tissue Injuries
Intervention: HYDRO, ACTIVE, HYDRO 2
Conditions: Soft Tissue Injuries
Intervention: HYDRO, ACTIVE, HYDRO 2
September 27, 2013
482
NCT02196948
Completed
Completed
Electrolysis Percutaneous Therapeutic (EPTE) for Supraspinatus Tendinopathy
Conditions: Supraspinatus Tendinopathy
Intervention: Electrolysis Percutaneous Therapeutic (EPTE), Eccentric Exercise
Conditions: Supraspinatus Tendinopathy
Intervention: Electrolysis Percutaneous Therapeutic (EPTE), Eccentric Exercise
December 2, 2014
483
NCT02998385
Recruiting
Recruiting
Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy)
Conditions: HNSCC
Intervention: Cisplatin, Radiotherapy
Conditions: HNSCC
Intervention: Cisplatin, Radiotherapy
December 27, 2018
484
NCT02828189
Completed
Completed
Therapeutic Exercise in Cancer-Related Fatigue in Women After Breast Cancer Treatment
Conditions: Fatigue; Breast Cancer
Intervention: Physical Exercise, Therapeutic Education, Therapeutic Exercise-Physiotherapy
Conditions: Fatigue; Breast Cancer
Intervention: Physical Exercise, Therapeutic Education, Therapeutic Exercise-Physiotherapy
December 10, 2018
485
NCT01317134
Unknown status
Unknown status
Endothelial Function in Patients With Pulmonary Arterial Hypertension
Conditions: Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Pathophysiology; Genetics
Intervention: EndoPAT Measurement, Blood Test
Conditions: Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Pathophysiology; Genetics
Intervention: EndoPAT Measurement, Blood Test
January 26, 2016
486
NCT01555996
Completed
Completed
Early Occupational Therapy for Delirium Prevention in Older Patients Admitted to Critical Care Unit
Conditions: Delirium; Alteration of Cognitive Function; Incompetence, Functional
Intervention: Early And Intensive Occupational Therapy, Standard Non-pharmacological Delirium Prevention
Conditions: Delirium; Alteration of Cognitive Function; Incompetence, Functional
Intervention: Early And Intensive Occupational Therapy, Standard Non-pharmacological Delirium Prevention
May 19, 2014
487
NCT00766779
Terminated
Terminated
HCT Versus CT in Elderly AML
Conditions: Acute Myeloid Leukemia
Intervention: Hematopoietic Cell Transplantation, Non-Transplant Treatment Approach For Consolidation
Conditions: Acute Myeloid Leukemia
Intervention: Hematopoietic Cell Transplantation, Non-Transplant Treatment Approach For Consolidation
August 30, 2017
488
NCT04058080
Completed
Completed
Bikram Yoga and Aerobic Exercise for the Treatment of Major Depression
Conditions: Depression
Intervention: Bikram Yoga, Aerobic Exercise
Conditions: Depression
Intervention: Bikram Yoga, Aerobic Exercise
August 13, 2019
489
NCT03531567
Completed
Completed
Game-Based Home Exercise Programs in Chronic Stroke: A Feasibility Study
Conditions: Chronic Stroke
Intervention: Virtual Reality Mystic Isle Game, Standard Home Exercise Program
Conditions: Chronic Stroke
Intervention: Virtual Reality Mystic Isle Game, Standard Home Exercise Program
October 9, 2018
490
NCT02298114
Unknown status
Unknown status
Mobilization With Neuromuscular Electrical Stimulation in Critical Care Patients
Conditions: Muscular Atrophy
Intervention: NEUROMUSCULAR ELECTRICAL STIMULATION, Conventional Physiotherapy
Conditions: Muscular Atrophy
Intervention: NEUROMUSCULAR ELECTRICAL STIMULATION, Conventional Physiotherapy
December 21, 2015
491
NCT03163160
Completed
Completed
Electrolysis Technique vs Manual Therapy in Pelvic Pain
Conditions: Dyspareunia; Pelvic Pain; Pelvic Floor Disorders; Musculoskeletal Pain; Perineal Tear
Intervention: Pelvic Floor Manual Therapy Group, Pelvic Floor Electrolysis Group
Conditions: Dyspareunia; Pelvic Pain; Pelvic Floor Disorders; Musculoskeletal Pain; Perineal Tear
Intervention: Pelvic Floor Manual Therapy Group, Pelvic Floor Electrolysis Group
March 27, 2019
492
NCT02166619
Unknown status
Unknown status
tDCS in Poststroke on Upper Limb Rehabilitation
Conditions: Stroke
Intervention: TDCS + Physical Therapy
Conditions: Stroke
Intervention: TDCS + Physical Therapy
June 17, 2014
493
NCT02799992
Unknown status
Unknown status
Pseudo-PDT in Central Serous Chorioretinopathy
Conditions: Chronic Central Serous Chorioretinopathy
Intervention: 689 Nm Laser Treatment Of The Macula, Half Dose Photodynamic Therapy
Conditions: Chronic Central Serous Chorioretinopathy
Intervention: 689 Nm Laser Treatment Of The Macula, Half Dose Photodynamic Therapy
June 9, 2016
494
NCT02226237
Completed
Completed
Effectiveness of Physiotherapy to Treat the Urinary Incontinence and Erectile Dysfunction Post Retropubic Prostatectomy
Conditions: Urinary Incontinence; Erectile Dysfunction
Intervention: Group Of Pelvic Floor Exercises, Anal Electrostimulation Group
Conditions: Urinary Incontinence; Erectile Dysfunction
Intervention: Group Of Pelvic Floor Exercises, Anal Electrostimulation Group
January 13, 2016
495
NCT02936076
Completed
Completed
Exercise as a Buffer Against Stress-induced Overeating
Conditions: Obesity
Intervention: Exercise Intervention, Delayed Exercise Intervention
Conditions: Obesity
Intervention: Exercise Intervention, Delayed Exercise Intervention
August 14, 2019
496
NCT02861027
Completed
Completed
Effect of Functional Electrical Stimulation in Gluteus Medius in Rehabilitation After Total Hip Arthroplasty
Conditions: OSTEOARTHRITIS
Intervention: PPTHA, FES And PPTHA
Conditions: OSTEOARTHRITIS
Intervention: PPTHA, FES And PPTHA
August 4, 2016
497
NCT03721965
Recruiting
Recruiting
Safety and Efficacy of Itacitinib in Combination With Corticosteroids for Treatment of Graft-Versus-Host Disease in Pediatric Subjects
Conditions: Acute Graft-versus-host Disease
Intervention: Itacitinib, Corticosteroids
Conditions: Acute Graft-versus-host Disease
Intervention: Itacitinib, Corticosteroids
June 13, 2019
498
NCT01272011
Completed
Completed
Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury
Conditions: Spinal Cord Injuries; Brown Sequard; Central Cord Syndrome
Intervention: Intermittent Hypoxia, Locomotor Training
Conditions: Spinal Cord Injuries; Brown Sequard; Central Cord Syndrome
Intervention: Intermittent Hypoxia, Locomotor Training
February 26, 2016
499
NCT03373526
Recruiting
Recruiting
Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation
Conditions: Lymphoma; Myeloma; Leukemia; Aplastic Anemia
Intervention: Inspiratory Muscle Training, Aerobic Training
Conditions: Lymphoma; Myeloma; Leukemia; Aplastic Anemia
Intervention: Inspiratory Muscle Training, Aerobic Training
December 14, 2017
500
NCT02892084
Completed
Completed
June 26, 2018
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Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.