Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] ALL
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NCTID/Status
Study
Last Changed
1751
NCT04167189
Enrolling by invitation
Enrolling by invitation
Assessing the Frequency of Lidocaine Ineffectiveness in ADHD
Conditions: ADHD
Intervention: Lidocaine Gel
Conditions: ADHD
Intervention: Lidocaine Gel
November 15, 2019
1752
NCT04167176
Not yet recruiting
Not yet recruiting
Comparison of Analgesic Efficacy of US Guided ESP Block With Port Site Infiltration Following Laparoscopic Cholecystectomy
Conditions: Postoperative Pain
Intervention: Erector Spinae Plane Block, Port Site Infiltration, Ultrasound Machine (Mindray DP 9900 Plus; Mindray Bio‑Medical Electronics, Shenzhen, China), Bupivacaine 0.5%, Lidocaine 2%
Conditions: Postoperative Pain
Intervention: Erector Spinae Plane Block, Port Site Infiltration, Ultrasound Machine (Mindray DP 9900 Plus; Mindray Bio‑Medical Electronics, Shenzhen, China), Bupivacaine 0.5%, Lidocaine 2%
November 14, 2019
1753
NCT04167163
Not yet recruiting
Not yet recruiting
Abaloparatide Before Total Knee Arthroplasty
Conditions: Osteoporosis; Arthroplasties, Knee Replacement
Intervention: Abaloparatide
Conditions: Osteoporosis; Arthroplasties, Knee Replacement
Intervention: Abaloparatide
December 2, 2019
1754
NCT04167150
Completed
Completed
Tart Cherry Supplementation and Women's Bone Health Study
Conditions: Osteoporosis, Postmenopausal; Osteoporosis, Age-Related
Intervention: Tart Cherry Juice Concentrate Is A Commercial Product Provided By King Orchards (Central Lake, MI)
Conditions: Osteoporosis, Postmenopausal; Osteoporosis, Age-Related
Intervention: Tart Cherry Juice Concentrate Is A Commercial Product Provided By King Orchards (Central Lake, MI)
November 15, 2019
1755
NCT04167137
Recruiting
Recruiting
Safety and Tolerability of SYNB1891 Injection Alone or in Combination With Atezolizumab in Adult Subjects
Conditions: Metastatic Solid Neoplasm; Lymphoma
Intervention: SYNB1891, Atezolizumab
Conditions: Metastatic Solid Neoplasm; Lymphoma
Intervention: SYNB1891, Atezolizumab
November 15, 2019
1756
NCT04167124
Active, not recruiting
Active, not recruiting
Evaluation of a Spatio-behavioral Application
Conditions: Physical Activity
Intervention: Multi-sensor Lifestyle Intervention
Conditions: Physical Activity
Intervention: Multi-sensor Lifestyle Intervention
November 15, 2019
1757
NCT04167111
Not yet recruiting
Not yet recruiting
Pilot Study- Treat to Target Vitamin D in End Stage Renal Disease
Conditions: Chronic Kidney Diseases
Intervention: Cholecalciferol
Conditions: Chronic Kidney Diseases
Intervention: Cholecalciferol
November 14, 2019
1758
NCT04167098
Recruiting
Recruiting
Effectiveness of Platelet-rich Plasma for Treatment of Trigger Finger
Conditions: Tendon Entrapment
Intervention: PRP Injection, Corticosteroid Injection, Placebo Injection
Conditions: Tendon Entrapment
Intervention: PRP Injection, Corticosteroid Injection, Placebo Injection
November 14, 2019
1759
NCT04167085
Recruiting
Recruiting
NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial
Conditions: Epistaxis
Intervention: Doxycycline, Placebo
Conditions: Epistaxis
Intervention: Doxycycline, Placebo
November 15, 2019
1760
NCT04167072
Recruiting
Recruiting
Observation vs Early Removal of LAMS in EUS Guided Cholecystoenterostomy
Conditions: Cholecystitis, Acute; Cholecystitis; Gallstone
Intervention: Stent Removal
Conditions: Cholecystitis, Acute; Cholecystitis; Gallstone
Intervention: Stent Removal
November 14, 2019
1761
NCT04167059
Not yet recruiting
Not yet recruiting
Telehealth Support to Increase Physical Activity in Rett Syndrome
Conditions: Rett Syndrome
Intervention: Telehealth-delivered Participation Strategies To Increase Physical Activity
Conditions: Rett Syndrome
Intervention: Telehealth-delivered Participation Strategies To Increase Physical Activity
November 14, 2019
1762
NCT04167046
Not yet recruiting
Not yet recruiting
Erector Spinae Block in First Rib Resection: a Monocentric Before-after Study
Conditions: Thoracic Surgery
Intervention: Erector Spinae Block
Conditions: Thoracic Surgery
Intervention: Erector Spinae Block
November 14, 2019
1763
NCT04167033
Not yet recruiting
Not yet recruiting
Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QT-IOP)
Conditions: Premature Ovarian Insufficiency
Intervention: Hormone Replacement Therapy:effect On Ventricular Repolarization, ECG
Conditions: Premature Ovarian Insufficiency
Intervention: Hormone Replacement Therapy:effect On Ventricular Repolarization, ECG
November 15, 2019
1764
NCT04167020
Not yet recruiting
Not yet recruiting
Hip Fracture and Muscle Resilience
Conditions: Hip Fracture, Post Surgery Recovery, Muscle Resilience
Intervention: High Definition Surface Electromyography (HD-sEMG)
Conditions: Hip Fracture, Post Surgery Recovery, Muscle Resilience
Intervention: High Definition Surface Electromyography (HD-sEMG)
November 15, 2019
1765
NCT04167007
Not yet recruiting
Not yet recruiting
FOLFOX vs Gemcitabine in Patients With Metastatic Pancreatic Cancer Non-fit to FOLFIRINOX
Conditions: Pancreatic Adenocarcinoma
Intervention: Gemcitabine, FOLFOX
Conditions: Pancreatic Adenocarcinoma
Intervention: Gemcitabine, FOLFOX
November 28, 2019
1766
NCT04166994
Not yet recruiting
Not yet recruiting
Pilot of IMPACT Intervention at the University of New Mexico
Conditions: Kidney Replacement
Intervention: Exercise And Diet, No Intervention: Usual Care
Conditions: Kidney Replacement
Intervention: Exercise And Diet, No Intervention: Usual Care
November 15, 2019
1767
NCT04166981
Recruiting
Recruiting
Instr. vs. Non-instr. Posterolateral Spinal Fusion in Patients With Spinal Stenosis and Degenerative Listhesis
Conditions: Spinal Stenosis; Spondylolisthesis Degenerative; Spinal Fusion
Intervention: Instrumented Posterolateral Spine Fusion., Non-instrumented Posterolateral Spine Fusion.
Conditions: Spinal Stenosis; Spondylolisthesis Degenerative; Spinal Fusion
Intervention: Instrumented Posterolateral Spine Fusion., Non-instrumented Posterolateral Spine Fusion.
November 14, 2019
1768
NCT04166968
Recruiting
Recruiting
Multicenter Study on the Efficacy of Transcranial Direct Current Stimulation (tDCS) in Post-stroke Motor Recovery
Conditions: Stroke, Ischemic; Stroke Hemorrhagic
Intervention: Anodal Transcranial Direct Current Stimulation (A-tDCS), Cathodal Transcranial Direct Current Stimulation (C-tDCS), Sham Stimulation (sham-tDCS), Neuromotor Training
Conditions: Stroke, Ischemic; Stroke Hemorrhagic
Intervention: Anodal Transcranial Direct Current Stimulation (A-tDCS), Cathodal Transcranial Direct Current Stimulation (C-tDCS), Sham Stimulation (sham-tDCS), Neuromotor Training
November 15, 2019
1769
NCT04166955
Recruiting
Recruiting
What'Sapp Based Intervention for Promoting Physical Activity Among Female College Students
Conditions: Physical Activity
Intervention: Promoting Physical Activity Through Mobile Application
Conditions: Physical Activity
Intervention: Promoting Physical Activity Through Mobile Application
November 15, 2019
1770
NCT04166942
Not yet recruiting
Not yet recruiting
Hepatic Impairment Study in Subjects With Normal Hepatic Function and Subjects With Varying Degrees of Hepatic Impairment
Conditions: Hepatic Impairment
Intervention: KD025
Conditions: Hepatic Impairment
Intervention: KD025
November 15, 2019
1771
NCT04166929
Not yet recruiting
Not yet recruiting
Haploidentical Bone Marrow Transplant With or Without NK Cell Infusion in AML and MDS
Conditions: Acute Myeloid Leukemia; Myelodysplasia
Intervention: Haplo BMT With NK Cells, Haplo BMT
Conditions: Acute Myeloid Leukemia; Myelodysplasia
Intervention: Haplo BMT With NK Cells, Haplo BMT
December 3, 2019
1772
NCT04166916
Not yet recruiting
Not yet recruiting
Role of Sleep in Cardiovascular Functions
Conditions: Sleep
Intervention: Acoustic Stimulation, SHAM Acoustic Stimulation
Conditions: Sleep
Intervention: Acoustic Stimulation, SHAM Acoustic Stimulation
November 14, 2019
1773
NCT04166903
Recruiting
Recruiting
Prospective Follow-up, Marathon, Long Term, Inflammation and Cardiovascular System
Conditions: Participants of the Be-MaGIC-Study 2009
Conditions: Participants of the Be-MaGIC-Study 2009
November 19, 2019
1774
NCT04166890
Enrolling by invitation
Enrolling by invitation
Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia
Conditions: Drug Effect; Tooth Extraction
Intervention: Articaine / EPINEPHrine Cartridge
Conditions: Drug Effect; Tooth Extraction
Intervention: Articaine / EPINEPHrine Cartridge
November 14, 2019
1775
NCT04166877
Not yet recruiting
Not yet recruiting
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
Conditions: Trauma; Acute Pain
Intervention: Magnesium Sulfate In Parenteral Dosage Form, Normal Saline Placebo
Conditions: Trauma; Acute Pain
Intervention: Magnesium Sulfate In Parenteral Dosage Form, Normal Saline Placebo
November 14, 2019
1776
NCT04166864
Active, not recruiting
Active, not recruiting
Spectral Correlation Coefficient-determine TMS for Depression
Conditions: Major Depressive Disorder
Intervention: Transcranial Magnetic Stimulation
Conditions: Major Depressive Disorder
Intervention: Transcranial Magnetic Stimulation
November 15, 2019
1777
NCT04166851
Not yet recruiting
Not yet recruiting
Using Open Contest and Neuro-influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men
Conditions: HIV/AIDS
Intervention: PrEP Campaign Messages Developed Via Open Contest, PrEP Campaign Messages Developed Via Social Marketing Approach
Conditions: HIV/AIDS
Intervention: PrEP Campaign Messages Developed Via Open Contest, PrEP Campaign Messages Developed Via Social Marketing Approach
November 14, 2019
1778
NCT04166838
Recruiting
Recruiting
The Clinical Study of CD19 UCAR-T Cells in Patients With B-cell Acute Lymphoblastic Leukemia (B-ALL)
Conditions: B-cell Acute Lymphoblastic Leukemia (B-ALL); Safety and Efficacy of CD19 UCAR-T Cells
Intervention: CD19 UCARTcells
Conditions: B-cell Acute Lymphoblastic Leukemia (B-ALL); Safety and Efficacy of CD19 UCAR-T Cells
Intervention: CD19 UCARTcells
November 14, 2019
1779
NCT04166825
Recruiting
Recruiting
Ovarian Hyperstimulation and Fibrin Clot Properties.
Conditions: Fibrin Blood Clot; Infertility, Female; Endometriosis
Intervention: Fibrin Clot Properties
Conditions: Fibrin Blood Clot; Infertility, Female; Endometriosis
Intervention: Fibrin Clot Properties
November 14, 2019
1780
NCT04166812
Recruiting
Recruiting
Change in Airway Peripheral Tone in COPD
Conditions: COPD; COPD, Early-Onset
Intervention: Oscillometry, Multiple Breath Washout Testing, Spirometry, Body Plethysmography, Fractional Exhaled Nitric Oxide, Transfer Factor, Health Status, Computed Tomography, Induced Sputum
Conditions: COPD; COPD, Early-Onset
Intervention: Oscillometry, Multiple Breath Washout Testing, Spirometry, Body Plethysmography, Fractional Exhaled Nitric Oxide, Transfer Factor, Health Status, Computed Tomography, Induced Sputum
November 22, 2019
1781
NCT04166799
Not yet recruiting
Not yet recruiting
Randomized Phase III Trial With Mepitel Film for the Prophylaxis of Radiation Dermatitis in Breast Cancer Patients
Conditions: Breast Cancer; Radiation Dermatitis
Intervention: Mepitel Film
Conditions: Breast Cancer; Radiation Dermatitis
Intervention: Mepitel Film
November 18, 2019
1782
NCT04166786
Completed
Completed
Steroid Profile: Differentiating Testosterone Administration From (Simultaneous) Ethanol Consumption
Conditions: Healthy Volunteers
Intervention: Testosterone Gel, Ethanol Solution, Testosterone Placebo (vaseline), Ethanol Placebo (lemon-flavoured Water)
Conditions: Healthy Volunteers
Intervention: Testosterone Gel, Ethanol Solution, Testosterone Placebo (vaseline), Ethanol Placebo (lemon-flavoured Water)
November 15, 2019
1783
NCT04166773
Recruiting
Recruiting
A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH)
Conditions: Nonalcoholic Steatohepatitis
Intervention: Tirzepatide, Placebo
Conditions: Nonalcoholic Steatohepatitis
Intervention: Tirzepatide, Placebo
December 2, 2019
1784
NCT04166760
Not yet recruiting
Not yet recruiting
Metabolic Effects of Whey Compounds in Patients With Diabetes Mellitus Type 2.
Conditions: Diabetes Mellitus, Type 2
Intervention: SpeWHE, WHE
Conditions: Diabetes Mellitus, Type 2
Intervention: SpeWHE, WHE
November 14, 2019
1785
NCT04166747
Recruiting
Recruiting
Effect of Virtual Reality on Functional Fitness and Quality of Life of Older Population
Conditions: Aging; Happiness; Quality of Life
Intervention: Virtual Reality Experience
Conditions: Aging; Happiness; Quality of Life
Intervention: Virtual Reality Experience
November 26, 2019
1786
NCT04166734
Not yet recruiting
Not yet recruiting
Pembrolizumab and Hypofractionated Stereotactic Radiotherapy in Patients With Malignant Pleural Mesothelioma
Conditions: Advanced Malignant Pleural Mesothelioma
Intervention: Pembrolizumab, Stereotactic Body Radiotherapy (SBRT)
Conditions: Advanced Malignant Pleural Mesothelioma
Intervention: Pembrolizumab, Stereotactic Body Radiotherapy (SBRT)
November 15, 2019
1787
NCT04166721
Not yet recruiting
Not yet recruiting
WaKING: Wnt and checKpoint INhibition in Gastric Cancer
Conditions: Metastatic Esophageal Cancer; Metastatic Gastric Cancer
Intervention: Atezolizumab
Conditions: Metastatic Esophageal Cancer; Metastatic Gastric Cancer
Intervention: Atezolizumab
November 15, 2019
1788
NCT04166708
Completed
Completed
The Footwork Step Technique in Flamenco Dancing
Conditions: Kinesics; Kinematics; Injuries
Conditions: Kinesics; Kinematics; Injuries
November 15, 2019
1789
NCT04166695
Recruiting
Recruiting
Clinical Performance of Long-span Fixed Partial Dentures
Conditions: Partial Edentulism
Intervention: Monolithic / Facially Veneered Zirconia Fixed Partial Denture, Completely Veneered CoCr Fixed Partial Denture
Conditions: Partial Edentulism
Intervention: Monolithic / Facially Veneered Zirconia Fixed Partial Denture, Completely Veneered CoCr Fixed Partial Denture
November 14, 2019
1790
NCT04166682
Not yet recruiting
Not yet recruiting
Impact of Home-based Cardiac Rehabilitation on Outcomes After TAVR
Conditions: Aortic Stenosis
Intervention: Home-based Cardiac Rehabilitation, Routine Care
Conditions: Aortic Stenosis
Intervention: Home-based Cardiac Rehabilitation, Routine Care
November 14, 2019
1791
NCT04166669
Recruiting
Recruiting
A Drug-Drug Interaction Study of CYP3A4 Inhibition and Pan-CYP Induction on APX001
Conditions: Fungal Infection
Intervention: APX001, Itraconazole, Rifampin
Conditions: Fungal Infection
Intervention: APX001, Itraconazole, Rifampin
November 14, 2019
1792
NCT04166656
Not yet recruiting
Not yet recruiting
Research Trial Assessing the Immunogenicity and Safety of Three Meningococal B Vaccine Strategies Among Patients With Asplenia.
Conditions: Splenectomy
Intervention: Trumenba®, Bexsero®
Conditions: Splenectomy
Intervention: Trumenba®, Bexsero®
November 14, 2019
1793
NCT04166643
Not yet recruiting
Not yet recruiting
The Worksite Heart Health Improvement Project-PLUS
Conditions: Worksite Health Promotion; Lifestyle Risk Reduction; Cardiovascular Diseases; Occupational Stress; Healthcare Workers
Intervention: WHHIP PLUS, Education Only Control
Conditions: Worksite Health Promotion; Lifestyle Risk Reduction; Cardiovascular Diseases; Occupational Stress; Healthcare Workers
Intervention: WHHIP PLUS, Education Only Control
November 19, 2019
1794
NCT04166630
Not yet recruiting
Not yet recruiting
Diagnosing Intensive Care Unit (ICU) Acquired Weakness
Conditions: ICU Acquired Weakness
Intervention: Clinical Electrical Stimulator
Conditions: ICU Acquired Weakness
Intervention: Clinical Electrical Stimulator
November 14, 2019
1795
NCT04166617
Active, not recruiting
Active, not recruiting
Assessment Effectiveness of the Leap Motion Capture® System on the Functionality of the Upper Limb in Acquired Brain Injury
Conditions: Stroke; Treatment Adherence; Patient Satisfaction; Brain Injuries, Traumatic
Intervention: Conventional Therapy, Leap Motion Plus Conventional Therapya
Conditions: Stroke; Treatment Adherence; Patient Satisfaction; Brain Injuries, Traumatic
Intervention: Conventional Therapy, Leap Motion Plus Conventional Therapya
November 14, 2019
1796
NCT04166604
Not yet recruiting
Not yet recruiting
LONsurf and G-CSF Use: Being On A Right Dose-intensity to Optimize Treatment Efficacy
Conditions: Metastatic Colorectal Cancer
Intervention: Trifluridine/Tipiracil
Conditions: Metastatic Colorectal Cancer
Intervention: Trifluridine/Tipiracil
November 14, 2019
1797
NCT04166591
Not yet recruiting
Not yet recruiting
Learning New Words From Overhearing in Children With Autism Spectrum Disorder (ASD)
Conditions: Autism Spectrum Disorder
Intervention: Overheard Speech, Addressed Speech
Conditions: Autism Spectrum Disorder
Intervention: Overheard Speech, Addressed Speech
November 14, 2019
1798
NCT04166578
Completed
Completed
Analgetic Effect of Two Solutions of Intracameral Anesthesia During Cataract Surgery in Patients
Conditions: Cataract; Analgesia; Ophthalmological Disorder
Intervention: Lignocaine, Phacoemulsyfication, Intraocular Lens Implantation, Visual Analog Scale For Pain, Brief Pain Inventory-short Form, Best Corrected Visual Acuity Measurment, Slit-lamp Biomicroscopy
Conditions: Cataract; Analgesia; Ophthalmological Disorder
Intervention: Lignocaine, Phacoemulsyfication, Intraocular Lens Implantation, Visual Analog Scale For Pain, Brief Pain Inventory-short Form, Best Corrected Visual Acuity Measurment, Slit-lamp Biomicroscopy
November 14, 2019
1799
NCT04166565
Recruiting
Recruiting
Daratumumab Combined With Bortezomib, Cyclophosphamide and Dexamethasone for the Treatment of Multiple Myeloma Patients Presenting With Extramedullary Disease
Conditions: Multiple Myeloma; Extramedullary Plasmacytoma
Intervention: Daratumumab, Bortezomib, Cyclophosphamide, Dexamethasone
Conditions: Multiple Myeloma; Extramedullary Plasmacytoma
Intervention: Daratumumab, Bortezomib, Cyclophosphamide, Dexamethasone
November 14, 2019
1800
NCT04166552
Not yet recruiting
Not yet recruiting
Evaluation of Safety, Tolerability and Preliminary Efficacy of EHP-101 in Diffuse Cutaneous Systemic Sclerosis
Conditions: Diffuse Cutaneous Systemic Sclerosis
Intervention: Patients Will Be Randomized To Receive EHP-101 Or Placebo, Patients Will Be Randomized To Receive EHP-101 Or Placebo
Conditions: Diffuse Cutaneous Systemic Sclerosis
Intervention: Patients Will Be Randomized To Receive EHP-101 Or Placebo, Patients Will Be Randomized To Receive EHP-101 Or Placebo
November 14, 2019
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Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.