Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[BasicSearch] Chelation
First Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Next Last
Completed
Conditions: Iron-deficiency; Iron Deficiency Anemia
Intervention: Phytic Acid
Completed
Conditions: Iron Overload; Excessive Body Iron Burden
Intervention: R2*-UTE, R2*-GRE, Liver Biopsy
Completed
Completed
Conditions: Chronic Liver Disease
Intervention: Nutritional Supplement, Standard Nutritional Treatment
Completed
Conditions: Sickle Cell Disease
Intervention: Music Therapy
Recruiting
Conditions: Beta-Thalassemia
Intervention: LJPC-401, LJPC-401
Completed
Conditions: Iron Deficiency Anemia
Intervention: Ferrous Bis-glycinate, Ferrous Glycine Sulphate
Unknown status
Conditions: Cardiotoxicity
Intervention: Remote Ischaemic Conditioning, Placebo
Completed
Conditions: Thalassemia Major; Chronic Blood Transfusion Related Iron Overload
Completed
Conditions: Beta Thalassemia Major
Intervention: Spirulina, Amlodipine
Completed
Conditions: Autism Spectrum Disorders; Autism
Completed
Conditions: Heart Failure; Iron Overload; Cardiomyopathies
Intervention: MR T2* Imaging
Completed
Conditions: Wilson Disease
Intervention: Once A Day Trientine
Completed
Conditions: Age-Related Macular Degeneration
Intervention: Alpha Lipoic Acid, Placebo
Recruiting
Conditions: Bone Marrow Transplant; Sickle Cell Disease; G-CSF
Completed
Conditions: Prosthetic Joint Infection
Unknown status
Conditions: Myelodysplastic Syndromes
Intervention: Darbepoetin And Filgrastim, Darbepoetin
Recruiting
Conditions: Trientine Treatment for Wilson's Disease
Intervention: Trientine
Completed
Conditions: Beta Thalassemia; Hemoglobinopathy
Intervention: Hydroxyurea
Completed
Conditions: Liver Iron Overload
Completed
Conditions: Beta Thalassemia
Intervention: 5-Azacytidine
Completed
Conditions: Hemodialysis; Citrate; Heparin
Intervention: Citrate Dialysate
Completed
Conditions: Idiopathic Pulmonary Fibrosis
Intervention: Tetrathiomolybdate
Completed
Conditions: Thalassemia; Iron Overload; Hemochromatosis
Intervention: Nifedipine, Phlebotomy, Urinalysis, Echocardiogram, Electrocardiogram
Completed
Conditions: Toxicity
Intervention: Transdermal DMPS
Active, not recruiting
Conditions: Iron Overload Due to Repeated Red Blood Cell Transfusions
Intervention: Deferiprone DR Tablets 1000 Mg (Low Dosage), Deferiprone DR Tablets 1000 Mg (High Dosage)
Completed
Conditions: Transfusional Hemosiderosis
Intervention: Deferasirox
Completed
Conditions: Immune Abnormalities
Intervention: Desferrioxamine, Legalon® (Silymarin), Silymarin (Legalon)
Completed
Conditions: Myelodysplastic Syndromes; Hemosiderosis
Intervention: Deferasirox
Recruiting
Conditions: Thalassemia
Intervention: Interleukin-6, HsC-RP, Adiponectin Level, Carotid Intima Media Thickness
Unknown status
Conditions: AL-Hijama in Thalassmia Major
Intervention: Al-hijamah, Deferasirox
Completed
Conditions: End-stage Renal Disease; Hyperphosphatemia
Completed
Conditions: Type 1 Diabetes; Oxidative Stress; Carnosine; Diabetic Nephropathy
Unknown status
Conditions: Sickle Cell Disease; Thalassemia; Diamond-Blackfan Anemia
Completed
Conditions: Follicular Lymphoma
Intervention: FM+R, Zevalin (Ibritumomab Tiuxetan)
Completed
Conditions: Diffuse Large B-Cell Lymphoma
Completed
Conditions: Wilson's Disease
Active, not recruiting
Conditions: Transfusion-dependent Thalassemia; Non-transfusion-dependent Thalassemia
Active, not recruiting
Conditions: Iron Over Load
Intervention: Deferasirox
Unknown status
Conditions: Acute Kidney Injury
Intervention: Deferiprone, Placebo
Completed
Conditions: Contrast-Induced Acute Kidney Injury
Intervention: CRMD-001-Deferiprone, Placebo
Completed
Conditions: Thalassemia; Iron Overload
Intervention: Deferasirox
Completed
Conditions: Parkinson's Disease
Intervention: Deferiprone, Placebo
Terminated
Conditions: Iron Overload; Beta-Thalassemia
Completed
Conditions: Myelodysplastic Syndrome
Intervention: Exjade
Completed
Conditions: Kidney Failure, Chronic; End-stage Renal Disease; Phosphorus Metabolism Disorders; Hyperphosphatemia
Intervention: Ferric Citrate
Terminated
Conditions: Refractory Cancer
Unknown status
Conditions: Breast Cancer
Intervention: Gadolinium-chelate, Conventional Surgery, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopic Imaging
Completed
Conditions: Beta-thalassemia; Iron Overload
Intervention: Deferasirox
Enrolling by invitation
Conditions: Iron Overload; Sickle Cell Disease; Other Anemias
Intervention: Deferiprone
First Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Next Last
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Examples:
97-h-0197
ia0006
actg 076
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
There are three types of studies available in ClinicalTrials.gov:
Observational:
Expanded Access:
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help Topics:
Basic Search:
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Open recruitment status values:
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Studies With Results, or
Studies Without Results
Observational, or
Expanded Access
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
Refine Search:
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
For example:
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.