ICH GCP | Clinical Trials Registry

Clinical Trials: SEARCH[STUDY] TILT[STUDY:STUDY-FIRST-POSTED] ( Chelation [STUDY:ALL-FIELDS] )



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#
NCTID/Status
Study
Last Changed
101
NCT02590224
Completed
The Effect of Iron Deficiency Anemia During Pregnancy
Conditions: Iron Deficiency Anemia
Intervention: Ferrous Bis-glycinate, Ferrous Glycine Sulphate
March 17, 2018
102
NCT02471885
Unknown status
Effect of Remote Ischaemic Conditioning in Oncology Patients
Conditions: Cardiotoxicity
Intervention: Remote Ischaemic Conditioning, Placebo
October 13, 2016
103
NCT02090699
Completed
MR Imaging of Diffuse Myocardial Fibrosis in Transfusion-Dependent Anemias
Conditions: Thalassemia Major; Chronic Blood Transfusion Related Iron Overload
July 16, 2014
104
NCT02671695
Completed
Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta Thalassemia
Conditions: Beta Thalassemia Major
Intervention: Spirulina, Amlodipine
July 11, 2018
105
NCT02191657
Completed
Antiretroviral Activity and Pharmacokinetics of Deferiprone in Healthy Volunteers and Asymptomatic HIV-infected Subjects
Conditions: HIV Infection
Intervention: Deferiprone
July 14, 2014
106
NCT00938054
Completed
Identification of Characteristics Associated With Symptom Remission in Autism
Conditions: Autism Spectrum Disorders; Autism
October 5, 2017
107
NCT02527330
Completed
Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging
Conditions: Heart Failure; Iron Overload; Cardiomyopathies
Intervention: MR T2* Imaging
July 23, 2017
108
NCT01472874
Completed
Single Daily Dosage of Trientine for Maintenance Treatment for Wilson Disease
Conditions: Wilson Disease
Intervention: Once A Day Trientine
May 19, 2014
109
NCT02613572
Completed
Alpha Lipoic Acid in Geographic Atrophy
Conditions: Age-Related Macular Degeneration
Intervention: Alpha Lipoic Acid, Placebo
August 12, 2019
110
NCT00695123
Recruiting
Screening for Subjects to Participate in Studies of Blood Disorders
Conditions: Bone Marrow Transplant; Sickle Cell Disease; G-CSF
August 9, 2019
111
NCT02413034
Completed
The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures
Conditions: Prosthetic Joint Infection
Intervention: Cefazolin, Control Group
June 22, 2016
112
NCT00234143
Unknown status
Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)
Conditions: Myelodysplastic Syndromes
Intervention: Darbepoetin And Filgrastim, Darbepoetin
March 11, 2009
113
NCT03299829
Recruiting
A Retrospective Study to Assess the Clinical Efficacy and Safety of Trientine in Wilson's Disease Patients
Conditions: Trientine Treatment for Wilson's Disease
Intervention: Trientine
February 11, 2019
114
NCT00001958
Completed
Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia)
Conditions: Beta Thalassemia; Hemoglobinopathy
Intervention: Hydroxyurea
March 3, 2008
115
NCT01033747
Completed
Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension Study
Conditions: Liver Iron Overload
Intervention: Deferasirox, Deferasirox
July 18, 2011
116
NCT00005934
Completed
5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia
Conditions: Beta Thalassemia
Intervention: 5-Azacytidine
March 3, 2008
117
NCT03470727
Completed
The Effect of Citrate Dialysate on Clot Formation and Anemia in Hemodialysis Patients
Conditions: Hemodialysis; Citrate; Heparin
Intervention: Citrate Dialysate
March 19, 2018
118
NCT00189176
Completed
Safety Study of Tetrathiomolybdate in Patients With Idiopathic Pulmonary Fibrosis
Conditions: Idiopathic Pulmonary Fibrosis
Intervention: Tetrathiomolybdate
February 5, 2013
119
NCT00712738
Completed
Oral Nifedipine to Treat Iron Overload
Conditions: Thalassemia; Iron Overload; Hemochromatosis
Intervention: Nifedipine, Phlebotomy, Urinalysis, Echocardiogram, Electrocardiogram
June 30, 2017
120
NCT03802916
Recruiting
Safety and Acceptability of Deferiprone Delayed Release Tablets in Patients With Systemic Iron Overload
Conditions: Iron Overload Due to Repeated Red Blood Cell Transfusions
Intervention: Deferiprone DR Tablets 1000 Mg (Low Dosage), Deferiprone DR Tablets 1000 Mg (High Dosage)
June 24, 2019
121
NCT01394029
Completed
Observation of Patients With Transfusional Hemosiderosis Treatment With Deferasirox
Conditions: Transfusional Hemosiderosis
Intervention: Deferasirox
February 1, 2016
122
NCT01752153
Completed
Immunomodulatory Effects of Silymarin in Patients With Beta-Thalassemia Major
Conditions: Immune Abnormalities
Intervention: Desferrioxamine, Legalon® (Silymarin), Silymarin (Legalon)
December 18, 2012
123
NCT01059474
Completed
Transdermal Absorption of Dimercaptopropane-1-Sulfonate (DMPS) and Effect on Urinary Mercury Excretion
Conditions: Toxicity
Intervention: Transdermal DMPS
June 21, 2011
124
NCT00469560
Completed
Safety, Tolerability, and Efficacy of Deferasirox in MDS
Conditions: Myelodysplastic Syndromes; Hemosiderosis
Intervention: Deferasirox
November 21, 2016
125
NCT03170245
Enrolling by invitation
Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients
Conditions: Thalassemia
Intervention: Interleukin-6, HsC-RP, Adiponectin Level, Carotid Intima Media Thickness
January 1, 2019
126
NCT02761395
Unknown status
Study of The Therapeutic Benefits of Al-hijamah in Children With Beta Thalassemia Major
Conditions: AL-Hijama in Thalassmia Major
Intervention: Al-hijamah, Deferasirox
April 24, 2017
127
NCT01965379
Completed
Effect of Restriction of Foods Containing Phosphorus Additives
Conditions: End-stage Renal Disease; Hyperphosphatemia
Intervention: Restriction On Food Containing Phosphorus Additives, Standard Care
March 9, 2015
128
NCT02928250
Completed
Role of Carnosine as an Adjuvant Therapy for Diabetic Nephropathy in Pediatrics With Type 1 Diabetes
Conditions: Type 1 Diabetes; Oxidative Stress; Carnosine; Diabetic Nephropathy
Intervention: Carnosine, Placebo
October 7, 2016
129
NCT01913548
Unknown status
Multi-Center Study of Iron Overload: Survey Study (MCSIO)
Conditions: Sickle Cell Disease; Thalassemia; Diamond-Blackfan Anemia
July 30, 2013
130
NCT00859001
Completed
Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) Study in Patients With Follicular Grade I-II Lymphoma After 4 Cycles of Fludarabine-Mitoxantrone-Rituximab (FMR) Therapy
Conditions: Follicular Lymphoma
Intervention: FM+R, Zevalin (Ibritumomab Tiuxetan)
March 10, 2009
131
NCT00850512
Completed
Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) in Elderly (More Than 60 Years) Patients With Diffuse Large B Cell Lymphoma After 4 Cycles of CHOP21-Rituximab (CHOP21-R) Therapy
Conditions: Diffuse Large B-Cell Lymphoma
Intervention: CHOP21-R, Zevalin
February 24, 2009
132
NCT01378182
Completed
Efficacy of Invitro Expanded Bone Marrow Derived Allogeneic Mesenchymal Stem Cell Transplantation Via Portal Vein or Hepatic Artery or Peripheral Vein in Patients With Wilson Cirrhosis
Conditions: Wilson's Disease
Intervention: Allogeneic Mesenchymal Stem Cell Transplantation
December 30, 2014
133
NCT02993224
Recruiting
Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet
Conditions: Transfusion-dependent Thalassemia; Non-transfusion-dependent Thalassemia
Intervention: Deferasirox Dispersable Tablet (DT), Deferasirox Film Coated Tablet (FCT)
July 16, 2019
134
NCT03372083
Active, not recruiting
Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis
Conditions: Iron Over Load
Intervention: Deferasirox
July 11, 2019
135
NCT01391520
Unknown status
Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent
Conditions: Acute Kidney Injury
Intervention: Deferiprone, Placebo
July 8, 2011
136
NCT01146925
Completed
Deferiprone for the Prevention of Contrast-Induced Acute Kidney Injury
Conditions: Contrast-Induced Acute Kidney Injury
Intervention: CRMD-001-Deferiprone, Placebo
June 23, 2011
137
NCT01905774
Completed
Renal Function Among Thalassemia Patients Treated by a Oral Chelator Deferasirox
Conditions: Thalassemia; Iron Overload
Intervention: Deferasirox
August 30, 2015
138
NCT00943748
Completed
Efficacy and Safety of the Iron Chelator Deferiprone in Parkinson's Disease
Conditions: Parkinson's Disease
Intervention: Deferiprone, Placebo
August 31, 2012
139
NCT02274233
Terminated
Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia
Conditions: Iron Overload; Beta-Thalassemia
Intervention: SP-420
September 28, 2015
140
NCT00452660
Completed
Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load
Conditions: Myelodysplastic Syndrome
Intervention: Exjade
June 13, 2014
141
NCT03256838
Completed
Assess the Safety and Efficacy of Nephoxil® in Subjects With End Stage Renal Disease (ESRD) on Dialysis
Conditions: Kidney Failure, Chronic; End-stage Renal Disease; Phosphorus Metabolism Disorders; Hyperphosphatemia
Intervention: Ferric Citrate
June 13, 2019
142
NCT02222363
Terminated
Study of Safety and Tolerability of VLX600, an Iron Chelator, in Patients With Refractory Advanced Solid Tumors
Conditions: Refractory Cancer
Intervention: VLX600
May 3, 2018
143
NCT00447694
Completed
Cardiac T2* in Beta-thalassemia Patients on Deferasirox Treatment
Conditions: Beta-thalassemia; Iron Overload
Intervention: Deferasirox
September 22, 2016
144
NCT02443545
Enrolling by invitation
Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias
Conditions: Iron Overload; Sickle Cell Disease; Other Anemias
Intervention: Deferiprone
January 10, 2019
145
NCT00811083
Completed
Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity
Conditions: Autism
Intervention: DMSA - Dimercaptosuccinic Acid
December 17, 2008
146
NCT01220115
Completed
A 5-year, Prospective, Non-interventional, Multicenter Registry in Sickle Cell Disease (SCD) Patients
Conditions: Sickle Cell Disease
May 18, 2015
147
NCT03397017
Enrolling by invitation
Transfusion Treatment in Patients With SCD
Conditions: Anemia, Sickle Cell
Intervention: Transfusion
April 3, 2019
148
NCT00419770
Completed
The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study
Conditions: Mucormycosis
Intervention: Deferasirox, Placebo, Liposomal Amphotericin B
September 2, 2011
149
NCT03816800
Recruiting
Iron and Pollen Allergy in Women
Conditions: Allergy Pollen; Healthy
Intervention: ImmunoBon, Placebo
February 11, 2019
150
NCT02133560
Completed
Use of Mobile Technology for Intensive Training in Medication Management
Conditions: Sickle Cell Disease; Thalassemia
Intervention: Video Recording, Medication Administration Log, Education
May 24, 2017

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Last Updated

The last updated date is the most recent date when changes to a clinical trial were submitted to ClinicalTrials.gov. There is often a delay of a few days before the updated trial is available on the clinical trials website.

Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

First Received

The first received date is the date when the clinical trial was first submitted to ClinicalTrials.gov. There is often a delay of a few days before the trial is available on the clinical trials website.

Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.

Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

Safety Issue

If selected, restricts search results to those studies which have an outcome measure designated as a safety issue. Note that this is a poor estimate of the safety of a treatment or intervention, but it is all we have now.

Funded By

Studies are supported by one or more organizations called sponsors. Support includes contributions of facilities, expertise, and/or financial resources. All sponsors in the database have been assigned one of the following organization types:

National Institutes of Health (NIH)

Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.

Industry - the pharmaceutical companies

University/Organization - all others, including community-based organizations

Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.

Study Phase

Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions that study is seeking to answer:

In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.

In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.

In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.

In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.

These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.

Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.

Age Group

Studies may be designed for participants of particular ages:

Children (birth-17 yrs old)

Adults (18-65 yrs old)

Senior (66+ yrs old)

Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.

Gender

Searches can be restricted to studies which accept female or male participants.
Location Terms

If you are interested in a specific city (such as Los Angeles) or facility name (such as the Mayo Clinic), enter it as a location term. Not all studies include this level of detail, but if they do, this will find them.

Countries and States

Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state.

Study IDs

Each trial is assigned one or more identification numbers by the institute, agency, or organization sponsoring the trial. In addition, clinical trials assigns a unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit. Use this box to search for a trial by NCT identifier or any other study identification numbers.

Examples:

NCT00001789
97-h-0197
ia0006
actg 076

Sponsor (Lead)

Use this box to specify the name of an institute, organization, or company that is conducting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.

When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators

Use this box to specify institutes, organizations, or companies that are conducting or otherwise supporting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.

When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb

Outcome Measures

Outcome measures are used to evaluate trial results. For example, an obesity treatment might be evaluated by a measure of weight loss after 6 months. Measures can also be used to quantify side effects, such as number of myocardial infarctions, number of patients with heart arrhythmia, number of suicides, etc.

Use this box to specify an outcome measure used to evaluate trial results.

Examples:

weight loss
heart failure
suicide

Interventions

Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied. Interventions can also include less intrusive possibilities such as surveys, education, and interviews.

Use this box to specify drugs, devices, procedures, or vaccines used in a trial.

Examples:

clofibrate
cyclosporine
vitamin e

Conditions

Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov, conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.

Use this box to specify the conditions being studied.

Examples:

lupus
heart attack
leukemia
risk factors for breast cancer

Study Type

There are three types of studies available in ClinicalTrials.gov:

Interventional:

Studies where individuals are assigned to receive specific interventions. Participants may receive diagnostic, therapeutic or other types of interventions. Assignment of the intervention may or may not be random. Individuals are tracked and biomedical and/or health outcomes are assessed.

Observational:

Studies without an intervention. Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals. Participants may receive diagnostic, therapeutic, or other interventions, but the investigator does not assign specific interventions to the participants of the study.

Expanded Access:

Records describing the procedure for obtaining an experimental drug or device for patients who are failing on currently available treatments for their condition and also are unable to participate in ongoing clinical trials. Expanded Access records are used to register all types of non-protocol access to experimental treatments, including protocol exception, single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.

Study Results

Searches can be restricted to studies with or without results.

The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.

Recruitment Status

Also known as Enrollment Status.

Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.

If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.

Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.

Full list of all possible recruitment status values:

Open recruitment status values:

Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:

Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Search Terms

Use this box to specify general search terms found anywhere in the trial record.

Multiple terms can be separated by an AND (all uppercase).

Examples:

type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study


Help for Searching clinical trials

Help Topics:
Basic Search
Advanced Search
Refine Search
Search Expressions


Basic Search:

On the Basic Search page, enter a word or word(s) that you want to use to find studies. These may include diseases, interventions, and/or locations.

Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks

A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.


Advanced Search:

Many searches are a single term and can be performed with a few words in the search box. But, sometimes you need more control. Click on the Advanced Search tab (if starting a new search) or Refine Search tab (if modifying an existing search) to show additional search fields.

The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.

Search Terms:
Performs a general search in all sections of the study record, including title, description, conditions, interventions, locations, etc. Terms in this field are searched the same as Basic Search.

Recruitment:
Limits search results to studies that are open or closed. New volunteers may be able to participate in open studies, but not closed studies.

Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Study Results:
Limits search results based on whether the study has results or not:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov. Only a few studies have results available.

Study Type:
Limits search results to any of the following study types:
Interventional,
Observational, or
Expanded Access

Conditions:
Performs a search on fields describing the diseases or conditions being studied.

Interventions:
Performs a search on fields listing the drugs or interventions being studied.

Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.

Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.

When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Sponsor (Lead):
Performs a search on the sponsor field of a study.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.

When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Study IDs:
Performs a search on fields listing ID numbers.

Country/State:
Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state (e.g., United States, Alabama).

Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic). Not all studies include this level of detail, but if they do, this will find them.

Gender:
Limits search results to those studies that accept female or male participants.

Age Group:
Limits search results to those studies that include at least one of the specified age ranges. More than one age group can be selected.

Phase:
Limits search results to studies that are labeled with at least one of the specified phases. More than one Phase can be selected.

Funded By:
Limits search results to studies that have at least one sponsor of the specified types. More than one sponsor type can be selected.

Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.

First Received:
Limits search results to studies that were received by clinical trials within a specified date range. The "From" or "To" field can be left blank.

Last Updated:
Limits search results to studies that were modified within a specified date range. The "From" or "To" field can be left blank.


Refine Search:

Searches display a list of studies found (List Results tab). If you are not content with the search results, click on the Refine Search tab at the top of the list to modify your search.

Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.

For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California

When you are done making changes, click Search to display the new results.


Search Expressions:

Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California

Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack

Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS

Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )

Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.

To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.

Conditions

Alphabetic (A-Z)
By Category

Rare Diseases

Alphabetic (A-Z)

Drug
Interventions

Alphabetic (A-Z)
By Category

Dietary
Supplements

Alphabetic (A-Z)
By Category

Sponsor/
Collaborators

Alphabetic (A-Z)
By Category

Locations

Alphabetic (A-Z)
By Category