Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[BasicSearch] Chelation
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NCTID/Status
Study
Last Changed
101
NCT03030703
Completed
Completed
Cystatin SN Binds to Phytic Acid and Predicts Non-heme Iron Bioavailability
Conditions: Iron-deficiency; Iron Deficiency Anemia
Intervention: Phytic Acid
Conditions: Iron-deficiency; Iron Deficiency Anemia
Intervention: Phytic Acid
January 24, 2017
102
NCT01572922
Completed
Completed
Massive Iron Deposit Assessment
Conditions: Iron Overload; Excessive Body Iron Burden
Intervention: R2*-UTE, R2*-GRE, Liver Biopsy
Conditions: Iron Overload; Excessive Body Iron Burden
Intervention: R2*-UTE, R2*-GRE, Liver Biopsy
June 3, 2019
103
NCT03233269
Completed
Completed
October 19, 2018
104
NCT02715973
Completed
Completed
Nutritional Assessment Tool and Nutritional Intervention in Childhood Chronic Liver Disease
Conditions: Chronic Liver Disease
Intervention: Nutritional Supplement, Standard Nutritional Treatment
Conditions: Chronic Liver Disease
Intervention: Nutritional Supplement, Standard Nutritional Treatment
December 4, 2018
105
NCT02466555
Completed
Completed
Music Therapy in Sickle Cell Transition Study
Conditions: Sickle Cell Disease
Intervention: Music Therapy
Conditions: Sickle Cell Disease
Intervention: Music Therapy
August 7, 2019
106
NCT03381833
Recruiting
Recruiting
A Study With LJPC-401 for the Treatment of Myocardial Iron Overload in Adult Patients With Transfusion-Dependent Beta Thalassemia
Conditions: Beta-Thalassemia
Intervention: LJPC-401, LJPC-401
Conditions: Beta-Thalassemia
Intervention: LJPC-401, LJPC-401
January 8, 2019
107
NCT02590224
Completed
Completed
The Effect of Iron Deficiency Anemia During Pregnancy
Conditions: Iron Deficiency Anemia
Intervention: Ferrous Bis-glycinate, Ferrous Glycine Sulphate
Conditions: Iron Deficiency Anemia
Intervention: Ferrous Bis-glycinate, Ferrous Glycine Sulphate
March 17, 2018
108
NCT02471885
Unknown status
Unknown status
Effect of Remote Ischaemic Conditioning in Oncology Patients
Conditions: Cardiotoxicity
Intervention: Remote Ischaemic Conditioning, Placebo
Conditions: Cardiotoxicity
Intervention: Remote Ischaemic Conditioning, Placebo
October 13, 2016
109
NCT02090699
Completed
Completed
MR Imaging of Diffuse Myocardial Fibrosis in Transfusion-Dependent Anemias
Conditions: Thalassemia Major; Chronic Blood Transfusion Related Iron Overload
Conditions: Thalassemia Major; Chronic Blood Transfusion Related Iron Overload
July 16, 2014
110
NCT02671695
Completed
Completed
Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta Thalassemia
Conditions: Beta Thalassemia Major
Intervention: Spirulina, Amlodipine
Conditions: Beta Thalassemia Major
Intervention: Spirulina, Amlodipine
July 11, 2018
111
NCT00938054
Completed
Completed
Identification of Characteristics Associated With Symptom Remission in Autism
Conditions: Autism Spectrum Disorders; Autism
Conditions: Autism Spectrum Disorders; Autism
October 5, 2017
112
NCT02527330
Completed
Completed
Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging
Conditions: Heart Failure; Iron Overload; Cardiomyopathies
Intervention: MR T2* Imaging
Conditions: Heart Failure; Iron Overload; Cardiomyopathies
Intervention: MR T2* Imaging
July 23, 2017
113
NCT01472874
Completed
Completed
Single Daily Dosage of Trientine for Maintenance Treatment for Wilson Disease
Conditions: Wilson Disease
Intervention: Once A Day Trientine
Conditions: Wilson Disease
Intervention: Once A Day Trientine
May 19, 2014
114
NCT02613572
Completed
Completed
Alpha Lipoic Acid in Geographic Atrophy
Conditions: Age-Related Macular Degeneration
Intervention: Alpha Lipoic Acid, Placebo
Conditions: Age-Related Macular Degeneration
Intervention: Alpha Lipoic Acid, Placebo
August 12, 2019
115
NCT00695123
Recruiting
Recruiting
Screening for Subjects to Participate in Studies of Blood Disorders
Conditions: Bone Marrow Transplant; Sickle Cell Disease; G-CSF
Conditions: Bone Marrow Transplant; Sickle Cell Disease; G-CSF
December 4, 2019
116
NCT02413034
Completed
Completed
The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures
Conditions: Prosthetic Joint Infection
Conditions: Prosthetic Joint Infection
June 22, 2016
117
NCT00234143
Unknown status
Unknown status
Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)
Conditions: Myelodysplastic Syndromes
Intervention: Darbepoetin And Filgrastim, Darbepoetin
Conditions: Myelodysplastic Syndromes
Intervention: Darbepoetin And Filgrastim, Darbepoetin
March 11, 2009
118
NCT03299829
Recruiting
Recruiting
A Retrospective Study to Assess the Clinical Efficacy and Safety of Trientine in Wilson's Disease Patients
Conditions: Trientine Treatment for Wilson's Disease
Intervention: Trientine
Conditions: Trientine Treatment for Wilson's Disease
Intervention: Trientine
February 11, 2019
119
NCT00001958
Completed
Completed
Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia)
Conditions: Beta Thalassemia; Hemoglobinopathy
Intervention: Hydroxyurea
Conditions: Beta Thalassemia; Hemoglobinopathy
Intervention: Hydroxyurea
March 3, 2008
120
NCT01033747
Completed
Completed
Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension Study
Conditions: Liver Iron Overload
Conditions: Liver Iron Overload
July 18, 2011
121
NCT00005934
Completed
Completed
5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia
Conditions: Beta Thalassemia
Intervention: 5-Azacytidine
Conditions: Beta Thalassemia
Intervention: 5-Azacytidine
March 3, 2008
122
NCT03470727
Completed
Completed
The Effect of Citrate Dialysate on Clot Formation and Anemia in Hemodialysis Patients
Conditions: Hemodialysis; Citrate; Heparin
Intervention: Citrate Dialysate
Conditions: Hemodialysis; Citrate; Heparin
Intervention: Citrate Dialysate
March 19, 2018
123
NCT00189176
Completed
Completed
Safety Study of Tetrathiomolybdate in Patients With Idiopathic Pulmonary Fibrosis
Conditions: Idiopathic Pulmonary Fibrosis
Intervention: Tetrathiomolybdate
Conditions: Idiopathic Pulmonary Fibrosis
Intervention: Tetrathiomolybdate
February 5, 2013
124
NCT00712738
Completed
Completed
Oral Nifedipine to Treat Iron Overload
Conditions: Thalassemia; Iron Overload; Hemochromatosis
Intervention: Nifedipine, Phlebotomy, Urinalysis, Echocardiogram, Electrocardiogram
Conditions: Thalassemia; Iron Overload; Hemochromatosis
Intervention: Nifedipine, Phlebotomy, Urinalysis, Echocardiogram, Electrocardiogram
June 30, 2017
125
NCT01059474
Completed
Completed
Transdermal Absorption of Dimercaptopropane-1-Sulfonate (DMPS) and Effect on Urinary Mercury Excretion
Conditions: Toxicity
Intervention: Transdermal DMPS
Conditions: Toxicity
Intervention: Transdermal DMPS
June 21, 2011
126
NCT03802916
Active, not recruiting
Active, not recruiting
Safety and Acceptability of Deferiprone Delayed Release Tablets in Patients With Systemic Iron Overload
Conditions: Iron Overload Due to Repeated Red Blood Cell Transfusions
Intervention: Deferiprone DR Tablets 1000 Mg (Low Dosage), Deferiprone DR Tablets 1000 Mg (High Dosage)
Conditions: Iron Overload Due to Repeated Red Blood Cell Transfusions
Intervention: Deferiprone DR Tablets 1000 Mg (Low Dosage), Deferiprone DR Tablets 1000 Mg (High Dosage)
November 14, 2019
127
NCT01394029
Completed
Completed
Observation of Patients With Transfusional Hemosiderosis Treatment With Deferasirox
Conditions: Transfusional Hemosiderosis
Intervention: Deferasirox
Conditions: Transfusional Hemosiderosis
Intervention: Deferasirox
February 1, 2016
128
NCT01752153
Completed
Completed
Immunomodulatory Effects of Silymarin in Patients With Beta-Thalassemia Major
Conditions: Immune Abnormalities
Intervention: Desferrioxamine, Legalon® (Silymarin), Silymarin (Legalon)
Conditions: Immune Abnormalities
Intervention: Desferrioxamine, Legalon® (Silymarin), Silymarin (Legalon)
December 18, 2012
129
NCT00469560
Completed
Completed
Safety, Tolerability, and Efficacy of Deferasirox in MDS
Conditions: Myelodysplastic Syndromes; Hemosiderosis
Intervention: Deferasirox
Conditions: Myelodysplastic Syndromes; Hemosiderosis
Intervention: Deferasirox
November 21, 2016
130
NCT03170245
Recruiting
Recruiting
Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients
Conditions: Thalassemia
Intervention: Interleukin-6, HsC-RP, Adiponectin Level, Carotid Intima Media Thickness
Conditions: Thalassemia
Intervention: Interleukin-6, HsC-RP, Adiponectin Level, Carotid Intima Media Thickness
September 16, 2019
131
NCT02761395
Unknown status
Unknown status
Study of The Therapeutic Benefits of Al-hijamah in Children With Beta Thalassemia Major
Conditions: AL-Hijama in Thalassmia Major
Intervention: Al-hijamah, Deferasirox
Conditions: AL-Hijama in Thalassmia Major
Intervention: Al-hijamah, Deferasirox
April 24, 2017
132
NCT01965379
Completed
Completed
Effect of Restriction of Foods Containing Phosphorus Additives
Conditions: End-stage Renal Disease; Hyperphosphatemia
Conditions: End-stage Renal Disease; Hyperphosphatemia
March 9, 2015
133
NCT02928250
Completed
Completed
Role of Carnosine as an Adjuvant Therapy for Diabetic Nephropathy in Pediatrics With Type 1 Diabetes
Conditions: Type 1 Diabetes; Oxidative Stress; Carnosine; Diabetic Nephropathy
Conditions: Type 1 Diabetes; Oxidative Stress; Carnosine; Diabetic Nephropathy
October 7, 2016
134
NCT01913548
Unknown status
Unknown status
Multi-Center Study of Iron Overload: Survey Study (MCSIO)
Conditions: Sickle Cell Disease; Thalassemia; Diamond-Blackfan Anemia
Conditions: Sickle Cell Disease; Thalassemia; Diamond-Blackfan Anemia
July 30, 2013
135
NCT00859001
Completed
Completed
Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) Study in Patients With Follicular Grade I-II Lymphoma After 4 Cycles of Fludarabine-Mitoxantrone-Rituximab (FMR) Therapy
Conditions: Follicular Lymphoma
Intervention: FM+R, Zevalin (Ibritumomab Tiuxetan)
Conditions: Follicular Lymphoma
Intervention: FM+R, Zevalin (Ibritumomab Tiuxetan)
March 10, 2009
136
NCT00850512
Completed
Completed
Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) in Elderly (More Than 60 Years) Patients With Diffuse Large B Cell Lymphoma After 4 Cycles of CHOP21-Rituximab (CHOP21-R) Therapy
Conditions: Diffuse Large B-Cell Lymphoma
Conditions: Diffuse Large B-Cell Lymphoma
February 24, 2009
137
NCT01378182
Completed
Completed
Efficacy of Invitro Expanded Bone Marrow Derived Allogeneic Mesenchymal Stem Cell Transplantation Via Portal Vein or Hepatic Artery or Peripheral Vein in Patients With Wilson Cirrhosis
Conditions: Wilson's Disease
Conditions: Wilson's Disease
December 30, 2014
138
NCT02993224
Active, not recruiting
Active, not recruiting
Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet
Conditions: Transfusion-dependent Thalassemia; Non-transfusion-dependent Thalassemia
Conditions: Transfusion-dependent Thalassemia; Non-transfusion-dependent Thalassemia
August 28, 2019
139
NCT03372083
Active, not recruiting
Active, not recruiting
Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis
Conditions: Iron Over Load
Intervention: Deferasirox
Conditions: Iron Over Load
Intervention: Deferasirox
July 11, 2019
140
NCT01391520
Unknown status
Unknown status
Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent
Conditions: Acute Kidney Injury
Intervention: Deferiprone, Placebo
Conditions: Acute Kidney Injury
Intervention: Deferiprone, Placebo
July 8, 2011
141
NCT01146925
Completed
Completed
Deferiprone for the Prevention of Contrast-Induced Acute Kidney Injury
Conditions: Contrast-Induced Acute Kidney Injury
Intervention: CRMD-001-Deferiprone, Placebo
Conditions: Contrast-Induced Acute Kidney Injury
Intervention: CRMD-001-Deferiprone, Placebo
June 23, 2011
142
NCT01905774
Completed
Completed
Renal Function Among Thalassemia Patients Treated by a Oral Chelator Deferasirox
Conditions: Thalassemia; Iron Overload
Intervention: Deferasirox
Conditions: Thalassemia; Iron Overload
Intervention: Deferasirox
August 30, 2015
143
NCT00943748
Completed
Completed
Efficacy and Safety of the Iron Chelator Deferiprone in Parkinson's Disease
Conditions: Parkinson's Disease
Intervention: Deferiprone, Placebo
Conditions: Parkinson's Disease
Intervention: Deferiprone, Placebo
August 31, 2012
144
NCT02274233
Terminated
Terminated
Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia
Conditions: Iron Overload; Beta-Thalassemia
Conditions: Iron Overload; Beta-Thalassemia
September 28, 2015
145
NCT00452660
Completed
Completed
Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load
Conditions: Myelodysplastic Syndrome
Intervention: Exjade
Conditions: Myelodysplastic Syndrome
Intervention: Exjade
June 13, 2014
146
NCT03256838
Completed
Completed
Assess the Safety and Efficacy of Nephoxil® in Subjects With End Stage Renal Disease (ESRD) on Dialysis
Conditions: Kidney Failure, Chronic; End-stage Renal Disease; Phosphorus Metabolism Disorders; Hyperphosphatemia
Intervention: Ferric Citrate
Conditions: Kidney Failure, Chronic; End-stage Renal Disease; Phosphorus Metabolism Disorders; Hyperphosphatemia
Intervention: Ferric Citrate
June 13, 2019
147
NCT02222363
Terminated
Terminated
Study of Safety and Tolerability of VLX600, an Iron Chelator, in Patients With Refractory Advanced Solid Tumors
Conditions: Refractory Cancer
Conditions: Refractory Cancer
May 3, 2018
148
NCT00602316
Unknown status
Unknown status
Multifunctional Magnetic Resonance Imaging in Predicting Breast Lesions in Women Undergoing Mastectomy for Breast Cancer
Conditions: Breast Cancer
Intervention: Gadolinium-chelate, Conventional Surgery, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopic Imaging
Conditions: Breast Cancer
Intervention: Gadolinium-chelate, Conventional Surgery, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopic Imaging
August 23, 2013
149
NCT00447694
Completed
Completed
Cardiac T2* in Beta-thalassemia Patients on Deferasirox Treatment
Conditions: Beta-thalassemia; Iron Overload
Intervention: Deferasirox
Conditions: Beta-thalassemia; Iron Overload
Intervention: Deferasirox
September 22, 2016
150
NCT02443545
Enrolling by invitation
Enrolling by invitation
Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias
Conditions: Iron Overload; Sickle Cell Disease; Other Anemias
Intervention: Deferiprone
Conditions: Iron Overload; Sickle Cell Disease; Other Anemias
Intervention: Deferiprone
January 10, 2019
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submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
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Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
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Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
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In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
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In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
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Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
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Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
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It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
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When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
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weight loss
heart failure
suicide
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to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
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weight loss
heart failure
suicide
Interventions
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clofibrate
cyclosporine
vitamin e
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clofibrate
cyclosporine
vitamin e
Conditions
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lupus
heart attack
leukemia
risk factors for breast cancer
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Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
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Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.