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Senior Scientist, ADME (Metabolite Identification)
Charles River Laboratories International Inc (CRL)
Mattawan, MI, US, 49071
For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.
Job Summary
We are seeking a Senior Scientist, ADME (Metabolite Identification) for our Safety Assessment site in Mattawan, MI.
The Senior Scientist will function independently as the Study Director/Principal Investigator and technical expert in the metabolite profiling and identification area.
Responsibilities:
- Develop, perform and troubleshoot bioanalytical laboratory experiments, tests and procedures supporting in-vivo ADME and in-vitro drug metabolism.
- Ensure raw data is accurate, complete, timely and in appropriate order to meet protocols and SOP specifications.
- Prepare high quality final reports appropriate for the study including method development, method optimization, sample analysis and data interpretation.
- Provide oversight of the laboratory and mentor scientific staff in areas such as protocol interpretation, method development and refinement, study-related problem resolution and technique validation.
- Provide scientific expertise in study conduct, design and interpretation.
- Perform advanced troubleshooting on analytical instrumentation including liquid chromatography and mass spectrometry systems.
- Attend and present novel work at scientific meetings.
The pay range for this position starts at $100,000 annually. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location.
Qualifications
Qualifications:
- Bachelor's degree or equivalent in a scientific related discipline. Master's degree or Ph.D. preferred.
- Minimum of 5 years related experience in the contract research, academic or pharmaceutical industry.
- An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
- Full understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs, as appropriate. Knowledge of applicable international guidelines for all types of studies. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives. Sponsor interactions, and business development. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including the Microsoft Suite and analytical instrumentation software.
Competencies
About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.
About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.
At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.
Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.
If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected] This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.
Job posted: 2023-06-01