French health care facility started a new clinical trial of nicotine substitution

Photo Abhishek Koli

The non-profit private health care facility is enrolling patients into the clinical trial of the benefit of systematic proposition of nicotine substitution for patients undergoing surgery (PATCHIR).

The overcoming the addiction is recommended and particularly interesting in scheduled surgery, because it allows smoking cessation well before the procedure. A real strategy must be constructed and evaluated for patients who cannot consider this smoking cessation.

This study seeks to assess the effectiveness of a systematic proposition of nicotine replacement therapy (NRT) in regular smokers.

The nicotine replacement therapy is proposed to every patient included in the study. The exhaled carbon monoxide is measured at the preoperative consultation (about 15 days before surgery) and the day of surgery by a nurse, whether the patient accepts the therapy or not. These two measures are compared to assess efficacy of nicotine replacement therapy.

The trial is designed to enroll male and female volunteers 18 years and older and is being conducted in the Groupe hospitalier Mutualiste de Grenoble, France.

The study start date is October 1, 2020.

The patients that can be enrolled into this study include the patients who smokes at least one cigarette or cannabis joint per day, every day. The patients with one of the following chronic diseases: diabetes, Chronic Obstructive Pulmonary Disease, glucose intolerance, hemolytic anemia, asthma and dilation of the bronchi (these diseases must be stable) could also be included.

The population that are excluded from participation: patients protected by French law from clinical research inclusion, patient using nicotine substitutes before the nurse consultation and patient already included in an interventional clinical research protocol.