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Senior Research Associate - Research Analytical Development/Quality Control
Charles River Laboratories International Inc (CRL)
Rockville, MD, US, 20850
IMPORTANT: In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process. Please make sure work history and education are added correctly.
Job Summary
The Senior Research Associate is responsible for implementing knowledge, research, and expertise to successfully develop and execute new analytical assays for viral vectors including AAV (Adeno Associated Virus), LV (Lentivirus), and ADV (Adenovirus). This role will apply in-depth technical knowledge and experience when performing across a broad range of research and laboratory processing tasks, some of which are complex, requiring independent action and initiative in order to design and execute experiments, methods, and tests, and perform smaller studies within a research environment.
Key Responsibilities and Duties:
• Perform testing and related tasks to support the Research Virus Production Department by performing in-process and lot release testing of viral vector products (AAV, LV, ADV, etc.). • Develop, optimize, and execute various testing methods for viral vectors including qPCR, SDS-PAGE, ELISA, sterility testing, mycoplasma, endotoxin, Host Cell Protein (HCP), infectivity testing, etc. • Experience with flow cytometry, AKTA purification, and HPLC systems desired • Work under the direction of the AD/QC Supervisor to promote internal research • Work with Production to qualify and validate viral vector testing processes as directed by the AD/QC Supervisor • Participate in decision-making processes within the project team by actively engaging in scientific and technical discussions • Build credibility within lab group by performing high quality work • Write, review, and revise production SOPs as aligned with updated procedures • Gather and organize data; perform data analysis • Other responsibilities as required
Job Qualifications
• HS Diploma or equivalent and 6 years of related experience, A.S. with 5 years, or a B.S. in biology/life sciences, bioengineering, or related discipline with 3 years of related experience. • Prior cell/gene therapy laboratory experience in a highly technical role covering a broad range of tasks within a bioprocessing, biopharmaceuticals, analytical, product development, and/or cGMP manufacturing biotech environment or other related industry. • Informal coaching or project management experience desirable. • Qualified as a LEAN trainer or willing to become qualified. • Able to work in accordance with and role model the Charles River Values. • Able to work independently and be a team player, with a positive attitude, professional tone, and demeanor. • Able to effectively plan, coordinate, and execute multiple projects simultaneously and deliver on time. • Able to engage and inspire others. • Demonstrate an operations and customer-focused mindset. • Willing to continuously learn and improve. • Strong attention to detail and excellent GDP skills. • Advanced analytical, critical thinking, and problem-solving skills. • Takes pride in own work – high quality, delivered on time, requiring limited rework. • Strong listening, clear written, and verbal communication skills. • In-depth knowledge/application of MS Word, Excel, PowerPoint, Teams, databases, etc. • Pass/maintain aseptic/PPE qualifications; work in a laboratory environment for at least 4 hours/day.
The pay range for this position is $33.66 - $36.06 per hour. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location.
IMPORTANT: A resume is required to be considered for this position. If you have not uploaded your resume in your candidate profile, please return to upload field and attach your resume/CV.
About Biologics Testing Solutions With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs. Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.
About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 20,000 employees within 110 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.
At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.
Equal Employment OpportunityCharles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, or national origin, veteran or disability status.
If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.
Job posted: 2023-03-11
