The study of antibiotic treatment following surgical drainage of perianal abscess

A research institute in Netherlands conducts a clinical trial of Antibiotic Treatment foLlowing Surgical drAinage of Perianal abScess; the ATLAS Trial, a Double-blind, Placebo-controlled, Randomized Trial.

dr. IJM Han-Geurts is recruiting patients for the clinical trial of Antibiotic Treatment foLlowing Surgical drAinage of Perianal abScess; the ATLAS Trial a Double-blind, Placebo-controlled, Randomized Trial (ATLAS).

Rationale: Perianal fistula is a burdening disease with an annual prevalence of 2/100.000 in the Dutch population. More than 90% of crypto-glandular fistulas originate from anorectal abscess. Despite adequate drainage of anorectal abscess up to 83% recurs or results in an anal fistula, the majority developing within 12 months. Up till now it is not common practice to routinely administer prophylactic antibiotics to prevent anal fistula development.

Objective: The objective of this trial is to establish if adding antibiotic treatment to surgical drainage of perianal abscess results in less perianal fistulas. 

The page dedicated to this clinical trial can be found here: https://ichgcp.net/clinical-trials-registry/NCT05385887.