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Senior Scientist - Automation Chemist

Pharmaceutical Product Development (PPD)

PA-Collegeville-FSP Collegeville PA

PPD is a leading global contract research organization. At PPD we are passionate, deliberate, and driven by our purpose - to improve health.

PPD Laboratories offers the most comprehensive set of laboratory services available in the industry and continues to deliver innovative solutions to our clients through our collaborative approach, including PPD® Laboratories FSP. PPD® Laboratories FSP is a unique partnership that allows our clients to leverage the experience of our PPD staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits/advantages of being a part of PPD.

Job Purpose

Our client's R&D has committed to increase the use of automation. The ten year vision of automation is where implementation will:

• Free the hands of our scientists, releasing energy to make on better-informed decisions

• Drive the reduction of attrition, by maximising our knowledge and capabilities, deliver more robust workflows and increase quality

As part of this strategy, a multi-million dollar core-testing facility has been built to support the development, evaluation, and optimization of drug products. This team will actively drive change in how automation is applied to daily decision making.

The High Throughput Automation team member role will ensure that current and future automation is appropriately used to deliver value to client projects. Accordingly, this person will implement innovative automated platforms and workflows with the following purpose:

• Successfully utilize the automation assets for rapid screening and/or development in order to reduce design selection risks and enhance product design across all phases of development.

• Develop appropriate automation protocols to meet the needs of the analysts, chemists, engineers and formulators across Medicinal Science and Technology (MST).

• Represent the APPM department for the evaluation of innovative automation platforms and development of robust automation workflows to increase the quality and quantity of science.

Key Responsibilities:

• Working in a matrix team, develop appropriate automation protocols to meet the needs of the scientists, analysts, chemists, engineers and formulators in MST.

• Conduct automated experiments, exploring both the physical properties of materials, excipients of pharmaceutical relevance and chemical reactions of synthetic intermediates.

• Participate on multidisciplinary project teams, and collaborate with colleagues to define and implement development strategies according to project timelines.

• Organize, evaluate, and present data in an effective and scientific manner.

• Contribute to the development of new automation approaches and knowledge within the global automation organization.

• Collaborate proactively with the analytical lines to identify standard analytical work packages and embed the use of automation so that it becomes the standard work practice for certain activities.

• Ensure the local capability to rapidly leverage existing laboratory automation in order to dramatically reduce the time to address design selection issues with drug development.

• Perform research and leadership in the development and implementation of innovative automation platforms and workflow solutions.

• Act as system owner for a Freeslate CM automation system and participate in IT systems and technical process reviews to ensure data integrity and updates in line with clientglobal standards.

• Identify and recommend processes and technologies that achieve more efficient and cost effective data and knowledge management.

• Write protocols for new automation workflows using Unchained Labs LEA Library Studio and Automation Studio.

At PPD we hire the best, develop ourselves and each other, and recognize the power of being one team. We offer continued career advancement opportunities, award winning training and benefits focused on the health and wellbeing of our employees.  

*LI-SW1

PPD is a leading global contract research organization. At PPD we are passionate, deliberate, and driven by our purpose - to improve health.

PPD Laboratories offers the most comprehensive set of laboratory services available in the industry and continues to deliver innovative solutions to our clients through our collaborative approach, including PPD® Laboratories FSP. PPD® Laboratories FSP is a unique partnership that allows our clients to leverage the experience of our PPD staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits/advantages of being a part of PPD.

Job Purpose

Our client's R&D has committed to increase the use of automation. The ten year vision of automation is where implementation will:

• Free the hands of our scientists, releasing energy to make on better-informed decisions

• Drive the reduction of attrition, by maximising our knowledge and capabilities, deliver more robust workflows and increase quality

As part of this strategy, a multi-million dollar core-testing facility has been built to support the development, evaluation, and optimization of drug products. This team will actively drive change in how automation is applied to daily decision making.

The High Throughput Automation team member role will ensure that current and future automation is appropriately used to deliver value to client projects. Accordingly, this person will implement innovative automated platforms and workflows with the following purpose:

• Successfully utilize the automation assets for rapid screening and/or development in order to reduce design selection risks and enhance product design across all phases of development.

• Develop appropriate automation protocols to meet the needs of the analysts, chemists, engineers and formulators across Medicinal Science and Technology (MST).

• Represent the APPM department for the evaluation of innovative automation platforms and development of robust automation workflows to increase the quality and quantity of science.

Key Responsibilities:

• Working in a matrix team, develop appropriate automation protocols to meet the needs of the scientists, analysts, chemists, engineers and formulators in MST.

• Conduct automated experiments, exploring both the physical properties of materials, excipients of pharmaceutical relevance and chemical reactions of synthetic intermediates.

• Participate on multidisciplinary project teams, and collaborate with colleagues to define and implement development strategies according to project timelines.

• Organize, evaluate, and present data in an effective and scientific manner.

• Contribute to the development of new automation approaches and knowledge within the global automation organization.

• Collaborate proactively with the analytical lines to identify standard analytical work packages and embed the use of automation so that it becomes the standard work practice for certain activities.

• Ensure the local capability to rapidly leverage existing laboratory automation in order to dramatically reduce the time to address design selection issues with drug development.

• Perform research and leadership in the development and implementation of innovative automation platforms and workflow solutions.

• Act as system owner for a Freeslate CM automation system and participate in IT systems and technical process reviews to ensure data integrity and updates in line with clientglobal standards.

• Identify and recommend processes and technologies that achieve more efficient and cost effective data and knowledge management.

• Write protocols for new automation workflows using Unchained Labs LEA Library Studio and Automation Studio.

At PPD we hire the best, develop ourselves and each other, and recognize the power of being one team. We offer continued career advancement opportunities, award winning training and benefits focused on the health and wellbeing of our employees.  

*LI-SW1

Education and Experience:  

Bachelor's degree in Chemical Engineering, Chemistry, Pharmaceutical Sciences, or Organic Chemistryor equivalent and relevant formal academic / vocational qualification (Master's Degree is preferred)

Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4 years).

In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Knowledge, Skills and Abilities:   Solid understanding and knowledge of general chemistry and separation science Demonstrated product development experience across multiple projects in pharmaceutical development environment, with evidence of achieving product deliverables within disciplinary expertise. Broad knowledge of analytical method development in support of NCE development or Broad knowledge of developability and pre-formulation applied to NCE development. Proficient in and demonstrates highly effective oral and written communication skills. Team player and ability to work in a matrix environment. Proven ability to troubleshoot and diagnosing problems in analytical platforms. Demonstrated ability to interface with multiple internal and external groups to successfully deliver projects. High learning agility has the ability and willingness to deal effectively with first-time situations or changing conditions. Knowledge and experience with statistical design of experiments and analysis of results. Knowledge of solid state analytical methods - eg microscopy, Raman, XRD, etc. Demonstrated ability to integrate, test, and troubleshoot equipment e.g. HPLC. Proven ability to translate scientific processes to new platforms and to identify new application areas Full understanding of laboratory requirements, PPD & client SOPs, ICH guidelines, USP requirements and FDA guidance Ability to utilize Microsoft Excel and Word to perform tasks Proficiency on technical operating systems Proven problem solving and troubleshooting abilities Effective oral and written communication skills Proven ability in technical writing skills Time management and project management skills Ability to work in a collaborative work environment with a team Proven problem solving and troubleshooting abilities Ability to train junior staff

Working Environment:  

PPD values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive.  Below is listed the working environment/requirements for this role: 

Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner. 

Able to work upright and stationary and/or standing for typical working hours.  

Able to lift and move objects up to 25 pounds  

Able to work in non-traditional work environments.  

Able to use and learn standard office equipment and technology with proficiency.  

May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments. 

Able to perform successfully under pressure while prioritizing and handling multiple projects or activities. 

PPD Defining Principles: 

- We have a strong will to win - We earn our customer’s trust - We are gamechangers - We do the right thing - We are one PPD - 

If you resonate with our five principles above, and ultimately wish to accelerate the delivery of safe and effective therapeutics for some of the world’s most urgent health needs, then please submit your application – we’d love to hear from you

Education and Experience:  

Bachelor's degree in Chemical Engineering, Chemistry, Pharmaceutical Sciences, or Organic Chemistryor equivalent and relevant formal academic / vocational qualification (Master's Degree is preferred)

Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4 years).

In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Knowledge, Skills and Abilities:   Solid understanding and knowledge of general chemistry and separation science Demonstrated product development experience across multiple projects in pharmaceutical development environment, with evidence of achieving product deliverables within disciplinary expertise. Broad knowledge of analytical method development in support of NCE development or Broad knowledge of developability and pre-formulation applied to NCE development. Proficient in and demonstrates highly effective oral and written communication skills. Team player and ability to work in a matrix environment. Proven ability to troubleshoot and diagnosing problems in analytical platforms. Demonstrated ability to interface with multiple internal and external groups to successfully deliver projects. High learning agility has the ability and willingness to deal effectively with first-time situations or changing conditions. Knowledge and experience with statistical design of experiments and analysis of results. Knowledge of solid state analytical methods - eg microscopy, Raman, XRD, etc. Demonstrated ability to integrate, test, and troubleshoot equipment e.g. HPLC. Proven ability to translate scientific processes to new platforms and to identify new application areas Full understanding of laboratory requirements, PPD & client SOPs, ICH guidelines, USP requirements and FDA guidance Ability to utilize Microsoft Excel and Word to perform tasks Proficiency on technical operating systems Proven problem solving and troubleshooting abilities Effective oral and written communication skills Proven ability in technical writing skills Time management and project management skills Ability to work in a collaborative work environment with a team Proven problem solving and troubleshooting abilities Ability to train junior staff

Working Environment:  

PPD values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive.  Below is listed the working environment/requirements for this role: 

Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner. 

Able to work upright and stationary and/or standing for typical working hours.  

Able to lift and move objects up to 25 pounds  

Able to work in non-traditional work environments.  

Able to use and learn standard office equipment and technology with proficiency.  

May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments. 

Able to perform successfully under pressure while prioritizing and handling multiple projects or activities. 

PPD Defining Principles: 

- We have a strong will to win - We earn our customer’s trust - We are gamechangers - We do the right thing - We are one PPD - 

If you resonate with our five principles above, and ultimately wish to accelerate the delivery of safe and effective therapeutics for some of the world’s most urgent health needs, then please submit your application – we’d love to hear from you

Job posted: 2021-02-25

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