Austrian Medical University conducts a clinical trial of Resuscitation and Capillary Reperfusion
The Medical University of Vienna is commencing recruitment for the clinical trial of the Resuscitation and Capillary Reperfusion.
The conditions are Cardiac Arrest, Cardiac Arrest, Out-Of-Hospital, Cardiopulmonary Arrest, Cardiopulmonary Arrest With Successful Resuscitation.
A new clinical trial is recruiting patients in the following locations: Austria.
The trial officially began on the March 3, 2021 and is planned to complete on December 2021.
Persistent microperfusion alterations after return of spontaneous circulation (ROSC) are associated with poor survival. To our knowledge, no human studies evaluating microperfusion during cardiopulmonary resuscitation (CPR) with simple and pre-hospital available tests have been published. Capillary refill time (CRT) and skin-mottling-score (SMS) are parameters for microperfusion and evaluated in septic and cardiogenic shock. In animal studies, microperfusion was impaired during cardiac arrest, although not correlating with systemic blood pressure.
The aim of this study is to investigate the correlation between impaired microcirculation (as measured with CRT and SMS) during resuscitation and ROSC resp. neurological outcome. The clinical impression in daily routine is, that the appearance of a patient undergoing CPR is often linked to the outcome. The investigators hypothesize, that this is due to changes in microperfusion of the skin.
Among the exclusion criteria are:
- insufficient manpower (e.g. study team has to provide CPR)
- hypovolemia (exsanguination, anaphylaxis, sepsis as underlying cause)
- presumed or known COVID-19 disease
- hypo-/hyperthermia (<36.0°, >37.5°C)
- Raynaud's disease
- Peripheral arterial disease
The link to the complete study profile: https://ichgcp.net/clinical-trials-registry/NCT04791995
