German University Hospital studies Personalized Neurorehabilitative Precision Medicine

University Hospital Tuebingen is starting a new clinical trial of Personalized Neurorehabilitative Precision Medicine - From Data to Therapies.

Stroke is the most common neurological disease leaving one third dead and one third with permanent impairment despite best medical treatment. The aim of the present study is to investigate why patients differ in how they benefit from neurorehabilitation by collecting clinical, electrophysiological, imaging and laboratory data in the acute phase of stroke as well as later on during rehabilitation and after 90 days. Following a closed-loop approach the data is analyzed by a machine learning algorithm to create a personalized neurorehabilitation strategy.

The clinical trial started in December 1, 2020 and will continue throughout June 30, 2022.

Motor outcome of the upper extremity (UE) after acute stroke will be primary outcome measure.

The researchers aim to include all patients with acute stroke affecting the UE (FMA less than 50) on our SU. Other symptoms like aphasia or neglect are no reason for exclusion since they intend to include as many patients as possible to capture the whole spectrum of stroke from mild to severe. Especially the last case, the inclusion of severely affected patients, is of utmost importance in researchers view. Due to their grave impairments they have the greatest need for neurorehabilitation; at the same time, this group of patients is the most vulnerable because of their preexisting comorbidities and conditions coming with immobility e. g. pneumonia. A personalized treatment would meet their need for intense rehabilitation while providing enough recreation time since unnecessary, ineffective rehabilitation could be omitted.

Among the collaborators in this study are Interfaculty Institute for Biomedical Informatics (IBMI), Cluster of Excellence - Machine Learning for Science, Department for diagnostic and interventional neuroradiology, University hospital of Tuebingen, Deparmet of biomedical magnetic resonance, University hospital of Tuebingen, Kliniken Schmieder and SRH-Kliniken.

The contacts and locations are the University hospital of Tuebingen, Tuebingen, Baden-Württemberg, Germany.

For more details: https://ichgcp.net/clinical-trials-registry/NCT04688970

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