Study of сanakinumab in patients with myelofibrosis

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The company John Mascarenhas is commencing recruitment for the clinical trial of the Study of Canakinumab in Patients With Myelofibrosis.

The conditions are Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, ET-MF, Post-polycythemia Vera Related Myelofibrosis, PV-MF.

The trial officially began on the July 2022 and is planned to complete on June 2024.

This is an open label, multicenter, phase 2 trial of Canakinumab in patients with primary myelofibrosis (PMF), post essential thrombocythemia/polycythemia vera related MF (Post ET/PV MF). Eligible patients will receive Canakinumab administered as a subcutaneous injection on day 1 of a 21 day cycle for a core study period of 8 cycles. Canakinumab will be given by subcutaneous injection (SC) injection at a starting dose of 200 mg (one 150 mg/mL syringe and one 50 mg/0.5 mL syringe) every 3 weeks.

The link to the complete study profile: https://ichgcp.net/clinical-trials-registry/NCT05467800.

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