Italian University studies a Prevalence of Periodontitis in Patients With Plaque Psoriasis
Photo by Coline Hasle
The University of Siena is commencing recruitment for the clinical trial of the Prevalence of Periodontitis in Patients With Plaque Psoriasis.
The conditions are Psoriasis, Plaque Psoriasis, Periodontal Diseases, Periodontitis.
A new clinical trial is recruiting patients in the following locations: Italy.
Psoriasis is a chronic inflammatory disease with a multi-factorial etiology which affects the epidermis and dermis. It affects around 1-3% of the general population and its most frequent form is plaque psoriasis (around 80-90% of the overall psoriasis cases). Psoriasis severity and extension are usually measured through 2 scores: Psoriasis Area Severity Index (PASI) and Body Surface Area (BSA). Periodontitis is a chronic inflammatory disease mediated by the biofilm and with a multi-factorial etiology. Its manifestation entails the destruction of the periodontal tissues surrounding the teeth; the final stage of disease is characterised by tooth loss. Periodontitis severity and extension are usually evaluated through surrogate variables such as: BoP (Bleeding on Probing), PPD (Probing Pocket Depth) e REC (Recession). Both diseases present overlapping genetic and pathophysiologic features, as well as common risk factors (e.g. genetic polymorphisms, smoking habit, obesity, diabetes etc.).
miRNAs are small non-coding molecules involved in the regulation of various biologic processes thanks to their interaction with mRNAs. Active inflammatory processes either in the oral cavity or at a systemic level tend to alter the concentration of salivary miRNAs. No study so far has ever profiled the levels of specific salivary miRNAs in patients with psoriasis and periodontitis.
Some case-control studies highlighted a higher prevalence of periodontitis in patients with psoriasis when compared to healthy controls. Nonetheless, epidemiological data regarding periodontitis prevalence in patients with psoriasis are lacking; moreover, few data are available regarding the relationship between the severity of psoriasis and the severity of periodontitis, together with the effect of common risk factors (e.g. diet, obesity, physical activity, sleep quality etc.).
The population that can be enrolled into this study includes:
- Age between 18 and 70 years old
- Diagnosis of plaque psoriasis
The trial officially began on the January 25, 2021 and is planned to complete on August 25, 2021.
The University of Siena (Università degli Studi di Siena, abbreviation: UNISI) in Siena, Tuscany, is one of the oldest and first publicly funded universities in Italy. Originally called Studium Senese, the institution was founded in 1240. Today, the University of Siena is best known for its Schools of Law, Medicine, and Economics and Management.
The link to the complete study profile: https://ichgcp.net/clinical-trials-registry/NCT04722094
