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Senior Scientist (Next Generation Sequencing - Oncology)

Parexel International Corporation

USA - Any Region - Home Based

Fantastic and rewarding opportunity for a PhD who is looking to transition to Industry!

We are currently seeking an individual who is looking to apply the knowledge gained from their PhD in bioinformatics, computational biology, statistical genetics, or other relevant scientific field with their lab related experience to join our team as a Senior Scientist.

This is an incredible opportunity for an individual who has previous pre/clinical oncology experience as well as next generation sequencing experience to gain tremendous exposure, grow professionally, and make an immediate contribution to our client. The opportunities for the Sr. Scientist to develop are limitless!

The Sr. Scientist is recognized as a subject matter expert and provides scientific leadership in at least one discipline of Biomarkers and Genomic Medicine. The Sr. Scientist develops strong client relationships and works closely with clients to develop and implement strategies to support their drug discovery and development programs.

Key Accountabilities:

• Define and execute biomarker data analysis plan for late stage oncology clinical studies, under the guidance of senior team members, clinical development team, biomarker scientist, biostatistician, and others key stakeholders.

• Perform analysis of clinical and biomarker datasets (e.g., large-scale omics datasets including RNASeq, WES, WGS) and derive clinically meaningful interpretations.

• Identify potential biomarkers for patient enrichment strategies and gain mechanistic insights of responses.

• Maintains a strong working knowledge of genomics, drug development and provides subject matter expertise to internal and external teams as needed

• Responsible for the operational delivery of multiple aspects of a client program or project to timelines, quality expectations and regulatory requirement.

• Authors or contributes to the development of clinical protocols, clinical study reports, regulatory responses and submissions and publications for peer review journals.

• Contributes to the development of departmental capabilities including procedures and technology

• Develops and maintains a positive relationship with internal and external clients and team members, building partnerships and promoting teamwork

• Represents Parexel and/or clients at marketing and scientific meetingsQualificationsSkills:

• Must be proficient with programming in R, Python, shell scripting, and/or other related

• Must possess basic hands-on experience with statistics

• Must possess at least intermediate-level expertise of UNIX/LINUX environment

• Proficiency with genomics data standards such as SAM, BAM, VCF, BED, WIG, and other related ones, is required

• Proficiency with genomics tools such as bedtools, GATK, samtools, vcftools, bwa, STAR, Salmon, DESeq, and other related, is required

• Experience with machine learning techniques is a plus

• Proficiency with analytics platform such as Spotfire is preferred

• Demonstrated understanding of the drug development process.

• Requires little instruction on day-to-day work, and takes on new areas of responsibility with general instruction and minimal oversight

• Ability to manage multiple and varied tasks with enthusiasm and independently prioritize workload; demonstrated flexibility to change

• Demonstrates independent thought and ability to influence design and implementation of projects and program deliverables

• Willingness to work in a matrix environment and to value and promote the importance of teamwork

• Excellent interpersonal, verbal and written communication skills.

• Clear and precise communication in English

Knowledge and Experience:

• One to five years’ experience in pharmaceutical industry, CRO or academia desired

• Strong experience in genetic analysis, bioinformatics and computational programming

• Knowledge and experience of common bioinformatics databases, resources and tools

• Experience handling, processing and analyzing large volume genetic, genomic, or other omics data, especially, next-generation sequencing, genotype arrays, etc., is required

• Strong experience in adapting to changing genomics tool and technology landscape, preferably in the oncology space, is required

• Knowledge of regulatory requirements impacting genomic medicine and drug development is a plus

• Experience with analyzing clinical trial data is a plus

• Experience working in the oncology disease area, is strongly preferred

Education:

• PhD by training in bioinformatics, computational biology, statistical genetics, or relevant scientific field, with 1-5 years of experience in drug development or MS degree with computational relevant skillsets and more extensive pharma experienceEEO DisclaimerParexel is an equal opportunity employer.  Qualified applicants will receive consideration for employment without regard to legally protected status, which in the US includes race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Job posted: 2020-09-11

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