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Research Scientist I - Formulations
Charles River Laboratories International Inc (CRL)
Stilwell, KS, US, 66085
Job Summary
We are seeking a Research Scientist I to join our Integrated Toxicology (ITox) Formulations team at the Kansas City (CR-KAN) Site. This site is the first of its kind, bridging CRL’s Discovery and Safety Assessment business units, while bringing automation to standard lead optimization toxicology study models to deliver rapid study results to our clients. When you join our family, you will have a significant impact on the health and well-being of people across the globe. The Research Scientist I – Formulations role is proficient in general wet chemistry laboratory skills and formulation procedures and works effectively in a team environment. The Research Scientist I has skills required to support a study, which include but are not limited to instruction/method development and writing, direct, hands-on in-lab formulation preparation and sampling, formulation troubleshooting, and understanding of dosing and general chemistry calculations. They will perform most skills independently but continue working under supervision to gain proficiency on advanced skills or work on advanced studies still in development.
Job Qualifications
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Recognize Formulation and/or data issues and communicate to minimize study impact.
- Prepare basic to complex dosing formulations and samples, utilizing a variety of mixing techniques and equipment, including aseptic formulations
- Calculate required amounts of reagents to complete each project based on study criteria
- Independently develop, draft, and/or review methods/instructions
- Ability to follow detailed protocols and reference materials to generate instructions/methods
- Apply laboratory experience to participate in troubleshooting
- Verify studies are scheduled appropriately
- Demonstrates effective communication skills through formal discussions, including interdepartmental coordination
- Effectively direct more junior technical staff in the execution of formulation instructions and preparation procedures
- Consult with Sponsor representatives and Principal Investigators/Study Directors on assigned compounds/projects
- Actively participate across functional areas on Method Development projects, as needed, to ensure thorough understanding of compounds
- Identify potential scientific issues and develop solutions
- Participate in scientific discussions with internal and external customers, and be able to advise on a course of action
- Participate in laboratory investigations, providing scientific input and direction
- Help drive laboratory development and process improvement initiatives
- Performs all other related duties as assigned
Certification/Licensure: None.
- Excellent written and verbal communication skills.
- Ability to manage multiple tasks and priorities to achieve goals.
- Computer skills (e.g., Microsoft Office Suite), commensurate with essential functions, including the ability to learn a validated system.
- Ability to ensure that a safe working environment is maintained by observing all safety procedures and working methods by making proper use of protective clothing and equipment, and by reading, understanding, and following all safety documents issued or notified of.
- Ability to ensure the integrity of the studies and fulfill the regulatory agencies requirements by performing the activities according to Standard Operating Procedures (SOP), Business Operating Procedures (BOP) and the Institutional Animal Care and Use Committee (IACUC) rules.
- Ability to work extended hours beyond normal work schedule to include, but not limited to evenings, weekends, extended shifts, and/or extra shifts, sometimes on short notice.
- Ability to work under specific time constraints.
PHYSICAL DEMANDS:
- Employees must be able to lift, move, manipulate, and/or hold heavy objects up to and including 50 pounds; this includes work materials and/or equipment.
- Must be able to perform laboratory procedures, which require, talking, hearing, standing, or sitting for long periods of time, entering data into a computer, using appropriate instruments, reaching with hands and arms, working in narrow spaces, and wearing safety equipment (PPE) according to OSHA regulations and company standards.
- Specific vision abilities required by this job include close vision, color vision, depth perception, and the ability to adjust focus.
About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.
About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.
At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.
Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.
Job posted: 2023-02-20
