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Associate / Principal Scientist - SPR Biophysics

Charles River Laboratories International Inc (CRL)

Saffron Walden, GB, CB10 1XL

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

The Role

Are you an experienced biophysicist with experience of Surface Plasmon Resonance in a Small Molecule research environment?

Do you want to join an established, versatile and experienced Biophysics team that support career progression and facilitate your personal and professional development?

Have you got the desire to make a career change and join a global CRO that improves health and lives?

Our state of the art site in Saffron Walden are recruiting for an Associate Principal or Principal Scientist to join their team.

This is a lab based role with understanding and wide application of scientific and technical standards, principles, theories, concepts, and techniques across Biophysics with particular focus on SPR.

Based within our Structural Biology department you will join an established Biophysics team, with opportunities to shape and influence the expansion of the discipline. The Biophysics team cover a range of biophysical methods (SPR, ITC, Thermal shift including nano (DSF), NMR) and work across-disciplines with colleagues in crystallography, cryo-EM and integrated drug discovery.  

The Biophysics team are integrated into early drug discovery programmes to deliver candidate selection across many modalities (small-molecules, protac, biologics, antibody and antibody like targets, peptide and nucleotide therapies).

It is an environment that is dynamic, inter-disciplinary and fast-paced and we are keen to recruit an enthusiastic self starter with good problem solving skills.

You have the opportunity to be involved with experimental design, execution and data analysis and presenting to clients. You will also be able to contribute to project proposal writing.

What You'll be Doing

  • Independently design and develop biophysical assays, in a range of formats, suitable for Drug Discovery across a wide range of target class and modalities.

  • Perform comprehensive data analysis of SPR data using specialised software to inform project teams on chemistry design and mode of actions.

  • Fragment library screening (SPR, NMR and/or Thermal Shift) to find initial hits.

  • Translate experimental SPR data into biologically meaningful information and compile experimental reports.

  • Interface directly with clients and colleagues to understand the needs and deliverables and define appropriate strategies that will achieve the scientific goals

  • Lead biophysics projects for clients.

  • Act as a role model by demonstrating effective communication, project management and representation of the Charles River Laboratories values.

  • Train and mentor junior staff.

Skills and Experience

  • Ph.D or equivalent experience in the application of SPR.

  • Experience with SPR systems (preferably Biacore) and data processing.

  • Industrial experience.

  • Ability to trouble-shoot and deliver to deadlines.

  • Dynamic ability to work effectively on concurrent projects within multi-disciplinary teams.

  • Excellent communication skills and collaborative approach to interact effectively with, and present to, a wide range of stake holders.

  • SPR using Small Molecules.

What We offer You

  • A very comprehensive and competitive benefits package from day one, including a generous pension contribution, private medical cover for you and family members, annual bonus, private dental, critical illness cover and much, much more!

  •  Global opportunities and strong career progression.

  • The chance to work on several varied projects in state of the art facilities.

  • To be able make a difference to health and wellbeing of people.

  • To continue your own career growth.

  • Flexible and hybrid working.

About Discovery Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.

At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to the principle of diversity and inclusion and work daily in this direction.

Job posted: 2023-03-29