Senior Research Scientist _Discovery Bioanalytical

Senior Research Scientist _Discovery Bioanalytical Req ID #:  184384 Location: 

Mattawan, MI, US, 49071 At Charles River, we are passionate about improving the quality of people’s lives. When you join our global family, you will help create healthier lives for millions of patients and their families. 

Charles River employees are innovative thinkers, who are dedicated to continuous learning and improvement. We will empower you with the resources you need to grow and develop in your career. 

As a Charles River employee, you will be part of an industry-leading, customer-focused company at the forefront of drug development. Your skills will play a key role in bringing life-saving therapies to market faster through simpler, quicker, and more digitalized processes. Whether you are in lab operations, finance, IT, sales, or another area, when you work at Charles River, you will be the difference every day for patients across the globe.

IMPORTANT:   In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process.  Please make sure work history and education are added correctly.  Job Summary  

We are seeking a Senior Research Scientist (SRS, Large Molecule LC/MS) for our Bioanalytical Chemistry Team, CRL located in Mattawan, MI.

The SRS in Discovery Bioanalytical will be responsible for developing LC/MS based large molecule bioanalytical methods and serve as subject matter expert on the above as well as establishing and overseeing the designated equipment/platforms. The SRS will also provide guidance to staff as needed during the validation of methods used for sample analysis according to applicable Standard Operating Procedures (SOPs), study protocols and/or GxP regulations. Individuals in this role demonstrate expertise in their field, lead others through scientific mentorship and/or publications, complete assigned projects on time, and communicate effectively. SRS is expected to work independently, participate in process improvement initiatives, may supervise others, and may function as a Principal Investigator, Contributing Scientist, and/ or Study Director.

Essential Functions: The fundamental Competencies/Skills& Responsibilities of the role (products and services provided/results accomplished) include, but are not limited to, those listed: 

•    Develop large molecule bioanalytical methods and serve as internal expert

•    Maintain external relationships and awareness of advancements in the field as a subject matter expert in the respective science.

•    Extraction and quantification of therapeutics biologics; Protein, oligonucleotides from various biological matrices, serum, plasma, tissues, urine using LC-MS

•    Advanced knowledge of general chemistry and separation science

•    Broad knowledge of protein and peptide chemistry.

•    Knowledge of sample preparation and chromatography optimization

•    Knowledge and direct experience with technologies for mass spectrometry

•    Advance technical proficiency in operation and troubleshooting on analytical instrumentation including chromatography and mass spectrometry

Systems (HPLC: Shimadzu Nexera, 30 and 40 series; Sciex Mass Spectrometer:  5000 & 6500 series)

•    Ability to maintain clear and efficient method development documentation

•    Ability to effectively interact and communicate with Sponsors regarding the planning and execution of research and method development, and for the design, conduct and reporting of studies

•    Ability to establish and maintain effective working relationships with coworkers, managers, and Sponsors.

  Job Qualifications  

(Knowledge, Experience, Skills and Abilities required to accomplish the essential functions) include but are not limited to: 

•    Doctoral degree in a relevant field and 5-8 years of relevant experience.

•    Bachelor's/Master's degree in a relevant field and 9-12 years of relevant experience; or

•    An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above

•    Experience in large molecule LC-MS/MS bioanalysis method development workflows (protein, peptide, oligonucleotides) 

•    Technical proficiency in operation and troubleshooting of analytical instrumentation including chromatography and mass spectrometry systems 

•    Proficient using laboratory software applications (i.e., LIMS and data acquisition software).

•    Knowledge of GxPs and industry guidance documents.

•    Ability to work extended hours beyond normal work schedule to include, but not limited to evenings, weekends, extended shifts, and/or extra shifts, sometimes on short notice

•    Ability to work under specific time constraints

•    Familiarity with Microsoft Office Suite.

IMPORTANT: A resume is required to be considered for this position. If you have not uploaded your resume in your candidate profile, please return to upload field and attach your resume/CV. 

Vaccine Mandate

Charles River is a U.S. Federal Contractor.  As a result, we must follow the Presidential Executive Order to mandate vaccinations, and ensure our employees are fully vaccinated against COVID-19.  Our main priority is the wellbeing, health, and safety of our people. We require proof of vaccination from all employees. 

Anyone with requests for disability-related and/or religious exemptions should contact Talent Acquisition (crrecruitment_US@crl.com) so that information can be provided about the accommodation process at Charles River.

About Safety Assessment

Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.  Each year approximately 120 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. 

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 18,000 employees within 100 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of >80% of the drugs approved by the FDA for the past 3 years.

Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

For more information, please visit www.criver.com.

Nearest Major Market: Kalamazoo

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