The Comparison of Dexmedetomidine and Midazolam for the Sleep in Intensive Care Unit
The Comparison of Dexmedetomidine and Midazolam for the Sleep of Mechanical Ventilated Intensive Care Unit Patients
研究概览
详细说明
Sleep is very important for cognitive and immune function. However, patients in intensive care unit (ICU) have a very poor sleep.
Almost all ventilated patients in intensive care unit (ICU) take a sedative drug. In Korea, most commonly used sedative drugs are dexmedetomidine and midazolam.
The investigators are going to compare the sleep quality and quantity between dexmedetomidine group and midazolam group using 24 hour polysomnography. And the investigators also compare the incidence of delirium between the two groups.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Gyeonggi-do
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Seongnam-si、Gyeonggi-do、大韩民国、463-707
- Seoul National University Bundang Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- sedation patients with dexmedetomidine or midazolam
- over 18 years old
Exclusion Criteria:
- Neurologic disease (stroke, seizure, dementia, hypoxic brain damage)
- Brain infection
- Alcoholics
- Major Depression Disorder, Schizophrenia, Anxiety disorder
- Hearing loss
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Dexmedetomidine group
Dexmedetomidine group is the patients who sedated with dexmedetomidine in intensive care unit. We will randomly allocate using www.randomizer.org. They will sedate at the level of RASS -2. The dose of dexmedetomidine will be 0.2-0.7ug/kg/hr. |
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Midazolam group
Midazolam group is the patients who sedated with midazolam in intensive care unit. We will randomly allocate using www.randomizer.org. They will sedate at the level of RASS -2. The dose of midazolam will be 0.05-0.1 mg/kg/hr. |
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
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The differences of sleep stage, sleep efficiency, arousal index and delirium between dexmedetomidine group and midazolam group
大体时间：during ICU stay
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during ICU stay
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合作者和调查者
调查人员
- 学习椅：Young-Jae Cho, MPH、Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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