Oxytocin, Trauma Disclosure and Intrusions
2018年2月1日 更新者：Rene Hurlemann、University Hospital, Bonn
Effects of a Prolonged Oxytocin Treatment on Intrusions and Amygdala Reactivity in an Analogue Trauma Model
Severe traumatic experiences such as falling victim to assault, torture, or rape have deleterious effects.
Clinical manifestations include intrusions, avoidance behavior, and hyperarousal, which are associated, at a circuit level, with hyperfunction of the amygdala and hypofunction of prefrontal cortex (PFC) subregions.
In up to 50 % of the cases, resilience is not sufficient and trauma-exposed individuals develop posttraumatic stress disorder (PTSD).
Oxytocin (OXT) is a hypothalamic peptide hormone that exerts anxiolytic effects.
Recent clinical trials provide preliminary evidence that post-trauma administration of OXT could be effective as a preventive intervention for PTSD in a subsample of individuals exhibiting early PTSD symptoms prior to the onset of the disorder.
However, the underlying neurobiological mechanisms are unclear.
Therefore, the rationale of the present project is to expose a sample of healthy participants to experimental trauma in order to explore the circuit mechanisms by which OXT influences, and interferes with, traumatic experience.
Functional magnetic resonance imaging (fMRI) will be employed in order to elucidate the long-term effects of intranasal OXT on trauma-induced intrusions, amygdala and PFC responses during an emotional face matching task and resting state functional connectivity.
研究概览
详细说明
Participants will be exposed to an experimental trauma (i.e. a highly aversive movie) at days 1 and 4 of the study.
After the first experimental trauma and after the first functional magnetic resonance imaging (fMRI) measurement, the participants will receive intranasal OXT or placebo in three different groups (1.
OXT for six days, 2. OXT for three days and then placebo for three days, 3. placebo for six days).
The same fMRI tasks will be used after the first and second trauma exposure (i.e. one measurement before the treatment and one measurement after three days of treatment).
研究类型
介入性
注册 (实际的)
70
阶段
- 阶段1
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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Bonn、德国、53105
- Department of Psychiatry, University of Bonn
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 40年 (成人)
接受健康志愿者
是的
有资格学习的性别
女性
描述
Inclusion Criteria:
- Healthy female volunteers
- Right-handed
Exclusion Criteria:
- Current or past psychiatric disease
- Current or past physical illness
- Psychoactive medication
- Hormonal contraception
- MRI contraindication (e.g. metal in body, claustrophobia)
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：三倍
武器和干预
参与者组/臂 |
干预/治疗 |
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有源比较器：Oxytocin (6 days)
Intranasal administration, 24 international units (IU) oxytocin for three days after the first trauma movie exposure and three days after the second trauma movie exposure (24 IU per day)
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Intranasal administration, 24 international units (IU) oxytocin.
其他名称：
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有源比较器：Oxytocin (3 days)
Intranasal administration, 24 international units (IU) oxytocin for three days after the first trauma movie exposure (24 IU per day) and placebo nasal spray for three days after the second trauma movie exposure
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Intranasal administration, 24 international units (IU) oxytocin.
其他名称：
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安慰剂比较：Placebo
Placebo nasal spray for six days
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安慰剂鼻腔喷雾剂含有相同的成分，除了肽本身。
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Total number of intrusions following the first trauma movie exposure.
大体时间：Three days following the first trauma movie exposure.
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The participants will be asked to complete intrusion diaries at home in the evening of the days 1 to 3. Intrusions will be defined as involuntary recollections relating to film events that appear, apparently spontaneously, in consciousness.
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Three days following the first trauma movie exposure.
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Total number of intrusions following the second trauma movie exposure.
大体时间：Three days following the second trauma movie exposure.
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The participants will be asked to complete intrusion diaries at home in the evening of the days 4 to 6. Intrusions will be defined as involuntary recollections relating to film events that appear, apparently spontaneously, in consciousness.
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Three days following the second trauma movie exposure.
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Neural responses to emotional faces in the amygdala.
大体时间：Neural activations will be measured with fMRI in an emotional face matching task that lasts 20 min.
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Functional magnetic resonance imaging (fMRI) will be performed to measure blood-oxygen-level dependent signal in response to emotional face stimuli.
The investigators specifically plan to investigate amygdala responses to emotional faces, because pilot data indicate that neural responses to emotional faces in these regions are associated with the total number of intrusions.
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Neural activations will be measured with fMRI in an emotional face matching task that lasts 20 min.
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Neural responses to emotional faces in the prefrontal cortex.
大体时间：Neural activations will be measured with fMRI in an emotional face matching task that lasts 20 min.
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Functional magnetic resonance imaging (fMRI) will be performed to measure blood-oxygen-level dependent signal in response to emotional face stimuli.
The investigators specifically plan to investigate prefrontal cortex responses to emotional faces, because pilot data indicate that neural responses to emotional faces in these regions are associated with the total number of intrusions.
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Neural activations will be measured with fMRI in an emotional face matching task that lasts 20 min.
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fMRI resting state data
大体时间：Functional data will be acquired for 6 min.
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Participants will be instructed to lie still with open eyes during the resting state measurement and not think of anything in particular.
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Functional data will be acquired for 6 min.
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Trauma disclosure (time spend discussing the movie)
大体时间：Six days following the first trauma movie exposure.
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The intrusion diaries will contain a question for how long participants discussed the trauma movie.
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Six days following the first trauma movie exposure.
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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Changes in pupil diameter in response to the trauma movie
大体时间：2 min baseline before the trauma movie and during 15 min of the trauma movie.
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Changes in pupil diameter will be measured.
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2 min baseline before the trauma movie and during 15 min of the trauma movie.
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Changes in skin conductance level in response to the trauma movie
大体时间：2 min baseline before the trauma movie and during 15 min of the trauma movie.
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Changes in skin conductance level will be measured.
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2 min baseline before the trauma movie and during 15 min of the trauma movie.
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Changes in respiration rate in response to the trauma movie
大体时间：2 min baseline before the trauma movie and during 15 min of the trauma movie.
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Changes in respiration rate will be measured.
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2 min baseline before the trauma movie and during 15 min of the trauma movie.
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Salivary oxytocin concentrations
大体时间：Immediately before the trauma movie, immediately after the trauma movie and 40 min after the trauma movie.
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Saliva samples will be collected before and after the trauma movie to assess changes in oxytocin concentrations.
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Immediately before the trauma movie, immediately after the trauma movie and 40 min after the trauma movie.
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Salivary cortisol concentrations
大体时间：Immediately before the trauma movie, immediately after the trauma movie and 40 min after the trauma movie.
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Saliva samples will be collected before and after the trauma movie to assess changes in cortisol concentrations.
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Immediately before the trauma movie, immediately after the trauma movie and 40 min after the trauma movie.
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Questionnaire measurement of mood (PANAS)
大体时间：10 min before and 10 min after the trauma movie.
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Positive and negative affect will be assessed via self-rating questionnaire 'The Positive and Negative Affect Schedule' using a categorical 5 point scale.
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10 min before and 10 min after the trauma movie.
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：René Hurlemann, MD, PhD、University of Bonn
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2016年6月1日
初级完成 (实际的)
2017年3月18日
研究完成 (实际的)
2017年3月18日
研究注册日期
首次提交
2018年1月28日
首先提交符合 QC 标准的
2018年2月1日
首次发布 (实际的)
2018年2月8日
研究记录更新
最后更新发布 (实际的)
2018年2月8日
上次提交的符合 QC 标准的更新
2018年2月1日
最后验证
2018年2月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
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