Postural Control Under Different Cognitive Loads in Adult Survivors of Acute Lymphoblastic Leukemia and Age-Matched Healthy Individuals
The purpose of this study is to determine if adult survivors of childhood Acute Lymphoblastic Leukemia (ALL) enrolled on the SJLife (St. Jude Life) protocol are at increased risk for postural control deficits compared to individuals with no cancer history. All participants will be assessed for their ability to maintain an upright posture, walk at their usual speed, and to tandem walk, all while engaged in a cognitive task.
Primary Objective
To compare changes in postural control in ALL survivors to changes in postural control in healthy controls, matched on age- and sex- in simple versus complex standing and walking activities (complex: standing or walking with added cognitive load).
Secondary Objective
To identify demographic and performance related risk factors for decreased postural control during complex standing or walking activities in survivors and controls and to evaluate associations between treatment and the changes in postural control during complex activities among survivors.
調査の概要
状態
条件
詳細な説明
Cognitive performance (attention and working memory) will be evaluated using the auditory N-Back test. The 0-back condition and the 2-back condition will be used. After cognitive assessment, participants will perform 3 different postural control tasks (standing balance, regular gait, and tandem gait) in a random order. Postural tasks for each participant will be determined by using random allocation envelopes.
Computerized dynamic posturography will be used to evaluate standing balance with no added cognitive load. Standing balance assessment will be repeated two more times, once with participants engaged in performing the auditory 0-back task, and then with simultaneously performing the auditory 2-back task. Regular gait at participants' preferred speed will be examined using 6 light-weight wearable inertial sensors. The regular walking assessment will be repeated with simultaneous performance of the 0-back task and then with simultaneous engagement in the 2-back task. We have also included a tandem gait (placing one foot directly in front of the other) in order to make the postural task more challenging. The wearable inertial sensors will be used to record participants' gait characteristics while tandem walking. The tandem walk assessment will be repeated once with the participant simultaneously perform the 0-back task and then with the 2-back task. The estimated required time to perform all of the assessments and with inclusion of 3 rest intervals is 2 hours.
In addition, data from the overall SJLIFE assessment will be used in analysis.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Tennessee
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Memphis、Tennessee、アメリカ、38105
- St. Jude Children's Research Hospital
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria - Cases:
- Diagnosis of childhood ALL
- At least 5 years post ALL diagnosis
- No history of secondary malignancies after an ALL diagnosis
- Enrollment on the SJLIFE protocol
- Ages 18.00 to 39.99
- Ability to stand and walk for 20 seconds or more
- Ability to answer the eligibility questions
- Ability to provide informed consent
Inclusion Criteria - Controls:
- No history of childhood or adult onset cancer
- Enrollment on the SJLIFE protocol
- Ages 18.00 to 39.99
- Ability to stand and walk for 20 seconds or more
- Ability to answer the eligibility questions
- Ability to provide informed consent
Inclusion of Women and Minorities:
• Male and females of all races and ethnic groups are eligible
Exclusion Criteria:
- Currently receiving treatment for cancer
- Weight ≥ 300 lb (the balance system has a weight limit)
- Does not speak English
- Self-reports of hearing issues
- Pregnant females
- Inability or unwillingness of research participant to give written informed consent.
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
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ALL Survivors
Adult survivors of Acute Lymphoblastic Leukemia (ALL) enrolled on the SJLIFE protocol
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Control Group
Healthy Individuals with no history of childhood or adult onset cancer, matched on age- and sex
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Regular gait speed
時間枠：Up to 1 hour
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Regular gait will be evaluated in three different testing conditions: regular gait assessment while participants are engaged in performing a challenging cognitive task (2-back), regular gait assessment while participants are engaged in performing an easy cognitive task (0-bak) and regular gait assessment with no additional cognitive load (baseline).
In each condition, the difference in gait speed of each survivor and his/her matched control will be obtained.
Then the obtained differences at regular gait assessment with no additional cognitive load (baseline) and regular gait while performing the challenging cognitive task (2-bck) will be compared using a paired t-test.
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Up to 1 hour
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Composite score from standing balance test
時間枠：Up to 1 hour
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Standing balance ability will be examined in three different testing conditions: standing balance while participants are engaged in performing a challenging cognitive task (2-back), standing balance while participants are engaged in performing an easy cognitive task (0-back), and standing balance assessment with no additional cognitive load.
In each condition, the difference in composite score of each survivor and his/her matched control will be obtained.
Then the obtained differences at standing balance assessment with no additional cognitive load (baseline) and standing balance assessment while performing the challenging cognitive task (2-back) will be compared using a paired t-test.
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Up to 1 hour
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協力者と研究者
捜査官
- 主任研究者：Kristen K Ness, PhD、St. Jude Children's Reearch Hospital
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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