Brain Fitness APP for Cognitive Enhancement
Brain Fitness APP for Cognitive Enhancement of People With Dementia
Memory and cognitive declines are associated with normal brain aging but are also precursors to dementia, in particular the so called the pandemic of the century, Alzheimer's disease. While currently there is no cure or "vaccine" against dementia, there are hopes to delay the onset of the disease by living a brain-healthy life style. The proposed research offers a novel approach to prevent dementia and age-related cognitive disorders.
We propose to use our developed brain fitness APP for the aging population with dementia. The proposed APP is based on the premise of brain plasticity, and targets the brain functions that are declining with normal aging and dementia. In a pilot study, we showed very positive effects of our custom designed brain exercises to strengthen left-right side brain connectivity in older adults when used regularly. Leveraging our previous design, we have developed an end-user product with additional features and enhanced user interface and user experience that will allow it to be used for neuro-cognitive rehabilitation by an individual without supervision The proposed APP will be tested on 30 individuals with cognitive impairment.
Additionally, participants can receive an optional electrical stimulation called transcranial alternating current stimulation. This applies an alternating current to a person's brain by two electrodes placed on the scalp. The participants, who choose this option, will receive simultaneous stimulation during the brain exercise tutored sessions. Studies have shown that simultaneous application of the electrical stimulation and cognitive exercises further enhances the cognitive function by boosting the working memory improvement. Thus, this may lead to further improvements from any potential positive effects of the brain exercises.
We anticipate the frequent use of the proposed APP will help to slow and even reverse the progression of the cognition decline in individuals with mild cognitive impairment or dementia.
調査の概要
詳細な説明
The research is on the frequent use of our designed APP (for iPADs) that contains a series of our recently developed brain exercises that contains a series of our recently developed brain exercises, including orientation, associative memory, word-image association, recall memory, etc. Participant can receive an optional electrical stimulation called transcranial alternating current stimulation (tACS) simultaneously during the brain exercise tutor sessions.
Each participant will have a dedicated tutor for Brain Exercises with three scheduling options:
A) 5 days/week, 2 sessions/day each 30 min) for a period of 4 weeks, B) 3 days/week, 2 sessions/day each 30 minute for a period of 8 weeks, C) Remote program, 5 days/week, 40min/day for a period of 4 weeks (this option is not available for participants receiving tACS).
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究場所
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Manitoba
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Winnipeg、Manitoba、カナダ、R3L 2P4
- 募集
- Riverview Health Center
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コンタクト：
- Zahra Moussavi, Ph.D.
- 電話番号：204-478-6163
- メール：zahra.moussavi@umanitoba.ca
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コンタクト：
- Cristina Francisco, Ph.D.
- 電話番号：204-478-6163
- メール：Cristina.Francisco@umanitoba.ca
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Age: 20+ years
- Have a score of 7≤ MoCA ≤ 25
- Being diagnosed with either mild cognitive impairment (MCI) or mild/moderate stage of Alzheimer's.
- Except the MCI/Alzheimer's diagnosis, have no known or diagnosis of major depression, bipolar disorder, schizophrenia, mood disorder, Parkinson's disease, Huntington disease, ALS, MS, and/or any other neurological disorder.
- Reading/writing fluency in English
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：非ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Brain fitness app
Daily tutored sessions of brain exercises on an iPAD (in-person or remote)
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Daily tutored sessions of brain exercises on an iPAD (in-person or remote)
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実験的：Brain fitness app with tACS
Daily tutored sessions of brain exercises on an iPAD combined with simultaneous transcranial alternating current stimulation (tACS)
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Daily tutored sessions of brain exercises on an iPAD with simultaneous transcranial alternating current stimulation (tACS)
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in Wechsler Memory Scale (WMS IV)
時間枠：baseline, post-intervention within a week after the end of 4-week trial and a month after the second assessment
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This assessment has a total of 11 tests, out of which we will use its six primary tests that assess our target brain functions, comprised of 12 subtests (subsections): Logical Memory 1, Verbal Paired Associates 1, Faces 1, Family Pictures 1, Logical Memory 2, Verbal Paired Associates 2, Faces 2, Family Pictures 2, Verbal Paired Associates 2 Recognition, Logical Memory 2 Recognition, Letter-Number Sequencing and Spatial Span.
They are classified into 3 major memory indexes: Immediate Memory, General Memory and Working Memory.
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baseline, post-intervention within a week after the end of 4-week trial and a month after the second assessment
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in Egocentric Spatial Orientation
時間枠：baseline, post-intervention within a week after the end of 4-week trial and a month after the second assessment
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This test is one of the PI's designs that has been in use since a few years ago.
It is used for detecting the onset of Alzheimer's.
In this test participants sit in a customized wheelchair and by waking the wheelchair they move within a virtual cubic building to reach a particular target room.
They can do this test either using the laptop screen or in its immersive version wearing a goggle (Oculus Rift 2).
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baseline, post-intervention within a week after the end of 4-week trial and a month after the second assessment
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Change in MONTGOMERY ASBERG DEPRESSION RATING SCALE (MADRS)
時間枠：baseline, post-intervention within a week after the end of 4-week trial and a month after the second assessment
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The MADRS is a ten item rating scale for rating levels of depression.
Each item is rated on a 7-point scale from 0 to 6, where 0 indicates absence of the symptom and 6 indicates extreme presence of the symptom.
The time frame for the scale is the previous four weeks.
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baseline, post-intervention within a week after the end of 4-week trial and a month after the second assessment
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。