Nutritional Status and Muscle Function in Ambulatory Multiple Sclerosis Patients With Dysphagia
Evaluation of Nutritional Status and Muscle Function in Ambulatory Patients With Multiple Sclerosis and Dysphagia
The aim of this study is to evaluate the relationship between dysphagia severity and indicators of nutritional status and muscle function in ambulatory patients diagnosed with Multiple Sclerosis (MS) who have swallowing difficulties. In patients with MS, the prevalence of swallowing disorders increases with disease duration and greater neurological involvement. Dysphagia may lead to important clinical consequences such as aspiration risk, inadequate oral intake, involuntary weight loss, and reduced quality of life.
Swallowing difficulties negatively affect both the adequacy and safety of nutrition, thereby increasing the risk of malnutrition. In addition, reduced energy and protein intake may lead to a decline in muscle strength and functional capacity.
However, in the MS population, dysphagia, nutritional status, and muscle function are often evaluated separately, and studies that assess these domains together are limited. There is a need for real-world data in ambulatory MS patients, particularly using age-independent nutritional screening tools and functional muscle assessment tests in combination.
This study aims to systematically and multidisciplinary evaluate nutritional status and muscle function in MS patients with dysphagia.
調査の概要
詳細な説明
This study is a cross-sectional observational research conducted in ambulatory patients diagnosed with Multiple Sclerosis (MS) who experience swallowing difficulties. Participants who meet the inclusion criteria will be informed about the study, and written informed consent will be obtained prior to enrollment.
Demographic and clinical data of the participants (such as age, gender, and disease duration) will be recorded. Swallowing function will be assessed using validated dysphagia screening and/or assessment tools.
Nutritional status will be evaluated using standardized nutritional screening tools and/or anthropometric measurements (such as body weight, height, and body mass index). Muscle function will be assessed using functional measures, including handgrip strength and/or other appropriate muscle performance tests.
The collected data will be statistically analyzed to investigate the relationship between dysphagia severity, nutritional status, and muscle function. No invasive procedures will be performed in this study; only observational and measurement-based assessments will be conducted.
研究の種類
入学 (推定)
連絡先と場所
研究場所
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şehitkamil
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Gaziantep、şehitkamil、トルコ（Türkiye）、27500
- Sanko Unıversıtesı
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参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Be 18 years of age or older
- Have a diagnosis of multiple sclerosis according to the 2017 Revised McDonald criteria
- Have difficulty swallowing (DYMUS >1)
- EDSS score must be available in clinical records
- Possess sufficient cognitive and physical capacity to participate in the questionnaires and assessments to be administered as part of the study
Exclusion Criteria:
- 1. A recent acute MS relapse or use of high-dose corticosteroids within the past 4 weeks 2. Acute orthopedic or traumatic conditions that prevent the performance of measurements 3. Severe cognitive impairment that prevents understanding or performing the tests 4. Being pregnant or breastfeeding 5. Presence of active malignancy or advanced systemic disease 6. Having any pathology in the cervical region
研究計画
研究はどのように設計されていますか？
デザインの詳細
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Body weight and height
時間枠：2 months
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These will be measured in accordance with standard anthropometric measurement protocols.
Height will be measured using a stadiometer with participants standing in the Frankfurt plane.
Body weight will be measured with a calibrated digital scale accurate to 0.1 kg.
Body mass index (BMI) will be calculated by dividing body weight in kilograms by the square of height in meters.
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2 months
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Eating Assessment Tool-10 (EAT-10)
時間枠：2 months
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Developed by Belafsky and colleagues , this is a 10-item self-report scale that assesses the severity of dysphagia as perceived by the patient.
Each item is scored on a scale of 0-4, and the total score ranges from 0 to 40.
A total score of 3 or higher indicates a clinically significant risk of dysphagia.
The validity and reliability of the scale in Turkish were established by Demir and colleagues.
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2 months
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Dysphagia in Multiple Sclerosis (DYMUS)
時間枠：2 months
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Dysphagia in Multiple Sclerosis (DYMUS): DYMUS is a 10-item self-administered questionnaire requiring "yes/no" responses, developed to assess symptoms and signs of swallowing difficulties specific to multiple sclerosis (MS) in relation to solid and liquid foods.
The validity and reliability study of the Turkish version was conducted by Arslan and colleagues, and it has been demonstrated that the Turkish version is a valid and reliable tool for assessing dysphagia in patients with MS.
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2 months
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Yale Swallowing Protocol
時間枠：2 months
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A standardized swallowing screening test developed to assess the risk of aspiration and the safety of oral feeding in individuals with swallowing disorders.
The protocol focuses specifically on determining the risk of aspiration during fluid intake and is used as a quick and reliable screening tool in clinical practice.
The test consists of a structured procedure requiring the individual to drink approximately 90 mL (3 ounces) of water without interruption.
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2 months
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Malnutrition Universal Screening Tool (MUST)
時間枠：2 months
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MUST is a short, practical, and age-independent nutritional screening tool developed to identify the risk of malnutrition in adults.
It consists of three components: Body Mass Index (BMI), unintentional weight loss in the past 3-6 months, and the impact of acute illness or inability to eat.
Based on the total score, individuals are classified as having low, moderate, or high risk of malnutrition.
British Association for Parenteral and Enteral.
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2 months
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- hakanpolat18
個々の参加者データ (IPD) の計画
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医薬品およびデバイス情報、研究文書
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米国FDA規制機器製品の研究
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