Spatial Scene Recognition Memory in Epilepsy Surgery
2026年5月6日 更新者：Nigel P. Pedersen, BSc MBBS、University of California, Davis
Investigations of Spatial Recognition Memory to Improve Cognitive Outcomes in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial/scene memory, recollective experience, and familiarity processing.
Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures.
In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions.
In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition.
In Aim III, intracranial EEG recordings (including local field potentials and single-unit activity) in epilepsy surgery patients at UC Davis determine the precise network dynamics underlying spatial scene familiarity and recall.
The long-term goal is to improve the prediction and prevention of cognitive morbidity from epilepsy surgery by providing a more complete model of spatial recognition memory circuits.
調査の概要
状態
募集
詳細な説明
Recognition memory can be divided into familiarity (a sense that something has been encountered before) and recollection (identification or elaborative recall).
Patients with temporal lobe epilepsy often report subjective memory difficulties that are not captured by conventional neuropsychological tests, which lack assessments of true episodic and scene memory.
This study uses a virtual tour paradigm that objectively separates familiarity-based recognition from recall for spatial scenes.
The central hypothesis is that spatial scene recognition memory critically involves the convergence of dorsal and ventral visual streams in the inferior parietal lobule and parahippocampal gyrus, with familiarity-based recognition involving neocortical structures and recall involving the parahippocampal gyrus, entorhinal cortices, and hippocampus.
The study employs three complementary approaches: (1) lesion-symptom mapping in ~310 surgical patients and 150 controls, (2) scalp ERP and eye-tracking in 80 healthy participants, and (3) intracranial electrophysiology (LFP and single-unit recordings) in ~80 patients undergoing stereoelectroencephalography (SEEG) for clinical seizure localization.
Research electrodes (FDA-approved Dixi micro-macro or Behnke-Fried with tetrode components) are placed at clinically determined locations to additionally capture single-neuron activity.
This study was classified as a Basic Experimental Studies in Humans (BESH) mechanism; it does not evaluate a health-related clinical outcome but uses clinical populations and FDA-approved research electrodes to study basic neuroscience questions about memory.
研究の種類
介入
入学 (推定)
620
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究連絡先
- 名前：Nigel P Pedersen, MD
- 電話番号：916-734-3251
- メール：nppedersen@health.ucdavis.edu
研究場所
-
-
California
-
Sacramento、California、アメリカ、95817
- 募集
- UC Davis Medical Center
-
コンタクト：
- Nigel P Pedersen, MD
- 電話番号：916-734-3251
- メール：nppedersen@health.ucdavis.edu
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-
Georgia
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Atlanta、Georgia、アメリカ、30322
- 募集
- Emory University Hospital
-
コンタクト：
- Daniel L Drane, PhD
- 電話番号：404-727-2844
- メール：ddrane@emory.edu
-
-
参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 大人
健康ボランティアの受け入れ
はい
説明
Inclusion Criteria:
- Age 18 years or older
- For Aims I and III: Diagnosis of focal epilepsy or temporal lobe lesion; patients undergoing evaluation for or having undergone epilepsy surgery
- For Aim II: Healthy adult participants
- Full-Scale IQ ≥ 70
- English proficiency sufficient to understand and complete the task
- For Aim I: Enrolled in or eligible for Emory University epilepsy surgery research registry
- For Aim III: Undergoing clinically indicated stereoelectroencephalography (SEEG) at UC Davis Medical Center
- Able to provide informed consent (or for Aim I retrospective component, prior consent in Emory registry)
Exclusion Criteria:
- Full-Scale IQ < 70
- Inability to provide informed consent
- For Aim III: Age > 55 years
- For Aim II: History of neurological or psychiatric disorder (as applicable per study protocol)
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：非ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Aim I: Lesion-Symptom Mapping
Patients with temporal lobe lesions (n≈310) and healthy controls (n≈150) at Emory University. Retrospective cohort with existing surgical lesions plus prospectively enrolled new surgical patients (~60 over 5 years). Intervention(s): Behavioral: Virtual Tour Recognition Memory Task; Diagnostic: MRI neuroimaging and neuropsychological assessment |
Participants are passively navigated through virtual tour scenes (5-second video clips) during a study phase and are asked to generate descriptive names for each scene.
During the test phase, they view novel, spatially similar (same configuration, different objects), or identical scenes and rate familiarity, indicate old/new judgments, report déjà vu sensations, and attempt to recall scene names.
The task consists of two study-test blocks.
This is a cognitive/behavioral assessment, not a therapeutic intervention.
Pre- and post-surgical structural MRI (T1-weighted, diffusion-weighted imaging, resting-state fMRI) obtained as part of the clinical epilepsy surgery evaluation at Emory University.
Extensive neuropsychological battery administered pre- and post-operatively (6 months and 1 year) including Wechsler memory scales, Rey-Osterrieth Complex Figure, confrontation naming, and additional measures.
|
|
実験的：Aim II: Scalp ERP Study
Healthy participants (n=80) recruited from UC Davis campus community.
Intervention: Behavioral: Virtual Tour Recognition Memory Task (still-image version) during Scalp EEG/ERP recording and eye tracking
|
Participants are passively navigated through virtual tour scenes (5-second video clips) during a study phase and are asked to generate descriptive names for each scene.
During the test phase, they view novel, spatially similar (same configuration, different objects), or identical scenes and rate familiarity, indicate old/new judgments, report déjà vu sensations, and attempt to recall scene names.
The task consists of two study-test blocks.
This is a cognitive/behavioral assessment, not a therapeutic intervention.
|
|
実験的：Aim III: Intracranial EEG
Patients with epilepsy undergoing clinically indicated SEEG (n≈80) at UC Davis Medical Center. Behavioral Intervention: Virtual Tour Recognition Memory Task; Other Intervention: Intracranial EEG recording via clinically placed electrodes, a minority of which have research microelectrodes (FDA-approved Dixi micro-macro or Behnke-Fried Ad-Tech electrodes) |
Participants are passively navigated through virtual tour scenes (5-second video clips) during a study phase and are asked to generate descriptive names for each scene.
During the test phase, they view novel, spatially similar (same configuration, different objects), or identical scenes and rate familiarity, indicate old/new judgments, report déjà vu sensations, and attempt to recall scene names.
The task consists of two study-test blocks.
This is a cognitive/behavioral assessment, not a therapeutic intervention.
Patients undergoing clinically indicated stereoelectroencephalography (SEEG) for seizure localization have electrodes implanted at locations determined solely by clinical need.
In a subset of patients, FDA-approved research electrodes (Dixi micro-macro electrodes or Behnke-Fried As-Tech electrodes with tetrode components) substitute standard clinical electrodes at the same clinically determined locations.
These electrodes have the same geometry as clinical electrodes and are FDA-approved.
The tetrode component enables single-neuron recording for research purposes and adds no additional risk.
Electrode placement is not altered by study participation.
Local field potentials (LFP) and, where available, single-unit data are recorded during the virtual tour task and resting state.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Scene familiarity discrimination accuracy
時間枠：From enrollment until the end of eight weeks, during which time testing is scheduled (Aim II), or during the hospitalization for invasive EEG studies (Aim III). Participants in Aim I can undergo repeat testing (six months, one year, etc.)
|
Rate of correct familiarity judgments for spatially similar test scenes versus novel scenes (recognition without identification/RWI effect), measured as the proportion of "familiar" responses to configurally matched scenes minus false alarm rate to novel scenes.
|
From enrollment until the end of eight weeks, during which time testing is scheduled (Aim II), or during the hospitalization for invasive EEG studies (Aim III). Participants in Aim I can undergo repeat testing (six months, one year, etc.)
|
|
Scene recall accuracy
時間枠：From enrollment until the end of eight weeks, during which time testing is scheduled (Aim II), or during the hospitalization for invasive EEG studies (Aim III). Participants in Aim I can undergo repeat testing (six months, one year, etc.)
|
Proportion of test scenes for which participants correctly recall the name or identifying details of the corresponding study scene (verified recall), separately for identical repeat scenes and configurally similar scenes.
|
From enrollment until the end of eight weeks, during which time testing is scheduled (Aim II), or during the hospitalization for invasive EEG studies (Aim III). Participants in Aim I can undergo repeat testing (six months, one year, etc.)
|
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Lesion-symptom correlation for familiarity and recall (Aim I)
時間枠：Testing is scheduled within eight weeks of enrollment for all patients, with repeat testing at six and 12 months after surgery for those enrolled pre-operatively
|
Voxel-based lesion-symptom mapping (VBLSM) correlating surgical lesion volumes in temporal lobe subregions (temporopolar, perirhinal, entorhinal, parahippocampal, hippocampal) with familiarity and recall behavioral scores.
|
Testing is scheduled within eight weeks of enrollment for all patients, with repeat testing at six and 12 months after surgery for those enrolled pre-operatively
|
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ERP amplitude and latency associated with familiarity and recall (Aim II)
時間枠：During EEG recording session
|
Amplitude and latency of event-related potential components (FN400, late positive component) in specified scalp regions (e.g., LAS, RAS, LPS, RPS) as a function of scene familiarity and recall conditions.
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During EEG recording session
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Intracranial theta and gamma power and connectivity during familiarity judgments (Aim III)
時間枠：During intracranial EEG monitoring (typically 1-2 weeks hospital stay)
|
Theta (3-7 Hz) and gamma-band (30-150 Hz) event-related synchronization/desynchronization in parahippocampal, perirhinal, entorhinal, and hippocampal contacts during familiarity versus recall conditions, plus functional connectivity measures (imaginary coherence, phase-amplitude coupling).
|
During intracranial EEG monitoring (typically 1-2 weeks hospital stay)
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Déjà vu report rate
時間枠：During testing sessions with the virtual tour
|
Proportion of test trials in which participants report a feeling of déjà vu, analyzed by scene condition (similar, repeat, novel).
|
During testing sessions with the virtual tour
|
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Vividness of Visual Imagery Questionnaire, Second Edition (VVIQ-2) scores (Aim I)
時間枠：During testing session
|
Self-reported vividness of visual imagery correlated with lesion location and recognition memory performance.
The VVIQ-2 is a 32-item self-report questionnaire in which each item is rated on a scale from 1 (no image at all) to 5 (perfectly clear and vivid).
Total scores range from 32 to 160.
Higher scores indicate more vivid visual imagery.
|
During testing session
|
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Hyperfamiliarity commission errors
時間枠：During testing session
|
Rate of false positive familiarity judgments for novel scenes (false alarms), as a measure of hyperfamiliarity.
|
During testing session
|
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Neuropsychological test performance (Aim I)
時間枠：Pre-surgery and 6 months / 1 year post-surgery
|
Standard neuropsychological battery scores (Wechsler Memory Scale, Rey-Osterrieth Complex Figure, confrontation naming, etc.) correlated with virtual tour performance and lesion characteristics.
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Pre-surgery and 6 months / 1 year post-surgery
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Single-unit firing rate (subset of patients in Aim III)
時間枠：During intracranial EEG monitoring
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Mean firing rate (spikes per second) of individual neurons recorded from parahippocampal and perirhinal cortex during familiarity versus recall conditions, in patients with tetrode/microelectrode recordings.
|
During intracranial EEG monitoring
|
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Single-unit stimulus selectivity (subset of patients in Aim III)
時間枠：During intracranial EEG monitoring
|
Selectivity index (area under the receiver operating characteristic curve) quantifying the discriminability of familiar versus novel scene conditions in individual neurons recorded from parahippocampal and perirhinal cortex, in patients with tetrode/microelectrode recordings.
|
During intracranial EEG monitoring
|
協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2024年7月1日
一次修了 (推定)
2030年6月30日
研究の完了 (推定)
2030年6月30日
試験登録日
最初に提出
2026年4月30日
QC基準を満たした最初の提出物
2026年5月6日
最初の投稿 (実際)
2026年5月12日
学習記録の更新
投稿された最後の更新 (実際)
2026年5月12日
QC基準を満たした最後の更新が送信されました
2026年5月6日
最終確認日
2026年5月1日
詳しくは
本研究に関する用語
キーワード
- 神経心理学
- イベント関連電位
- 意識
- 海馬
- シーグ
- てんかん手術
- 空間記憶
- 親しみやすさ
- 頭蓋内脳波検査
- ステレオ脳波検査
- recognition memory
- recollection
- neural circuits of memory
- phenomenology of memory
- scene memory
- virtual tour
- lesion-symptom mapping
- network-symptom mapping
- cognitive electrophysiology
- iEEG
- parahippocampal gyrus
- perirhinal cortex
- tetrodes
- deja vu
追加の関連 MeSH 用語
その他の研究ID番号
- 2347891
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
はい
IPD プランの説明
De-identified behavioral data, EEG/ERP data, and intracranial electrophysiology data will be shared via OpenNeuro and Emory Dataverse upon reasonable request.
Identifiable data will remain at collection sites.
IPD 共有時間枠
Data will be made available by the end of the performance period or upon publication.
IPD 共有アクセス基準
De-identified data will be freely available.
Requests prior to publication will be by discussion with the PI.
A data use agreement may be required for certain datasets.
IPD 共有サポート情報タイプ
- STUDY_PROTOCOL
- SAP
- ICF
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米国FDA規制医薬品の研究
いいえ
米国FDA規制機器製品の研究
はい
米国で製造され、米国から輸出された製品。
いいえ
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。