Influence of Tea Consumption on Human Glycemic Response
調査の概要
状態
条件
詳細な説明
This study aims to investigate the effects of tea and food consumption on postprandial metabolic responses, specifically focusing on blood glucose (glycemia) and blood lipid levels. The primary objective is to generate scientifically grounded insights that can inform consumer education and product communication regarding the metabolic impacts of tea and food intake. The study will recruit healthy male volunteers of Chinese ethnicity, aged 21 to 60 years inclusive. Eligible participants will be required to attend seven study visits: (1) an initial screening session, (2) a 2-hour Oral Glucose Tolerance Test (OGTT), and (3-7) five 3-hour intervention sessions.
During the screening, participants will undergo body composition measurement, and a blood draw to confirm eligibility. Participants will also be provided with standardized dinner meals to be consumed the day before each subsequent visits as their last meal of the day before an overnight fast. In the OGTT session, participants will fast overnight. They will be cannulated and consume a glucose beverage; blood samples will be collected at seven timepoints over two hours to analyze for glucose, insulin, lipids, and other metabolic biomarkers. Each of the five intervention sessions will also require overnight fasting. Participants will consume either: one of two tea beverages, each tea beverage with a standardized meal, or the meal alone. Participants will be cannulated and blood will be drawn at nine timepoints over three hours per session. They will also complete satiety questionnaires at each timepoint. Blood samples will be analyzed for glucose, insulin, lipid panel, hormones, and other metabolic biomarkers to evaluate the postprandial effects of the interventions.
The findings are expected to clarify whether tea modulates postprandial glycemic and lipid responses compared to typical intake conditions. Results may support evidence-based communication about tea's metabolic effects and inform future product development and consumer guidance.
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究場所
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Singapore、シンガポール
- National University of Singapore, Department of Food Science & Technology
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参加基準
適格基準
就学可能な年齢
- 大人
健康ボランティアの受け入れ
説明
Inclusion Criteria:
- Male
- Chinese ethnicity
- Ages 21-60 years old (inclusive)
- Healthy
- Weigh at least 50kg
- Must be English-literate and able to give informed consent in English
- Reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures
Exclusion Criteria:
- Female
- A current smoker, or has smoked in the past 2 years
- Fasting glucose >= 7 mmol/L
- History of type 1/type 2 diabetes
- Regular use of medication that may affect glucose metabolism (e.g., steroids)
- Being diagnosed with cancer, heart disease, stroke, renal failure, serious mental or physical illnesses at the time of recruitment
- History of food allergies to test products (milk tea) i.e. milk allergies, or lactose intolerance
- History of food allergies to any of the ready made meals (such as soy, peanuts, eggs, shellfish etc)
- Have donated blood of more than 500 mL within 8 weeks of study enrolment
- Any other conditions, which, in the opinion of the Investigator would make the subject unsuitable for inclusion or could interfere with the subject participating in or completing the study
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：他の
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Tea Type #1
In this intervention, participants will be cannulated and required to consume a specific tea beverage #1.
Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers.
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This is a specific tea variety #1 that will be consumed by participants.
It contains milk, a small amount of sugar, and will be served cold with ice.
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実験的：Tea Type #2
In this intervention, participants will be cannulated and required to consume a specific tea beverage #2.
Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers.
|
This is a specific tea variety #1 that will be consumed by participants.
It contains milk, a small amount of sugar, and will be served cold with ice.
|
|
実験的：Tea Type #1 + Standardized Meal
In this intervention, participants will be cannulated and required to consume a specific tea beverage #1 and a standardized meal.
Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers.
|
This is a specific tea variety #1 that will be consumed by participants.
It contains milk, a small amount of sugar, and will be served cold with ice.
This is a ready to eat meal that can be purchased off the shelves in local stores.
The same meal is used for several study arms to serve as a standardization on the nutritional content consumed.
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実験的：Tea Type #2 + Standardized Meal
In this intervention, participants will be cannulated and required to consume a specific tea beverage #2 and a standardized meal.
Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers.
|
This is a specific tea variety #1 that will be consumed by participants.
It contains milk, a small amount of sugar, and will be served cold with ice.
This is a ready to eat meal that can be purchased off the shelves in local stores.
The same meal is used for several study arms to serve as a standardization on the nutritional content consumed.
|
|
実験的：Standardized Meal
In this intervention, participants will be cannulated and required to consume a standardized meal.
Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers.
|
This is a ready to eat meal that can be purchased off the shelves in local stores.
The same meal is used for several study arms to serve as a standardization on the nutritional content consumed.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
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Changes in laboratory analysis of blood glucose and insulin measurements at 9 timepoints over 3 hours for each session
時間枠：Approximately 16 weeks from enrolment to the end of study
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Approximately 16 weeks from enrolment to the end of study
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協力者と研究者
捜査官
- 主任研究者：Mei Hui Liu, PhD、National University of Singapore
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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