Effects of Whole Body Vibration Versus Proprioceptive Neuromuscular Facilitation Pattern With Rhythmic Based Training on Clinical Outcomes in Patients With Parkinson's Disease.
2026年7月20日 更新者：Lahore University of Biological and Applied Sciences
This study has important clinical, academic, and practical relevance in neuromuscular rehabilitation.
Clinically, it aims to identify effective and tolerable rehabilitation strategies for individuals with Parkinson's disease by comparing whole-body vibration therapy with proprioceptive neuromuscular facilitation (PNF) patterns combined with rhythmic-based training, thereby supporting evidence-based physiotherapy practice and improving patient adherence.
Academically, it contributes to the limited literature on comparative effectiveness of these interventions and incorporates patient-centered outcomes such as exercise perception, which are often underreported.
From a practical and societal perspective, identifying a more acceptable and effective approach may enhance long-term participation in rehabilitation, potentially slow disease progression, improve quality of life, and reduce the overall healthcare burden associated with Parkinson's disease.
調査の概要
状態
完了
条件
詳細な説明
Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms such as tremor, rigidity, bradykinesia, and postural instability.
It also presents with non-motor symptoms including cognitive decline, autonomic dysfunction, and reduced quality of life.
The title of the present study focuses on evaluating the effectiveness of a combined rehabilitation approach integrating rhythmic-based training, whole-body vibration, and proprioceptive neuromuscular facilitation to improve gait, balance, and functional mobility in individuals with Parkinson's disease.
The proposed protocols involve structured rhythmic auditory cueing exercises to enhance movement coordination and timing, whole-body vibration sessions aimed at improving neuromuscular activation and muscle strength, and proprioceptive neuromuscular facilitation techniques to facilitate motor control, flexibility, and functional movement patterns; these interventions are delivered in a progressive manner, tailored to patient tolerance and disease severity, with close monitoring to ensure safety and adherence.
The study design is a randomized clinical trial with two experimental groups.
The study duration is expected to span 8 to 12 weeks, allowing sufficient time for neuromuscular adaptations and observable functional improvements while maintaining feasibility and participant compliance.
Outcome measures include standardized and validated tools such as the Unified Parkinson's Disease Rating Scale for assessing disease severity, the Timed Up and Go test for functional mobility, the 10-Meter Walk Test for gait speed, the Mini-BESTest for dynamic balance, and quality of life scales to evaluate overall patient well-being; these measures are recorded at baseline and post-intervention to determine the effectiveness of the combined rehabilitation protocol, providing comprehensive insight into motor performance, balance control, and functional independence in individuals with Parkinson's disease.
研究の種類
介入
入学 (実際)
42
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Punjab Province
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Shakargarh、Punjab Province、パキスタン、51580
- THQ Shakargarh
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 大人
健康ボランティアの受け入れ
いいえ
説明
Inclusion Criteria:
- Age between 40 and 60 years.
- Patients of both genders (male and female).
- Parkinson's disease severity at Hoehn and Yahr (H&Y) stage 2 and 3.
- Ability to walk independently for 6 minutes without an assistive device.
- Score greater than 40 on the Berg Balance Scale.
Exclusion Criteria:
- Presence of impaired Cognition.
- Significant Orthopedic and Musculoskeletal conditions that limit the adherence to exercise and WBV requirements.
- Other medical conditions like thrombosis, cardiovascular conditions and medical implants that are contradicted for WBV.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：ダブル
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的：Whole Body Vibration with Rhythmic Based Training
Whole Body Vibration (WBV) and Rhythm-Based Training (RBT) are adjunct therapeutic interventions used to enhance functional mobility, balance, and motor coordination.
WBV provides mechanical oscillatory stimuli to the body through a vibration platform, aiming to improve neuromuscular activation and postural control.
RBT utilizes external auditory cues to guide movement timing, promoting auditory-motor entrainment and improving movement coordination and gait performance.
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WBV will be applied during standing exercises using a vibration platform set at a frequency of 11 Hz and an amplitude of 3-6 mm (vertical oscillation).
The intervention will be administered in intermittent cycles of 1 minute of vibration followed by 1 minute of rest, with a total cumulative exposure of 10-14 minutes per session (5-7 bouts).
Concurrently, RBT will be delivered using an auditory metronome providing rhythmic cues synchronized with the exercise movements, with the tempo maintained between 110-130 beats per minute (BPM) to facilitate timing, coordination, and motor performance.
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実験的：Proprioceptive Neuromuscular Facilitation Pattern with Rhythmic Based Training
Proprioceptive Neuromuscular Facilitation (PNF) Rhythmic Initiation (RI) D1 patterns combined with Rhythm-Based Training (RBT) are used to facilitate motor learning, improve movement initiation, and enhance neuromuscular coordination.
The D1 flexion and extension patterns of PNF target coordinated multi-planar upper and lower limb movements, progressing through passive, active-assisted, and active-resistive phases to improve motor control, normalize muscle tone, and increase movement efficiency.
RBT provides external auditory cueing to enhance timing and rhythmic synchronization of voluntary movement.
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The patient will perform PNF Rhythmic Initiation (RI) D1 flexion and extension patterns for both upper and lower extremities in standing.
The D1 flexion pattern involves shoulder extension, abduction, and external rotation progressing to flexion, adduction, and internal rotation, while the D1 extension pattern represents the reverse movement.
The exercise will be progressed from passive to active-assisted and then to active-resistive movements to facilitate motor control and movement initiation.
In addition, Rhythm-Based Training (RBT) will be applied using an auditory metronome to provide rhythmic cues synchronized with the active phase of the PNF movements, particularly during transitions between flexion and extension, with a consistent tempo of 110-130 beats per minute (BPM).
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Timed Up and Go (TUG) Test
時間枠：[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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The Timed Up and Go (TUG) test is a simple functional mobility assessment that measures the time taken (in seconds) to stand from a chair, walk 3 meters, turn, walk back, and sit down.
It evaluates balance, gait, and functional mobility in a single task.
Lower scores indicate better performance, with <10 seconds considered normal, 10-20 seconds indicating mostly independent mobility, and >20 seconds suggesting functional limitation.
It is also commonly used as an indicator of fall risk, especially in neurological populations such as Parkinson's disease.
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[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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Unified Parkinson's Disease Rating Scale - Part III (UPDRS-III)
時間枠：[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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The Unified Parkinson's Disease Rating Scale (UPDRS-III) is a clinician-administered tool used to evaluate motor impairment in Parkinson's disease.
It assesses key motor domains including tremor, rigidity, bradykinesia, posture, gait, and postural stability through direct observation.
Each item is scored on a 0-4 scale, where 0 represents normal function and 4 indicates severe impairment, with a maximum total score of 132.
Higher scores reflect greater motor dysfunction.
The scale is widely used for monitoring disease severity and progression in both clinical and research settings.
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[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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Mini-Balance Evaluation Systems Test (Mini-BESTest)
時間枠：[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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The Mini-BESTest is a clinical balance assessment designed to evaluate dynamic balance and postural control across multiple systems, including anticipatory postural adjustments, reactive postural control, sensory orientation, and gait stability.
It consists of 14 items scored from 0 to 2, with a total score ranging from 0 to 28, where higher scores indicate better balance performance.
It is particularly sensitive in detecting balance impairments and fall risk in individuals with neurological conditions such as Parkinson's disease.
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[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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10-Meter Walk Test (10MWT)
時間枠：[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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The 10-Meter Walk Test (10MWT) is a standardized measure of gait speed, where the time taken to walk a central 10-meter distance is recorded and converted into meters per second (m/s).
It assesses functional walking ability and mobility performance.
The test can be performed at a comfortable or fast pace to evaluate functional capacity.
It is widely used in Parkinson's disease to monitor gait impairments and response to rehabilitation, as gait speed is a strong indicator of overall functional status.
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[Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]
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研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2026年5月1日
一次修了 (実際)
2026年7月9日
研究の完了 (実際)
2026年7月9日
試験登録日
最初に提出
2026年7月20日
QC基準を満たした最初の提出物
2026年7月20日
最初の投稿 (実際)
2026年7月23日
学習記録の更新
投稿された最後の更新 (実際)
2026年7月23日
QC基準を満たした最後の更新が送信されました
2026年7月20日
最終確認日
2026年7月1日
詳しくは
本研究に関する用語
その他の研究ID番号
- UBAS/ERB/26/04/038
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