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Targeted Muscle Activation During Strength Training for Children With CP (TACT-CP)

2026年8月28日 更新者：Kaat Desloovere、Universitaire Ziekenhuizen KU Leuven

Targeted Muscle Activation During Strength Training for Children With Cerebral Palsy

Cerebral palsy (CP) is the most common cause of physical disability in children and is associated with muscle weakness, spasticity, and impaired motor control. These impairments often lead to compensatory movement strategies, in which other muscles are recruited or movements are adapted to offload weaker target muscles. Although lower limb strengthening is widely used to improve motor function in children with CP, outcomes remain inconsistent. One potentially important but rarely examined factor is whether the intended muscles are actually activated during training. This study aims to develop and apply an activation-driven assessment protocol that combines individualized exercise selection, real-time electromyography (EMG) biofeedback, and compensation monitoring to identify conditions that promote target-muscle activation while limiting compensatory mechanisms. The focus is on three key muscle groups: hip extensors (HE), knee extensors (KE), and plantar flexors (PF). In this prospective[JV2.1], within-subject repeated-measures study, 30 ambulant children aged 5-12 years with spastic CP and Gross Motor Function Classification System levels I-III will complete three assessment visits in which exercise conditions and feedback strategies are compared using surface EMG and three-dimensional movement analysis.

調査の概要

状態

まだ募集していません

条件

詳細な説明

CP causes primary neurological impairments such as spasticity, muscle weakness, and reduced selective motor control. Over time, these impairments contribute to secondary musculoskeletal changes, including muscle contractures and skeletal deformities, which further limit mobility and affect gait. Muscle weakness in CP is multifactorial and results not only from reduced force-generating capacity but also from impaired muscle activation, altered muscle morphology, and biomechanical disadvantages. Consequently, children may compensate through alternative muscle recruitment and altered movement strategies that offload weaker muscles.

Lower limb strength training is a common intervention and has shown benefits for muscle strength, gait, and gross motor function. However, findings across studies are highly variable. One potentially important but rarely examined factor is whether strengthening exercises activate the intended target muscles. Due to impaired selective motor control, children with CP may unintentionally train compensatory muscles rather than the weaker muscles that require strengthening.

To address this limitation, the present study proposes an activation-driven approach to lower limb strengthening. The protocol combines individualized exercise selection, EMG-biofeedback, and explicit management of compensatory mechanisms to promote more selective muscle activation. The ultimate goal is to improve training specificity and support the development of more effective strengthening interventions for children with spastic CP. The study specifically focuses on the gluteus maximus, vastus lateralis, and soleus, as these muscles play a crucial role in gait, are commonly weakened in CP, and may be offloaded through compensatory muscle recruitment.

In this prospective, [JV3.1]within-subject repeated-measures study, 30 ambulant children aged 5-12 years with spastic CP and Gross Motor Function Classification System levels I-III will complete three assessment visits. Visit 1 will evaluate 3-5 bodyweight exercise conditions per muscle group and select up to three individualized conditions based on target-muscle activation and compensatory mechanisms. Visit 2 will compare standardized instruction, patient-tailored verbal feedback, and visual single-target EMG feedback. Visit 3 will compare single-target EMG feedback with dual-target EMG feedback and combined EMG and biomechanical feedback. Surface EMG, three-dimensional motion capture, and force platforms will be used to assess the immediate effects of these conditions on target-muscle activation, compensatory muscle activity, and compensatory movement patterns.

研究の種類

観察的

入学 (推定)

30

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究連絡先

研究連絡先のバックアップ

研究場所

  • ベルギー
    • Vlaams-Brabant
      • Leuven、Vlaams-Brabant、ベルギー、3000

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

  • 子

健康ボランティアの受け入れ

いいえ

サンプリング方法

非確率サンプル

調査対象母集団

Children with spastic cerebral palsy, who have routine follow-up care at the CP reference center of the university hospitals Leuven

説明

Inclusion Criteria:

  • Confirmed diagnosis of spastic cerebral palsy
  • Aged 5 - 12 years at the time of inclusion
  • GMFCS level I - III
  • At least 3 months post-injection with Botulinum neurotoxin in muscles relevant to the target or compensatory activation patterns (rationale: there is no expected residual neuromuscular effect of Botulinum neurotoxin injections on muscle activation patterns ≥3 months post Botulinum neurotoxin injection)
  • ≥12 months post lower-limb orthopaedic surgery

Exclusion Criteria:

  • Dyskinetic or ataxic cerebral palsy
  • Severe spasticity (Modified Ashworth ≥3)
  • Severe bony deformities or comorbidities precluding valid assessments
  • Insufficient ability to understand instructions or cooperate with the assessment procedures.

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか？

デザインの詳細

コホートと介入

グループ/コホート
Children with cerebral palsy
Children with spastic cerebral palsy, aged 5-12 years, GMFCS levels I-III

この研究は何を測定していますか？

主要な結果の測定

結果測定
メジャーの説明
時間枠
Peak EMG amplitude of the target muscles
時間枠：Assessed across three study visits over approximately 4 weeks.
Peak normalized EMG amplitude during the exercise, used as a measure of maximal targeted activation of the hip extensors (HE), knee extensors (KE), and plantar flexors (PF).
Assessed across three study visits over approximately 4 weeks.
Integrated EMG of the target muscles
時間枠：Assessed across three study visits over approximately 4 weeks.
Integrated normalized EMG over the duration of the complete task or phase of interest, used as a measure of total targeted muscle activation.
Assessed across three study visits over approximately 4 weeks.
Co-activation index
時間枠：Assessed across three study visits over approximately 4 weeks.

Quantification of simultaneous activation of the target muscle and relevant antagonist or compensatory muscle, used to assess co-activation during strengthening exercises.

It is calculated as: Co-activation index (%) = 2 × (Common Area of A and B / (Area of A + Area of B)) × 100 where A and B represent the two muscles being compared. Values range from 0% to 100%, with higher values indicating greater simultaneous muscle activation (co-activation).
Assessed across three study visits over approximately 4 weeks.
Selectivity ratio
時間枠：Assessed across three study visits over approximately 4 weeks.
Integrated EMG of the point-by-point ratio between the time-normalized activation waveform of the target muscle and the corresponding activation waveform of a relevant synergistic or compensatory muscle, used as a measure of target muscle selectivity during the exercise.
Assessed across three study visits over approximately 4 weeks.
Joint angle compensation parameter
時間枠：Assessed across three study visits over approximately 4 weeks.
A predefined joint angle (expressed in °) selected according to the exercise task, used to quantify compensatory movement strategies.
Assessed across three study visits over approximately 4 weeks.
Joint moment compensation parameter
時間枠：Assessed across three study visits over approximately 4 weeks.
A predefined joint moment (expressed in Nm/kg) selected according to the exercise task, used to quantify compensatory movement strategies.
Assessed across three study visits over approximately 4 weeks.
Joint power compensation parameter
時間枠：Assessed across three study visits over approximately 4 weeks.
A predefined joint power (expressed in W/kg) selected according to the exercise task, used to quantify compensatory movement strategies.
Assessed across three study visits over approximately 4 weeks.

二次結果の測定

結果測定
メジャーの説明
時間枠
Continuous EMG waveforms
時間枠：Assessed across three study visits over approximately 4 weeks.
Time-normalized EMG waveforms of target, antagonist, and compensatory muscles across the full exercise cycle and relevant task phases.
Assessed across three study visits over approximately 4 weeks.
Continuous joint angle waveforms
時間枠：Assessed across three study visits over approximately 4 weeks.
Time-normalized joint angle waveforms across the full exercise cycle and task-specific phases. Values are expressed in degrees (°) and reported over 0-100% of the exercise cycle.
Assessed across three study visits over approximately 4 weeks.
Continuous joint moment waveforms
時間枠：Assessed across three study visits over approximately 4 weeks.
Time-normalized joint moment waveforms across the full exercise cycle and task-specific phases. Values are expressed in Nm/kg and reported over 0-100% of the exercise cycle.
Assessed across three study visits over approximately 4 weeks.
Continuous joint power waveforms
時間枠：Assessed across three study visits over approximately 4 weeks.
Time-normalized joint power waveforms across the full exercise cycle and task-specific phases. Values are expressed in W/kg and reported over 0-100% of the exercise cycle.
Assessed across three study visits over approximately 4 weeks.
Mean EMG amplitude
時間枠：Assessed across three study visits over approximately 4 weeks.
Mean normalized EMG amplitude of the target muscle during the exercise, expressed as a percentage (%) relative to the reference signal used for EMG normalization.
Assessed across three study visits over approximately 4 weeks.
Muscle activation timing
時間枠：Assessed across three study visits over approximately 4 weeks.
Activation onset and offset timing of the target muscle, determined from the normalized EMG signal and expressed in milliseconds (ms).
Assessed across three study visits over approximately 4 weeks.
Additional co-activation measures
時間枠：Assessed across three study visits over approximately 4 weeks.

Co-activation indices (expressed in %) for other relevant muscle pairs, including agonist-antagonist and proximal-distal muscle combinations. Co-activation is calculated as:

Co-activation Index (%) = 2 × (Common Area of A and B / (Area of A + Area of B)) × 100 where A and B represent the two muscles being compared. Values range from 0% to 100%, with higher values indicating greater simultaneous muscle activation.
Assessed across three study visits over approximately 4 weeks.
Additional selectivity measures
時間枠：Assessed across three study visits over approximately 4 weeks.
Selectivity ratios involving other target, synergistic, antagonist, or compensatory muscles to further describe the specificity of muscle recruitment. The selectivity ratio is calculated as the integrated EMG of the point-by-point ratio between the time-normalized activation waveform of the target muscle and the corresponding activation waveform of the comparison muscle. Values are expressed as a %, with higher values indicating greater selective activation of the target muscle relative to the comparison muscle.
Assessed across three study visits over approximately 4 weeks.
Additional kinematic parameters
時間枠：Assessed across three study visits over approximately 4 weeks.
Exercise-specific kinematic variables, including joint range of motion, peak joint angles, trunk inclination, pelvic movement, knee position, ankle strategy. Values are expressed in degrees (°).
Assessed across three study visits over approximately 4 weeks.
Peak joint moments
時間枠：Assessed across three study visits over approximately 4 weeks.
Exercise-specific peak joint moments. Values are expressed in Nm/kg.
Assessed across three study visits over approximately 4 weeks.
Peak joint powers
時間枠：Assessed across three study visits over approximately 4 weeks.
Exercise-specific peak joint powers. Values are expressed in W/kg.
Assessed across three study visits over approximately 4 weeks.
Movement variability
時間枠：Assessed across three study visits over approximately 4 weeks.
Variability of biomechanical parameters across repeated exercise trials, calculated as the standard deviation of the parameter of interest.
Assessed across three study visits over approximately 4 weeks.
Number of repetitions completed
時間枠：Assessed across three study visits over approximately 4 weeks.
Number of exercise repetitions successfully completed during the exercise task.
Assessed across three study visits over approximately 4 weeks.
Exercise duration parameters
時間枠：Assessed across three study visits over approximately 4 weeks.
Task execution measures including movement duration and task phase duration during strengthening exercises. Values are expressed in seconds.
Assessed across three study visits over approximately 4 weeks.
Task execution success
時間枠：Assessed across three study visits over approximately 4 weeks.
Success of task execution during strengthening exercises, expressed as the proportion of successfully completed repetitions to the total number of attempted repetitions.
Assessed across three study visits over approximately 4 weeks.
Ability to perform the exercise under feedback conditions
時間枠：Assessed across three study visits over approximately 4 weeks.
Ability to perform the exercise across the different feedback conditions, expressed as the proportion of feedback conditions in which the participant is able to complete the exercise.
Assessed across three study visits over approximately 4 weeks.
Maximal isometric strength
時間枠：Assessed across three study visits over approximately 4 weeks.
Maximal voluntary isometric strength of the hip extensors (HE), knee extensors (KE), and plantar flexors (PF), measured with a hand-held dynamometer during the maximal voluntary isometric contraction (MVIC) procedures to characterize participant-specific strength capacity.
Assessed across three study visits over approximately 4 weeks.
Age
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
Age of the participant at study inclusion (expressed in years).
Collected during screening and/or Visit 1, before the experimental exercise assessments.
Sex
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
Sex of the participant (male, female, other).
Collected during screening and/or Visit 1, before the experimental exercise assessments.
Gross Motor Function Classification System (GMFCS) level
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
GMFCS Levels I-III (higher levels indicate greater functional limitation).
Collected during screening and/or Visit 1, before the experimental exercise assessments.
General treatment history
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
General treatment history relevant to the management of cerebral palsy.
Collected during screening and/or Visit 1, before the experimental exercise assessments.
Previous strength training experience
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
Previous participation in strength training activities.
Collected during screening and/or Visit 1, before the experimental exercise assessments.
Botulinum neurotoxin history
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
Previous treatment with botulinum neurotoxin.
Collected during screening and/or Visit 1, before the experimental exercise assessments.
Orthopaedic surgery history
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
Previous lower-limb orthopaedic surgery.
Collected during screening and/or Visit 1, before the experimental exercise assessments.
Use of orthoses or assistive devices
時間枠：Collected during screening and/or Visit 1, before the experimental exercise assessments.
Current use of orthoses or assistive devices.
Collected during screening and/or Visit 1, before the experimental exercise assessments.

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

Universitaire Ziekenhuizen KU Leuven

捜査官

  • 主任研究者：Kaat Desloovere, Prof. dr.、Department of Rehabilitation Sciences, KU Leuven, Belgium

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始 (推定)

2026年9月1日

一次修了 (推定)

2029年2月28日

研究の完了 (推定)

2029年2月28日

試験登録日

最初に提出

2026年8月24日

QC基準を満たした最初の提出物

2026年8月28日

最初の投稿 (実際)

2026年9月2日

学習記録の更新

投稿された最後の更新 (実際)

2026年9月2日

QC基準を満たした最後の更新が送信されました

2026年8月28日

最終確認日

2026年8月1日

詳しくは

本研究に関する用語

キーワード

追加の関連 MeSH 用語

その他の研究ID番号

  • S72414

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米国FDA規制医薬品の研究

いいえ

米国FDA規制機器製品の研究

いいえ

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