Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study
Effects of a Two-Week Stair-Climbing "Exercise Snacks" Intervention on Body Composition, Cardiovascular Fitness, and Metabolic Responses in Overweight and Obese Adults: A Pilot Study
This pilot study will evaluate whether brief bouts of stair climbing performed throughout the day for two weeks can improve metabolic health, cardiovascular fitness, and other health-related outcomes in adults with overweight or obesity who do not regularly exercise. Participants will complete approximately 6-8 brief stair-climbing "exercise snacks" per day for 14 days, with each bout consisting of approximately 60 total stair steps performed at a challenging but safe self-selected pace.
Participants will complete baseline and post-intervention assessments at Saint Louis University. These assessments will include continuous glucose monitoring and standardized meal testing to evaluate glucose responses, as well as measures of aerobic fitness, anaerobic power, body composition, waist circumference, and muscular strength. The study will also evaluate adherence, perceived exercise intensity, and the feasibility of incorporating brief stair-climbing bouts into daily life.
調査の概要
詳細な説明
This is a pilot intervention study designed to examine the short-term effects and feasibility of frequent stair-climbing "exercise snacks" in adults with overweight or obesity. Exercise snacks are brief bouts of physical activity performed intermittently throughout the day and may provide a time-efficient approach to increasing physical activity.
The study will enroll approximately 12 adults aged 18-35 years with a body mass index of 25.0-34.9 kg/m² who are otherwise healthy and do not regularly participate in structured exercise. Participants must have regular access to a safe staircase.
Participants will complete three in-person study visits at Saint Louis University over approximately 15-16 days. Baseline assessments will include anthropometric and body composition measurements, resting cardiovascular measures, handgrip strength, aerobic fitness testing, and anaerobic power testing. Participants will also complete a standardized meal challenge while wearing a continuous glucose monitor to assess postprandial glucose responses.
Following baseline testing, participants will complete a two-week stair-climbing intervention. They will perform approximately 6-8 stair-climbing bouts per day for approximately 14 days. Each bout will consist of approximately 60 total stair steps completed at a self-selected challenging but safe pace. Participants may use one or more flights of stairs repeatedly if approximately 60 continuous upward steps are not available. The intervention will be completed in participants' usual daily environments, such as home, work, or campus.
Participants will wear a continuous glucose monitor during the intervention period and will complete activity, dietary, and study-related logs. After the two-week intervention, participants will repeat the standardized meal challenge and laboratory assessments.
The primary study outcomes include changes in postprandial glucose response, glycemic variability, and aerobic fitness from baseline to post-intervention. Secondary outcomes include changes in body composition, waist circumference, anaerobic power, and muscular strength. Exploratory outcomes include adherence and feasibility of the stair-climbing intervention.
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：Hossein Rafiei, PhD, RD
- 電話番号：314-977-8675
- メール：hossein.rafiei@health.slu.edu
研究場所
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Missouri
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St Louis、Missouri、アメリカ、63104
- 募集
- Saint Louis University
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コンタクト：
- Hossein Rafiei, PhD RD
- 電話番号：314-977-8675
- メール：hossein.rafiei@health.slu.edu
-
主任研究者：
- Hossein Rafiei, PhD, RD
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-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Age 18-35 years and able to provide informed consent.
- Body mass index (BMI) 25.0-34.99 kg/m² and otherwise healthy, without chronic disease.
- Sedentary or low-active lifestyle, defined as no regular structured exercise ≥3 days/week for ≥30 minutes per session during the past 3 months.
- Access to a safe staircase that permits completion of approximately 60 total stair steps per exercise bout. Approximately 60 upward steps are preferred when available; one or more flights may be used repeatedly if needed.
- No contraindications or increased-risk findings identified on the PAR-Q+ or health history screening.
Exclusion Criteria:
- Known cardiovascular, pulmonary, metabolic, renal, neurological, or musculoskeletal disease, or signs or symptoms suggesting increased risk during vigorous exercise, including diagnosed diabetes mellitus, cardiovascular disease, uncontrolled hypertension, chronic pulmonary disease, kidney disease, fainting or unexplained dizziness during exercise, chest pain with exertion, or severe shortness of breath with mild-to-moderate activity.
- Current use of medications that may affect exercise tolerance, heart-rate response, balance, glucose metabolism, or safety during vigorous exercise, including insulin or other glucose-lowering medications, beta-blockers, anti-arrhythmic medications, systemic corticosteroids, or medications that may cause dizziness, impaired balance, or altered exercise response.
- Orthopedic or joint conditions that could be aggravated by repeated stair climbing.
- Allergy, intolerance, dietary restriction, or other condition preventing safe consumption of the standardized meal replacement shake.
- Pregnancy or plans to become pregnant during the study period.
- Any other medical or psychological condition that, in the investigator's judgment, could make adherence difficult or place the participant at risk.
- Individuals currently enrolled in a course taught by the PI or other study personnel, or who are directly supervised, graded, or formally evaluated by a member of the study team.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：防止
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Two-Week Stair-Climbing Exercise Snacks
Participants will complete a two-week stair-climbing exercise snack intervention. They will perform approximately 6-8 brief stair-climbing bouts per day for approximately 14 days. Each bout will include approximately 60 total stair steps completed at a self-selected challenging but safe pace. Participants will otherwise be asked to maintain their usual diet and lifestyle and avoid beginning a new exercise or diet program during the study. |
Participants will perform brief stair-climbing exercise snacks 6-8 times per day for 14 days. Each bout will consist of approximately 60 total stair steps completed at a self-selected challenging but safe pace. When possible, participants will complete approximately 60 upward steps. If 60 continuous upward steps are not available, participants may use one or more flights repeatedly by ascending and descending carefully until approximately 60 total steps are completed. The intervention will be completed independently in participants' usual daily environments, such as home, work, or campus. Participants will be instructed to use the handrail when needed, descend slowly and carefully, and not run down the stairs. |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in 2-Hour Postprandial Glucose Area Under the Curve (AUC)
時間枠：Baseline (Day 1) and post-intervention (Day 15)
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Postprandial glucose response will be assessed using continuous glucose monitoring during a standardized meal challenge performed before and after the two-week stair-climbing intervention. Glucose area under the curve (AUC) over the approximately 2-hour post-meal period will be calculated using the trapezoidal method and compared between pre- and post-intervention assessments. |
Baseline (Day 1) and post-intervention (Day 15)
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Change in CGM-Derived Glucose Standard Deviation
時間枠：Early intervention (Days 2-4) and late intervention (Days 11-13)
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Glucose standard deviation will be calculated from continuous glucose monitoring data over three complete 24-hour periods during the early and late intervention periods and compared within participants. |
Early intervention (Days 2-4) and late intervention (Days 11-13)
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|
Change in Aerobic Capacity (VO₂max or Estimated VO₂max)
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Aerobic capacity will be assessed using a VO₂max or estimated VO₂max test with metabolic cart analysis/indirect calorimetry during a graded exercise test. Peak oxygen uptake will be expressed in mL/kg/min and compared between baseline and post-intervention assessments. If a maximal test is not appropriate or feasible, a submaximal test with VO₂ extrapolation may be used. |
Baseline (Day 0) and post-intervention (Day 15)
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Change in CGM-Derived Glucose Coefficient of Variation
時間枠：Early intervention (Days 2-4) and late intervention (Days 11-13)
|
Glucose coefficient of variation will be calculated from continuous glucose monitoring data over three complete 24-hour periods during the early and late intervention periods and compared within participants. |
Early intervention (Days 2-4) and late intervention (Days 11-13)
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in Body Weight
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Body weight will be measured using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
|
|
Change in Body Fat Percentage
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Total body fat percentage will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
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Change in Fat Mass
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Total body fat mass will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
|
|
Change in Lean Mass
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Total lean mass will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
|
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Change in Phase Angle
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Phase angle will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
|
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Change in Waist Circumference
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Waist circumference will be measured using a measuring tape at the iliac crest and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
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Change in Wingate Peak Power
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Peak anaerobic power will be assessed during a 30-second Wingate anaerobic test performed on a cycle ergometer and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
|
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Change in Wingate Mean Power
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Mean anaerobic power will be assessed during a 30-second Wingate anaerobic test performed on a cycle ergometer and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
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Change in Handgrip Strength
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Handgrip strength will be measured using an InBody handgrip dynamometer. The best of three trials for each hand will be recorded, with dominant-hand grip strength used for the primary comparison between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
|
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Change in Segmental Body Fat Percentage
時間枠：Baseline (Day 0) and post-intervention (Day 15)
|
Segmental body fat percentage will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments. |
Baseline (Day 0) and post-intervention (Day 15)
|
|
Change in 24-Hour Mean Glucose
時間枠：Early intervention (Days 2-4) and late intervention (Days 11-13)
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Mean glucose will be calculated from continuous glucose monitoring data over prespecified early- and late-intervention periods and compared within participants. |
Early intervention (Days 2-4) and late intervention (Days 11-13)
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Change in Time in Range
時間枠：Early intervention (Days 2-4) and late intervention (Days 11-13)
|
The percentage of CGM readings within the prespecified glucose target range will be calculated over early- and late-intervention periods and compared within participants. |
Early intervention (Days 2-4) and late intervention (Days 11-13)
|
協力者と研究者
スポンサー
捜査官
- 主任研究者：Hossein Rafiei, PhD, RD、St. Louis University
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- STUDY00000657
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
Individual participant data will not be shared with researchers outside the study team, in accordance with the IRB-approved protocol and informed consent. Study findings may be disseminated in aggregate form through scientific presentations and peer-reviewed publications.
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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