- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT00260468
Brain Abnormalities in Late-Onset Major Depression
Structural and Functional Cerebral Findings in Late-Onset Major Depression
연구 개요
상세 설명
Major depression is a frequent and serious disorder with different prognoses and complications with respect to lack of treatment response, recurrence and suicide.
MRI of the brain can provide information about changes in the brain tissue with depression, e.g. lesions of nerve connections, small thrombi or changes in the blood flow. These changes appear primarily after the age of 50 and are seen in cases of diabetes and high blood pressure. Furthermore, the connection between disruptions in the body's stress response system and depression will be explored, which is very important since studies indicate that stress and depression can affect certain brain parts permanently. This will give us a better understanding of the connection between brain changes, neuropsychology and depression prognosis, which is decisive for accurate diagnostics, effective treatment and targeted prevention of the disease in the long run.
The project is part of a larger clinical assessment programme in the Neuropsychiatric Unit under the Centre for Basic Psychiatric Research, Aarhus Psychiatric Hospital, Denmark, which gives us unique possibilities of combining research and daily clinical work. The hope is in the future to be able to offer patients in the risk group better assessment and treatment to prevent complications and recurrence.
연구 유형
등록 (실제)
연락처 및 위치
연구 장소
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Risskov, 덴마크, DK-8240
- Centre for Psychiatric Research, Aarhus University Hospital
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
- Subjects with first-episode late-onset major depression from psychiatric hospital or clinic
- Healthy controls
설명
Inclusion Criteria:
- first time major depression
- age over 50 years
- Caucasian
- admitted at a psychiatric hospital or treated at a local psychiatric clinic in Aarhus Amt
Exclusion Criteria:
- major brain damage (e.g. stroke, epilepsy, trauma)
- major alcohol or drug abuse
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
공동 작업자 및 조사자
수사관
- 연구 책임자: Raben Rosenberg, Professor, MD, DrMedSc, Aarhus University Hospital
- 수석 연구원: Videbech Poul, Professor, MD, DrMedSc, Aarhus University Hospital
- 연구 의자: Leif Østergaard, Professor, MD, DrMedSc, PhD, Center for Functionally Integrative Neuroscience (CFIN), Aarhus University Hospital, Denmark
연구 기록 날짜
연구 주요 날짜
연구 시작
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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