AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation (APAF-CSP)
2026년 5월 19일 업데이트: M. Rienstra, University Medical Center Groningen
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation: The APAF-CSP All-cause Mortality and Quality of Life Trial
The goal of this clinical trial is to learn if conduction system pacing works as well as cardiac resynchronization therapy (CRT) post atrioventricular (AV) node ablation in adult patients with symptomatic heart failure and atrial fibrillation that is not suitable for rhythm control.
The main question it aims to answer is:
Is AV node ablation with conduction system pacing noninferior to AV node ablation with CRT for the hierarchical composite outcome of all-cause mortality, heart failure hospitalization or urgent heart failure visit, and meaningful improvement in heart failure-related quality of life?
Participants will undergo:
- An AV node ablation and be randomly assigned to receive either a conduction system pacing or a CRT.
- Attend follow-up visits (in clinic or by telephone) at baseline, intervention day, 3-month, 12-month, 24-month, and 36-month after the procedure.
- Complete questionnaires about heart failure symptoms and quality of life at baseline, 12 months, and yearly.
- Have an echocardiogram, an electrocardiogram, and blood tests at baseline and 1 year
- At selected centers: they will be asked to wear a bracelet that measures arterial stiffness for 30 minutes and provide a urine sample at baseline and 1 year.
연구 개요
상태
아직 모집하지 않음
상세 설명
- Study Rationale:
Therapeutic options for patients with symptomatic HF and AF that is not suitable for rhythm control are limited to pharmacological rate control and/or AV node ablation plus CRT implantation (Class IIa, Level of Evidence B). CSP is gaining more and more attention, and it has the advantage of utilizing the native conduction system to activate both ventricles simultaneously. This would achieve more physiologically synchronized ventricular contraction and circulation dynamics. We hypothesize that conduction system pacing would be as efficient as CRT pacing in patients with symptomatic heart failure and AF that is not suitable for rhythm control who are receiving the "ablate and pace" treatment strategy.
+Objective:
Primary Objective:
To compare AV node ablation with conduction system pacing versus AV node ablation with cardiac resynchronization therapy (CRT) among the trial population with respect to the hierarchical composite endpoint of all-cause mortality, HF hospitalization or unplanned/urgent HF visit, and ≥5 point improvement (increase) in the Kansas City Cardiomyopathy Questionnaire (KCCQ) score.
Secondary Objectives:
To determine the effect of AV node ablation with conduction system pacing compared to AV node ablation with cardiac resynchronization therapy (CRT) among the trial population in the following outcomes:
-≥5 point improvement (increase) in the Kansas City Cardiomyopathy Questionnaire (KCCQ) score.
- Quality of life measures (EQ-5D and AFEQT questionnaires). -HF hospitalization or unplanned/urgent HF visit. -Cardiovascular related hospitalization. -All-cause mortality. -Cardiovascular related mortality. Tertiary (Exploratory) Objectives: To determine the effect of AV node ablation with conduction system pacing compared to AV node ablation with cardiac resynchronization therapy (CRT) among the trial population in the following outcomes:
- Duration of hospitalization for cardiovascular causes
- Worsening heart failure (NYHA class at baseline,1 year and at end of follow-up),
- Healthcare costs and cost-effectiveness,
- Trends of NT-proBNP levels at baseline and follow up
- Change in left ventricular ejection fraction (LVEF) at baseline and 1 year
- Change in renal function metrics (Glomerular Filtration Rate (GFR), Creatinine (Cr) and blood Urea levels (BUN)) at baseline and 1 year.
- Change in urine Microalbumin (by urine dipstick) at baseline and 1 year (only in the subgroup analysis).
- Change in measured arterial stiffness index measured by the photoplethysmography (PPG) signals through a non-invasive blood-volume sensing wearable bracelet, at baseline and 1 year (only in the subgroup analysis).
- Short-term safety outcomes: This includes the composite of short-term (i.e. within 3 months) post procedure related complications (i.e. Cardiac tamponade, Pneumothorax, postoperative wound infection, Pocket hematomas, lead dislodgment, vascular injury, Thromboembolism, and Pericarditis).
Long term safety outcomes: This includes the composite of long-term (i.e. within 3 years) post procedure related complications (Device and Lead integrity related complications (i.e. lead dislodgment, lead malfunction, generator malfunction, lead related infections)).
- Study design:
The APAF-CSP trial is a prospective, multicenter, international, randomized, open-label, non-inferiority, parallel-arms trial. Patients who have atrial fibrillation (AF), that is not suitable for rhythm control, and a history of at least one hospitalization or unplanned/urgent care visit due to heart failure within the last 2 years, regardless of left ventricular ejection fraction or QRS duration, will be invited to participate. The trial will take place in 23 participating hospitals in Europe (Netherlands, Germany, Italy and France).
+Study population: Adult patients aged 18 years or older, with confirmed AF that is unsuitable for rhythm control and symptomatic HF (with a history of at least one hospitalization or unplanned/urgent care visit due to HF exacerbation within the 2 years before enrolment), regardless of left ventricular ejection fraction or QRS duration, will be invited to participate in this trial. Based on sample size estimations, the trial needs 292 patients with a median follow-up of 2.5 years.
+Intervention: All patients meeting the inclusion criteria and not meeting any exclusion criteria will be randomized in a 1:1 ratio to undergo either AV node ablation with CSP or AV node ablation with CRT implantation. Throughout the trial, patients will be followed up at predefined intervals for endpoint data collection.
+Main study endpoint: The hierarchical primary composite endpoint is the composite of all-cause mortality, HF hospitalization or unplanned/urgent HF visit, and ≥5 point improvement (increase) in the Kansas City Cardiomyopathy Questionnaire (KCCQ).
+Nature and extent of the burden and risks associated with participation, benefit and group relatedness: AV node catheter ablation and pacemaker implantation, whether CRT or CSP, are well-established and safe techniques. They are well-known for their efficiency for rate control in the appropriate population. The follow-up assessments will be conducted either physically (i.e. patient visits) and/or (when possible) remotely (i.e. telephone encounter) to minimize patient effort. Additional study procedures, such as transthoracic echocardiography and blood sample collection, will be performed at baseline during the screening assessment and during the 1-year follow-up visit. These procedures are part of usual clinical care for these patients undergoing AV nodal ablation with pacemaker implantation. Consequently, the additional effort and time to fill out a few "Quality-of-Life" questionnaires are determined to be the main extra burden that consumes time for both the patient and the treating physician. However, this increased burden is non-invasive and will be highlighted in the consent/participation form. In pre-selected centers (subgroup analyses), a urine sample for the microalbumin check will be collected at baseline and the 1-year visit. Furthermore, the vascular stiffness index (VSI) will be measured by a wearable bracelet. This VSI measurement will be performed at the baseline visit and at the 1-year follow up visit, where the participant will be asked to wear the device for 30 minutes (during the visit). The VSI recording and urine microalbumin check are painless, non-invasive and fully funded by the study. The patient will not be required to come for an extra visit to the study site for the sole reason of this recording or for the urine sample, and instead, this is incorporated into the scheduled study visits. However, the increased burden of providing a urine sample and wearing the bracelet during the visit is fully acknowledged and will be highlighted in the consent/participation forms.
연구 유형
중재적
등록 (추정된)
292
단계
- 해당 없음
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
- 이름: Michiel Rienstra, MD, PhD, MHA, Professor
- 전화번호: +31503611327
- 이메일: m.rienstra@umcg.nl
연구 연락처 백업
- 이름: Ahmed S Yassin, MD
- 이메일: a.s.e.m.yassin@umcg.nl
연구 장소
-
-
-
's-Hertogenbosch, 네덜란드
- Jeroen Bosch Ziekenhuis
-
연락하다:
- Wouter Wieringa, MD
- 이메일: w.wieringa@jbz.nl
-
Leeuwarden, 네덜란드
- FrisiusMC
-
연락하다:
- Marnix Van Bemmel, MD
- 이메일: marnixvanbemmel@outlook.com
-
Maastricht, 네덜란드
- Maastricht UMC
-
연락하다:
- Twan Van Stipdonk, MD
- 이메일: twan.van.stipdonk@mumc.nl
-
Nieuwegein, 네덜란드
- Antonius hospital
-
연락하다:
- Vincent Van Dijk, MD
- 이메일: v.van.dijk@antoniusziekenhuis.nl
-
-
Provincie Groningen
-
Groningen, Provincie Groningen, 네덜란드
- University Medical Center Groningen
-
수석 연구원:
- Yuri Blaauw, MD, PhD
-
연락하다:
- Michiel Rienstra, MD, PhD, MHA, Professor
- 전화번호: +31503611327
- 이메일: m.rienstra@umcg.nl
-
-
-
-
-
Gelsenkirchen, 독일
- Marienhospital Gelsenkirchen
-
연락하다:
- Axel Kloppe, MD
- 전화번호: +49 209 1723601
- 이메일: kardiologie@marienhospital.eu
-
Mainz, 독일
- University Medical Center Mainz
-
연락하다:
- Peter Seidel, MD
- 전화번호: +49 1791957811
- 이메일: peseidel@uni-mainz.de
-
München, 독일
- Klinikum rechts der Isar
-
연락하다:
- Eimo Martens, MD
- 전화번호: +49 1714124861
- 이메일: eimo.martens@mri.tum.de
-
Paderborn, 독일
- St. Vincenz-Krankenhaus GmbH
-
연락하다:
- Andreas Goette, MD
- 전화번호: +49 5251861651
- 이메일: Andreas.Goette@vincenz.de
-
Stade, 독일
- Klinik für Kardiologie und Intensivmedizin
-
연락하다:
- Peter Lüdike, MD
- 전화번호: +49 5413264662
- 이메일: peter.luedike@niels-stensen-kliniken.de
-
-
-
-
-
Florence, 이탈리아
- Azienda Ospedaliero-Universitaria Careggi
-
연락하다:
- Paolo Pieragnoli, MD
- 이메일: pieragnolip@aou-careggi.toscana.it
-
Lavagna, 이탈리아
- Department of Cardiology, Ospedali del Tigullio
-
연락하다:
- Paolo Donateo, MD
- 이메일: Paolo.donateo@gmail.com
-
Milan, 이탈리아
- Ospedale San Raffaele
-
연락하다:
- Bisceglia Caterina, MD
- 이메일: bisceglia.caterina@hsr.it
-
Milan, 이탈리아
- Department of Cardiology, IRCCS Instituto Auxologico Italiano, Ospedale San Luca
-
연락하다:
- Michele Brignole, MD, Professor
- 이메일: mbrignole@outlook.it
-
Nola, 이탈리아
- Ospedale Santa Maria della Pieta
-
연락하다:
- Mario Volpicelli, MD
- 이메일: epvolpicelli@gmail.com
-
Reggio Emilia, 이탈리아
- Department of Cardiology, Ospedale S. Maria Nuova
-
연락하다:
- Matteo Iori, MD
- 이메일: Matteo.Iori@ausl.re.it
-
Roma, 이탈리아
- Ospedale San Pietro Fatebenefratelli
-
연락하다:
- Daniele Porcelli, MD
- 이메일: daniele.porcelli@hotmail.it
-
Tricase, 이탈리아
- Department of Cardiology, Ospedale Panico
-
연락하다:
- Pietro Palmisano, MD
- 이메일: dr.palmisano@libero.it
-
-
-
-
-
Grenoble, 프랑스
- CHU de GRENOBLE
-
연락하다:
- Pascal Defaye, MD
- 이메일: PDefaye@chu-grenoble.fr
-
Marseille, 프랑스
- CHU La Timone
-
연락하다:
- Jean-claude Deharo, MD
- 이메일: jean-claude.deharo@ap-hm.fr
-
Paris, 프랑스
- Hôpital Europeén Georges Pompidou
-
연락하다:
- Eloi Marijon, MD
- 이메일: eloi.marijon@aphp.fr
-
Rouen, 프랑스
- CHU de Rouen
-
연락하다:
- Frederic Anselme, MD
- 이메일: frederic.anselme@chu-rouen.fr
-
Toulouse, 프랑스
- Clinique Pasteur Toulouse
-
연락하다:
- Serge Boveda, MD
- 이메일: sboveda@clinique-pasteur.com
-
-
참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
아니
설명
Inclusion Criteria:
- Age 18 years or above.
- Patient is diagnosed with AF and deemed not amenable to rhythm control. This diagnosis of AF will be demonstrated by at least one Electrocardiograph (ECG) showing AF that was performed within one year prior to enrollment.
- Has history of stable heart failure (regardless left ventricular ejection fraction) and has a history of at least one HF related hospitalization or emergency room/urgent care visit within 2 years prior to enrollment, despite being on maximally tolerable guideline directed medical therapy.
- Willing and capable to provide informed consent.
Exclusion Criteria:
- NYHA functional class IV.
- Severe concomitant non-cardiac disease.
- Patient who require any cardiac surgical intervention.
- Previously implanted pacing devices (pacemaker/ICD/CRT) with ≥40% pacing burden.
Any of the following within the 3 months prior to enrollment:
- Myocardial infarction
- Unstable angina
- Percutaneous coronary intervention
- Stroke or TIA
- Significant bleeding
- Pericarditis/effusions
- Coronary artery bypass surgery/atriotomy within 6 months prior to enrolment.
- Women who are pregnant or breastfeeding.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
다른: CSP Group (Intervention Group)
AV node ablation plus Conduction System Pacing implantation.
CSP is established pacing strategy evaluated in comparison with CRT.
|
The implantation of a pacing device with a pacing lead that aims to capture and pace the native conduction system.
|
|
활성 비교기: CRT Group (Control Group)
AV node ablation plus cardiac resynchronization therapy implantation.
CRT is established standard pacing strategy.
|
The implantation of a pacing device with a pacing leads that aims to capture and pace both ventricles in a synchronized fashion, to achieve the best possible hemodynamic parameters and synchrony.
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
The hierarchical composite endpoint of all-cause mortality, HF hospitalization or unplanned/urgent HF visit, and ≥5 point improvement (increase) in the Kansas City Cardiomyopathy Questionnaire (KCCQ) score.
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
The Kansas City Cardiomyopathy Questionnaire (KCCQ) scores are scaled 0-100 (the higher score indicates a better condition).
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Major secondary endpoint: ≥5 point improvement (increase) in the Kansas City Cardiomyopathy Questionnaire (KCCQ) score.
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
The Kansas City Cardiomyopathy Questionnaire (KCCQ) scores are scaled 0-100 (the higher score indicates a better condition).
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
|
Quality of Life Improvement (AFEQT Questionnaire)
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
The AFEQT is a disease-specific questionnaire that focuses on assessing the impact of AF on a person's QoL.
It covers several domains, including symptoms, daily activities, treatment concerns, and treatment satisfaction.
The AFEQT provides scores for each domain as well as a total score, allowing for a comprehensive evaluation of the specific aspects affected by AF on an individual's QoL.
Scale 0-100, higher scores indicate no limitation or disability.
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
|
Quality of Life Improvement (EQ-5D-5L Questionnaire)
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
The EQ-5D-5L is a questionnaire used to assess health-related QoL across five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression.
Each dimension has five response levels indicating the level of problems experienced by the individual ( 1= no problems, 2= slight problems, 3= moderate problems, 4= severe problems, and 5= extreme problems).
The EQ-5D-5L also generates a summary index score that represents overall health status based on societal preferences for different health states.
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
|
HF Hospitalization or Unplanned/urgent HF Visit
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
|
|
Cardiovascular Related Hospitalization
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
|
|
All-cause Mortality
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
|
|
Cardiovascular Related Mortality
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
기타 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Duration of hospitalization for cardiovascular causes
기간: From enrollment to the end of follow up (median follow-up of 2.5 years)
|
Tertiary (Exploratory) Endpoint
|
From enrollment to the end of follow up (median follow-up of 2.5 years)
|
|
Clinical heart failure status (New York Heart Association (NYHA) Functional Classification)
기간: At baseline,1-year, and at end of follow-up (median of 2.5 years follow-up).
|
Tertiary (Exploratory) Endpoint. NYHA Classification (scale I-IV): Class I: No limitation of physical activity. Class II: Slight limitation of physical activity. Class III: Marked limitation of physical activity. Class IV: Unable to carry on any physical activity without discomfort. Symptoms of heart failure at rest. |
At baseline,1-year, and at end of follow-up (median of 2.5 years follow-up).
|
|
Healthcare costs and cost-effectiveness parameters
기간: At the end of follow up (Median of 2.5 years follow up)
|
Tertiary (Exploratory) Endpoint
|
At the end of follow up (Median of 2.5 years follow up)
|
|
NT-proBNP levels
기간: At baseline and 1-year follow up.
|
Tertiary (Exploratory) Endpoint
|
At baseline and 1-year follow up.
|
|
Left ventricular ejection fraction (LVEF)
기간: At baseline and 1-year follow up.
|
Tertiary (Exploratory) Endpoint
|
At baseline and 1-year follow up.
|
|
Glomerular Filtration Rate (GFR)
기간: At baseline and 1-year follow up.
|
Tertiary (Exploratory) Endpoint
|
At baseline and 1-year follow up.
|
|
Creatinine (Cr) level
기간: At baseline and 1-year follow up.
|
Tertiary (Exploratory) Endpoint
|
At baseline and 1-year follow up.
|
|
Blood Urea level (BUN)
기간: At baseline and 1-year follow up.
|
Tertiary (Exploratory) Endpoint
|
At baseline and 1-year follow up.
|
|
Urine Microalbumin levels (Only in the subgroup analysis in selected centers)
기간: At baseline and 1-year follow up.
|
Tertiary (Exploratory) Endpoint
|
At baseline and 1-year follow up.
|
|
Arterial stiffness index measured by the photoplethysmography (PPG) signals (Only in the subgroup analysis in selected centers).
기간: At baseline and 1-year follow up.
|
Tertiary (Exploratory) Endpoint
|
At baseline and 1-year follow up.
|
|
Short-term safety endpoints
기간: Within 3 months post the procedure
|
Tertiary (Exploratory) Endpoints.
These includes the short-term (i.e.
within 3 months) post procedure related complications (i.e.
Cardiac tamponade, Pneumothorax, postoperative wound infection, Pocket hematomas, lead dislodgment, vascular injury, Thromboembolism, and Pericarditis)
|
Within 3 months post the procedure
|
|
Long term safety endpoints
기간: Within 3 years post the procedure
|
Tertiary (Exploratory) Endpoints.
These includes the long-term (i.e.
within 3 years) post procedure related complications (Device and Lead integrity related complications (i.e.
lead dislodgment, lead malfunction, generator malfunction, lead related infections)).
|
Within 3 years post the procedure
|
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- 연구 의자: Michiel Rienstra, MD, PhD, MHA, Professor, University Medical Center Groningen, Groningen, The Netherlands
- 수석 연구원: Yuri Blaauw, MD, PhD, University Medical Center Groningen
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Van Gelder IC, Groenveld HF, Crijns HJ, Tuininga YS, Tijssen JG, Alings AM, Hillege HL, Bergsma-Kadijk JA, Cornel JH, Kamp O, Tukkie R, Bosker HA, Van Veldhuisen DJ, Van den Berg MP; RACE II Investigators. Lenient versus strict rate control in patients with atrial fibrillation. N Engl J Med. 2010 Apr 15;362(15):1363-73. doi: 10.1056/NEJMoa1001337. Epub 2010 Mar 15.
- Spertus J, Dorian P, Bubien R, Lewis S, Godejohn D, Reynolds MR, Lakkireddy DR, Wimmer AP, Bhandari A, Burk C. Development and validation of the Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) Questionnaire in patients with atrial fibrillation. Circ Arrhythm Electrophysiol. 2011 Feb;4(1):15-25. doi: 10.1161/CIRCEP.110.958033. Epub 2010 Dec 15.
- Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L; Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005 Apr 14;352(15):1539-49. doi: 10.1056/NEJMoa050496. Epub 2005 Mar 7.
- Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J; MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002 Jun 13;346(24):1845-53. doi: 10.1056/NEJMoa013168.
- Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes NA 3rd, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W; MADIT-CRT Trial Investigators. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009 Oct 1;361(14):1329-38. doi: 10.1056/NEJMoa0906431. Epub 2009 Sep 1.
- Linde C, Abraham WT, Gold MR, St John Sutton M, Ghio S, Daubert C; REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group. Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. J Am Coll Cardiol. 2008 Dec 2;52(23):1834-1843. doi: 10.1016/j.jacc.2008.08.027. Epub 2008 Nov 7.
- Wood MA, Brown-Mahoney C, Kay GN, Ellenbogen KA. Clinical outcomes after ablation and pacing therapy for atrial fibrillation : a meta-analysis. Circulation. 2000 Mar 14;101(10):1138-44. doi: 10.1161/01.cir.101.10.1138.
- Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, Kellen JC, Greene HL, Mickel MC, Dalquist JE, Corley SD; Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002 Dec 5;347(23):1825-33. doi: 10.1056/NEJMoa021328.
- Van Gelder IC, Hagens VE, Bosker HA, Kingma JH, Kamp O, Kingma T, Said SA, Darmanata JI, Timmermans AJ, Tijssen JG, Crijns HJ; Rate Control versus Electrical Cardioversion for Persistent Atrial Fibrillation Study Group. A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation. N Engl J Med. 2002 Dec 5;347(23):1834-40. doi: 10.1056/NEJMoa021375.
- Padeletti L, Musilli N, Porciani MC, Colella A, Di Biase L, Ricciardi G, Pieragnoli P, Michelucci A, Gensini G. Atrial fibrillation and cardiac resynchronization therapy: the MASCOT study. Europace. 2004 Sep;5 Suppl 1:S49-54. doi: 10.1016/j.eupc.2004.07.007.
- Tang AS, Wells GA, Talajic M, Arnold MO, Sheldon R, Connolly S, Hohnloser SH, Nichol G, Birnie DH, Sapp JL, Yee R, Healey JS, Rouleau JL; Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med. 2010 Dec 16;363(25):2385-95. doi: 10.1056/NEJMoa1009540. Epub 2010 Nov 14.
- Orlov MV, Gardin JM, Slawsky M, Bess RL, Cohen G, Bailey W, Plumb V, Flathmann H, de Metz K. Biventricular pacing improves cardiac function and prevents further left atrial remodeling in patients with symptomatic atrial fibrillation after atrioventricular node ablation. Am Heart J. 2010 Feb;159(2):264-70. doi: 10.1016/j.ahj.2009.11.012.
- Vijayaraman P, Ponnusamy S, Cano O, Sharma PS, Naperkowski A, Subsposh FA, Moskal P, Bednarek A, Dal Forno AR, Young W, Nanda S, Beer D, Herweg B, Jastrzebski M. Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: Results From the International LBBAP Collaborative Study Group. JACC Clin Electrophysiol. 2021 Feb;7(2):135-147. doi: 10.1016/j.jacep.2020.08.015. Epub 2020 Oct 28.
- Sharma PS, Patel NR, Ravi V, Zalavadia DV, Dommaraju S, Garg V, Larsen TR, Naperkowski AM, Wasserlauf J, Krishnan K, Young W, Pokharel P, Oren JW, Storm RH, Trohman RG, Huang HD, Subzposh FA, Vijayaraman P. Clinical outcomes of left bundle branch area pacing compared to right ventricular pacing: Results from the Geisinger-Rush Conduction System Pacing Registry. Heart Rhythm. 2022 Jan;19(1):3-11. doi: 10.1016/j.hrthm.2021.08.033. Epub 2021 Sep 3.
- Su L, Wang S, Wu S, Xu L, Huang Z, Chen X, Zheng R, Jiang L, Ellenbogen KA, Whinnett ZI, Huang W. Long-Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single-Center Study. Circ Arrhythm Electrophysiol. 2021 Feb;14(2):e009261. doi: 10.1161/CIRCEP.120.009261. Epub 2021 Jan 9.
- Ezzat VA, Lee V, Ahsan S, Chow AW, Segal O, Rowland E, Lowe MD, Lambiase PD. A systematic review of ICD complications in randomised controlled trials versus registries: is our 'real-world' data an underestimation? Open Heart. 2015 Feb 17;2(1):e000198. doi: 10.1136/openhrt-2014-000198. eCollection 2015.
- Kirkfeldt RE, Johansen JB, Nohr EA, Jorgensen OD, Nielsen JC. Complications after cardiac implantable electronic device implantations: an analysis of a complete, nationwide cohort in Denmark. Eur Heart J. 2014 May;35(18):1186-94. doi: 10.1093/eurheartj/eht511. Epub 2013 Dec 17.
- Vlachos K, Letsas KP, Korantzopoulos P, Liu T, Efremidis M, Sideris A. A review on atrioventricular junction ablation and pacing for heart rate control of atrial fibrillation. J Geriatr Cardiol. 2015 Sep;12(5):547-54. doi: 10.11909/j.issn.1671-5411.2015.05.005.
- Pothineni NVK, Gondi S, Cherian T, Kovelamudi S, Schaller RD, Lakkireddy D, Gopinathannair R, Deshmukh A. Complications of Cardiac Resynchronization Therapy: Comparison of Safety Outcomes from Real-world Studies and Clinical Trials. J Innov Card Rhythm Manag. 2022 Aug 15;13(8):5121-5125. doi: 10.19102/icrm.2022.130805. eCollection 2022 Aug.
- Vijayaraman P, Sharma PS, Cano O, Ponnusamy SS, Herweg B, Zanon F, Jastrzebski M, Zou J, Chelu MG, Vernooy K, Whinnett ZI, Nair GM, Molina-Lerma M, Curila K, Zalavadia D, Haseeb A, Dye C, Vipparthy SC, Brunetti R, Moskal P, Ross A, van Stipdonk A, George J, Qadeer YK, Mumtaz M, Kolominsky J, Zahra SA, Golian M, Marcantoni L, Subzposh FA, Ellenbogen KA. Comparison of Left Bundle Branch Area Pacing and Biventricular Pacing in Candidates for Resynchronization Therapy. J Am Coll Cardiol. 2023 Jul 18;82(3):228-241. doi: 10.1016/j.jacc.2023.05.006. Epub 2023 May 21.
- Karimpour P, May JM, Kyriacou PA. Photoplethysmography for the Assessment of Arterial Stiffness. Sensors (Basel). 2023 Dec 17;23(24):9882. doi: 10.3390/s23249882.
- Reddy VY, Gerstenfeld EP, Natale A, Whang W, Cuoco FA, Patel C, Mountantonakis SE, Gibson DN, Harding JD, Ellis CR, Ellenbogen KA, DeLurgio DB, Osorio J, Achyutha AB, Schneider CW, Mugglin AS, Albrecht EM, Stein KM, Lehmann JW, Mansour M; ADVENT Investigators. Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2023 Nov 2;389(18):1660-1671. doi: 10.1056/NEJMoa2307291. Epub 2023 Aug 27.
- Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM, De Potter TJR, Dwight J, Guasti L, Hanke T, Jaarsma T, Lettino M, Lochen ML, Lumbers RT, Maesen B, Molgaard I, Rosano GMC, Sanders P, Schnabel RB, Suwalski P, Svennberg E, Tamargo J, Tica O, Traykov V, Tzeis S, Kotecha D; ESC Scientific Document Group. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024 Sep 29;45(36):3314-3414. doi: 10.1093/eurheartj/ehae176. No abstract available.
- Wyndham CR. Atrial fibrillation: the most common arrhythmia. Tex Heart Inst J. 2000;27(3):257-67.
- Spertus JA, Jones PG, Sandhu AT, Arnold SV. Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Nov 17;76(20):2379-2390. doi: 10.1016/j.jacc.2020.09.542.
- van Barreveld M, Verstraelen TE, van Dessel PFHM, Boersma LVA, Delnoy PPHM, Tuinenburg AE, Theuns DAMJ, van der Voort PH, Kimman GJ, Buskens E, Zwinderman AH, Wilde AAM, Dijkgraaf MGW; DO-IT Registry Investigators. Dutch Outcome in Implantable Cardioverter-Defibrillator Therapy: Implantable Cardioverter-Defibrillator-Related Complications in a Contemporary Primary Prevention Cohort. J Am Heart Assoc. 2021 Apr 6;10(7):e018063. doi: 10.1161/JAHA.120.018063. Epub 2021 Mar 31.
- Brignole M, Pentimalli F, Palmisano P, Landolina M, Quartieri F, Occhetta E, Calo L, Mascia G, Mont L, Vernooy K, van Dijk V, Allaart C, Fauchier L, Gasparini M, Parati G, Soranna D, Rienstra M, Van Gelder IC; APAF-CRT Trial Investigators. AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial. Eur Heart J. 2021 Dec 7;42(46):4731-4739. doi: 10.1093/eurheartj/ehab569.
- Chatterjee S, Sardar P, Lichstein E, Mukherjee D, Aikat S. Pharmacologic rate versus rhythm-control strategies in atrial fibrillation: an updated comprehensive review and meta-analysis. Pacing Clin Electrophysiol. 2013 Jan;36(1):122-33. doi: 10.1111/j.1540-8159.2012.03513.x. Epub 2012 Sep 14.
- Weerasooriya R, Davis M, Powell A, Szili-Torok T, Shah C, Whalley D, Kanagaratnam L, Heddle W, Leitch J, Perks A, Ferguson L, Bulsara M. The Australian Intervention Randomized Control of Rate in Atrial Fibrillation Trial (AIRCRAFT). J Am Coll Cardiol. 2003 May 21;41(10):1697-702. doi: 10.1016/s0735-1097(03)00338-3.
- Ueng KC, Tsai TP, Tsai CF, Wu DJ, Lin CS, Lee SH, Chen SA. Acute and long-term effects of atrioventricular junction ablation and VVIR pacemaker in symptomatic patients with chronic lone atrial fibrillation and normal ventricular response. J Cardiovasc Electrophysiol. 2001 Mar;12(3):303-9. doi: 10.1046/j.1540-8167.2001.00303.x.
- Brignole M, Menozzi C, Gianfranchi L, Musso G, Mureddu R, Bottoni N, Lolli G. Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation: a randomized, controlled study. Circulation. 1998 Sep 8;98(10):953-60. doi: 10.1161/01.cir.98.10.953.
- Brignole M, Gianfranchi L, Menozzi C, Alboni P, Musso G, Bongiorni MG, Gasparini M, Raviele A, Lolli G, Paparella N, Acquarone S. Assessment of atrioventricular junction ablation and DDDR mode-switching pacemaker versus pharmacological treatment in patients with severely symptomatic paroxysmal atrial fibrillation: a randomized controlled study. Circulation. 1997 Oct 21;96(8):2617-24. doi: 10.1161/01.cir.96.8.2617.
- Brignole M, Gianfranchi L, Menozzi C, Bottoni N, Bollini R, Lolli G, Oddone D, Gaggioli G. Influence of atrioventricular junction radiofrequency ablation in patients with chronic atrial fibrillation and flutter on quality of life and cardiac performance. Am J Cardiol. 1994 Aug 1;74(3):242-6. doi: 10.1016/0002-9149(94)90364-6.
- Yeung-Lai-Wah JA, Qi A, Uzun O, Humphries K, Kerr CR. Long-term survival following radiofrequency catheter ablation of atrioventricular junction for atrial fibrillation: clinical and ablation determinants of mortality. J Interv Card Electrophysiol. 2002 Feb;6(1):17-23. doi: 10.1023/a:1014168021615.
- Eckardt L, Doldi F, Anwar O, Gessler N, Scherschel K, Kahle AK, von Falkenhausen AS, Thaler R, Wolfes J, Metzner A, Meyer C, Willems S, Kobe J, Lange PS, Frommeyer G, Kuck KH, Kaab S, Steinbeck G, Sinner MF. Major in-hospital complications after catheter ablation of cardiac arrhythmias: individual case analysis of 43 031 procedures. Europace. 2023 Dec 28;26(1):euad361. doi: 10.1093/europace/euad361.
- Ponnusamy SS, Vijayaraman P. Late dislodgement of left bundle branch pacing lead and successful extraction. J Cardiovasc Electrophysiol. 2021 Aug;32(8):2346-2349. doi: 10.1111/jce.15155. Epub 2021 Jul 16.
- De Pooter J, Calle S, Timmermans F, Van Heuverswyn F. Left bundle branch area pacing using stylet-driven pacing leads with a new delivery sheath: A comparison with lumen-less leads. J Cardiovasc Electrophysiol. 2021 Feb;32(2):439-448. doi: 10.1111/jce.14851. Epub 2021 Jan 4.
- Chen X, Wei L, Bai J, Wang W, Qin S, Wang J, Liang Y, Su Y, Ge J. Procedure-Related Complications of Left Bundle Branch Pacing: A Single-Center Experience. Front Cardiovasc Med. 2021 Mar 24;8:645947. doi: 10.3389/fcvm.2021.645947. eCollection 2021.
- Ravi V, Larsen T, Ooms S, Trohman R, Sharma PS. Late-onset interventricular septal perforation from left bundle branch pacing. HeartRhythm Case Rep. 2020 Jun 17;6(9):627-631. doi: 10.1016/j.hrcr.2020.06.008. eCollection 2020 Sep. No abstract available.
- Ponnusamy SS, Vijayaraman P. Aborted ST-elevation myocardial infarction-An unusual complication of left bundle branch pacing. HeartRhythm Case Rep. 2020 May 26;6(8):520-522. doi: 10.1016/j.hrcr.2020.05.010. eCollection 2020 Aug. No abstract available.
- Vijayaraman P, Subzposh FA, Naperkowski A, Panikkath R, John K, Mascarenhas V, Bauch TD, Huang W. Prospective evaluation of feasibility and electrophysiologic and echocardiographic characteristics of left bundle branch area pacing. Heart Rhythm. 2019 Dec;16(12):1774-1782. doi: 10.1016/j.hrthm.2019.05.011. Epub 2019 May 25.
- Palmisano P, Ziacchi M, Dell'Era G, Donateo P, Ammendola E, Coluccia G, Guido A, Piemontese GP, Lazzeri M, Ghiglieno C, Veroli A, Maggi R, Russo V, Rago A, Nigro G, Senes J, Patti G, Biffi M, Accogli M. Rate and nature of complications of conduction system pacing compared with right ventricular pacing: Results of a propensity score-matched analysis from a multicenter registry. Heart Rhythm. 2023 Jul;20(7):984-991. doi: 10.1016/j.hrthm.2023.03.009. Epub 2023 Mar 10.
- Vijayaraman P, West M, Dresing T, Oren J, Abbey S, Zimmerman P, Bauer R, Butler K, Mangrolia H. Safety and performance of conduction system pacing: Real-world experience from a product surveillance registry. Heart Rhythm. 2025 Feb;22(2):318-324. doi: 10.1016/j.hrthm.2024.06.061. Epub 2024 Jul 3.
- Rushton L. Further follow up of mortality in a United Kingdom oil distribution centre cohort. Br J Ind Med. 1993 Jun;50(6):561-9. doi: 10.1136/oem.50.6.561.
- Zhan C, Baine WB, Sedrakyan A, Steiner C. Cardiac device implantation in the United States from 1997 through 2004: a population-based analysis. J Gen Intern Med. 2008 Jan;23 Suppl 1(Suppl 1):13-9. doi: 10.1007/s11606-007-0392-0.
- Kobe J, Andresen D, Maier S, Stellbrink C, Kleemann T, Gonska BD, Reif S, Hochadel M, Senges J, Eckardt L. Complications and 1-year benefit of cardiac resynchronization therapy in patients over 75 years of age - Insights from the German Device Registry. Int J Cardiol. 2017 Feb 1;228:784-789. doi: 10.1016/j.ijcard.2016.11.212. Epub 2016 Nov 10.
- Providencia R, Marijon E, Lambiase PD, Bouzeman A, Defaye P, Klug D, Amet D, Perier MC, Gras D, Algalarrondo V, Deharo JC, Leclercq C, Fauchier L, Babuty D, Bordachar P, Sadoul N, Piot O, Boveda S. Primary Prevention Implantable Cardioverter Defibrillator (ICD) Therapy in Women-Data From a Multicenter French Registry. J Am Heart Assoc. 2016 Feb 12;5(2):e002756. doi: 10.1161/JAHA.115.002756.
- Banks H, Torbica A, Valzania C, Varabyova Y, Prevolnik Rupel V, Taylor RS, Hunger T, Walker S, Boriani G, Fattore G; MedtecHTA group. Five year trends (2008-2012) in cardiac implantable electrical device utilization in five European nations: a case study in cross-country comparisons using administrative databases. Europace. 2018 Apr 1;20(4):643-653. doi: 10.1093/europace/eux123.
- Jastrzebski M, Kielbasa G, Cano O, Curila K, Heckman L, De Pooter J, Chovanec M, Rademakers L, Huybrechts W, Grieco D, Whinnett ZI, Timmer SAJ, Elvan A, Stros P, Moskal P, Burri H, Zanon F, Vernooy K. Left bundle branch area pacing outcomes: the multicentre European MELOS study. Eur Heart J. 2022 Oct 21;43(40):4161-4173. doi: 10.1093/eurheartj/ehac445.
- Koniari I, Gerakaris A, Kounis N, Velissaris D, Rao A, Ainslie M, Adlan A, Plotas P, Ikonomidis I, Mplani V, Hung MY, de Gregorio C, Kolettis T, Gupta D. Outcomes of Atrioventricular Node Ablation and Pacing in Patients with Heart Failure and Atrial Fibrillation: From Cardiac Resynchronization Therapy to His Bundle Pacing. J Cardiovasc Dev Dis. 2023 Jun 26;10(7):272. doi: 10.3390/jcdd10070272.
- Vijayaraman P, Pokharel P, Subzposh FA, Oren JW, Storm RH, Batul SA, Beer DA, Hughes G, Leri G, Manganiello M, Jastremsky JL, Mroczka K, Johns AM, Mascarenhas V. His-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy vs Biventricular Pacing: HOT-CRT Clinical Trial. JACC Clin Electrophysiol. 2023 Dec;9(12):2628-2638. doi: 10.1016/j.jacep.2023.08.003. Epub 2023 Sep 13.
- Herweg B, Mumtaz M, Vijayaraman P. Conduction System Pacing for CRT: A Physiological Alternative. Arrhythm Electrophysiol Rev. 2025 Feb 18;14:e04. doi: 10.15420/aer.2024.10. eCollection 2025.
- Vijayaraman P, Chelu MG, Curila K, Dandamudi G, Herweg B, Mori S, Jastrzebski M, Sharma PS, Shivkumar K, Tung R, Upadhyay G, Vernooy K, Welter-Frost A, Whinnett Z, Zanon F, Ellenbogen KA. Cardiac Conduction System Pacing: A Comprehensive Update. JACC Clin Electrophysiol. 2023 Nov;9(11):2358-2387. doi: 10.1016/j.jacep.2023.06.005. Epub 2023 Aug 16.
- Vernooy K, Keene D, Huang W, Vijayaraman P. Implant, assessment, and management of conduction system pacing. Eur Heart J Suppl. 2023 Nov 9;25(Suppl G):G15-G26. doi: 10.1093/eurheartjsupp/suad115. eCollection 2023 Nov.
- Burri H, Jastrzebski M, Cano O, Curila K, de Pooter J, Huang W, Israel C, Joza J, Romero J, Vernooy K, Vijayaraman P, Whinnett Z, Zanon F. EHRA clinical consensus statement on conduction system pacing implantation: endorsed by the Asia Pacific Heart Rhythm Society (APHRS), Canadian Heart Rhythm Society (CHRS), and Latin American Heart Rhythm Society (LAHRS). Europace. 2023 Apr 15;25(4):1208-1236. doi: 10.1093/europace/euad043.
- Hua W, Gu M, Niu H, Gold MR. Advances of Implantation Techniques for Conduction System Pacing. JACC Clin Electrophysiol. 2022 Dec;8(12):1587-1598. doi: 10.1016/j.jacep.2022.09.022. Epub 2022 Nov 30.
- Burri H, Starck C, Auricchio A, Biffi M, Burri M, D'Avila A, Deharo JC, Glikson M, Israel C, Lau CP, Leclercq C, Love CJ, Nielsen JC, Vernooy K; Reviewers:; Dagres N, Boveda S, Butter C, Marijon E, Braunschweig F, Mairesse GH, Gleva M, Defaye P, Zanon F, Lopez-Cabanillas N, Guerra JM, Vassilikos VP, Martins Oliveira M. EHRA expert consensus statement and practical guide on optimal implantation technique for conventional pacemakers and implantable cardioverter-defibrillators: endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin-American Heart Rhythm Society (LAHRS). Europace. 2021 Jul 18;23(7):983-1008. doi: 10.1093/europace/euaa367.
- Yousaf A, Ahmad S, Peltz J, Ahsan MJ, Abbas KS, Muhammad S, Watson C, Asad ZUA, Kim MH. Left bundle branch area pacing vs biventricular pacing for cardiac resynchronization: A systematic review and meta-analysis. Heart Rhythm O2. 2023 Nov 11;4(11):671-680. doi: 10.1016/j.hroo.2023.06.011. eCollection 2023 Nov.
- Morcos R, Vijayaraman P, Cano O, Zanon F, Ponnusamy SS, Herweg B, Sharma PS, Jastrzebski M, Molina-Lerma M, Whinnett ZI, Vernooy K, Zou J, Nair GM, Pathak RK, Tung R, Upadhyay GA, Curila K, Chelu MG, Ellenbogen KA. Left bundle branch area pacing compared with biventricular pacing for cardiac resynchronization therapy in patients with left ventricular ejection fraction </=50%: Results from the International Collaborative LBBAP Study (I-CLAS). Heart Rhythm. 2025 Aug;22(8):2028-2037. doi: 10.1016/j.hrthm.2025.04.005. Epub 2025 Apr 25.
- Zheng Z, Jiang L, Gao Y, Peng X, Feng H, Lu J. Left bundle branch area pacing vs. biventricular pacing significantly improves clinical outcomes and cardiac remodeling in cardiac resynchronization therapy: a systematic review and meta-analysis. Front Cardiovasc Med. 2025 Nov 21;12:1644033. doi: 10.3389/fcvm.2025.1644033. eCollection 2025.
- Kumar N, Kumar A, Akhtar S, Khan AA, Khan RFU, Lohana N, Ladhani D, Memon B, Kumaran SS, Barzallo P, Rana JS, Shah S, Alraies MCC. Left Bundle Branch Area Pacing vs. Biventricular Pacing in Cardiac Resynchronization Therapy: A Systematic Review and Meta-Analysis. Crit Pathw Cardiol. 2026 Jan 15. doi: 10.1097/HPC.0000000000000414. Online ahead of print.
- Burri H, Leclercq C, Behar N, Deharo JC, Jastrzebski M, Joza J, Nielsen JC. Controversy: in heart failure patients with a reduced ejection fraction and left bundle branch block, conduction system pacing can be a valid alternative to biventricular pacing-pro and contra. Europace. 2025 Dec 1;27(12):euaf312. doi: 10.1093/europace/euaf312.
- Cleland JG, Calvert MJ, Verboven Y, Freemantle N. Effects of cardiac resynchronization therapy on long-term quality of life: an analysis from the CArdiac Resynchronisation-Heart Failure (CARE-HF) study. Am Heart J. 2009 Mar;157(3):457-66. doi: 10.1016/j.ahj.2008.11.006. Epub 2009 Jan 20.
- Leventopoulos G, Travlos CK, Anagnostopoulou V, Patrinos P, Papageorgiou A, Perperis A, Gale CP, Gatzoulis KAlpha, Davlouros P. Clinical Outcomes of Left Bundle Branch Area Pacing Compared with Biventricular Pacing in Patients with Heart Failure Requiring Cardiac Resynchronization Therapy: Systematic Review and Meta-Analysis. Rev Cardiovasc Med. 2023 Nov 9;24(11):312. doi: 10.31083/j.rcm2411312. eCollection 2023 Nov.
- Khan MS, Shahid I, Anker SD, Fonarow GC, Fudim M, Hall ME, Hernandez A, Morris AA, Shafi T, Weir MR, Zannad F, Bakris GL, Butler J. Albuminuria and Heart Failure: JACC State-of-the-Art Review. J Am Coll Cardiol. 2023 Jan 24;81(3):270-282. doi: 10.1016/j.jacc.2022.10.028.
- Claudel SE, Verma A. Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review. Circulation. 2025 Mar 11;151(10):716-732. doi: 10.1161/CIRCULATIONAHA.124.071079. Epub 2025 Mar 10.
- Li Y, Jiang R, Ouyang C, Wang J, Yu Q, Lu J, Hong W, Liu S, Chen Y, Cai J, Yuan H, Zhang L, Lu Y. Chronic kidney disease is associated with increased risk of sudden cardiac death. Nat Commun. 2025 Oct 16;16(1):9180. doi: 10.1038/s41467-025-64254-9.
- Huang YJ, Hsu YL, Chuang YH, Lin HY, Chen YH, Chan TC. Association between renal function and cardiovascular mortality: a retrospective cohort study of elderly from health check-up. BMJ Open. 2021 Sep 21;11(9):e049307. doi: 10.1136/bmjopen-2021-049307.
- Diana G, Scardulla F, Puleo S, Pasta S, D'Acquisto L. Non-Invasive Estimation of Arterial Stiffness Using Photoplethysmography Sensors: An In Vitro Approach. Sensors (Basel). 2025 May 24;25(11):3301. doi: 10.3390/s25113301.
- Chirinos JA. Arterial stiffness: basic concepts and measurement techniques. J Cardiovasc Transl Res. 2012 Jun;5(3):243-55. doi: 10.1007/s12265-012-9359-6. Epub 2012 Mar 24.
- Vajapey R, Chung MK. Emerging Technologies in Cardiac Pacing. Annu Rev Med. 2024 Jan 29;75:475-492. doi: 10.1146/annurev-med-051022-042616. Epub 2023 Nov 21.
- Joza J, Burri H, Andrade JG, Linz D, Ellenbogen KA, Vernooy K. Atrioventricular node ablation for atrial fibrillation in the era of conduction system pacing. Eur Heart J. 2024 Dec 7;45(46):4887-4901. doi: 10.1093/eurheartj/ehae656.
- Alam M, Bandeali SJ, Shahzad SA, Lakkis N. Real-life global survey evaluating patients with atrial fibrillation (REALISE-AF): results of an international observational registry. Expert Rev Cardiovasc Ther. 2012 Mar;10(3):283-91. doi: 10.1586/erc.12.8.
- Fusco A, Hansen ML, Ruwald MH, Zorner CR, Riis-Vestergaard L, Middelfart C, Hein R, Rasmussen PV, Di Sabatino A, Gislason G, Tonnesen J. Temporal Trends in Atrial Fibrillation Ablation in the Elderly: Incidence of MACE and Recurrence Rates. JACC Clin Electrophysiol. 2025 Jan;11(1):83-94. doi: 10.1016/j.jacep.2024.09.024. Epub 2024 Nov 13.
- Kneeland PP, Fang MC. Trends in catheter ablation for atrial fibrillation in the United States. J Hosp Med. 2009 Sep;4(7):E1-5. doi: 10.1002/jhm.445.
- Sohns C, Moersdorf M, Marrouche NF, Bergau L, Costard-Jaeckle A, Crijns HJGM, Fox H, Hindricks G, Dagres N, Sossalla S, Schramm R, Fink T, Hamriti ME, Sciacca V, Didenko M, Konietschke F, Rudolph V, Gummert J, Tijssen JGP, Sommer P; CASTLE HTx Investigators. Catheter Ablation in Patients With End-Stage Heart Failure and Atrial Fibrillation: Two-Year Follow-Up of the CASTLE-HTx Trial. Circulation. 2024 Dec 3;150(23):1904-1906. doi: 10.1161/CIRCULATIONAHA.124.071517. Epub 2024 Aug 30. No abstract available.
- Marrouche NF, Kheirkhahan M, Brachmann J. Catheter Ablation for Atrial Fibrillation with Heart Failure. N Engl J Med. 2018 Aug 2;379(5):492. doi: 10.1056/NEJMc1806519. No abstract available.
- Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J. 2015 Feb 1;36(5):255-6. doi: 10.1093/eurheartj/ehu476. No abstract available.
- Jaramillo AP, Jaramillo L, Briones Andriuoli RR, Revilla JC, Castells J, Ibrahimli S, Villacres JL, Garzon Mora N. The Effectiveness of Ablation Therapy for Atrial Fibrillation: A Systematic Review. Cureus. 2023 Aug 23;15(8):e43992. doi: 10.7759/cureus.43992. eCollection 2023 Aug.
- Sugumar H, Nanayakkara S, Chieng D, Wong GR, Parameswaran R, Anderson RD, Al-Kaisey A, Nalliah CJ, Azzopardi S, Prabhu S, Voskoboinik A, Lee G, McLellan AJ, Ling LH, Morton JB, Kalman JM, Kistler PM. Arrhythmia recurrence is more common in females undergoing multiple catheter ablation procedures for persistent atrial fibrillation: Time to close the gender gap. Heart Rhythm. 2020 May;17(5 Pt A):692-698. doi: 10.1016/j.hrthm.2019.12.013. Epub 2019 Dec 19.
- Is atrial fibrillation the "new epidemic" in heart health? Understanding that the condition is a permanent one is an important first step is adjusting life with this common arrhythmia. Heart Advis. 2011 Sep;14(9):5. No abstract available.
- Clinical and Scientific Affairs Council; AAPA. Atrial fibrillation: more help for the most common arrhythmia. JAAPA. 2007 May;20(5):18, 21. No abstract available.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (추정된)
2026년 7월 1일
기본 완료 (추정된)
2030년 6월 1일
연구 완료 (추정된)
2030년 6월 1일
연구 등록 날짜
최초 제출
2026년 5월 12일
QC 기준을 충족하는 최초 제출
2026년 5월 19일
처음 게시됨 (실제)
2026년 5월 22일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2026년 5월 22일
QC 기준을 충족하는 마지막 업데이트 제출
2026년 5월 19일
마지막으로 확인됨
2026년 5월 1일
추가 정보
이 연구와 관련된 용어
키워드
추가 관련 MeSH 약관
기타 연구 ID 번호
- NL-011147
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
예
IPD 공유 지원 정보 유형
- 연구_프로토콜
- 수액
- ICF
- ANALYTIC_CODE
- CSR
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
아니
미국 FDA 규제 기기 제품 연구
아니
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .