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Implementing Improved Blood Pressure Measurement in General Practice: A Multisite Implementation Trial Using Automated Office Blood Pressure (AOBP)

2026년 9월 9일 업데이트: James E Sharman, Menzies Institute for Medical Research

The goal of this clinical trial is to evaluate whether implementation of guideline-recommended Automated Office Blood Pressure (AOBP) measurement in Australian general practice clinics improves hypertension control among adults aged 18 years and older who are eligible for blood pressure assessment as part of routine clinical care. The study will also evaluate the implementation, sustainability, and health economic impact of AOBP in real-world primary care settings.

The main questions it aims to answer are:

  • Does implementation of AOBP increase the proportion of patients with treated and controlled hypertension compared with the pre-implementation period?
  • Can AOBP be successfully adopted, implemented, integrated into routine general practice workflows, and maintained over time?

Researchers will compare outcomes following implementation of AOBP with routinely collected clinical data from the period before implementation.

Participants will:

  • Provide informed consent and have their AOBP measurements performed during routine general practice visits.
  • Consent to the collection of AOBP measurement and relevant clinical information from their medical records for study evaluation.
  • Continue to receive usual clinical care from their general practitioner.

General practice staff will receive AOBP training, perform AOBP measurements, and participate in implementation evaluation activities.

연구 개요

상세 설명

Hypertension is the most common condition managed in general practice and remains one of the leading modifiable risk factors for cardiovascular disease (CVD). Accurate blood pressure (BP) measurement is fundamental to hypertension diagnosis and management; however, guideline-recommended clinic BP measurement procedures are often difficult to implement in routine practice because of time, staffing, and workflow constraints. General practitioners have reported that guideline-recommended BP measurement approaches are frequently impractical in routine clinical care, which may contribute to reduced confidence in clinic BP readings and therapeutic inertia.

Automated Office Blood Pressure (AOBP) measurement is a standardized approach to clinic BP assessment designed to reduce observer and procedural bias. The method incorporates an automated rest period followed by repeated automated measurements obtained while the patient remains seated, quiet, and undisturbed. AOBP values correlate closely with out-of-office BP measurement methods and, in 2025, AOBP was endorsed by Hypertension Australia and the National Hypertension Taskforce as the recommended standard for clinic BP measurement in Australia.

AOBP is typically performed by a trained staff member before the patient sees the general practitioner, in a quiet area outside the consultation room. This approach is intended to provide a more standardized BP assessment, reduce demands on consultation time, and support clinical decision-making through more reliable BP information while maintaining existing clinical care pathways and clinician responsibility for diagnosis, treatment, follow-up, and referral decisions.

Despite guideline endorsement and supporting evidence, AOBP has not been routinely implemented in Australian general practice. Barriers to implementation are predominantly structural rather than clinical and include limited access to validated equipment, staff training requirements, workflow integration challenges, and the absence of coordinated implementation support.

The study was informed by extensive co-design work involving general practitioners, practice staff, partner organisations, and community members. Previous pilot implementation work demonstrated that AOBP could be integrated into general practice workflows and was considered feasible, acceptable, and adaptable across diverse practice settings when supported by appropriate training, workflow integration, and governance arrangements. GPs participating in pilot implementation work reported increased trust in BP readings and greater confidence in hypertension management.

This study is a pragmatic, multisite, hybrid type 2 implementation-effectiveness trial using a non-randomised pre-post design. Approximately 40 Australian general practice clinics will participate in the study, with implementation occurring within each clinic over a 12-month period followed by a 6-month maintenance phase. The study has been designed to evaluate implementation of Automated Office Blood Pressure (AOBP) measurement within routine primary care settings and examine factors influencing implementation and sustainability in general practice.

The hybrid type 2 implementation-effectiveness design was selected to enable simultaneous evaluation of implementation and effectiveness under real-world conditions. Evaluation is guided by the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework and the Practical, Robust Implementation and Sustainability Model (PRISM). RE-AIM provides the overarching framework for evaluation of effectiveness and implementation outcomes, while PRISM is used to identify barriers, enablers, contextual factors, adaptations, and determinants of implementation and sustainability.

In addition to implementation and effectiveness evaluations, the study will examine health economic considerations associated with implementation of AOBP in general practice and will explore longer-term health outcomes through approved linkage to routinely collected administrative and health datasets where available. These evaluations are intended to complement trial findings and inform future implementation, scale-up, and sustainability of AOBP in Australian primary care settings.

연구 유형

중재적

등록 (추정된)

6000

단계

  • 해당 없음

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 연락처

연구 장소

    • Tasmania
      • Hobart, Tasmania, 호주, 7000
        • Menzies Institute for Medical Research, University of Tasmania
        • 연락하다:
        • 수석 연구원:
          • James E Sharman, PhD

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

  • 성인
  • 고령자

건강한 자원 봉사자를 받아들입니다

예

설명

Inclusion Criteria:

Patients will be eligible to participate if they meet Australian guideline-recommended criteria for BP measurement, either for absolute CVD risk assessment or for BP assessment as an individual risk factor, and are attending a participating general practice clinic during the study period.

Eligible participants include:

Adults attending participating general practice clinics who are eligible for BP measurement for absolute CVD risk assessment, including:

  • Adults aged 45 to 79 years without known CVD
  • Adults aged 35 to 79 years with diabetes and without known CVD
  • First Nations peoples aged 30 to 79 years without known CVD

Adults eligible for BP assessment as an individual risk factor, including:

  • First Nations peoples aged 18 to 29 years
  • Adults aged 18 years and over where BP measurement is clinically indicated based on individual risk factors or clinical judgement (e.g. suspected hypertension from BP measurements outside the clinic, obesity, abnormal cholesterol levels, secondary causes of hypertension, or time elapsed since last BP measurement)

Exclusion Criteria:

  • Patients who are unable to provide informed consent.
  • Patients whose participation is deemed clinically inappropriate by the treating general practitioner.

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 건강 서비스 연구
  • 할당: 해당 없음
  • 중재 모델: 단일 그룹 할당
  • 마스킹: 없음(오픈 라벨)

무기와 개입

참가자 그룹 / 팔
개입 / 치료
다른: AOBP Implementation Intervention
Implementation of a standardized AOBP measurement protocol using a validated automated sphygmomanometer. AOBP measurements will be conducted by trained general practice staff. Patients will be seated in a quiet area with back supported, feet flat on the floor, arm supported at heart level, and an appropriately sized cuff applied. Following a 5-minute automated rest period, the device automatically records three seated blood pressure measurements at 30-second intervals and a fourth brief measurement to detect arrhythmia/atrial fibrillation. The device automatically calculates and records the average of the three seated measurements, heart rate, and arrhythmia status. Where clinically indicated, a standing protocol will be performed following the seated protocol and consists of two standing blood pressure measurements recorded at 30-second intervals after 1 minute of standing, followed by an arrhythmia assessment. Results are provided to the treating general practitioner.

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
The proportion of patients with treated and controlled hypertension, with the primary estimand being the absolute difference in this proportion between the pre-implementation period and 12-month AOBP implementation period.
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.

Hypertension control will be defined according to Australian guideline recommendations using AOBP thresholds (average systolic BP <135 mmHg and diastolic BP <85 mmHg).

"Treated" refers to patients receiving antihypertensive therapy.

Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.

2차 결과 측정

결과 측정
측정값 설명
기간
Average systolic and diastolic BP measured using AOBP
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Heart rate recording during AOBP measurement
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Frequency of repeat AOBP measures during the study period
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Changes in systolic and diastolic blood pressure values over time, measured using AOBP
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Clinician-measured BP values recorded in the electronic medical record, where available
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Initiation of antihypertensive therapy
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Intensification of antihypertensive therapy
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Changes in antihypertensive medication prescribing patterns
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Changes in cardiovascular medication prescribing patterns
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Proportion of participants receiving treatment for hypertension
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Documented referral for further assessment related to elevated BP (detected by AOBP device)
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Documented follow-up investigations related to elevated BP (detected by AOBP device [e.g. electrocardiogram monitoring, standard clinic blood pressure measurement, home BP monitoring, 24-hour ambulatory BP monitoring])
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Dates of clinic visits related to elevated BP (detected by AOBP device), where available
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Proportion of participants with possible arrhythmia (including AF) indicated by the AOBP device
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Documented referral for further assessment of possible arrhythmia (including AF) indicated by the AOBP device
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Dates of clinic visits related to possible arrhythmia (including AF) indicated by AOBP device, where available
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Completion of an absolute CVD risk calculation
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Documentation of patient characteristics relevant to cardiovascular risk (e.g. age, sex, smoking status, relevant CVD risk factors and pathology [i.e. cholesterol, glucose] and clinical conditions such as diabetes)
기간: Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Assessed during the 12-month AOBP implementation period. Patients included in longitudinal treatment-response analyses must have ≥6 weeks of follow-up after the index AOBP measurement.
Implementation outcomes will be evaluated within the overarching RE-AIM framework and will include measures of Reach, Adoption, Implementation and Maintenance.
기간: Assessed throughout the 12-month AOBP implementation period, with Maintenance assessed at 18 months following the 6-month maintenance phase.
These will examine participation and uptake of AOBP, fidelity, feasibility, acceptability, integration into routine practice, and sustained use during the maintenance period.
Assessed throughout the 12-month AOBP implementation period, with Maintenance assessed at 18 months following the 6-month maintenance phase.
PRISM (Practical, Robust Implementation and Sustainability Model) will guide the implementation component by identifying anticipated and experienced barriers and enablers, and contextual factors influencing implementation and sustainability.
기간: Assessed throughout the 12-month AOBP implementation period, with Maintenance assessed at 18 months following the 6-month maintenance phase.
Assessed throughout the 12-month AOBP implementation period, with Maintenance assessed at 18 months following the 6-month maintenance phase.
Costs associated with implementation of AOBP at the practice level, including equipment, staff training, workflow integration, and ongoing quality assurance
기간: Outcome assessed 12-months following AOBP implementation period.
Outcome assessed 12-months following AOBP implementation period.
Costs per patient correctly diagnosed and managed for hypertension using AOBP compared with usual care BP measurement
기간: Outcome assessed 12-months following AOBP implementation period.
Outcome assessed 12-months following AOBP implementation period.
Practice level and system level costs related to changes in clinical management, including antihypertensive prescribing and follow up
기간: Outcome assessed 12-months following AOBP implementation period.
Outcome assessed 12-months following AOBP implementation period.
Downstream health service utilisation and cost implications associated with CVD events, hospitalisations, and mortality (where data permit)
기간: Outcome assessed 12-months following AOBP implementation period.
Outcome assessed 12-months following AOBP implementation period.

기타 결과 측정

결과 측정
측정값 설명
기간
Cardiovascular disease risk factors ascertained via data linkage
기간: Exploratory outcome assessed 12-months following AOBP implementation period.
Obesity, hypertension, hyperlipidaemia, Type II diabetes mellitus, smoking status
Exploratory outcome assessed 12-months following AOBP implementation period.
Death
기간: Exploratory outcome assessed 12-months following AOBP implementation period.
CVD death, all-cause mortality
Exploratory outcome assessed 12-months following AOBP implementation period.
Hospitalization ascertained via data linkage
기간: Exploratory outcome assessed 12-months following AOBP implementation period.
Emergency department presentations, public hospital admissions, private hospital admissions
Exploratory outcome assessed 12-months following AOBP implementation period.
Cardiovascular disease events ascertained via data linkage
기간: Exploratory outcome assessed 12-months following AOBP implementation period.
Including: angina, acute myocardial infarction, ischemic heart disease, cardiomyopathy, atrial fibrillation, hypertensive heart disease, heart failure, heart valve disease, presence of cardiac and vascular implants and grafts, cerebrovascular disease, peripheral artery disease, chronic kidney disease
Exploratory outcome assessed 12-months following AOBP implementation period.

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (추정된)

2026년 10월 1일

기본 완료 (추정된)

2029년 10월 1일

연구 완료 (추정된)

2030년 10월 1일

연구 등록 날짜

최초 제출

2026년 9월 9일

QC 기준을 충족하는 최초 제출

2026년 9월 9일

처음 게시됨 (실제)

2026년 9월 16일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 9월 16일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 9월 9일

마지막으로 확인됨

2026년 9월 1일

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

  • H40663
  • Grant ID 2053493 (기타 보조금/기금 번호: National Health and Medical Research Council of Australia)

약물 및 장치 정보, 연구 문서

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아니

미국 FDA 규제 기기 제품 연구

아니

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