Proteases in Patients With Prostate Cancer That Has Spread to the Bone
Proteases in Prostate Cancer Bone Metastasis
RATIONALE: Collecting and storing samples of bone marrow and tissue from patients to test in the laboratory may help the study of cancer.
PURPOSE: This laboratory study is comparing proteases (enzymes that break down protein) in patients with prostate cancer that has spread to the bone with patients who do not have cancer that has spread to the bone.
研究概览
地位
详细说明
OBJECTIVES:
- Examine the roles of proteases and protease-associated molecules in bone metastases in patients with metastatic prostate cancer.
OUTLINE: Patients undergo bone marrow aspiration and core bone biopsies. Tissues are analyzed by immunohistochemistry methods, in situ hybridization assays, gelatin zymography and/or Western blot analysis, and gene profiling analysis in order to visualize and quantitate protease or protease-related levels.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Michigan
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Detroit、Michigan、美国、48076
- Barbara Ann Karmanos Cancer Institute
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Diagnosis of metastatic prostate cancer
- Patients with documented bone metastases on radiologic imaging studies must undergo bone marrow biopsy
Male patients ≥ 50 years of age without cancer who are scheduled to undergo bone biopsy for other clinically indicated reasons, including any of the following:
- Myelodysplasia
- Anemia
- Monoclonal gammopathy of undetermined significance
- Male or female patients ≥ 40 years of age without metastatic bone cancer who are scheduled to undergo an orthopedic procedure involving removal of bone specimen
PATIENT CHARACTERISTICS:
- See Disease Characteristics
PRIOR CONCURRENT THERAPY:
- Not specified
学习计划
研究是如何设计的？
研究衡量的是什么？
主要结果指标
结果测量 |
|---|
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Expression and activity of proteases and related molecules
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合作者和调查者
调查人员
- 学习椅：Michael L. Cher, MD、Barbara Ann Karmanos Cancer Institute
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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