此页面是自动翻译的,不保证翻译的准确性。请参阅 英文版 对于源文本。

Hoarding Older Adults

2018年6月26日 更新者:VA Office of Research and Development

Treatment of Late Life Compulsive Hoarding

The purpose of this investigation is to examine treatment outcome of a new intervention for hoarding in older adults compared to standard case management for hoarding. The new intervention combines exposure therapy and cognitive remediation.

研究概览

详细说明

Research has shown that hoarding disorder (HD) is debilitating chronic and progressive condition that has significant public health implications. Older adults represent the largest group of HD suffers due to increasing severity with age. Often, Veterans with HD are seen in the VA system and the status of their hoarding is never assessed. Providers are treating patients for other health and social service issues yet missing an important source of disability and distress. This insidious, often undetected condition leads to greater medical and social disability and is costly to the VA system as patients continue to decompensate. When HD is even detected, patients in the VA receive indefinite case management and inadequate treatment. The cases the investigators know about have caused significant financial burden to the investigators' system. Most importantly, HD causes significant impairment and poor quality of life for the Veterans, particularly older Veterans. Unfortunately, the investigators know nothing about how to treat late life HD. Nor do the investigators know how neurocognitive features impact treatment response, which the investigators strongly suspect influence treatment outcome. HD is a potentially treatable source of disability in the VA system - one that the VA must research and treat. This study represents the first randomized controlled trial of a novel intervention for the treatment of HD in older Veterans. The main objective of this proposal is to further refine and test a new treatment for hoarding in older Veterans (age 60-85) which will be accomplished through a series of treatment development phases (case series, open labeled trial) and a randomized controlled trial. The new treatment (Cognitive Remediation and Exposure Therapy for hoarding; CogRET) is hypothesis driven and based on late life anxiety literature, consultation with mentors, results of the pilot study using a standard cognitive-behavioral intervention, and several case series that will be completed prior to the start of the Career Development Award (CDA). The first draft of CogRET is complete and is currently being used with several case studies. The research and training plan is divided into 5 phases; 1) training and preparation 2) training, further case studies using CogRET, further modification of CogRET 3)training, open label trial of CogRET, further modification of CogRET 4) randomized controlled trial and 5) presenting, publishing, dissemination of results and submission of a VA Merit grant. Primary hypotheses include 1) when randomized to CogRET, older Veterans with HD will show significant decreases in acquisition, difficulty discarding, and excessive clutter compared to those randomized to case management and 2) executive functioning (EF) is a significant moderator of treatment response. Other mediators and moderates of treatment response (psychiatric, medical, demographic, etc.) will be explored.

研究类型

介入性

注册 (实际的)

58

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习地点

    • California
      • San Diego、California、美国、92161
        • VA San Diego Healthcare System, San Diego, CA

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

60年 至 85年 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

描述

Inclusion Criteria:

Participants must be between the ages of 60 - 85 years old and meet clinical criteria for Compulsive Hoarding (CH) developed by the Steketee and Frost (2000) research group. These criteria include:

  • significant amount of clutter in active living spaces
  • the urge to collect, buy, or acquire things
  • an extreme reluctance to part with items
  • clutter accumulation that causes distress or interferes with functioning
  • symptom duration of at least 6 months
  • the reluctance to part with items is not accounted for by other psychiatric conditions.

To be enrolled, patients must have:

  • a score of 20 or greater on the University of California, Los Angeles Hoarding Severity Scale (UHSS)
  • 40 or greater on the Savings Inventory-Revised (SI-R)
  • severity rating of 4 or higher on the Anxiety Disorders Interview Schedule (ADIS-IV) rating scales for clutter and difficulty discarding
  • and diagnosis confirmed at a consensus conference including at least two licensed professionals with expertise in CH (myself and at least one mentor).

Exclusion Criteria:

  • Individuals with moderate to severe cognitive deficits (scores below 23 on the MMSE) will be excluded.
  • Prospective participants must not have active substance abuse problems.
  • Participants will also be excluded if they are currently in other forms of psychotherapy.
  • Participants must have no change in any psychotropic medications for at least three months prior to the initial assessment.
  • Patients with current psychosis or mania will be excluded.
  • Mood and anxiety disorders are permitted as long as compulsive hoarding is the primary diagnosis.
  • Participants will are not eligible if they have active suicidal ideation, those participants will be given immediate medical or mental health attention.

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

  • 主要用途:治疗
  • 分配:随机化
  • 介入模型:并行分配
  • 屏蔽:单身的

武器和干预

参与者组/臂
干预/治疗
实验性的:Arm 1: Cognitive Rehabilitation
Cognitive rehabilitation and exposure therapy for hoarding
The intervention includes cognitive remediation for deficits in executive functioning and exposure therapy for discarding/acquiring.
有源比较器:Arm 2: Case Management
Case management
Case management

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
Hoarding Symptom Severity as Measured by the Saving Inventory-Revised (SI-R) at 6 Months
大体时间:6 months
Hoarding symptom severity (primary outcome) will be measured using the Savings Inventory-Revised (SI-R), a 23-item self-report measure used to assess common hoarding symptoms. Subtests include excessive clutter, compulsive acquisition, and difficulty discarding. The SI-R has demonstrated good internal consistency, divergent validity, concurrent validity, divergent validity, test-retest reliability in clinical samples with hoarding. The total score will be used for analyses. The range of the total score is 0-92, with higher scores indicating worse hoarding severity.
6 months

次要结果测量

结果测量
措施说明
大体时间
The Activities of Daily Living in Hoarding (ADL-H)
大体时间:6 months
The Activities of Daily Living in Hoarding (ADL-H) was used to assess functional impairment. Higher scores represent increased impairment. Mean score is 1-75, with higher scores indicating worse impairment due to hoarding.
6 months
Executive Functioning as Measured by the Delis Kaplan Executive Functioning System (D-KEFS) at 6 Months
大体时间:6 months
The D-KEFS Trail Making Test Condition 4: Number-Letter Switching Scaled Score was used to assess executive functioning. Scaled scores range from 1-19. Higher scores represent less impairment.
6 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

调查人员

  • 首席研究员:Catherine R Ayers, PhD、VA San Diego Healthcare System, San Diego, CA

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2010年11月1日

初级完成 (实际的)

2015年4月1日

研究完成 (实际的)

2015年4月1日

研究注册日期

首次提交

2010年10月20日

首先提交符合 QC 标准的

2010年10月20日

首次发布 (估计)

2010年10月22日

研究记录更新

最后更新发布 (实际的)

2018年7月24日

上次提交的符合 QC 标准的更新

2018年6月26日

最后验证

2018年6月1日

更多信息

与本研究相关的术语

其他研究编号

  • CSRD-068-10S

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

订阅