The Effects of Muscles Strength on Physical Performance in Patients With Multiple Sclerosis
The Effects of Extremity and "Core" Muscles Strength on Walking and Sit-to-Stand Performance in Patients With Multiple Sclerosis
Muscle weakness, which is one of the most common symptoms in patients with MS, limits the activities of daily life activities of patients by causing balance and gait disturbance. Lower extremity muscle strengths of MS patients are reported to be weaker than healthy individuals. Broekmans et al. showed that the weakness of the knee flexor and extensor muscles in patients with MS caused a decrease in walking distance and they are important determinants of walking capacity.
The effects of the endurance and strength of core muscles, as well as the extremity muscles, are important on physical performance. The weakness of the extremities and core muscles in MS patients also affects the sit-to-stand performance negatively as well as a decrease in walking speed and capacity.
In this study, it was aimed to investigate the effects of extremity and core muscle strength on walking and sitting-up performance of MS patients.
研究概览
地位
条件
详细说明
Patients with MS between 0-5,5 score according to the Extended Disability Status Scale (EDSS) and healthy individuals of similar age and sex to patients will be included in the study. The strength of the extremity and core muscles, walking capacity, and sit-to-stand performance will be evaluated once.
Investigators will use descriptive statistics and t-tests to compare variables between groups. Investigators will examine the correlations between variables using Pearson bivariate correlations. The significance level is set at p<0,05
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
-
Ankara、火鸡
- Gazi University
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Participants who 18-65 years of age
- MS patients who are ambulatory (Expanded Disability Status Scale score ≤ 5,5 ) in a stable phase of the disease, without relapses in the last 3 month.
Exclusion Criteria:
- Participants who have orthopedic, vision, hearing, or perception problems
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
|
Multiple sclerosis
Patients with MS between 0-5,5 score according to the Extended Disability Status Scale (EDSS)
|
|
Control
Healthy individuals of similar age and sex to patients
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
strength of extremity muscles
大体时间：baseline
|
The isometric strength of lower extremity muscles will be assessed respectively using a hand-held dynamometer (Baseline®, White Plains, New York, USA).
|
baseline
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
6 minutes walking test
大体时间：baseline
|
The Six-Minute Walking Test (6MWT) was performed to determine walking capacity.
|
baseline
|
|
timed up and go test
大体时间：baseline
|
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
|
baseline
|
|
sit-to-stand test
大体时间：baseline
|
In this test, the participants will stand up from and sit down on 43 cm high armless chair as quickly as possible 5 times.
|
baseline
|
|
Side Bridge Test (core muscles endurance)
大体时间：baseline
|
The subjects were asked to lay on their left or right sides and to extend their legs fully.
Then The subjects are asked to create a straight line with their body by lifting their hip from the floor.The measurements are recorded with a chronometer as seconds.
The tests end when the subjects break the test positions.
|
baseline
|
|
Modified Biering-Sorensen test (core muscles endurance)
大体时间：baseline
|
In this test, the subjects are asked to lie down on a workout bench, aligning their anterior superior iliac spine with the edge of the bench, which allowed the upper body to be planked out over the edge.
The subjects are asked to fold their arms on their chest and to put their hands on their shoulders.
The measurements are recorded with a chronometer as seconds.
The tests end when the subjects break the test positions.
|
baseline
|
|
Trunk Flexion Test (core muscles endurance)
大体时间：baseline
|
This test is initiated when the subjects are in a sit-up position with their back resting against a wedge that was angled 55° from the floor.
The measurements are recorded with a chronometer as seconds.
The tests end when the subjects break the test positions.
|
baseline
|
|
Prone bridge test (core muscles endurance)
大体时间：baseline
|
In this test, the subjects put their elbows on the ground as the starting position and open their feet about the width of their hips while keeping their body straight as they are required not to arch or bow.
The measurements are recorded with a chronometer as seconds.
The tests end when the subjects break the test positions.
|
baseline
|
合作者和调查者
出版物和有用的链接
一般刊物
- Broekmans T, Gijbels D, Eijnde BO, Alders G, Lamers I, Roelants M, Feys P. The relationship between upper leg muscle strength and walking capacity in persons with multiple sclerosis. Mult Scler. 2013 Jan;19(1):112-9. doi: 10.1177/1352458512444497. Epub 2012 May 4.
- Bliss LS, Teeple P. Core stability: the centerpiece of any training program. Curr Sports Med Rep. 2005 Jun;4(3):179-83. doi: 10.1007/s11932-005-0064-y.
- Yahia A, Ghroubi S, Mhiri C, Elleuch MH. Relationship between muscular strength, gait and postural parameters in multiple sclerosis. Ann Phys Rehabil Med. 2011 May;54(3):144-55. doi: 10.1016/j.rehab.2011.02.004. Epub 2011 Mar 9. English, French.
- Ketelhut NB, Kindred JH, Manago MM, Hebert JR, Rudroff T. Core muscle characteristics during walking of patients with multiple sclerosis. J Rehabil Res Dev. 2015;52(6):713-24. doi: 10.1682/JRRD.2015.01.0006.
- Fry DK, Huang M, Rodda BJ. Core muscle strength and endurance measures in ambulatory persons with multiple sclerosis: validity and reliability. Int J Rehabil Res. 2015 Sep;38(3):206-12. doi: 10.1097/MRR.0000000000000109.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.