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The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Amateur Athletes With Chronic Ankle Instability

2026年8月13日 更新者：Mustafa Fatih Çetintaş、Bahçeşehir University

The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training on Visuo-Motor Reaction Performance, Fear Avoidance Behaviors Related to Sports Injuries and Kinesiophobia in Amateur Athletes With Chronic Ankle Instability

Chronic ankle instability (CAI) is a common condition after lateral ankle sprain. CAI is characterized by mechanical and/or functional instability, or recurrent episodes of "giving way," persisting for at least 12 months after the initial injury, and is associated with limitations in activity and and participation. Contemporary theoretical models emphasize that CAI should not be explained solely by biomechanical or neuromuscular deficits, but rather as a dynamic condition shaped by the interaction of motor-behavioral, sensory-perceptual, psychological, and environmental factors.

Postural stabilization training is commonly used to improve balance and neuromuscular control in individuals with CAI. However, individuals with CAI may show increased reliance on visual information and altered visual-vestibular sensory reweighting during postural control tasks. The vestibulo-ocular reflex (VOR) contributes to gaze stability and visual clarity during head movements and may also be related to neurocognitive processes such as attention and processing speed. This study is designed as a randomized controlled, prospective, parallel-group, pretest-posttest design trial to investigate whether VOR exercises added to postural stabilization training improve visuo-motor reaction performance, fear avoidance behavior related to sports injuries and kinesiophobia in amateur athletes with CAI.

研究概览

地位

招聘中

条件

干预/治疗

详细说明

Chronic ankle instability (CAI) is a common condition following lateral ankle sprain and is characterized by mechanical and/or functional instability, recurrent episodes of "giving way," and activity limitations persisting for at least 12 months after the initial injury. Contemporary models suggest that CAI should not be explained only by biomechanical or neuromuscular deficits, but rather as a multidimensional condition influenced by motor-behavioral, sensory-perceptual, psychological, and environmental factors. In amateur athletes, CAI may be overlooked or undertreated despite the high sensorimotor and cognitive demands of sport-specific activities. During dynamic sport-related tasks, athletes must rapidly perceive visual information, select an appropriate motor response, and execute this response while maintaining postural control. Therefore, visuo-motor reaction performance assessed during dynamic balance may provide a meaningful functional outcome for evaluating sport-specific sensorimotor control in individuals with CAI.

Postural stabilization training is commonly used in CAI rehabilitation to improve balance, proprioceptive function, and neuromuscular control. However, individuals with CAI may demonstrate increased reliance on visual information and altered visual-vestibular sensory reweighting during postural control tasks. The vestibulo-ocular reflex (VOR) contributes to gaze stability and visual clarity during head movements. Therefore, integrating VOR exercises into postural stabilization training may support visual stabilization, sensory integration, and motor response performance during dynamic balance tasks.

Psychological factors may also influence functional performance and return-to-sport behavior after musculoskeletal injury. Fear-avoidance behavior related to sports injuries and kinesiophobia may lead individuals to avoid movement or sport-specific activities due to fear of reinjury. These factors may be associated not only with traditional motor performance outcomes, but also with visual attention strategies, attentional resource allocation, and reactive motor response processes.

This study is designed as a randomized controlled, prospective, parallel-group, pretest-posttest design trial to investigate whether VOR exercises added to postural stabilization training improve visuo-motor reaction performance, fear avoidance behavior related to sports injuries and kinesiophobia in amateur athletes with CAI. Visuo-motor reaction performance will be assessed using a Reactive Balance Test, Fear-avoidance behavior related to sports injuries will be evaluated through Athlete Fear Avoidance Questionnaire - Turkish Version and kinesiophobia will be assessed using Tampa Scale for Kinesiophobia - Turkish Version. Approximately 56 participants with CAI will participate in an exercise program for six weeks, three days a week. Each session will last approximately 45 minutes, including 40 minutes of exercise and 5 minutes of ankle mobilization. Participants will be randomized into either a Postural Stabilization Training Group or a Postural Stabilization Training plus Vestibulo-Ocular Reflex (VOR) Exercises Group. Outcomes will be assessed at baseline, at the end of the six week intervention and at 4-week follow-up.

研究类型

介入性

注册 (估计的)

56

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

  • 姓名：Mustafa Fatih Çetintaş, PT, PhD (c)
  • 电话号码：+905336654580
  • 邮箱：mfcetintas@gmail.com

研究联系人备份

学习地点

  • 土耳其（türkiye）
    • Turkey
      • Istanbul、Turkey、土耳其（türkiye）、34728
        • 招聘中
        • Reset Fizyoterapi
        • 接触：
        • 接触：
        • 首席研究员：
          • Mustafa Fatih Çetintaş, PT, PhD (c)

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

不

描述

Inclusion Criteria:

  • Being between 18 and 35 years of age.
  • Being classified as a Tier 2 athlete according to the McKay et al. Participant Classification Framework (trained/developmental level).
  • Having a history of at least one lateral ankle sprain (LAS) occurring at least 12 months before enrollment, resulting in swelling, pain, and functional impairment, and followed by persistent instability.
  • Having the most recent ankle sprain at least 3 months before study enrollment.
  • Having a history of recurrent ankle sprains or episodes of "giving way."
  • Having a diagnosis of unilateral chronic ankle instability (CAI).
  • Having a Cumberland Ankle Instability Tool - Turkish Version (CAIT-T) score of ≤24.
  • Having a Foot and Ankle Ability Measure (FAAM) score of <90%.
  • Having a Foot and Ankle Ability Measure Sports subscale (FAAM-S) score of <80%.
  • A side-to-side difference of ≥2.5 cm in Weight-Bearing Lunge Test distance, with the affected side demonstrating less dorsiflexion than the unaffected side.

Exclusion Criteria:

  • History of acute lateral ankle sprain within the last 3 months.
  • History of lower extremity surgery.
  • History of acute injury to other musculoskeletal structures of the lower extremity joints within the last 3 months that affected joint integrity and function and caused interruption of desired physical activity for at least one day.
  • History of balance or vestibular disorders, including cerebellar, vestibular, cochlear, or inner ear dysfunction.
  • Visual problems that may affect the administration or interpretation of the Dynamic Visual Acuity Test, including a history of amblyopia, diplopia, or significant visual loss.
  • Persistent symptoms related to a previous concussion or traumatic brain injury.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
有源比较器：Postural Stabilization Training Group
Participants in this group will receive ankle joint mobilization followed by a structured postural stabilization training program. The program will include single-leg stance progression, hop stabilization tasks, and number-sequence hop tasks. Exercises will be progressed according to the participant's ability to complete each task without errors. Ankle joint mobilization will include talocrural anteroposterior mobilization and distal fibular mobilization with movement, applied before the exercise session for approximately 5 minutes.
其他：Postural Stabilization Training
Participants in this group will receive ankle joint mobilization followed by a structured postural stabilization training program. The program will include single-leg stance progression, hop stabilization tasks and number-sequence hop tasks. Exercises will be progressed according to the participant's ability to complete each task without errors. Ankle joint mobilization will include talocrural anteroposterior mobilization and distal fibular mobilization with movement, applied before the exercise session for approximately 5 minutes. The total session will last approximately 45 minutes and will be performed 3 times per week for 6 weeks.
其他名称：
  • Talocrural joint mobilization
实验性的：Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training Group
Participants in this group will receive the same ankle joint mobilization and postural stabilization training program as the Postural Stabilization Training Group. In addition, vestibulo-ocular reflex (VOR) exercises involving fixation on a visual target during head movements will be implemented. VOR exercises will be structured to progressively increase postural demands and will include sitting, standing, walking, and single-leg stance positions.
其他：Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training
Participants in this group will receive the same ankle joint mobilization and postural stabilization training program as the Postural Stabilization Training Group. In addition, vestibulo-ocular reflex (VOR) exercises involving fixation on a visual target during head movements will be implemented. VOR exercises will be structured to progressively increase postural demands and will include sitting, standing, walking, and single-leg stance positions. The total session will last approximately 45 minutes and will be performed 3 times per week for 6 weeks.
其他名称：
  • Talocrural joint mobilization

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Reactive Balance Test
大体时间：baseline, 6 weeks after baseline, and 10-week after baseline

This test will be used to assess visuo-motor reaction performance during dynamic postural control. The test will combine the Y-Balance Test setup with a smartphone-controlled LED light system (BlazePod). LED targets will be placed at 80% of each participant's maximum reach distance in the anterior, posteromedial, and posterolateral directions.

Participants will stand in the standard Y-Balance Test position and will be instructed to touch the target LED stimulus as quickly as possible without losing balance. A total of 45 randomized visual stimuli will be presented, with inter-stimulus intervals ranging from 0.5 to 2.5 seconds.

Visuo-motor reaction time will be recorded in milliseconds, and accuracy will be calculated based on missed stimuli, multiple attempts, and decision errors. The test will be performed twice on the limb with a history of instability; the first trial will be used for familiarization, and the second trial will be used for analysis.
baseline, 6 weeks after baseline, and 10-week after baseline

次要结果测量

结果测量
措施说明
大体时间
The Athlete Fear Avoidance Questionnaire - Turkish Version (AFAQ-TR)
大体时间：baseline, 6 weeks after baseline, and 10-week after baseline

The questionnaire will be used to assess fear-avoidance behavior related to return to sport after injury. The questionnaire consists of 10 items scored on a 5-point Likert scale ranging from 0 (strongly disagree) to 4 (strongly agree).

The total score ranges from 0 to 40, with higher scores indicating greater fear-avoidance behavior.
baseline, 6 weeks after baseline, and 10-week after baseline
The Tampa Scale for Kinesiophobia - Turkish Version (TSK-TR)
大体时间：baseline, 6 weeks after baseline, and 10-week after baseline

The scale will be used to assess fear of movement after musculoskeletal injury. The scale consists of 17 items scored on a 4-point Likert scale ranging from 1 (strongly disagree) to 4 (strongly agree).

After reverse scoring items 4, 8, 12, and 16, a total score will be calculated. The total score ranges from 17 to 68, with higher scores indicating greater kinesiophobia.
baseline, 6 weeks after baseline, and 10-week after baseline

其他结果措施

结果测量
措施说明
大体时间
Weight-Bearing Lunge Test
大体时间：baseline, 6 weeks after baseline, and 10-week after baseline
The Weight-Bearing Lunge Test will be used to assess ankle dorsiflexion range of motion in a weight-bearing position. The maximum distance at which the knee can touch the wall without heel lift will be measured in centimeters. A dorsiflexion distance on the affected side that is ≥2.5 cm less than the unaffected side will be considered indicative of dorsiflexion limitation.
baseline, 6 weeks after baseline, and 10-week after baseline
Foot and Ankle Ability Measure Turkish Version (FAAM-T)
大体时间：baseline, 6 weeks after baseline, and 10-week after baseline
The Foot and Ankle Ability Measure Turkish Version (FAAM-T) will be used to evaluate postural stability and foot/anklerelated functional ability following chronic ankle instability and lateral ankle sprain. The FAAM consists of 29 items and includes two subscales: the Activities of Daily Living subscale (FAAM-ADL, 21 items) and the Sports subscale (FAAMS, 8 items). The Sports subscale is specifically designed to assess sport-related function and complex motor tasks and is widely used as a self-reported outcome measure in athletic populations. Scores are expressed as a percentage, with lower scores indicating greater sport-related functional limitation.
baseline, 6 weeks after baseline, and 10-week after baseline
Cumberland Ankle Instability Tool - Turkish Version
大体时间：baseline, 6 weeks after baseline, and 10-week after baseline

The Cumberland Ankle Instability Tool is a 9-item questionnaire used to evaluate perceived ankle instability and functional limitations. The total score ranges from 0 to 30, with lower scores indicating greater ankle instability.

A score of 24 or lower is considered consistent with functional ankle instability.
baseline, 6 weeks after baseline, and 10-week after baseline
Dynamic Visual Acuity Test
大体时间：baseline, 6 weeks after baseline, and 10-week after baseline

The Dynamic Visual Acuity Test will be used to assess the functional status of the vestibulo-ocular reflex (VOR). Static visual acuity (SVA) and dynamic visual acuity (DVA) during active head movements will be measured, and the difference between these two values will be used as an indicator of VOR function.

For both measurements, the smallest line that can be read with at least 50% accuracy will be recorded. The change in the SVA-DVA difference will be reported after the intervention.
baseline, 6 weeks after baseline, and 10-week after baseline

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Bahçeşehir University

调查人员

  • 首席研究员：Mustafa Fatih Çetintaş, PT, PhD (c)、Bahçeşehir University
  • 学习椅：Pelin Pişirici, PT, PhD、Bahçeşehir University
  • 研究主任：Gamze Kılıç, PT, PhD、Istanbul Nisantasi University
  • 研究主任：Barış Kocaoğlu Kocaoğlu, MD、Acibadem University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2026年7月25日

初级完成 (估计的)

2027年7月25日

研究完成 (估计的)

2027年7月25日

研究注册日期

首次提交

2026年8月7日

首先提交符合 QC 标准的

2026年8月7日

首次发布 (实际的)

2026年8月12日

研究记录更新

最后更新发布 (实际的)

2026年8月17日

上次提交的符合 QC 标准的更新

2026年8月13日

最后验证

2026年7月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • MFP-CAI-VOR-2027

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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