The Impact of Insomnia on Pain Sensitivity and the Trajectory of Exercise-induced Muscular Pain
2026年9月14日 更新者：The Hong Kong Polytechnic University
The Impact of Insomnia on Pain Sensitivity and the Trajectory of Exercise Induced Muscular Pain: a Case Control Study
Sleep is a critical determinant of physiological recovery and pain regulation. Growing evidence suggests that sleep disruption directly heightens central and peripheral pain sensitivity to sensory stimuli (e.g., mechanical pressure, thermal stimuli), serving as a significant risk factor for the onset and persistence of musculoskeletal pain. However, the precise mechanisms through which sleep quality regulates bodily sensory sensitivity and influences the onset, progression, and recovery trajectories of acute musculoskeletal pain in the general public remain insufficiently understood.
This study aims to investigate the relationship between sleep condition, pain sensitivity, and musculoskeletal pain dynamics in healthy adults from the general population, regardless of their physical activity levels. Utilizing a standardized, safe, and fully reversible exercise-induced muscle soreness (EIMS) protocol as an experimental pain model, this project will continuously evaluate participants' quantitative sensory testing (QST) profiles and sleep parameters.
The findings from this study will advance the mechanistic understanding of sleep-mediated pain modulation, providing evidence-based insights to inform future targeted sleep management and pain prevention interventions.
研究概览
研究类型
观察性的
注册 (估计的)
80
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Leo Guohui Lin
- 电话号码：+852 94267004
- 邮箱：guohui-leo.lin@connect.polyu.hk
学习地点
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Hong Kong、香港
- 招聘中
- The Hong Kong Polytechnic University
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接触：
- Leo Guohui Lin
- 电话号码：+852 94267004
- 邮箱：guohui-leo.lin@connect.polyu.hk
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
接受健康志愿者
是的
取样方法
非概率样本
研究人群
Healthy Adult with or without insomnia
描述
Inclusion Criteria:
- Adults aged 18 to 60 years
- Right hand and foot dominant
Exclusion Criteria:
- History of any chronic musculoskeletal pain or presence of existing pain during recruitment
- Previous major injuries or surgery involving the lower limbs
- Sleep disorders other than insomnia
- Clinically diagnosed psychiatric disorders
- Contraindications to vigorous exercise identified through the physical activity readiness questionnaire (PAR-Q)
- Work night shifts or rotating shift schedules
- Pregnant
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Insomnia
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Eccentric hamstring exercise
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Healthy contry
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Eccentric hamstring exercise
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Muscle damage severity: Muscle pain
大体时间：Day 0 to Day 14
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Muscle pain will be measured by an 11-point NRS, with 0 represents "no pain" and 10 indicating "worst imaginable pain".
The Outcome will be recorded at rest, reach for the floor with knees straight, and during a validated hamstring provocative manoeuvre, the "taking-off shoe" test.
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Day 0 to Day 14
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Muscle damage severity: Muscle soreness
大体时间：Day 0 to Day 14
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Muscle soreness will be measured by an 7-point Likert scale, with 0= A complete absence of soreness," 1 = "A light soreness in the muscle felt only when touched/a vague ache," 2 = "A moderate soreness felt only when touched/a slight persistent pain," 3 = "A light muscle soreness when walking up and down stairs," 4 = "A light muscle soreness when walking on flat surface," 5 = "A moderate muscle soreness, stiffness, or weakness when walking," 6 = "A severe muscle soreness, stiffness, or weakness that limits my ability to move."
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Day 0 to Day 14
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Pain Sensitivity: Thermal pain threshold
大体时间：Day 7 and Day 9
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Thermal thresholds will be measured with a 30 × 30 mm thermode (TSA 2, Medoc Ltd., Ramat Yishai, Israel).
The thermode will be placed gently on the skin without causing deformation.
Using the method of limits, temperature will increase or decrease at 1℃/second within a 0 - 51℃ range, with a baseline temperature of 32℃.
Participants will press the stop button when the thermal sensation first becomes painful.
The mean value of five consecutive trials will be used in the analysis.
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Day 7 and Day 9
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Pain Sensitivity: Mechanical pain threshold
大体时间：Day 7 and Day 9
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Mechanical pain threshold will be evaluated using standardised weighted pinprick stimulators (MRC System GmbH, Heidelberg, Germany) with a 0.25mm flat contact area.
Seven fixed intensities (8 mN - 512 mN) will be applied.
The final threshold will be calculated as the geometric mean of the ascending and descending stimulus intensities from five series.
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Day 7 and Day 9
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Pain Sensitivity: Pressure pain threshold
大体时间：Day 7 and Day 9
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Pressure pain threshold will be assessed with a digital pressure algometer (Medoc Ltd., Ramat Yishai, Israel) equipped with a 1 cm2 rubber probe.
Pressure will be applied at 30 Kpa per second until participants perceive painful.
Three trials will be performed, and the mean scores will be calculated to determine the PPT.
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Day 7 and Day 9
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Pain Sensitivity: Temporal summation of mechanical pain (TSP-M)
大体时间：Day 7 and Day 9
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The pinprick stimulator will assess TSP-M at 256 mN.
Ten stimuli will be delivered at 1-second intervals over a 1 cm2 area.
Pain intensity will be rated on an 11-point NRS after the first and the 10th stimuli.
If the NRS pain rating remains 0 out of 10 for three consecutive 256 mN stimuli, intensity will be increased to 512 mN, and the trial will be repeated.
TSP-M will be calculated as the NRS difference between the first stimulus and the 10th stimulus.
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Day 7 and Day 9
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Pain Sensitivity: Temporal summation of heat pain (TSP-H)
大体时间：Day 7 and Day 9
|
TSP-H will be measured with a 9 cm2 thermode (TSA 2, Medoc Ltd., Ramat Yishai, Israel).
Two sequences of 10 heat pulses at 46 ℃ and 48 ℃ will be delivered with a 5-minute interval.
Each pulse has a 0.5 s duration and will be delivered from a 40 ˚C baseline at a 13°C/s ramp rate and 2.5 s interstimulus interval.
The participant will rate pain intensity on an 11-point NRS after each stimulus.
TSP-H will be defined as the NRS difference between the 10th stimulus and the first stimulus for each temperature.
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Day 7 and Day 9
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Pain Sensitivity: Conditioned pain modulation (CPM)
大体时间：Day 7 and Day 9
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CPM will be evaluated using a noxious conditioning stimulus (CS) and a test stimulus (TS).
The CS will be contact heat applied to the dominant volar forearm between the distal third of the forearm and the ulnar styloid.
Temperature will be set 1.1 °C above the participant's HPT for 120s, starting from 32 ℃ with an 8°C/s ramp using the TSA 2 device (Medoc Ltd., Ramat Yishai, Israel).
During the CPM assessment, if participants could not tolerate the CS (i.e., pain intensity over 8 on the11-point NPRS) or if they reported a pain intensity below 4 on the 11-point NPRS, the temperature of the CS will be adjusted to ensure a safe and adequate stimulus intensity.
The TS will be applied to the thenar eminence of the non-dominant hand using a pressure algometer (Medoc Ltd., Ramat Yishai, Israel) to determine PPT before and immediately after the CS.
The CPM effect will be calculated by subtracting the PPT measured before the CS from the PPT measured after the CS.
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Day 7 and Day 9
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Sleep diary: Sleep Onset Latency (SOL)
大体时间：Day 0 to Day 14
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Assessed using a daily consensus sleep diary.
Sleep Onset Latency is the estimated time (in minutes) it takes to fall asleep after turning off the lights.
Lower values indicate better sleep onset.
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Day 0 to Day 14
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Sleep diary: Wake After Sleep Onset (WASO)
大体时间：Day 0 to Day 14
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Assessed using a daily consensus sleep diary.
WASO is calculated as the total duration of wakefulness (in minutes) between initial sleep onset and final awakening, derived from the number of night awakenings multiplied by their average duration.
Lower values indicate better sleep continuity.
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Day 0 to Day 14
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Sleep diary: Sleep Efficiency (SE)
大体时间：Day 0 to Day 14
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Assessed using a daily consensus sleep diary.
Sleep Efficiency is calculated as the percentage of time in bed spent asleep: [(Total Sleep Time / Total Time in Bed) × 100].
Total Sleep Time is derived from total time in bed (time between bedtime and rise time) minus sleep onset latency and nocturnal wakefulness (calculated from the number and duration of night awakenings).
Scores range from 0% to 100%, with higher percentages indicating better sleep quality.
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Day 0 to Day 14
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Actigraphy: Total Sleep Time (TST)
大体时间：Day 0 to Day 14
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Measured objectively using a wrist-worn ActiGraph accelerometer and validated sleep-scoring algorithms.
Total Sleep Time is defined as the total amount of time spent sleeping between bedtime and rise time.
Higher values indicate longer sleep duration.
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Day 0 to Day 14
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Actigraphy: Wake After Sleep Onset (WASO)
大体时间：Day 0 to Day 14
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Measured objectively using a wrist-worn ActiGraph accelerometer.
WASO is defined as the total number of minutes spent awake after initial sleep onset and before final awakening, as determined by epoch-by-epoch movement counts.
Lower values indicate better sleep continuity and fewer night awakenings.
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Day 0 to Day 14
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Actigraphy: Sleep Efficiency (SE)
大体时间：Day 0 to Day 14
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Measured objectively using a wrist-worn ActiGraph accelerometer.
Sleep Efficiency is calculated as the percentage of time in bed spent asleep: [(Total Sleep Time / Total Time in Bed) × 100].
Values range from 0% to 100%, with higher percentages indicating better sleep quality and efficiency.
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Day 0 to Day 14
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Sleep Questionnaires: the Insomnia Severity Index (ISI)
大体时间：Day 0 and Day 7
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The ISI is a 7-item self-report questionnaire assessing the nature, severity, and impact of insomnia.
Each item is rated on a 5-point Likert scale (0 to 4).
The total score ranges from 0 to 28, with higher scores indicating greater severity of insomnia
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Day 0 and Day 7
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Sleep Questionnaires: The Pittsburgh Sleep Quality Index (PSQI)
大体时间：Day 0 and Day 7
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The PSQI is a 19-item self-report questionnaire that evaluates sleep quality and disturbances over a 1-month time interval.
It generates seven component scores: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction.
Each component is scored from 0 to 3. The sum of these seven component scores yields a global PSQI score ranging from 0 to 21, where higher scores indicate poorer sleep quality.
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Day 0 and Day 7
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Psychological measurement: Depression, Anxiety, and Stress Scale (DASS-21)
大体时间：Day 0, Day 7, and Day 9
|
Assessed using the 21-item Depression Anxiety Stress Scales (DASS-21).
The instrument consists of three 7-item subscales measuring depression, anxiety, and stress.
Each item is rated on a 4-point Likert scale ranging from 0 ("did not apply to me at all") to 3 ("applied to me very much or most of the time").
Sum scores for each subscale are calculated and multiplied by 2 to yield total scores ranging from 0 to 42 for each dimension (Depression: 0-42, Anxiety: 0-42, Stress: 0-42), with a total overall score ranging from 0 to 126.
Higher scores indicate greater levels of psychological distress/severity.
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Day 0, Day 7, and Day 9
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Psychological measurement: Pain Catastrophizing Scale (PCS)
大体时间：Day 0, Day 7, and Day 9
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Assessed using the 13-item Pain Catastrophizing Scale (PCS) to evaluate catastrophic thoughts and feelings associated with pain (comprising rumination, magnification, and helplessness subscales).
Each item is rated on a 5-point Likert scale from 0 ("not at all") to 4 ("all the time").
The total score ranges from 0 to 52, with higher scores indicating higher levels of pain catastrophizing.
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Day 0, Day 7, and Day 9
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Psychological measurement: Fear of Pain Questionnaire (FPQ-9)
大体时间：Day 0, Day 7, and Day 9
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Assessed using the 9-item short form of the Fear of Pain Questionnaire (FPQ-9) to assess fear of different painful experiences across severe pain, minor pain, and medical pain domains.
Each item is rated on a 5-point Likert scale from 1 ("not at all") to 5 ("extreme").
The total score ranges from 9 to 45, with higher scores indicating greater fear of pain.
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Day 0, Day 7, and Day 9
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Psychological measurement: Tampa Scale for Kinesiophobia (TSK-11)
大体时间：Day 0, Day 7, and Day 9
|
Assessed using the 11-item Tampa Scale for Kinesiophobia (TSK-11) to evaluate fear of movement or (re)injury.
Each item is scored on a 4-point Likert scale ranging from 1 ("strongly disagree") to 4 ("strongly agree").
The total score ranges from 11 to 44, with higher scores indicating greater fear of movement/kinesiophobia.
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Day 0, Day 7, and Day 9
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Sleep diary: Total Sleep Time
大体时间：Day 0 to Day 14
|
Assessed using a daily consensus sleep diary.
Total Sleep Time is calculated as the total time spent asleep, derived from the total time in bed (bedtime to rise time) minus sleep onset latency and wake after sleep onset.
Higher values indicate longer sleep duration.
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Day 0 to Day 14
|
|
Actigraphy: Sleep Onset Latency (SOL)
大体时间：Day 0 to Day 14
|
Measured objectively using a wrist-worn ActiGraph accelerometer.
Sleep Onset Latency is defined as the period of time (in minutes) between the initial bedtime (lights out) and the onset of continuous sleep detected by the algorithm.
Lower values indicate faster sleep onset and better sleep initiation.
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Day 0 to Day 14
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Physical Activity Level: International Physical Activity Questionnaire - Short Form (IPAQ-SF)
大体时间：Day 0, Day 7, and Day 9
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Assessed using the 7-item International Physical Activity Questionnaire - Short Form (IPAQ-SF).
The questionnaire measures the duration (minutes) and frequency (days) of walking, moderate-intensity activities, and vigorous-intensity activities performed over the last 7 days.
Total physical activity volume is calculated as MET-minutes per week (MET-min/week) using standardised MET energy expenditure values: Walking = 3.3 METs, Moderate PA = 4.0 METs, and Vigorous PA = 8.0 METs.
Total score is the sum of (METs × minutes × days) across all three domains, with scores starting from 0 and no strict upper limit.
Higher scores indicate higher levels of overall physical activity.
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Day 0, Day 7, and Day 9
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年8月26日
初级完成 (估计的)
2027年8月31日
研究完成 (估计的)
2027年8月31日
研究注册日期
首次提交
2026年9月2日
首先提交符合 QC 标准的
2026年9月14日
首次发布 (实际的)
2026年9月18日
研究记录更新
最后更新发布 (实际的)
2026年9月18日
上次提交的符合 QC 标准的更新
2026年9月14日
最后验证
2026年8月1日
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- Insomnia-DOMS-2026
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
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