Stress Through Audition: Uptake, Recovery, Oscillations During Nature Exposure (SAURON)
A Stress Study Through Auditory Soundscapes: Uptake, Recovery and Cerebral Oscillations During Nature Versus Urban Exposure
The protocol the investigators propose aims to address certain gaps by developing a multimodal paradigm, based on:
- Induction of acute stress via the Maastricht Acute Stress Test (MAST), a standardised protocol recognised for its effectiveness in activating both the HPA axis and the autonomic nervous system.
- A 10-minute auditory exposure to two types of soundscapes (natural vs urban), designed in accordance with ecological standards (recordings taken from real-world environments and featuring representative natural and anthropogenic sound components, with the aim of making the stimulus as close as possible to real-life experiences).
- A battery of synchronised, multimodal measurements, including hormonal measurements (salivary cortisol at 10 time points), continuous autonomic nervous system measurements (HR, HRV, BP), a high-density EEG and analysis via EEG Source Imaging (ESI), a battery of cognitive tests typically sensitive to stress (Continuous Visual Attention Task, N-back, Delay Discounting Task), and a light polysomnography study conducted at home to assess delayed effects on sleep.
This design will enable the investigators to examine, as comprehensively as possible, the dynamics of post-stress recovery across several levels of analysis (biological, cerebral, cognitive and behavioural). It will also enable the investigators to identify the specific effects of the sound environment on each of these levels. By cross-referencing neurophysiological, hormonal and behavioural responses, we hope to document how natural sound environments actively regulate stress and cognition and to explore the mechanisms involved.
This project could pave the way for applications in mental health, preventive neuroscience, acoustic urban planning and non-pharmacological interventions, by providing a rigorous scientific foundation to support recommendations for the design or management of stress in professional, educational or clinical settings.
研究概览
地位
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Frédéric Pr Frédéric Haesebaert, PhD
- 电话号码：+33 (0)4 37 91 55 34
- 邮箱：frederic.haesebaert@ch-le-vinatier.fr
研究联系人备份
- 姓名：Jérôme Dr Jérôme BRUNELIN
- 电话号码：+33 (0)4 37 91 55 65
- 邮箱：jerome.brunelin@ch-le-vinatier.fr
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Men and women between 18 and 45 years of age inclusive;
- Informed about the study and having signed the consent form;
- With normal vision (with or without correction);
- Able to understand the experimental instructions;
- Covered by the French social security system;
- Proficient in spoken, read, and written French.
Exclusion Criteria:
- Having a vision or hearing impairment that could prevent the proper performance of tasks involving reading on a screen or paper and listening to auditory stimuli;
- Being a smoker;
- Having a somatic condition, particularly a neurological or endocrine disorder, or a circulatory disorder in the extremities (Raynaud's disease);
- Having or having had a personal or first-degree family history of diagnosed psychiatric disorders (according to Axis 1 of the criteria in the Diagnostic and Statistical Manual of Mental Disorders - DSM-5);
- Taking medication (except for oral contraceptives);
- Being pregnant or breastfeeding;
- Being under a protective measure (guardianship, conservatorship, protective order, etc.)
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Participants exposed to the natural soundscape
Participants undergo the Maastricht Acute Stress Test (MAST) to induce acute stress, followed by a 10-minute auditory exposure to a standardized natural soundscape delivered via headphones. Physiological (cortisol, HR, HRV, BP), cerebral (high-density EEG with source imaging), and cognitive measures are collected before and after the stress induction and the soundscape exposure. |
10-minute passive auditory exposure to a standardized natural soundscape assembled from real-world recordings normalized and characterized. Delivered via headphones in a seated, resting position immediately following MAST-induced acute stress. Single administration per participant |
|
有源比较器：Participants exposed to the urban soundscape
Participants undergo the Maastricht Acute Stress Test (MAST) to induce acute stress, followed by a 10-minute auditory exposure to a standardized urban soundscape delivered via headphones. Physiological (cortisol, HR, HRV, BP), cerebral (high-density EEG with source imaging), and cognitive measures are collected before and after the stress induction and the soundscape exposure. |
10-minute passive auditory exposure to a standardized urban soundscape assembled from real-world recordings normalized and characterized. Delivered via headphones in a seated, resting position immediately following MAST-induced acute stress. Single administration per participant. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in salivary cortisol concentration following acute stress and a natural soundscape exposure.
大体时间：Day 1
|
Salivary cortisol will be measured as a biological marker of hypothalamic-pituitary-adrenal (HPA) axis activation, in response to an acute stress induction (MAST) followed by a 10-minute auditory exposure to a natural soundscape. |
Day 1
|
|
Change in salivary cortisol concentration following acute stress and an urban soundscape exposure.
大体时间：Day 1
|
Salivary cortisol will be measured as a biological marker of hypothalamic-pituitary-adrenal (HPA) axis activation, in response to an acute stress induction (MAST) followed by a 10-minute auditory exposure to an urban soundscape. |
Day 1
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Post-stress cognitive performance across sustained attention task for the urban soundscape arm.
大体时间：Day 1
|
Cognitive performance assessed via computerized task: the Continuous Visual Attention Task (CVAT, sustained attention) for the urban soundscape arm. |
Day 1
|
|
Post-stress cognitive performance across sustained attention task for the natural soundscape arm.
大体时间：Day 1
|
Cognitive performance assessed via computerized task: the Continuous Visual Attention Task (CVAT, sustained attention) for the natural soundscape arm. |
Day 1
|
|
Post-stress cognitive performance across working memory task for the urban soundscape arm.
大体时间：Day 1
|
Cognitive performance assessed via computerized task: the N-back task (working memory) for the urban soundscape arm. |
Day 1
|
|
Post-stress cognitive performance across working memory task for the natural soundscape arm.
大体时间：Day 1
|
Cognitive performance assessed via computerized task: the N-back task (working memory) for the natural soundscape arm. |
Day 1
|
|
Post-stress cognitive performance across decision-making task for the urban soundscape arm.
大体时间：Day 1
|
Cognitive performance assessed via computerized task: the Delay Discounting Task (decision-making) for the urban soundscape arm. |
Day 1
|
|
Post-stress cognitive performance across decision-making task for the natural soundscape arm.
大体时间：Day 1
|
Cognitive performance assessed via computerized task: the Delay Discounting Task (decision-making) for the natural soundscape arm. |
Day 1
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- PRVT-03
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.