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Effect of Meal Sequence and Eating Speed on Blood Glucose After Eating Western Breakfast Among Healthy Young Adults

2026年11月5日 更新者：University of Veterinary and Animal Sciences, Lahore - Pakistan

Impact of Meal Sequence and Eating Speed on Postprandial Glycemic Response of an Isocaloric Western Breakfast Among Healthy Young Adults

The goal of this clinical trial is to investigate the effects of meal sequence(the order in which carbohydrates/starches and non-starchy vegetables are consumed) and eating speed(slow or fast) on postprandial blood glucose response in healthy young adults (n=22) aged 20-25 years. The main questions it aims to answer are:

  • Does consuming carbohydrate-containing foods before or after non-starchy vegetables influence postprandial blood glucose response?
  • Does eating a standardized breakfast slowly (over approximately 20 minutes) or quickly (over approximately 10 minutes) affect postprandial blood glucose response?
  • Do meal sequence and eating speed together influence postprandial glycemic response? Researchers will compare four breakfast conditions combining two meal sequences (carbohydrate-first and non-starchy vegetable-first) with two eating speeds (slow and fast) to determine their individual and combined effects on postprandial metabolic responses.

Participants will:

  • Consume a standardized, isocaloric Western-style breakfast under four different experimental conditions.
  • Consume the breakfast in the assigned food order and within the specified eating duration during each experimental visit.
  • Attend four experimental visits in a randomized order, with a washout period between visits.
  • Provide blood samples before and at 30, 60, 90, and 120 minutes after breakfast consumption to assess blood glucose levels.
  • Undergo assessment of serum insulin and triglyceride responses according to the study protocol.

研究概览

地位

尚未招聘

条件

干预/治疗

研究类型

介入性

注册 (估计的)

22

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

学习地点

  • 巴基斯坦
    • Punjab Province
      • Lahore、Punjab Province、巴基斯坦
        • University of Veterinary and Animal Sciences, Paksitan
        • 接触：
        • 接触：

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 25年 (成人)

接受健康志愿者

是的

有资格学习的性别

男性

描述

Inclusion Criteria:

Healthy male adults aged 18-25 years, with a BMI of 18.0-24.9 kg/m², without known diseases, regular medication use, or allergies to study food ingredients.

Exclusion Criteria:

Individuals with diabetes or other diagnosed diseases, those using medications, following specific diets, or having dietary restrictions or allergies to study food ingredients will be excluded.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：基础科学
  • 分配：随机化
  • 介入模型：交叉作业
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：Sequence 1: A-B-D-C

Arm 1 - Sequence 1 (A-B-D-C): A: Carbohydrate-first + slow eating (20 minutes); B: Carbohydrate-first + fast eating (10 minutes) ; C: Vegetable-first + slow eating (20 minutes) ; D: Vegetable-first + fast eating (10 minutes). Participants receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables, in the sequence as :carbohydrate-first with slow eating, carbohydrate-first with fast eating, vegetable-first with fast eating, and vegetable-first with slow eating, in that order, over four weekly visits.
行为的：Intervention A: Carbohydrate-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of the standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention B: Carbohydrate-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.

行为的：Intervention C: Vegetable-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention D: Vegetable-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.
实验性的：Sequence 2: B-C-A-D

Arm 2: Sequence 2 (B-C-A-D) A: Carbohydrate-first + slow eating (20 minutes); B: Carbohydrate-first + fast eating (10 minutes) ; C: Vegetable-first + slow eating (20 minutes) ; D: Vegetable-first + fast eating (10 minutes).

Experimental arm. Participants receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables, in the following order: carbohydrate-first with fast eating, vegetable-first with slow eating, carbohydrate-first with slow eating, and vegetable-first with fast eating.
行为的：Intervention A: Carbohydrate-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of the standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention B: Carbohydrate-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.

行为的：Intervention C: Vegetable-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention D: Vegetable-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.
实验性的：Sequence 3: C-D-B-A

Arm 3 - Sequence 3 (C-D-B-A): A: Carbohydrate-first + slow eating (20 minutes); B: Carbohydrate-first + fast eating (10 minutes) ; C: Vegetable-first + slow eating (20 minutes) ; D: Vegetable-first + fast eating (10 minutes). Participants receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables, in the sequence as: vegetable-first with slow eating, vegetable-first with fast eating, carbohydrate-first with fast eating, and carbohydrate-first with slow eating, in that order, over four weekly visits.
行为的：Intervention A: Carbohydrate-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of the standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention B: Carbohydrate-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.

行为的：Intervention C: Vegetable-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention D: Vegetable-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.
实验性的：Sequence 4: D-A-C-B A:

Arm 4: Sequence 4 (D-A-C-B) Experimental arm: A: Carbohydrate-first + slow eating (20 minutes); B: Carbohydrate-first + fast eating (10 minutes) ; C: Vegetable-first + slow eating (20 minutes) ; D: Vegetable-first + fast eating (10 minutes). Participants receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables in the following order: vegetable-first with fast eating, carbohydrate-first with slow eating, vegetable-first with slow eating, and carbohydrate-first with fast eating.
行为的：Intervention A: Carbohydrate-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of the standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention B: Carbohydrate-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the carbohydrate-containing portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.

行为的：Intervention C: Vegetable-First, Slow Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed slowly over approximately 20 minutes.

行为的：Intervention D: Vegetable-First, Fast Eating

Participants will receive an Isocaloric breakfast containg toasted white bread, scrambled eggs and stir fired non-starchy vegetables. Participants will consume the non-starchy vegetable portion of a standardized, isocaloric Western-style breakfast first, followed by the remaining meal components. The entire breakfast is to be consumed quickly over approximately 10 minutes.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Change in Postprandial Blood Glucose Incremental Area Under the Curve (iAUC) from 0 to 120 Minutes Across Four Breakfast Conditions
大体时间：At baseline and 30, 60, 90, and 120 minutes after breakfast consumption during each of the four intervention visits (approximately 4 weeks).

Measurement details: Blood glucose concentrations measured at baseline (0 minutes) and 30, 60, 90, and 120 minutes after breakfast consumption. The incremental area under the curve (iAUC) will be calculated to compare postprandial glycemic responses across the four conditions.
At baseline and 30, 60, 90, and 120 minutes after breakfast consumption during each of the four intervention visits (approximately 4 weeks).

次要结果测量

结果测量
措施说明
大体时间
Postprandial Serum Insulin Response Across Four Breakfast Conditions.
大体时间：At baseline and 30, 60, 90, and 120 minutes after breakfast consumption during each intervention visit.

Serum insulin concentrations will be assessed following consumption of each breakfast condition to evaluate differences in postprandial insulin responses associated with meal sequence and eating speed.
At baseline and 30, 60, 90, and 120 minutes after breakfast consumption during each intervention visit.
Postprandial Serum Triglyceride Response Across Four Breakfast Conditions
大体时间：At baseline and 30, 60, 90, and 120 minutes after breakfast consumption during each intervention visit.

Serum triglyceride concentrations will be assessed following consumption of each breakfast condition to compare postprandial lipid responses associated with meal sequence and eating speed.
At baseline and 30, 60, 90, and 120 minutes after breakfast consumption during each intervention visit.

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

University of Veterinary and Animal Sciences, Lahore - Pakistan

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年12月1日

初级完成 (估计的)

2027年3月1日

研究完成 (估计的)

2027年3月1日

研究注册日期

首次提交

2026年11月5日

首先提交符合 QC 标准的

2026年11月5日

首次发布 (实际的)

2026年11月12日

研究记录更新

最后更新发布 (实际的)

2026年11月12日

上次提交的符合 QC 标准的更新

2026年11月5日

最后验证

2026年10月1日

更多信息

与本研究相关的术语

关键字

其他研究编号

  • MealSequence-GlycemicResponse

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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