Clinical Trials on CIC-Rearranged Sarcoma

Total 3727 results

UNICANCER

Active, not recruiting

A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas (REGOBONE)

Chondrosarcomas | Ewing Sarcomas | Osteosarcomas | Chondroma | CIC-Rearranged Sarcoma

France
Michael Wagner, MD
Edgewood Oncology Inc.

Active, not recruiting

BTX-A51 in Patients With Liposarcoma or CIC-rearranged Sarcoma

Liposarcoma | Myxoid Liposarcoma | MDM2 Gene Amplification | Metastatic Liposarcoma | CIC-Rearranged Sarcoma | Unresectable Liposarcoma | Recurrent Liposarcoma

United States
Children's Oncology Group

Active, not recruiting

Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body

Metastatic Ewing Sarcoma | CIC-Rearranged Sarcoma | Round Cell Sarcoma With EWSR1-non-ETS Fusion | Metastatic High Grade Sarcoma | Sarcoma With BCOR Genetic Alterations | Metastatic Undifferentiated Round Cell Sarcoma | Metastatic Undifferentiated Sarcoma, Not Otherwise Specified

United States
Grupo Espanol de Investigacion en Sarcomas

Recruiting

Multicohort Trial of Different Schemes of PM14 in Monotherapy and in Combination with Radiotherapy in Soft Tissue Sarcomas and Other Solid Tumor (PRIME)

Advanced Solid Tumor | Advanced Soft-tissue Sarcoma | Advanced L-sarcomas | Other Advanced Sarcomas | Localized Soft-tissue Sarcoma

Spain
German Cancer Research Center
German Consortium for Translational Cancer Research

Completed

Afatinib in Advanced NRG1-Rearranged Malignancies

Metastatic and Locally Advanced NRG1-rearranged Malignancies

Germany
University Health Network, Toronto

Not yet recruiting

BOLD-100 Plus Doxorubicin in Advanced Soft Tissue Sarcomas

Sarcoma | Sarcoma,Soft Tissue | Sarcomas | Sarcoma, Soft-tissue

Canada
Takara Bio Inc.

Recruiting

Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma

Synovial Sarcomas

Japan
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarker Differences in Samples From Patients With Undifferentiated Sarcomas

Soft Tissue Sarcoma

United States
University of Alabama at Birmingham

Withdrawn

Phase I Study of Safety and Feasibility of Transarterial Embolization of Incurable Hypervascular Pediatric Soft Tissue Sarcomas

Soft Tissue Sarcomas

United States
Institut Bergonié
PharmaMar

Completed

Targeting Microenvironment and Cellular Immunity in Sarcomas Weekly Trabectedin Combined With Metronomic Cyclophosphamide (TARMIC)

Soft-tissue Sarcomas

France
Tata Memorial Hospital
Terry Fox Foundation

Completed

An Adequate Cost Effective Follow Up Protocol For Bone and Soft Tissue Sarcomas (TOSS)

Sarcomas

India
Henan Cancer Hospital

Completed

Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule

Soft Tissue Sarcomas

China
University of Florida

Withdrawn

Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas (SA02)

Soft Tissue Sarcomas
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Withdrawn

Fluorothymidine F-18 PET in Diagnosing Patients With Intermediate or High Grade Soft Tissue Sarcoma

Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Stage II Adult Soft Tissue Sarcoma | Stage IIA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma
The Netherlands Cancer Institute
Leiden University Medical Center

Active, not recruiting

Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas (SCOPES)

Soft Tissue Sarcomas

Netherlands
Ruijin Hospital

Recruiting

The Value of 68Ga-grazytracer PET in Monitoring Responses to Immunotherapy of Advanced Soft Tissue Sarcomas

Advanced Soft Tissue Sarcomas

China
Vanderbilt-Ingram Cancer Center

Recruiting

Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas

Soft Tissue Sarcomas

United States
Institut Bergonié
Ministry of Health, France; National Cancer Institute, France

Recruiting

CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study. (NEOSarcomics)

Soft-tissue Sarcomas

France
NYU Langone Health
Bristol-Myers Squibb

Withdrawn

Study of Nivolumab With or Without Pazopanib in Metastatic or Unresectable Soft Tissue Sarcomas

Soft Tissue Sarcomas

United States
National Institutes of Health Clinical Center (CC)

Completed

Isolated Limb Perfusion of Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Soft Tissue Sarcoma of the Arm or Leg

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IVA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma | Stage IVB Adult Soft Tissue Sarcoma
National Cancer Institute (NCI)

Completed

Cabozantinib for Adults With Advanced Soft Tissue Sarcoma

Refractory Soft Tissue Sarcomas

United States
Merck Sharp & Dohme LLC
Ariad Pharmaceuticals

Completed

Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) (SUCCEED)

Metastatic Soft-Tissue Sarcomas | Metastatic Bone Sarcomas
M.D. Anderson Cancer Center

Not yet recruiting

A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas

Soft Tissue Sarcomas

United States
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Withdrawn

Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IVA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma

United States, Canada
Zai Lab (Shanghai) Co., Ltd.
Zai Lab (US) LLC

Recruiting

Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors

Solid Tumors | Sarcomas

United States
M.D. Anderson Cancer Center
Aadi Bioscience

Recruiting

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Leiomyosarcoma | Soft-tissue Sarcomas

United States
Asan Medical Center
Novartis

Completed

RAD001 in Advanced Sarcoma

Soft Tissue Sarcomas | Bone Sarcomas

Korea, Republic of
Onxeo
Spectrum Pharmaceuticals, Inc

Completed

A Phase I/II Clinical Trial of PXD101 in Combination With Doxorubicin in Patients With Soft Tissue Sarcomas

Dose Escalation: Solid Tumors | MTD: Soft Tissue Sarcomas

Denmark, United Kingdom
Grupo Espanol de Investigacion en Sarcomas

Recruiting

Multicohort Trial of Trabectedin and Low-dose Radiation Therapy in Advanced/Metastatic Sarcomas (SYNERGIAS)

Soft Tissue Sarcoma | Bone Tumors | Small Round-cell Sarcomas

Spain
Albert Einstein College of Medicine
National Cancer Institute (NCI)

Terminated

Gemcitabine Hydrochloride, Docetaxel, and Radiation Therapy in Treating Patients With Uterine Sarcoma That Has Been Removed By Surgery

Uterine Corpus Leiomyosarcoma | Stage IIA Uterine Sarcoma | Stage IIB Uterine Sarcoma | Stage IIIA Uterine Sarcoma | Stage IIIB Uterine Sarcoma | Stage IIIC Uterine Sarcoma | Stage IVA Uterine Sarcoma | Stage IVB Uterine Sarcoma | Stage IA Uterine Sarcoma | Stage IB Uterine Sarcoma | Stage IC Uterine Sarcoma

United States
National Cancer Institute (NCI)

Completed

Blood and Tissue Study of Patients in NIH Protocol 08-C-0800

Sarcomas

United States
St. Jude Children's Research Hospital

Withdrawn

Markers of Anthracycline-Related Cardiac Muscle Injury

Osteosarcoma | Rhabdomyosarcoma | Ewing's Sarcoma Family of Tumors | Non-rhabdomyosarcoma Soft Tissue Sarcomas
Jonsson Comprehensive Cancer Center

Recruiting

Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)

Abdominopelvic Sarcomas

United States
Ardelyx

Recruiting

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

Chronic Idiopathic Constipation (CIC)

United States
Jonathan Trent, MD, PhD
Merck Sharp & Dohme LLC; Pfizer

Completed

Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas

Alveolar Soft Part Sarcoma | Soft Tissue Sarcomas

United States
Oslo University Hospital
University Hospital of North Norway; Haukeland University Hospital; St. Olavs...

Recruiting

Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. (PROSARC-2)

Soft Tissue Sarcoma Adult | Liposarcoma | Pleomorphic Liposarcoma | Myxofibrosarcoma | Leiomyosarcoma (LMS) | Pleomorphic Rhabdomyosarcoma | Soft Tissue Sarcoma of the Trunk and Extremities | Soft Tissue Sarcoma (STS) | Undifferentiated Pleomorphic Sarcoma (UPS) | Synovial Sarcomas

Norway
Sidnei Epelman

Unknown

Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Rhabdomyosarcoma and Other Soft Tissue Sarcomas

Refractory or Relapsed RMS and Soft Tissue Sarcomas

Brazil
Oslo University Hospital
Haukeland University Hospital; St. Olavs Hospital; University Hospital of Northern...

Recruiting

Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma (PROSARC-1)

Leiomyosarcoma | Soft Tissue Sarcoma Adult | Liposarcoma | Pleomorphic Rhabdomyosarcoma | Soft Tissue Sarcoma (Excluding GIST) | Soft Tissue Sarcoma of the Trunk and Extremities | Undifferentiated Pleomorphic Sarcoma (UPS) | Myxofibrosarcoma (MFS) | Synovial Sarcomas

Norway
The Netherlands Cancer Institute
Royal Marsden NHS Foundation Trust

Terminated

Clinical Study of Concurrent Pazopanib and Radiotherapy for Non-metastatic Sarcoma Patients (PASART-2)

Sarcoma | Soft Tissue Sarcomas

United Kingdom, Netherlands
Centre Leon Berard
Ministry of Health, France

Completed

Study of Continuous Dosing of Sunitinib in Non GIST Sarcomas With Concomitant Radiotherapy

Non GIST Sarcomas

France
Case Comprehensive Cancer Center

Recruiting

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Relapsed Sarcomas

United States
Italian Sarcoma Group
French Sarcoma Group; Grupo Espanol de Investigacion en Sarcomas

Completed

Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy

Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults

Spain, Italy
Children's Hospital of Philadelphia
Children's Hospital Colorado; Exelixis; Alex's Lemonade Stand Foundation

Recruiting

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

Osteosarcoma | Ewing Sarcoma | Sarcomas

United States
Azienda Ospedaliera Ospedale Infantile Regina Margherita...
Associazione Italiana Ematologia Oncologia Pediatrica

Recruiting

Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas

Diagnosed or Relapsed/Refractory Sarcomas

Italy
Memorial Sloan Kettering Cancer Center
Johns Hopkins University; M.D. Anderson Cancer Center; Merck Sharp & Dohme LLC; Dana-Farber Cancer Institute and other collaborators

Completed

Clinical Study of Vorinostat in Combination With Etoposide in Pediatric Patients < 21 Years at Diagnosis With Refractory Solid Tumors

Solid Tumors | Relapsed/Refractory Sarcomas

United States, Canada
AEterna Zentaris
Sarcoma Alliance for Research through Collaboration

Completed

A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas

Chondrosarcomas | Alveolar Soft Part Sarcomas | Extra Skeletal Myxoid Chondrosarcomas
Albert Einstein College of Medicine
National Cancer Institute (NCI)

Terminated

Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Uterine Cancer

Uterine Carcinosarcoma | Stage IIA Uterine Sarcoma | Stage IIB Uterine Sarcoma | Stage IIIA Uterine Sarcoma | Stage IIIB Uterine Sarcoma | Stage IIIC Uterine Sarcoma | Stage IVA Uterine Sarcoma | Stage IVB Uterine Sarcoma | Stage IA Uterine Sarcoma | Stage IB Uterine Sarcoma | Stage IC Uterine Sarcoma

United States
Centre Georges Francois Leclerc

Completed

Validation of a Genetic Signature to Predict the Development of Sarcomas (PREDISARC)

Genetic Signature in Development of Sarcomas

France
Di Wu

Not yet recruiting

Study of Anlotinib Hydrochloride and Toripalimab in Subjects With Unresectable or Metastatic Undifferentiated Pleomorphic Sarcoma

Undifferentiated Pleomorphic Sarcoma | Soft Tissue Sarcomas

China
Massachusetts General Hospital
Bristol-Myers Squibb; Kura Oncology, Inc.

Not yet recruiting

Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML

KMT2A-rearranged | NPM1-mutant Refractory or Relapsed AML

United States

Clinical Trials on CIC-Rearranged Sarcoma

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