Clinical Trials on Complement Abnormality

Total 529 results

Cedars-Sinai Medical Center
Alexion Pharmaceuticals, Inc.

Terminated

Complement Regulation to Undo Systemic Harm in Preeclampsia (CRUSH)

Pregnancy Related | Preeclampsia | HELLP Syndrome | Severe Preeclampsia | HELLP | Complement Regulatory Factor Defect | PNH | Eculizumab | HELLP Syndrome Second Trimester | AHUS | Complement Abnormality | HELLP Syndrome Third Trimester

United States
Longbio Pharma

Not yet recruiting

Efficacy and Safety of LP-005 Injection in Patients With Complement-Mediated Kidney Disease

Complement-mediated Renal Diseases

China
Universitair Ziekenhuis Brussel

Recruiting

The Role of Natural Killer, Complement and T-lymphocytes in COVID-19 Disease, a Prospective Monocentric Study (TONIC)

Covid19 | Peripheral Blood Mononuclear Cells | Complement Abnormality

Belgium
CSL Behring

Completed

First-In-Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Escalating Single And Multiple Doses Of CSL040 In Healthy Subjects

Complement-mediated Disorders

Australia
Cairo University

Enrolling by invitation

The Study Examined the Acute Effects of Wim Hof on Aerobic Training and Cardiodynamics.

Exercise Training | Pulmonary | Respiratory Abnormality

Lebanon
Region Skane

Recruiting

Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy

C3 Glomerulopathy | C3 Glomerulonephritis | Dense Deposit Disease | Membranoproliferative Glomerulonephritis | Complement Abnormality

Sweden
Centre Hospitalier Régional Metz-Thionville

Not yet recruiting

Referral of Patients With Biological Abnormalities to an Emergency Department (ORA)

Emergency Department Visit | General Practitioner | Biological Abnormality

France
Johns Hopkins University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

The Use of Eculizumab in HELLP Syndrome

Morbidity;Newborn | Preeclampsia Severe | Complement Abnormality | HELLP Syndrome (HELLP), Third Trimester | Maternal Injury

United States
Instituto Bernabeu

Completed

Validation of a NICS Method Using the Culture Medium

Chromosome Abnormality | Abnormality

Spain
Ankara City Hospital Bilkent

Completed

Endometriosis and Complement System

Endometriosis | Complement System | Alternative Complement Pathway

Turkey
Intalight, Inc
Illinois College of Optometry

Recruiting

Performance Evaluation of Dream OCT: AP Study

Normal Healthy Eyes | Eyes With Corneal Abnormality | Glaucoma Patients | Retina Patients

United States
Amway (China) R&D Center

Not yet recruiting

Evaluating Metabolic Health in People Aged 18 to 60 by Nutrilite Metabolic Health Index

Metabolic Disorders | Metabolic Abnormality

China
University Hospital Muenster
Study Chair and Principal Investigator: Univ.-Prof. Dr. Alexander Zarbock; Principal...

Recruiting

PLAIAR-Trial: Platelets in Inflammation and Resolution (PLAIAR)

ARDS | Platelet Abnormality

Germany
Nanjing Chia-tai Tianqing Pharmaceutical

Not yet recruiting

A Phase 1 Clinical Trial of NTQ5082 in Healthy Volunteers

Complement-mediated Hemolytic Diseases

China
Catalyst Biosciences

Terminated

Screening Study to Identify Patients With Complement Factor I Deficiencies

Previous Diagnosis With a Complement-mediated Disease and/or With Clinical Manifestations Reasonably Associated With Complement Factor I Deficiency

United States
Institut Pasteur de Lille

Completed

Fish Collagen Peptide Food Supplement on Weight and Body Composition (NATICOL)

Weight Management | Food Complement

France
Heeger, Peter, M.D.
Icahn School of Medicine at Mount Sinai; Alexion Pharmaceuticals

Terminated

Eculizumab for Prevention of Delayed Graft Function (DGF) in Kidney Transplantation

Kidney Transplantation | Delayed Graft Function | Complement Activity

United States
Assiut University

Not yet recruiting

Balloon Vaginoplasty for Treatment of Vaginal-aplasia

Vaginal Abnormality
Sharp HealthCare

Completed

Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU) (MINVIFU)

Neurodevelopmental Abnormality

Canada, United States, Poland
University of Seville

Not yet recruiting

Relationship of Muscular Agenesis: Thin Plantar and Palmar Long as a Biomarker of Injury and Performance Marker in the Lower Limb and Upper Limb Respectively (MA-TP-PL)

Abnormality, Congenital

Spain
Nanjing Chia-tai Tianqing Pharmaceutical

Not yet recruiting

Effect of Food of NTQ5082 in Healthy Subjects

Complement-mediated Hemolytic Diseases

China
Chengdu Suncadia Medicine Co., Ltd.

Completed

Investigation of Pharmacokinetics,Safety,and Pharmacodynamics of HRS-5965 in Subjects With Hepatic Impairment

Complement Mediated Primary or Secondary Glomerular Diseases

China
Chengdu Suncadia Medicine Co., Ltd.

Completed

A Study to Evaluate the Mass Balance of [14C] HRS-5965 in Healthy Adult Male Volunteers

Complement Mediated Primary or Secondary Glomerular Diseases

China
Nanfang Hospital of Southern Medical University
Xiangya Hospital of Central South University; Peking University People's Hospital and other collaborators

Unknown

Risk-stratified Therapy Based on Molecular Cytogenetic Aberration and Treatment Response in AML

MRD | Risk-directed Therapy | Cytogenetic Abnormality | Molecular Abnormality

China
Cairo University

Recruiting

Efficacy of Laser Acupuncture on Neurophysiological Parameters of Median Nerve in Postpartum Women (CTSLA)

Neurophysiologic Abnormality

Egypt
Croma-Pharma GmbH
Proinnovera GmbH

Completed

THIODERM ELATE for Augmentation of Very Thin, Thin, and Moderately Thick Lips (TILI)

Lip Abnormality

Austria
Ain Shams University

Completed

Outcomes of Trabecular Metal Augments Used in the Flying Buttress Position

Acetabular Abnormality
National Taiwan University Hospital

Completed

The Construction of a Chinese Picture Naming Test and Its Preliminary Normative Data

Normality

Taiwan
Centre Psychothérapique de Nancy
Centre Hospitalier Régional et Universitaire de Nancy

Recruiting

Creation and Evaluation of a Mobile Intervention Team in Perinatal Psychiatry (0-3 Years) in Meurthe-et-Moselle Sud (EMPER)

Abnormality

France
Apellis Pharmaceuticals, Inc.

Active, not recruiting

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALE)

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States, Australia, Brazil, Czechia, France, Italy, Netherlands, Spain, Switzerland, United Kingdom, Japan, Belgium, Israel, Argentina, South Korea
Apellis Pharmaceuticals, Inc.

Completed

Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALIANT)

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States, Spain, France, Germany, United Kingdom, Netherlands, Brazil, Israel, Japan, Australia, Switzerland, Austria, Italy, Czechia, Belgium, Argentina, Canada, Poland, South Korea
Apellis Pharmaceuticals, Inc.

Approved for marketing

C3G/Primary IC-MPGN EAP

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States
Stanford University

Not yet recruiting

Transhepatic Versus Subcostal Views to Assess Inferior Vena Cava Variation in Pediatric Patients

Inferior Vena Cava Abnormality
Prince of Wales Hospital, Shatin, Hong Kong

Enrolling by invitation

Prince of Wales Hospital Structural Heart Registry

Structural Heart Abnormality

Hong Kong
Cairo University

Completed

Evaluation of Platelet Rich Fibrin / Biphasic Calcium Phosphate Effect Versus Autogenous Bone Graft on Reconstruction of Alveolar Cleft

Alveolar Ridge Abnormality

Egypt
Centre Hospitalier Universitaire Dijon

Recruiting

The Diagnostic Observatory: Combating Diagnostic Wandering and Impasse Within the AnDDI-Rares Network (Obs du Diag)

Developmental Abnormality

France
Central Hospital, Nancy, France

Unknown

Modal Anatomy of the Ethmoid Bone (AME)

Anatomic Abnormality
Ohio State University Comprehensive Cancer Center
University of Michigan

Completed

Community Awareness, Resources and Education (CARE I): Project 3

Cervical Abnormality

United States
Jessa Hospital
Hasselt University; Ziekenhuis Oost-Limburg

Recruiting

Photobiomodulation Therapy in the Prevention and Management of Radiotherapy-induced Vaginal Toxicity (GynLight)

Radiotherapy Side Effect | Vaginal Abnormality

Belgium
Apellis Pharmaceuticals, Inc.

Completed

Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN (NOBLE)

Renal Transplant | C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative... and other conditions

United States, United Kingdom, Australia, Austria, Brazil, Argentina, France, Italy, Netherlands, Spain, Switzerland
Chinese University of Hong Kong

Recruiting

Retrospective Review on Uterovaginal Anomalies

Vaginal Abnormality | Abnormalities Uterine

Hong Kong
Istanbul University - Cerrahpasa
Balikesir University

Not yet recruiting

Validity and Reliability of the Turkish Form of the Enjoyment of Physical Activity Scale-8 in Geriatrics With Minimal Cognitive Impairment

Elderly | Geriatric | Cognitive Abnormality

Turkey (Türkiye)
Groupe Hospitalier Pitie-Salpetriere
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Monitoring the HeMAtological TOXicity of Drugs (HeMATOX) (HeMATOX)

Hematological Abnormality | Hematotoxicity

France
Nobel Biocare

Completed

A Study of Dental Implants Coated With Bone Morphogenetic Protein

Alveolar Ridge Abnormality

United States
Central Hospital, Nancy, France

Completed

Long-term Neurodevelopmental Disorders of Prematurely Born Children and Parental Experience (PREMA7)

Neurodevelopmental Abnormality

France
Oslo University Hospital

Terminated

Hyperbaric Oxygen Treatment as Adjuvant Treatment for Frost Injury (FROST)

Wound (Morphologic Abnormality)

Norway
ITAB - Institute for Advanced Biomedical Technologies
Italian Society of Cardiology

Completed

Italian Registry of Cardiovascular Magnetic Resonance on Congenital Anomalies of the Coronary Arteries (ITACA-Registry) (ITACA)

Congenital Coronary Artery Abnormality

Italy
Cairo University

Unknown

Augmentation of Maxillary Horizontal And Vertical Bone Deficiency Using Mineralized Plasmatic Matrix

Alveolar Ridge Abnormality of Maxilla

Egypt
Chinese PLA General Hospital

Completed

Application of Monitoring and Intervention Technologies in Suboptimal Health Status

Suboptimal Health Status | Metabolic Abnormality

China
University Medical Centre Ljubljana

Enrolling by invitation

Immune System in Diabetic Kidney Disease (KID-CODE)

Diabetes | Diabetic Kidney Disease | Complement System

Slovenia

Clinical Trials on Complement Abnormality

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Burkina Faso

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations