Clinical Trials on Complement Abnormality

Total 446 results

Region Skane

Recruiting

Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy

C3 Glomerulopathy | C3 Glomerulonephritis | Dense Deposit Disease | Membranoproliferative Glomerulonephritis | Complement Abnormality

Sweden
Cedars-Sinai Medical Center
Alexion Pharmaceuticals, Inc.

Terminated

Complement Regulation to Undo Systemic Harm in Preeclampsia (CRUSH)

Pregnancy Related | Preeclampsia | HELLP Syndrome | Severe Preeclampsia | HELLP | Complement Regulatory Factor Defect | PNH | Eculizumab | HELLP Syndrome Second Trimester | AHUS | Complement Abnormality | HELLP Syndrome Third Trimester

United States
Universitair Ziekenhuis Brussel

Recruiting

The Role of Natural Killer, Complement and T-lymphocytes in COVID-19 Disease, a Prospective Monocentric Study (TONIC)

Covid19 | Peripheral Blood Mononuclear Cells | Complement Abnormality

Belgium
CSL Behring

Recruiting

First-In-Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Escalating Single And Multiple Doses Of CSL040 In Healthy Subjects

Complement Deficiencies

Australia
Johns Hopkins University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

The Use of Eculizumab in HELLP Syndrome

Morbidity;Newborn | Preeclampsia Severe | Complement Abnormality | HELLP Syndrome (HELLP), Third Trimester | Maternal Injury

United States
Institut Pasteur de Lille

Completed

Fish Collagen Peptide Food Supplement on Weight and Body Composition (NATICOL)

Weight Management | Food Complement

France
Instituto Bernabeu

Completed

Validation of a NICS Method Using the Culture Medium

Chromosome Abnormality | Abnormality

Spain
University Hospital Muenster
Study Chair and Principal Investigator: Univ.-Prof. Dr. Alexander Zarbock; Principal...

Recruiting

PLAIAR-Trial: Platelets in Inflammation and Resolution (PLAIAR)

ARDS | Platelet Abnormality

Germany
Catalyst Biosciences

Terminated

Screening Study to Identify Patients With Complement Factor I Deficiencies

Previous Diagnosis With a Complement-mediated Disease and/or With Clinical Manifestations Reasonably Associated With Complement Factor I Deficiency

United States
Heeger, Peter, M.D.
Icahn School of Medicine at Mount Sinai; Alexion Pharmaceuticals

Terminated

Eculizumab for Prevention of Delayed Graft Function (DGF) in Kidney Transplantation

Kidney Transplantation | Delayed Graft Function | Complement Activity

United States
Assiut University

Not yet recruiting

Balloon Vaginoplasty for Treatment of Vaginal-aplasia

Vaginal Abnormality
Sharp HealthCare

Completed

Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU) (MINVIFU)

Neurodevelopmental Abnormality

Canada, United States, Poland
Nanfang Hospital of Southern Medical University
Xiangya Hospital of Central South University; Peking University People's Hospital and other collaborators

Unknown

Risk-stratified Therapy Based on Molecular Cytogenetic Aberration and Treatment Response in AML

MRD | Risk-directed Therapy | Cytogenetic Abnormality | Molecular Abnormality

China
Apellis Pharmaceuticals, Inc.

Active, not recruiting

Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALIANT)

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States, Spain, France, Germany, United Kingdom, Netherlands, Brazil, Israel, Japan, Australia, Austria, Italy, Switzerland, Korea, Republic of, Czechia, Belgium, Argentina, Canada, Poland
Apellis Pharmaceuticals, Inc.

Active, not recruiting

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALE)

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States, Australia, Brazil, Czechia, France, Italy, Korea, Republic of, Netherlands, Spain, Switzerland, United Kingdom
Apellis Pharmaceuticals, Inc.

Available

C3G/Primary IC-MPGN EAP

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States
Centre Psychothérapique de Nancy
Centre Hospitalier Régional et Universitaire de Nancy

Recruiting

Creation and Evaluation of a Mobile Intervention Team in Perinatal Psychiatry (0-3 Years) in Meurthe-et-Moselle Sud (EMPER)

Abnormality

France
National Taiwan University Hospital

Completed

The Construction of a Chinese Picture Naming Test and Its Preliminary Normative Data

Normality

Taiwan
Cairo University

Recruiting

Efficacy of Laser Acupuncture on Neurophysiological Parameters of Median Nerve in Postpartum Women (CTSLA)

Neurophysiologic Abnormality

Egypt
Croma-Pharma GmbH
Proinnovera GmbH

Active, not recruiting

THIODERM ELATE for Augmentation of Very Thin, Thin, and Moderately Thick Lips (TILI)

Lip Abnormality

Austria
Stanford University

Not yet recruiting

Transhepatic Versus Subcostal Views to Assess Inferior Vena Cava Variation in Pediatric Patients

Inferior Vena Cava Abnormality
Centre Hospitalier Universitaire Dijon

Recruiting

The Diagnostic Observatory: Combating Diagnostic Wandering and Impasse Within the AnDDI-Rares Network (Obs du Diag)

Developmental Abnormality

France
Central Hospital, Nancy, France

Unknown

Modal Anatomy of the Ethmoid Bone (AME)

Anatomic Abnormality
Ohio State University Comprehensive Cancer Center
University of Michigan

Completed

Community Awareness, Resources and Education (CARE I): Project 3

Cervical Abnormality

United States
Cairo University

Unknown

Evaluation of Platelet Rich Fibrin / Biphasic Calcium Phosphate Effect Versus Autogenous Bone Graft on Reconstruction of Alveolar Cleft

Alveolar Ridge Abnormality

Egypt
Jessa Hospital
Hasselt University; Ziekenhuis Oost-Limburg

Recruiting

Photobiomodulation Therapy in the Prevention and Management of Radiotherapy-induced Vaginal Toxicity (GynLight)

Radiotherapy Side Effect | Vaginal Abnormality

Belgium
Groupe Hospitalier Pitie-Salpetriere
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Monitoring the HeMAtological TOXicity of Drugs (HeMATOX) (HeMATOX)

Hematological Abnormality | Hematotoxicity

France
Nobel Biocare

Completed

A Study of Dental Implants Coated With Bone Morphogenetic Protein

Alveolar Ridge Abnormality

United States
Chinese University of Hong Kong

Recruiting

Retrospective Review on Uterovaginal Anomalies

Vaginal Abnormality | Abnormalities Uterine

Hong Kong
Central Hospital, Nancy, France

Completed

Long-term Neurodevelopmental Disorders of Prematurely Born Children and Parental Experience (PREMA7)

Neurodevelopmental Abnormality

France
Oslo University Hospital

Terminated

Hyperbaric Oxygen Treatment as Adjuvant Treatment for Frost Injury (FROST)

Wound (Morphologic Abnormality)

Norway
Apellis Pharmaceuticals, Inc.

Active, not recruiting

Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN (NOBLE)

Renal Transplant | C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative... and other conditions

United States, Australia, Austria, United Kingdom, Brazil, Argentina, France, Italy, Netherlands, Spain, Switzerland
University of Oxford
Wellcome Trust

Completed

Complement 2: Blood Donations to Develop Vaccines Against Infectious Diseases (C2)

Complement Mediated Bacterial Killing in Healthy Adults

United Kingdom
ITAB - Institute for Advanced Biomedical Technologies
Italian Society of Cardiology

Completed

Italian Registry of Cardiovascular Magnetic Resonance on Congenital Anomalies of the Coronary Arteries (ITACA-Registry) (ITACA)

Congenital Coronary Artery Abnormality

Italy
Cairo University

Unknown

Augmentation of Maxillary Horizontal And Vertical Bone Deficiency Using Mineralized Plasmatic Matrix

Alveolar Ridge Abnormality of Maxilla

Egypt
Chinese PLA General Hospital

Completed

Application of Monitoring and Intervention Technologies in Suboptimal Health Status

Suboptimal Health Status | Metabolic Abnormality

China
Derince Training and Research Hospital
Kocaeli University

Completed

Evaluation of a Femoralis, n Femoralis and m Iliopsoas Tendon Sonoanatomy According to Age Groups in Children

Pediatrics | Anatomic Abnormality | Anatomy | Anatomic Landmarks | Anthropometry

Turkey
Agricultural University of Athens

Completed

Determining the Glycemic Effects of Three Types of Spaghetti

Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
University of California, San Diego

Withdrawn

Inferior Vena Cava (IVC) Diameters Before & After Interscalene Block

IVC - Inferior Vena Cava Abnormality

United States
Hanyang University

Completed

Comparison of Repeatability Between SS and SD-OCT for Measuring Retinal Thickness in Various Retinal Diseases

Macula Abnormality

Korea, Republic of
Acibadem University

Completed

Comparison of Factor XII Levels in Gestational Diabetic and Healthy Pregnancies

Pregnancy Related | Diabetic Pregnancy | Complement System; Disorder

Turkey
Biruni University

Not yet recruiting

The Effect of Blood Flow Restriction Method in Patellar Instability

Patellar Abnormality
Hopitaux de Saint-Maurice

Active, not recruiting

Evaluation of the Functional Outcome of Hero Arm Prosthesis in Children After One Year of Use. (EFPHA)

Abnormality of Upper Lip

France
Wenzhou Medical University

Active, not recruiting

Repeatability and Reproducibility of Lens Zonule Length Measurement Using ArcScan Insight 100

Zonule of Zinn Abnormality | Zonular Cataract

China
Wenzhou Medical University

Not yet recruiting

Influence of Different Tamponade Eyes on IOL-capsular Complex

Cataract | Vitreoretinal Abnormality
Marmara University

Completed

Reliability and Acceptability of Real-time Virtual Video Pediatric Gait, Arms, Legs and Spine (V-pGALS)

Pediatric | Musculoskeletal Abnormality

Turkey
The University of Texas Health Science Center,...

Terminated

Serial Third Trimester Abdominal Circumference and Amniotic Fluid Measurements Versus Routine Care (STAR)

Amniotic Fluid; Disorder | Fetal Growth Abnormality

United States
Amyndas Pharmaceuticals S.A.

Completed

First-In-Human Clinical Study of the C3 Complement Inhibitor AMY- 101 in Healthy Male Volunteers

Complement Mediated Diseases

United States
University Tunis El Manar

Completed

Cortisol Level After Repeated Doses of Etomidate

Adrenocortical Abnormality

Tunisia
Mindchild Medical Inc.

Completed

Fetal Intrapartum Heart Rate FHR/ECG Study

Abnormality in Fetal Heart Rate or Rhythm

United States

Clinical Trials on Complement Abnormality

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Azerbaijan

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Rare Diseases

Drug Interventions

Dietary Supplements

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