Clinical Trials on Locally Advanced Operable

Total 8185 results

Tata Memorial Hospital

Terminated

Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in Women With Large Operable Breast Cancer and Locally Advanced Breast Cancer

Locally Advanced Breast Cancer and Large Operable Breast Cancer

India
Novartis Pharmaceuticals

Terminated

Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer

Metastatic Breast Cancer (MBC) | Inoperable Locally Advanced Breast Cancer

France, Spain
AstraZeneca

Recruiting

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292) (CAPItello-292)

Locally Advanced (Inoperable) or Metastatic Breast Cancer

United States, China, Germany, Canada, Malaysia, Taiwan, France, Japan, Thailand, Italy, Australia, Argentina, Brazil, India, Poland, Spain, Sweden, United Kingdom, Vietnam, Belgium, Denmark, South Korea, Turkey (Türkiye)
AstraZeneca

Active, not recruiting

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer (CAPItello-291)

Locally Advanced (Inoperable) or Metastatic Breast Cancer

United States, Italy, Spain, Belgium, Hungary, Canada, France, Germany, Japan, Peru, Poland, United Kingdom, China, Taiwan, Israel, Australia, Argentina, South Korea, Russia
AstraZeneca

Active, not recruiting

CRT( Chemo-Radiation Therapy) Patterns and Short-term Outcomes on Unresectable NSCLC and SCLC in Routine Practices in Russia (PASSAT)

Unresectable /Inoperable Locally Advanced (Stage II-III) NSCLC and Locally Advanced LS-SCLC (Stage I-III)

Russia
Hoffmann-La Roche

Recruiting

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

United States, Spain, Australia, Israel, South Korea
Ohio State University Comprehensive Cancer Center

Recruiting

Studying Off Label Insurance Coverage for Patients With Cutaneous Cancers a "Filter" Observational Study

Locally Advanced Basal Cell Carcinoma | Locally Advanced Merkel Cell Carcinoma | Locally Advanced Squamous Cell Carcinoma | Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 | Locally Advanced Malignant Skin Neoplasm | Locally... and other conditions

United States
Jiangsu Alphamab Biopharmaceuticals Co., Ltd

Recruiting

Study of JSKN016 Combination Therapy in Inoperable Locally Advanced or Metastatic HER2-Negative Breast Cancer

Inoperable Locally Advanced HER2-Negative Breast Cancer | Metastatic HER2-Negative Breast Cancer

China
AstraZeneca

Terminated

Selumetinib (AZD6244, ARRY-142886) J-BTC Phase 1 Study

Inoperable Locally Advanced or Metastatic Biliary Tract Cancer

Japan
John Kirkwood
Regeneron Pharmaceuticals

Recruiting

Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma

Locally Advanced Melanoma

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Pre-Test Genetic Education and Remote Genetic Counseling in Communicating Tumor Profiling Results to Patients With Advanced Cancer

Advanced Malignant Neoplasm | Locally Advanced Malignant Neoplasm

United States
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital... and other collaborators

Not yet recruiting

Neoadjuvant Docetaxel, Cisplatin, and Dual Immunotherapy for Sinonasal Carcinoma (PANDA)

Locally Advanced Sinonasal Carcinoma
Chen Lizhu

Not yet recruiting

Ipilimumab (N01) Plus Sintilimab and Modified XELOX as Conversion Therapy in Unresectable Locally Advanced Gastric Cancer (DIAMC-GC)

Locally Advanced Gastric Cancer
Ruijin Hospital

Recruiting

IRE Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy

Pancreatic Adenocarcinoma Locally Advanced

China
Xuekui Liu

Recruiting

Neoadjuvant Cadonilimab in Combination With Cisplatin and Nab-paclitaxel in Resectable Head and Neck Squamous Cell Carcinoma (NCCCNRHNSCC)

Head and Neck Squamous Cell Carcinoma | Locally Advanced Operable

China
Fujian Cancer Hospital

Not yet recruiting

A Clinical Study of QL1706 Combined With Chemotherapy as Neoadjuvant Therapy for High-Risk Locally Advanced Cervical Cancer

Locally Advanced Cervical Carcinoma

China
Chinese PLA General Hospital

Recruiting

A Single-arm Phase II Clinical Study of Camrelizumab Combined With Long-course Chemoradiotherapy for Total Neoadjuvant Therapy in Locally Advanced Low pMMR/MSS Rectal Cancer

Locally Advanced Rectal Cancer

China
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

A Prospective, Single-Arm, Phase II Study: PD-L1 Monoclonal Antibody + Chemoradiotherapy as Bridge Therapy to Liver Transplantation for Locally Advanced Perihilar Cholangiocarcinoma (ACHIEVE-LT) (ACHIEVE-LT)

Locally Advanced Perihilar Cholangiocarcinoma

China
Ruijin Hospital

Not yet recruiting

Cadonilimab Combined With RT in LACC Patients Ineligible for CCRT

Locally Advanced Cervical Cancer
Union Hospital, Tongji Medical College, Huazhong...
Akesobio

Recruiting

A Clinical Study on the Treatment of LACC With Cadonilimab Combined With Chemotherapy Followed by CCRT

Locally Advanced Cervical Carcinoma

China
Fujian Cancer Hospital

Not yet recruiting

Timing Optimization of Immunotherapy During Neoadjuvant Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma

Locally Advanced Nasopharyngeal Carcinoma
Peking Union Medical College Hospital

Not yet recruiting

Simultaneous Boost in Neoadjuvant Radiotherapy for Rectal Cancer (SIB-NCRT-pumch)

Locally Advanced Rectal Adenocarcinoma
Union Hospital, Tongji Medical College, Huazhong...

Not yet recruiting

Serplulimab Combined With Induction Chemotherapy and Radiotherapy in Nasopharyngeal Carcinoma

Locally Advanced Nasopharyngeal Carcinoma

China
University of Cincinnati

Recruiting

Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

Cancer | Metastatic Cancer | Locally Advanced Solid Tumor | Locally Advanced | Locally Advanced Carcinoma

United States
Chinese PLA General Hospital

Not yet recruiting

Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer (LARC)

China
NRT MedTech Australia Pty Ltd

Not yet recruiting

Safety and Efficacy of NRT6008 Administered in Combination With Chemotherapy in Patients With Unresectable Locally Advanced Pancreatic Carcinoma (LAPC)

Unresectable Locally Advanced Pancreatic Carcinoma

Australia
Jiangsu vcare pharmaceutical technology co., LTD

Recruiting

Phase III Clinical Study of VC004 in Patients With Localized Advanced/ Metastatic Solid Tumors

Locally Advanced Solid Tumor

China
University Medical Center Groningen

Recruiting

CD8 PET Imaging in Metastatic Solid Tumours

Locally Advanced Solid Tumor

Netherlands, Spain, United Kingdom
Bio-Thera Solutions

Recruiting

Assess Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BAT8009

Locally Advanced/Metastatic Solid Tumours

China
Beijing Bio-Targeting Therapeutics Technology Co...

Withdrawn

A Clinical Study to Explore the Safety, Tolerability, and Efficacy of Recombinant Human nsIL12 Oncolytic Adenovirus Injection (BioTTT001) Combined With Neoadjuvant Treatment for Locally Advanced Breast Cancer

Locally Advanced Breast Cancer (LABC)

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Pembrolizumab Before Surgery for the Treatment of Mismatch Repair Deficient Locally Advanced Solid Cancers

Locally Advanced Malignant Solid Neoplasm

United States
Jiangsu Aosaikang Pharmaceutical Co., Ltd.

Completed

Drug-drug Interaction Study Beteewn ASK120067 and Rifampicin or Itraconazole

Locally Advanced or Metastatic NSCLC

China
Dr. Te Vuong

Not yet recruiting

Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer (IMPERIA)

Locally Advanced Rectal Cancer

Canada
IRCCS San Raffaele

Not yet recruiting

Preoperative, Adaptive Radiotherapy Concomitant to Chemotherapy for Rectal Adenocarcinoma (Adaptive Rectal Cancer Trial 02)

Locally Advanced Rectal Carcinoma

Italy
Fudan University

Not yet recruiting

Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer

Locally Advanced Colorectal Cancer
Fujian Cancer Hospital

Not yet recruiting

Short-Course RT Plus CAPOX and Tislelizumab vs Long-Course CRT Plus Tislelizumab for Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Fundacion Arturo Lopez Perez

Not yet recruiting

ONCO-RET: Supervised Resistance Training During Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (ONCO-RET)

Locally Advanced Rectal Cancer

Chile
Assiut University

Not yet recruiting

Endoscopic Ultrasound-Guided Loco-regional Chemotherapy Injection as Adjuvant Therapy for Locally Advanced Pancreatic Cancer.

Locally Advanced Pancreatic Cancer
Institute of Oncology Ljubljana

Recruiting

Combined Chemotherapy And Ablative Radiotherapy (SBRT) As First-Line Treatment In Locally Advanced Inoperable Pancreatic Cancer (SBRT-PANC)

Locally Advanced Pancreatic Cancer

Slovenia
Ruijin Hospital

Recruiting

Cryoablation Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy

Pancreatic Adenocarcinoma Locally Advanced

China
NovoCure GmbH

Temporarily not available

Continued Access Program for Tumor Treating Fields (TTFields) Used With Chemotherapy (Gemcitabine and Nab-Paclitaxel) in Adults With Locally Advanced Pancreatic Cancer (PANOVA-3CA) (PANOVA-3CA)

Locally Advanced Pancreatic Adenocarcinoma
Xerient Pharma

Recruiting

A Phase 1 Study to Evaluate Safety and Efficacy of XER-001 (Amifostine for Nasoduodenal Delivery) in Combination With Sterotactic Body Radiotherapy for Treatment in Patients With Locally Advanced Pancreatic Cancer. (XER-001)

Locally Advanced Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Ductal Adenocarcinoma | Locally Advanced Pancreas Cancer

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Active, not recruiting

Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy (IMAGINE)

Metastatic Bladder Urothelial Carcinoma | Metastatic Renal Pelvis Urothelial Carcinoma | Metastatic Ureter Urothelial Carcinoma | Metastatic Urethral Urothelial Carcinoma | Metastatic Urothelial Carcinoma | Locally Advanced Bladder Urothelial Carcinoma | Locally Advanced Renal Pelvis Urothelial... and other conditions

United States
National Cancer Institute, Naples

Recruiting

Real-world Efficacy and Safety of Neoadjuvant Dostarlimab in Patients With dMMR/MSI-H Locally Advanced Rectal Cancer (RW-NEDOS)

Locally Advanced Rectal Cancer (LARC)

Italy
The First Affiliated Hospital with Nanjing Medical...
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Not yet recruiting

A Prospective, Single-arm, Multicenter Exploratory Clinical Study of Anlotinib Combined With Bempegaldesleukin and Conventional Chemoradiotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Soft Tissue Sarcoma.

Locally Advanced Soft Tissue Sarcoma

China
Jiangsu Simcere Pharmaceutical Co., Ltd.

Recruiting

A Phase I Study of SIM0686 in Participants With Locally Advanced/Metastatic Solid Tumors

Locally Advanced Solid Tumors

China
Cai Zerong

Completed

Development and Validation of a Post-operative Risk Of Local Recurrence Model Integrating Serology and Evalution (PROMISE) in Local Advanced Rectal Cancer Receiving Neoadjuvant Therapy: a Multicenter Study (PROMISE model)

Locally Advanced Rectal Cancer (LARC)
Suzhou Forlong Biotechnology Co., Ltd

Completed

First-in-Human, Phase I, Open-label, Multicenter, Dose Escalation Clinical Study

Locally Advanced/Metastatic Solid Tumors

United States
Adlai Nortye Biopharma Co., Ltd.

Completed

Double/Triple Combinations of AN2025, AN0025 and Atezolizumab in Advanced Solid Tumors

Locally Advanced Solid Tumor

United States
OBI Pharma, Inc

Terminated

Phase 1/2 Study of OBI-999 in Patients With Advanced Solid Tumors

Locally Advanced Solid Tumor

United States

Clinical Trials on Locally Advanced Operable

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