Clinical Trials on Multiple System Atrophy, MSA

Total 10167 results

University of Michigan
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)

Multiple System Atrophy - Parkinsonian Subtype (MSA-P) | Multiple System Atrophy - Cerebellar Subtype (MSA-C)

United States
Brigham and Women's Hospital
Biohaven Pharmaceuticals, Inc.

Completed

Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients

Multiple System Atrophy | Multiple System Atrophy, Parkinson Variant (Disorder) | Multiple System Atrophy, Cerebellar Variant | Multiple System Atrophy (MSA) With Orthostatic Hypotension

United States
Ono Pharmaceutical Co. Ltd

Recruiting

A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy

Multiple System Atrophy (MSA)

United States
Biohaven Pharmaceuticals, Inc.

No longer available

Expanded Access Protocol of Verdiperstat in Patients With Multiple System Atrophy (MSA)

Multiple System Atrophy (MSA)

United States
University Hospital, Bordeaux

Completed

Oligomeric Alpha-synuclein in Multiple System Atrophy (BIOAMS)

Multiple System Atrophy (MSA)

France
AstraZeneca

Completed

AZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA Patients

Multiple System Atrophy, MSA

United States, Finland, Austria, France, Sweden, United Kingdom, Italy
University of Texas Southwestern Medical Center

Recruiting

Multiple System Atrophy Multidisciplinary Clinic

Multiple System Atrophy (MSA)

United States
Cytora Ltd.

Recruiting

Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early- to Moderate Stage MSA

Multiple System Atrophy | MSA - Multiple System Atrophy

Israel
University Hospital, Bordeaux
Institut National de Recherche en Informatique et en Automatique

Completed

Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis (Voice4PD-MSA)

Parkinson Disease | MSA - Multiple System Atrophy

France
University of Oxford
Oxford University Hospitals NHS Trust

Recruiting

MotIoN aDaptive Deep Brain Stimulation for MSA (MINDS)

MSA - Multiple System Atrophy

United Kingdom
Theravance Biopharma

Recruiting

Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy (CYPRESS)

MSA - Multiple System Atrophy | Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, United Kingdom, Hungary, Italy, Argentina, Austria, Poland, Germany, Portugal, Belgium, Brazil, Denmark, Canada, France, Chile, Estonia
University of Oxford
Mayo Clinic; University of California, San Francisco; Surrey Sleep Research Centre...

Completed

Manipulating and Optimising Brain Rhythms for Enhancement of Sleep (MORPHEUS)

Epilepsy | Chronic Pain | Parkinson Disease | MSA - Multiple System Atrophy

United Kingdom
Fondazione I.R.C.C.S. Istituto Neurologico Carlo...
Neuromed IRCCS; Fondazione IRCCS Istituto Neurologico Nazionale Casmiro Mondino and other collaborators

Recruiting

Integrated Management of Atypical Parkinsonism: A Home-based Patient-Centered Healthcare Delivery Based on Telenursing (IMPACT Study)

Nurse-Patient Relations | Atypical Parkinsonism | MSA - Multiple System Atrophy | Nurse Physician Relations | PSP

Italy
Brigham and Women's Hospital

Recruiting

Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders

Synucleinopathies | Neurodegenerative Diseases | Ataxia | sca3 | MSA - Multiple System Atrophy

United States
Assistance Publique - Hôpitaux de Paris

Completed

Study to Evaluate the Efficacy of Riluzole in Children and Young Adults With Spinal Muscular Atrophy (SMA) (ASIRI)

SMA

France
Mayo Clinic
National Institute of Neurological Disorders and Stroke (NINDS); Food and Drug...

Active, not recruiting

Mesenchymal Stem Cell Therapy in Multiple System Atrophy

MSA

United States
prof. dr. Koen Van Laere
Universitaire Ziekenhuizen KU Leuven; KU Leuven; University Hospital, Ghent; Fund...

Not yet recruiting

[18F]-MFBG Versus [123I]-MIBG and [18F]-PE2I in PD vs. MSA and DBL vs. AD

Parkinson Disease | Alzheimer Disease | Dementia With Lewy Bodies | MSA - Multiple System Atrophy

Belgium
University College, London
University of Oxford; Newcastle University; University of Cambridge; University... and other collaborators

Recruiting

PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M)

Corticobasal Degeneration | Multiple System Atrophy (MSA) | Progressive Supranuclear Palsy (PSP)

United Kingdom
Theravance Biopharma

Completed

TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)

Parkinson Disease | Orthostatic Hypotension | Neurogenic Orthostatic Hypotension | Hypotension, Orthostatic | Pure Autonomic Failure | Multiple System Atrophy (MSA) With Orthostatic Hypotension | Pure Autonomic Failure With Orthostatic Hypotension | Parkinson Disease With Orthostatic Hypotension

United States
Rambam Health Care Campus

Completed

Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkinsonism (FUSAP)

Dementia With Lewy Bodies | Atypical Parkinsonism | Multiple System Atrophy, MSA

Israel
AveXis, Inc.
United BioSource, LLC

Recruiting

Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

Spinal Muscular Atrophy (SMA)

Japan, United States, Korea, Republic of, Israel, Greece, Ireland, Portugal, Russian Federation, Taiwan
Biocad

Recruiting

Study of the Safety and Efficacy of an Adeno-Associated Viral Vector Carrying the SMN Gene After a Single Intravenous Administration of Escalating Doses in Children With Spinal Muscular Atrophy (BLUEBELL) (BLUEBELL)

Spinal Muscular Atrophy (SMA)

Belarus, Russian Federation
Ohio State University
Massachusetts General Hospital; National Institute of Neurological Disorders... and other collaborators

Completed

Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development

Spinal Muscular Atrophy (SMA)

United States
Hoffmann-La Roche

Recruiting

A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy (MANATEE)

Spinal Muscular Atrophy (SMA)

Belgium, United States, Croatia, Japan, Netherlands, Spain, Canada, Poland, United Kingdom, Portugal, Italy, Australia
Hugh McMillan
Families of Spinal Muscular Atrophy; Gwendolyn Strong Foundation

Terminated

Effect of Low-Dose Celecoxib on SMN2 in Patients With Spinal Muscular Atrophy (SMA)

Spinal Muscular Atrophy (SMA)

Canada
Milton S. Hershey Medical Center

Completed

Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)

Parkinsonism | Parkinson's Disease (PD) | Multiple System Atrophy (MSA) | Progressive Supranuclear Palsy (PSP)

United States
Novartis Gene Therapies

Completed

Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1 (STR1VE)

Gene Therapy | SMA - Spinal Muscular Atrophy

United States
GE Healthcare
PPD

Completed

A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients

Essential Tremor | Multiple System Atrophy (MSA) | Parkinsonian Syndrome | Parkinson Disease(PD) | Progressive Supranuclear Palsy (PSP)

China
Biohaven Pharmaceuticals, Inc.

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy (RESILIENT)

Neuromuscular Diseases | Spinal Muscular Atrophy | SMA

United States, Netherlands, United Kingdom, Spain, Czechia, Belgium, Germany, Italy, Poland
Novartis Gene Therapies

Completed

Single-Dose Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1 (STRIVE-EU)

SMA

France, United Kingdom, Italy, Belgium
Biogen

Recruiting

Virtual Reality for the Mitigation of Anxiety During Intrathecal Administration in Participants With Spinal Muscular Atrophy (REALITY)

Spinal Muscular Atrophy (SMA)

France
Natera, Inc.

Withdrawn

Multi-disease Carrier Screening Test Validation

Genetic Testing | Spinal Muscular Atrophy (SMA) | Carrier Screening

United States
Association de Recherche Bibliographique pour les...
Centre Hospitalier Universitaire de Nice; Centre Hospitalier Princesse Grace

Completed

Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography (EYE-SEP)

Healthy | Clinically Isolated Syndrome | Multiple Sclerosis (MS) | Radiologically Isolated Syndrome | Multiple Sclerosis (MS) Relapsing Remitting | Multiple Sclerosis (MS) Primary Progressive | Multiple Sclerosis (MS) Secondary Progressive

Monaco
GeneCradle Inc

Recruiting

Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type 2 Patients

SMA II

China
McMaster University

Unknown

n3 PUFA and Muscle-disuse Atrophy in Older Women

Sarcopenia | Muscle Atrophy | Muscle Disuse Atrophy

Canada
St Mary's University College

Not yet recruiting

Blood Flow Restricted Electrical Stimulation During Immobilisation

Atrophy, Muscular | Atrophy, Disuse
South Dakota State University
Sanford Research

Completed

The Efficacy of Protein Supplementation on Attenuating Muscle Atrophy Following Disuse in the Collegiate Population

Disuse Atrophy

United States
Kaohsiung Medical University Chung-Ho Memorial...
National Taiwan University Hospital; Mackay Memorial Hospital; Shin Kong Wu Ho-Su... and other collaborators

Completed

Natural History of Spinal Muscular Atrophy Type 1 in Taiwan

Natural History of Type 1 Spinal Muscular Atrophy (SMA)
United States Army Research Institute of Environmental...

Recruiting

Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse

Muscular Disorders, Atrophic | Muscle Atrophy | Disuse Atrophy | Atrophy, Disuse | Disuse Atrophy Muscle of Thigh

United States
McGill University

Recruiting

Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy

Muscle Atrophy | Muscle Disuse Atrophy

Canada
Novartis Pharmaceuticals

Recruiting

Long-term Follow-up of Patients With Spinal Muscular Atrophy Treated With OAV101 in Clinical Trials (SPECTRUM)

Spinal Muscular Atrophy (SMA)

Spain, Canada, Taiwan, Belgium, Malaysia, China, Japan, Italy, Singapore, United Kingdom, France, Australia, Thailand, Denmark, United States
McMaster University
University of Guelph

Completed

n3 PUFA and Muscle-disuse Atrophy in Young Women

Muscle Atrophy

Canada
University of Exeter

Completed

Muscle Damage and Disuse Atrophy

Muscle Disuse Atrophy

United Kingdom
Bispebjerg Hospital

Recruiting

Prehabilitative Exercise Prior to Immobilization (PREHAB)

Sarcopenia | Disuse Atrophy | Skeletal Muscle Atrophy

Denmark
Danish Headache Center

Completed

The Effect of Levcromakalim Infusion on the Cranial Arteries Over Several Hours Using a High Resolution MRA Technique in a Randomized, Double-blind Placebo-controlled Design in Healthy Volunteers.

Headache | Dilatation of Cranial Arteries; MMA, STA and MCA

Denmark
McMaster University

Completed

The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation (HYPAT)

Muscle Atrophy | Disuse Atrophy (Muscle) of Lower Leg

Canada
Newcastle University
Roche Pharma AG; Biogen; Adult SMA REACH; SMA REACH UK

Recruiting

UK SMA Patient Registry

Spinal Muscular Atrophy | SMA

United Kingdom
Instituto Ecuatoriano de Enfermedades Digestivas

Completed

Grading Atrophic Gastritis by Confocal Laser Endomicroscopy Probe (p-CLE)

Atrophic Gastritis

Ecuador
University of Birmingham

Completed

Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy? (LEU-DIMA)

Muscle Disuse Atrophy

United Kingdom
Texas Christian University

Recruiting

Strength Training Augmenting Rehabilitation (STAR)

Muscle Disuse Atrophy

United States

Clinical Trials on Multiple System Atrophy, MSA

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