Clinical Trials on Normal Hepatic Function

Total 10000 results

Novartis Pharmaceuticals

Completed

Evaluation of Hepatic Function Impairment on the Pharmacokinetics of LEE011

Normal Hepatic Function | Impaired Hepatic Function

United States
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDE225..

Normal Hepatic Function | Impaired Hepatic Function

Belgium, Germany, Israel, Bulgaria, United States
Institut de Recherches Internationales Servier...

Not yet recruiting

Pharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control Participants

Severe Hepatic Impairment | Normal Hepatic Function
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDK378 Pharmacokinetics

Normal Hepatic Function | Impaired Hepatic Function

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Hepatic Impairment | Normal Hepatic Function

United States
GlycoMimetics Incorporated

Completed

A Study to Evaluate the Effect of IV Doses of Rivipansel in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function

Moderate Hepatic Impairment | Normal Hepatic Function

United States
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Investigate the Effect of Severely Diminished Liver Function on the Metabolism, Safety, and Tolerability of a Single Oral Dose of Enzalutamide in Men

Severe Hepatic Impairment | Normal Hepatic Function

Bulgaria
Sanofi

Completed

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States
Principia Biopharma, a Sanofi Company

Completed

A Study to Evaluate the Effect of Mild and Moderate Hepatic Impairment on the Single-Dose Pharmacokinetics of Rilzabrutinib (PRN1008)

Healthy Volunteers | Hepatic Function Abnormal

United States
Neurodawn Pharmaceutical Co., Ltd.

Not yet recruiting

Y-3 for Injection in Patients With Hepatic Insufficiency and Healthy Subjects

Normal Hepatic Function | Pharmacokinetic Differences | Y-3 | Saftey | Mild Hepatic Insufficiency | Moderate Hepatic Insufficiency
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Sanofi

Terminated

Pharmacokinetics of Amcenestrant in Female Hepatic Impaired Participants as Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

Germany, South Korea
Sanofi

Completed

A Pharmacokinetic and Tolerability Study of Fexinidazole in a Single Oral Dose in Adult Participants With Mild and Moderate Hepatic Impairment

Hepatic Function Abnormal

Bulgaria, France
NGM Biopharmaceuticals, Inc

Completed

Study of Aldafermin (NGM282) in Participants With Impaired Hepatic Function

Impaired Hepatic Function

United States
Tetraphase Pharmaceuticals, Inc.

Completed

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects

Impaired Hepatic Function

United States
Taiho Oncology, Inc.

Completed

Evaluating Patients With Impaired Hepatic Function

Impaired Hepatic Function

United States
Alexion Pharmaceuticals, Inc.

Terminated

Study of ALXN2050 in Participants With Hepatic Impairment

Healthy | Impaired Hepatic Function

United States
Klinikum Ludwigshafen

Completed

Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function

Inflammatory Response | Hepatic Function

Germany
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Martin Angst

Completed

Evaluation of Immune Signaling Networks in Healthy Human Volunteers

Normal Immune Cell Function

United States
Klinikum Ludwigshafen
Universitätsmedizin Mannheim

Completed

Inhalative Sedation in ICU With Sevoflurane Via Anaesthetic Conserving Device Compared to Propofol

Renal Function | Hepatic Function | Recovery From Sedation | Cardioprotection | Sevoflurane Consumption
Astellas Pharma Inc

Completed

Pharmacokinetics Study in Patients With Impaired Hepatic Function

Patients With Impaired Hepatic Function

Japan
Englewood Hospital and Medical Center

Withdrawn

Neuropsychological Testing Using Mobile Devices

Inpatients With Normal Neurological Function

United States
UCB Biopharma S.P.R.L.

Terminated

A Pharmacokinetic Study of Padsevonil in Study Participants With Either Normal or Moderately Impaired Hepatic Function

Impaired Hepatic Function | Healthy Study Participants

United States
Daiichi Sankyo, Inc.

Completed

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Hepatic Impairment | Moderate Impaired Hepatic Function

United States
Genta Incorporated

Terminated

Pharmacokinetics of G3139 in Subjects With Advanced Melanoma, Including Those With Normal Hepatic Function and Those With Moderate Hepatic Impairment

Advanced Melanoma and Normal or Impaired | Hepatic Function
Scale Media Inc
Citruslabs

Completed

A Clinical Trial to Evaluate the Efficacy of a Men's Supplement in Supporting Testosterone, Improving Cognitive Function, Mood, and Sexual Function

Sexual Function | Testosterone | Cognitive Functions

United States
SunWay Biotech Co., LTD.

Recruiting

Effect of ExoBDNF Lactic Acid Bacteria Supplement on Cognitive Functions, Sleep and Psychological

Sleep | Psychological | Cognitive Function Abnormal | Cognitive Functions Perceptual Disturbances

Taiwan
Shanghai Vinnerna Biosciences Co., Ltd.
Sponsor GmbH

Completed

A Study in Subjects With Liver Function Injury and Subjects With Normal Liver Function

Subjects With Liver Function Injury | Normal Liver Function Subject

China
AstraZeneca

Completed

Open-label Study to Assess the Pharmacokinetics of NKTR-118 in Patients With Impaired Hepatic Function

Hepatic; Functional Disturbance

United States
Hong Kong Children's Hospital

Recruiting

Ultrasound Measurements of Hepatic Vasculatures and Hepatic Doppler Assessment of Healthy Children

Portal Vein | Hepatic Veins | Hepatic Artery | Liver Circulation

Hong Kong
Northern Jiangsu People's Hospital

Not yet recruiting

Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up) (LSD-RFPH)

Portal Hypertension | Cirrhosis, Liver | Splenectomy; Status | Renal Function Abnormal
Genta Incorporated

Completed

Pharmacokinetic Study of Genasense in Subjects With Normal Renal Function, Mildly Impaired Renal Function, and Moderately Impaired Renal Function

Normal Renal Function | Mildly Impaired Renal Function | Moderately Impaired Renal Function

United States
Al-Azhar University
University Hospital Fattouma Bourguiba

Completed

Laparoscopic Assisted Dismembered Pyeloplasty Versus Open Pyeloplasty in (UPJO) With Poorly Function Kidney in Pediatrics

Uretro-pelvic Junction Obstruction | Poorly Function Kidney

Egypt
VA Office of Research and Development

Completed

Implementing a Skills-Based Caregiver Training Program (Caregivers FIRST): Function QUERI 2.0

Cognitive Function | Functional Status

United States
Seoul National University Bundang Hospital

Not yet recruiting

Surface Electromyographic Analysis of Normal Swallowing in Children: An Exploratory Study

Swallowing Function | Normal Pediatric Swallowing Physiology | Swallowing Muscle Activation Patterns in Children

South Korea
Geisinger Clinic

Completed

Comparison of 19g FNA and 19g FNB Needles for EUS-LB

Abnormal Liver Function

United States
Novartis Pharmaceuticals

Completed

Evaluation of Renal Function Impairment on the Pharmacokinetics of LEE011

Impaired Renal Function | Normal Renal Function

United States, Germany, Bulgaria, Czechia
Cylite Pty Ltd

Completed

Agreement and Precision Study of UNITY® DX and a Comparator Biometer

Normal Eyes | Abnormal Eyes

United States
University of Louisville

Completed

Louisville Cooperative Tissue Biorepository (LCTB)

Normal and Abnormal Tissue

United States
Astellas Pharma Europe B.V.
FibroGen

Completed

A Phase 1 Study of Roxadustat in Subjects With Different Degrees of Renal Function

Impaired Renal Function | Normal Renal Function

Germany, United Kingdom
Nhat Nhat Pharmaceutical Company

Unknown

TONKA Versus Legalon for Lowering Hepatic Enzymes in Liver Function Disorder Patients.

Liver Function Failure

Vietnam
University of Saskatchewan
Canadian Institutes of Health Research (CIHR)

Completed

Synchrotron Imaging of Human Ovaries Ex Situ

Abnormal Female Reproductive Function

Canada
H. Lundbeck A/S

Completed

Pharmacokinetics Properties of Single Oral Dosing of Lu AE58054 in Subjects With Hepatic Impairment (Mild and Moderate) and in Healthy Subjects

Heptic Impairment

Germany
Alanya Alaaddin Keykubat University

Active, not recruiting

Effects of Adapted Sports on Balance, Physical Function, and Cognitive Function in Older Adults (ASF)

Aging | Physical Function | Balance | Functional Mobility

Turkey (Türkiye)
Stealth BioTherapeutics Inc.

Completed

A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal Function

Normal and Impaired Renal Function

United States
National Central University

Completed

Autonomic Modulation After Spinal Anesthesia With Depth of Anesthesia and Vital Signs.

Participants Scheduled for Surgery Under Spinal Anesthesia Without Impairment of Renal, Hepatic, Cardiac or Respiratory Function

Taiwan
Xuzhou Central Hospital
The Affiliated Hospital of Xuzhou Medical University

Not yet recruiting

rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction

Functional Magnetic Resonance Imaging | Executive Function Disorder
Sahlgrenska University Hospital, Sweden

Completed

Optimization of Hepatic Hemodynamics During Liver Surgery

Liver Surgery | Portal Blood Pressure | Hepatic Hemodynamics
Istanbul Medeniyet University

Completed

Validity of the Children's Chelsea Critical Care Physical Assessment Tool (cCPAx-TR) in Turkish Pediatric Intensive Care Patients

Pediatric Critical Illness; Physical Function Assessment; Functional Status; Rehabilitation

Turkey (Türkiye)

Clinical Trials on Normal Hepatic Function

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