Search clinical trials for: First-Line Therapy Failure

Total 63711 results

Hunan Cancer Hospital

Not yet recruiting

Cadonilimab in Combination With Anlotinib in the Treatment of Locally Progressive or Metastatic Melanoma With First-Line Therapy Failure

Melanoma
Centre Leon Berard

Recruiting

Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas (REGOSTA)

Osteosarcoma | Ewing Sarcoma | Chondrosarcoma | Leiomyosarcoma | Angiosarcoma | Bone Sarcoma | Undifferentiated Pleomorphic Sarcoma

France
Novartis Pharmaceuticals

Terminated

This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure (PARADIGM-HF)

Heart Failure With Reduced Ejection Fraction

China, Germany, United States, Colombia, Korea, Republic of, Romania, South Africa, Canada, Belgium, Estonia, Hungary, Italy, Russian Federation, Taiwan, Turkey, United Kingdom, Spain, France, Netherlands, Hong Kong, Bulgaria, Israel and more
Fresenius Medical Care Deutschland GmbH
Winicker Norimed GmbH

Not yet recruiting

Influence of Variable Inflow Volume, Dwell Duration and Glucose Concentration on Ultrafiltration Volume in APD Patients (pPD)

Chronic Kidney Diseases | Renal Failure
Yale University
Roivant Sciences (HekaHeart)

Not yet recruiting

HekaHeart Phase 1 Proof of Concept (HekaHeart POC)

Heart Failure With Reduced Ejection Fraction

United States
China-Japan Friendship Hospital

Recruiting

The Effects of Low-Dose Versus High-Dose Intravenous IRON Therapy With Ferric DerisomaltOSE in Patients With Chronic Heart Failure and Iron Deficiency (IRONDOSE)

Heart Failure | Iron Deficiency

China
Fundación para la Investigación del Hospital Clínico...

Recruiting

Compression Therapy of the Lower Limbs in Patients With Decompensated Heart Failure

Heart Failure

Spain
Cairo University
National Heart Institute, Egypt

Not yet recruiting

Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload

Edema | Acute Decompensated Heart Failure | Volume Overload

Egypt
Fresenius Medical Care Deutschland GmbH
Alcedis GmbH

Not yet recruiting

Clinical Performance of the Therapy Option FlexPoint of the PD Cycler Sleep•Safe Harmony (FlexPoint)

Renal Failure | Chronic Kidney Disease
Indiana University
Purdue University

Not yet recruiting

Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Shanghai Zhongshan Hospital

Recruiting

Ultrasound Evaluations of Diaphragm and Intercostal Muscle to Predict the Failure of High-Flow Nasal Cannula Therapy

Ultrasound Evaluation | High-flow Nasal Cannula | Diaphragm and Intercostal Muscle

China
RenJi Hospital

Recruiting

Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations

End Stage Renal Disease | Kidney Transplantation | Delayed Graft Function

China
Azienda Ospedaliera Universitaria Integrata Verona
Abbott Medical Devices

Recruiting

Microvascular Dysfunction Assessment to Predict Left Ventricular Reverse Remodeling (MICROREV)

Heart Failure | Left Ventricular Dysfunction | Idiopathic Dilated Cardiomyopathy

Italy
Academisch Medisch Centrum - Universiteit van Amsterdam...
Yale University; AstraZeneca

Not yet recruiting

PRagmatic Study Of Messaging to Providers of Patients With Heart Failure in Amsterdam UMC (PROMPT-HF-AUMC)

Heart Failure With Reduced Ejection Fraction
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI); Francis Family Foundation

Recruiting

Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention (SMARA)

Critical Illness | Respiratory Failure | Anxiety

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Combination Immunotherapy of Adebrelimab With Apatinib and Tegafur for Immune Rechallenge Therapy in Esophageal Squamous Cell Carcinoma

Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma

China
National Medical Research Center for Therapy and...

Recruiting

Middle-aged Women With Adverse Pregnancy Outcomes and Heart Failure With Preserved Ejection Fraction (MAPO-HF)

Pregnancy Complications | Heart Failure Preserved Ejection Fraction

Russian Federation
Help Therapeutics
TEDA International Cardiovascular Hospital

Recruiting

Epicardial Injection of hiPSC-CMs to Treat Severe Chronic Ischemic Heart Failure

Heart Failure

China
Fondazione IRCCS Policlinico San Matteo di Pavia

Recruiting

Tacrolimus and Personalized Therapy to Prevent Acute Rejection Episodes

Heart Transplant Failure

Italy
Xingui Dai

Not yet recruiting

Diaphragmatic Ultrasound to Predict the Therapeutic Effect of High-flow Nasal Cannula Oxygen Therapy

Hypoxic Respiratory Failure
University Hospital of Ferrara

Recruiting

ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing (TREEBEARD)

Atrial Fibrillation | Arrhythmias, Cardiac | Left Bundle-Branch Block | Bundle-Branch Block | Ventricular Fibrillation | Ventricular Tachycardia | Ventricular Dysfunction | Atrioventricular Block | Heart Failure, Systolic | Ventricular Arrythmia | Heart Failure，Congestive | Bradyarrhythmia | Heart Arrhythmia | Reduced... and other conditions

Italy
Bark Technology LLP

Recruiting

Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative Period

Cardiac Surgical Patients (CABG,Mammary Coronary Bypass Surgery,Plastic and Replacement of Valves, Atrial Septal Defect,Ventricular Septal Defect)

Kazakhstan
University of Sao Paulo General Hospital

Not yet recruiting

Isolated Resistance Training and Neuromuscular Electrical Stimulation in Patients With Femoral Intra Aortic Balloon Pump.

Heart Failure | Physical Therapy | Neuromuscular Electrical Stimulation

Brazil
University Hospital of Ferrara

Recruiting

Multicenter Evaluation of Patients Using LATITUDE Monitoring System (Multitude)

Cardiovascular Diseases | Heart Failure | Arrhythmias, Cardiac | Sudden Cardiac Death

Italy
University of Pennsylvania

Not yet recruiting

Light Therapy in End Stage Kidney Disease

End Stage Renal Disease
Tenaya Therapeutics
Medical University of South Carolina; Johns Hopkins University; University of... and other collaborators

Recruiting

Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (RIDGE)

Arrhythmogenic Right Ventricular Cardiomyopathy

United States, Italy, United Kingdom, France, Sweden, Germany
MedRegen LLC
Vanderbilt University Medical Center

Not yet recruiting

MRG-001 as an Immunoregulatory and Regenerative Therapy for ARDS Patients (SUMMIT)

Respiratory Tract Diseases | Respiratory Failure | Acute Respiratory Distress Syndrome | Respiratory Distress Syndrome | Cytokine Storm
Brigham and Women's Hospital
Boston Scientific Corporation

Not yet recruiting

Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE (SONIC-PE)

Pulmonary Embolism | Right Ventricular Dysfunction | Right Ventricular Failure
I.M. Sechenov First Moscow State Medical University

Recruiting

ContriBution of Digital RemOte MoniToring to IMPROVing The Effectiveness of Treatment in Patients With Chronic Heart Failure With Low Ejection Fraction (BOT-IMPROVE-HF)

Chronic Heart Failure With Low Ejection Fraction

Russian Federation
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

D-1553 Tablet Versus Docetaxel Injection for KRAS G12C Mutation-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer After Prior Standard Therapy Failure

Non Small Cell Lung Cancer

China
Lawson Health Research Institute

Not yet recruiting

RAFT-P&A Randomized Control Trial

Heart Failure | Atrial Fibrillation | Pacemaker | Arrhythmia Atrial

Canada
Cairo University

Recruiting

Effect of Aquatic High Intensity Resistive Training on Patients With Chronic Heart Failure

Heart Failure

Egypt
McGill University Health Centre/Research Institute...

Not yet recruiting

Whole Heart Radiotherapy for End-stage Heart Failure (ESHF-WHRT)

Heart Failure NYHA Class III | Heart Failure With Reduced Ejection Fraction | Heart Failure NYHA Class IV | End-stage Heart Failure
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Factors and Prognosis of Obstructive Pyelonephritis Patients (PYELO-OBS)

Pyelonephritis | Prognostic

France
Tampere University

Recruiting

Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency (InNIVALS)

ALS | Chronic Respiratory Failure | Ventilation Therapy

Finland
Puerta de Hierro University Hospital
Hospital Clinic of Barcelona; Hospital Universitario Ramon y Cajal; Fundación... and other collaborators

Not yet recruiting

Effect of Acetazolamide on Diuresis and Natriuresis in Patients With Acute Heart Failure (SANDI STUDY) (SANDI)

Heart Failure | Persistent Congestion

Spain
Vojtech Melenovsky, MD, PhD

Not yet recruiting

Metabolic Response to Iniciation of Heart Failure Therapy (GliF)

Heart Failure

Czechia
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy

Heart Failure | Mitral Regurgitation

China
Medstar Health Baltimore

Recruiting

Intensive Education Versus Usual Education of Patients for Improving Guideline Directed Medical Therapy (GDMT) Prescription in Heart Failure With Reduced Ejection Fraction

Heart Failure | Patient Acceptance of Health Care

United States
Busra Nur Temur

Recruiting

The Effect of Mandala Therapy on Anxiety and Comfort in Kidney Transplant Recipients

Anxiety | Transplant;Failure,Kidney | Transplant Complication

Turkey
Azienda Ospedaliera SS. Antonio e Biagio e Cesare...

Recruiting

Single Breath Counting Test for Acute Respiratory Failure in Emergency Department (STARED)

Acute Respiratory Failure

Italy
BioCardia, Inc.

Not yet recruiting

CardiAMP Heart Failure II Trial for Patients With Ischemic Heart Failure With Reduced Ejection Fraction

Ischemic Heart Failure
Chulalongkorn University

Not yet recruiting

Venous Excess and Lung Ultrasound During Continuous Kidney Replacement Therapy in Critically Ill Patients (VExLUS-KRT)

Acute Kidney Failure Stage 3

Thailand
Skane University Hospital
Lund University; The Swedish Research Council; ResMed; Vastra Gotaland Region; Region... and other collaborators

Not yet recruiting

Effect of HIgh-flow Therapy in Long-term Oxygen Therapy (HILOT)

Interstitial Lung Disease | Chronic Respiratory Failure With Hypoxia | Chronic Obstructive Pulmonary Disease Severe
Cardiff and Vale University Health Board

Not yet recruiting

High Flow Oxygen Therapy After Spinal Cord Injury

Respiratory Failure | Spinal Cord Injuries
Takeda

Not yet recruiting

A Study of Maribavir in Adults With Kidney Failure Who Have a Cytomegalovirus (CMV) Infection After Transplantation

Kidney Failure | Cytomegalovirus (CMV) | Kidney Disease
Columbia University
Abbott

Not yet recruiting

The CardioClip Study (CardioClip)

Mitral Regurgitation | Heart Failure With Reduced Ejection Fraction

United States
The First Affiliated Hospital with Nanjing Medical...
First Affiliated Hospital, Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital... and other collaborators

Recruiting

CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy (CSP-UPGRADE)

Heart Failure | Cardiac Resynchronization Therapy | Right Ventricular Pacing | Biventricular Pacing | Conduction System Pacing

China
Fresenius Medical Care Deutschland GmbH
Metronomia Clinical Research GMBH

Not yet recruiting

Retrospective Data Analysis of CKRT (Continuous Kidney Replacement Therapy) Treatments in Adult Mode With multiFiltratePRO (CKRT-AKI)

Renal Failure | Acute Kidney Injury
Institute of Hematology & Blood Diseases Hospital...
Juventas Cell Therapy Ltd.

Recruiting

CNCT19 for Patients With Autoimmune Hemolytic Anemia After Failure ≥3 Lines of Therapy.

Autoimmune Hemolytic Anemia | Autologous CD19 CAR-T | Failure of Three or More Lines of Therapy

China

Search clinical trials for: First-Line Therapy Failure

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