Search clinical trials for: Human Genetic Variation

Total 41753 results

University Hospital Tuebingen

Recruiting

The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans

Type 2 Diabetes | Impaired Insulin Secretion

Germany
Eunice Kennedy Shriver National Institute of Child...

Recruiting

Gonadal Tissue Freezing for Fertility Preservation in Individuals at Risk for Ovarian Dysfunction, Premature Ovarian Insufficiency and Clinically Indicated Gonadectomy

Turner Syndrome | Galactosemia | Ovarian Disfunction | Post-menarcheal Adolescents | Variations in Sex Characteristics | Differences in Sex Development

United States
National Human Genome Research Institute (NHGRI)

Completed

Physicians' Understanding of Human Genetic Variation

Genetics

United States
Institut Pasteur

Completed

Genetic & Environmental Determinants Of Immune Phenotype Variance: A Longitudinal Assessment (MI-V3)

Healthy Subjects

France
Icahn School of Medicine at Mount Sinai
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD

ADHD | Attention Deficit Hyperactivity Disorder

United States
University of Colorado, Denver
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY (TESTO)

Klinefelter Syndrome

United States
National Human Genome Research Institute (NHGRI)

Completed

Personalized Genomic Research

Genetics | Birth Defects | Genetic Disease | Genetic Linkage | Genetic Variation

United States
National Human Genome Research Institute (NHGRI)

Completed

Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes Mellitus

Diabetes | Genetic Variation

Norway, Finland
National Human Genome Research Institute (NHGRI)

Completed

Use of Population Descriptors in Human Genetic Research

Disease | Qualitative Research | Population Groups | Genetics, Medical | Ethnology

United States
National Human Genome Research Institute (NHGRI)

Completed

Patients' Perspectives on Identity, Ancestry and Genetics

Family History

United States
Estella S. Poloni
Swiss National Science Foundation

Completed

Human Genomic Population Structure and Phenotype-genotype Variation in ADME Genes in Four Populations

Healthy

Czechia, Ethiopia, Greece, Oman
University of Guelph

Completed

Efficacy Study Regarding the Beneficial Effects of Omega-3 Fatty Acids on Cardiometabolic Health (FOHS)

Metabolic Syndrome X

Canada
Hookipa Biotech GmbH

Not yet recruiting

Safety, Reactogenicity and Immunogenicity of HB-502 and HB-501 Versus Placebo in People With HIV on Suppressive ART

Human Immunodeficiency Virus (HIV) Infection

United States
Hospices Civils de Lyon

Not yet recruiting

Circadian Variation of Urinary Copper Excretion in Wilson Disease Patients (VARCUWIC)

Wilson Disease

France
University of Vienna

Not yet recruiting

PRObing The Efficacy of Commercial Stage Storage Buffers and Evaluating Gut Metaproteome Variability Between Individuals (PROTEGI)

Gut Microbiome | Fecal Microbiota | Variability | Methodology Study | Buffer

Austria
Assistance Publique - Hôpitaux de Paris
Institut Pasteur

Recruiting

Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations (SPLEENVIVO)

Splenectomy

France
IRCCS Ospedale San Raffaele

Not yet recruiting

Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

Rare Diseases | Corneal Neovascularization | Limbal Stem Cell Deficiency | Aniridia | Neurotrophic Keratopathy | Ocular Cicatricial Pemphigoid | Ocular Graft-versus-host Disease | EEC Syndrome
Masonic Cancer Center, University of Minnesota

Not yet recruiting

MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.

Acquired Pure Red Cell Aplasia | Paroxysmal Nocturnal Hemoglobinuria | Severe Aplastic Anemia | Acquired Amegakaryocytic Thrombocytopenia
York University
University of Alberta; Australian Catholic University; Social Sciences and Humanities...

Not yet recruiting

Tackling Two of the Most Important Unresolved Tasks in Reading Intervention

Dyslexia, Developmental
Natural Resources Institute Finland
Tampere University

Recruiting

Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis (BIWE)

Microbial Colonization | Atopic Dermatitis | Immune System and Related Disorders | Nature, Human

Finland
BioMarin Pharmaceutical

Not yet recruiting

A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature

Idiopathic Short Stature
Octapharma

Recruiting

Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks

Acute Hereditary Angio Edema

Romania
Chiesi Farmaceutici S.p.A.
ICON plc

Not yet recruiting

A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry Disease (FLY)

Fabry Disease
Istituto Clinico Humanitas

Recruiting

A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients (EOrOS)

Colorectal Cancer

Italy
Istituto Clinico Humanitas

Recruiting

Genetic Architecture of Chronic Inflammatory Demyelinating Polyradiculoneuropathy (GEARCIDP)

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Italy
University of Rochester

Not yet recruiting

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

Age-Related Macular Degeneration | Retinitis Pigmentosa | Retinal Dystrophies | Alcohol Use Disorder | Stargardt Disease

United States
Chia Tai Tianqing Pharmaceutical Group Nanjing...

Not yet recruiting

A Clinical Study of Recombinant Human Coagulation Factor VIII for Injection in Patients With Severe Hemophilia A

Hemophilia A

China
Istituto Auxologico Italiano

Recruiting

Short Stature and Psychological Well-being (PSICOSHORT)

Short Stature | Short; Stature, Psychosocial

Italy
Eli Lilly and Company

Recruiting

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Elevated Lp(a) | Atherosclerotic Cardiovascular Disease (ASCVD)

United States, Australia, Spain, Canada, Argentina, China, Italy, France, Japan, Taiwan, Korea, Republic of, Denmark, Germany, Hungary, Israel, Austria, Belgium, Netherlands, Brazil, Mexico, Romania, United Kingdom, Greece, Czechia, Poland and more
National Human Genome Research Institute (NHGRI)

Recruiting

Care Choreographies and the Making of the Psychosocial in Genetic Counseling

Genetic Counselor

United States
Duke University
National Human Genome Research Institute (NHGRI)

Not yet recruiting

Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase (GRACE)

Liver Diseases | Cardiovascular Diseases | Cancer | Hyperthermia

United States
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Recruiting

A Study of SSGJ-613 in Gout Subjects Initiating Urate-Lowering Treatment.

Gout Arthritis

China
The Affiliated Hospital of Xuzhou Medical University

Recruiting

Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM

Type 2 Diabetes Mellitus | Susceptibility, Genetic

China
Apyx Medical

Recruiting

Histological Evaluation of Human Skin Bx to Assess the Effects of APR Tx as an Adjunct Procedure in Facelift Surgery

Skin Laxity | Tissue Breakdown | Collagen Degeneration | Collagen Shrinkage | Tissue Degeneration

United States
Incyte Corporation

Recruiting

A Study to Evaluate the Efficacy, and Safety Study of Ruxolitinib Cream in Adults With Moderate Atopic Dermatitis (TRuE-AD4)

Atopic Dermatitis

Germany, Poland, United States, Spain, United Kingdom, Italy, Belgium, Canada, Netherlands, Australia, Bulgaria, France, Switzerland, Hungary, Korea, Republic of
Children's Hospital Medical Center, Cincinnati
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Alpha Auditory Entrainment for Cognitive Enhancement and Sensory Hypersensitivity in Youth With Developmental Disorders (ENTRAIN)

Autism Spectrum Disorder | Autistic Disorder | Fragile X Syndrome | Asperger Syndrome

United States
Samsung Medical Center

Not yet recruiting

Evaluate the Safety and Potential Efficacy of Human Wharton's Jelly-derived Mesenchymal Stem Cells With Charcot-Marie-Tooth Disease Type 1E

Charcot-Marie-Tooth Disease, Type 1
Perha Pharmaceuticals
Fondation Jérôme Lejeune; European Innovation Council; France 2030 program

Recruiting

Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease (LEUCETTA)

Healthy Volunteers | Down Syndrome | Alzheimer's Disease

France
Unity Health Toronto

Not yet recruiting

A Pilot Crossover Trial of Prophylactic Wilate Compared to Placebo for Heavy Menstrual Bleeding in Patients With VWD (EMPOWER)

Von Willebrand Diseases
Grace Science, LLC

Recruiting

Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency

NGLY1 Deficiency

United States
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Recruiting

Evaluation of 611(Recombinant Humanized Anti-interleukin-4 Receptor Alpha IgG4 Monoclonal Antibody) in Chinese Adults With Moderate to Severe Atopic Dermatitis

Dermatitis, Atopic

China
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Not yet recruiting

A Study of Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection in Chinese Participants With Acute Gout

Acute Gout
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1, First-in-human Study of VX-828

Cystic Fibrosis

United States
Jiangsu Gensciences lnc.

Recruiting

Phase 3 Clinical Project of Pegylated Recombinant Human Coagulation Factor VIII-Fc Fusion Protein

Severe Hemophilia A

China
Jiangsu Gensciences lnc.

Not yet recruiting

Study of Efficacy and Safety of FRSW107 in Pediatric Patients With Severe Hemophilia A

Severe Hemophilia A

China
Faculdade de Motricidade Humana
Fundação para a Ciência e a Tecnologia

Not yet recruiting

Exercise Timing and the Circadian Clock in Individuals With Type 2 Diabetes and Those at Risk (EX-TIMING)

Diabetes Mellitus, Type 2

Portugal
Xiaoping Luo

Recruiting

Long-term Efficacy and Safety Evaluation of Growth Hormone in Children in China(CGLS)

Childhood Short Stature

China
Igenomix

Recruiting

International Non-selection Study for ERA® Test in Patients With Previous Implantation Failures

Infertility of Uterine Origin | Implantation Failure

Brazil, Spain, Peru, United Kingdom, United States, Panama
National Human Genome Research Institute (NHGRI)

Recruiting

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Metabolic Disease | Purine-Pyrimidine Metabolism | AICDA, OMIM *605257, Immunodeficiency With Hyper-IgM, Type 2; HIGM2 | UNG, OMIM *191525, Hyper-IgM Syndrome 5 | NT5C3A<TAB>, OMIM *606224, Anemia, Hemolytic, Due to UMPH1 Deficiency | UMPS, OMIM *613891, Orotic Aciduria | DHODH, OMIM *126064,... and other conditions

United States
Octapharma

Not yet recruiting

Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

Acquired Antithrombin Deficiency

Search clinical trials for: Human Genetic Variation

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