Search clinical trials for: PI3K Pathway

Total 1638 results

Xie Kangjie

Recruiting

Predictive Effect of TGF-β Combined With INS-PI3K-AKT Signaling Pathway Related Proteins (ADNP, MAP6, Pgc-1α) for POD on Diabetes Patients

Diabetes | Postoperative Delirium

China
University of California, San Francisco
National Institute of Neurological Disorders and Stroke (NINDS); The Chad-Tough... and other collaborators

Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent WHO Grade III Glioma | WHO Grade III Glioma

United States, Netherlands, Israel, Australia, New Zealand, Switzerland
Peking Union Medical College

Not yet recruiting

Inetetamab Plus Rapamycin and Chemotherapy for HER2+ Metastatic Breast Cancer With Abnormal Activation of PAM Pathway

Breast Cancer

China
Tianjin Medical University Second Hospital
Tianjin Medical University General Hospital; Tianjin First Central Hospital; The...

Not yet recruiting

Everolimus in Castrated Resistant Prostate Cancer(CRPC)Patients With PI3K-AKT-mTOR Signaling Pathway Deficiency

Prostate Cancer

China
Children's Hospital of Fudan University

Recruiting

Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome

Activated PI3K-delta Syndrome | Immunodeficiency Primary

China
Anna Martling
Skane University Hospital; Uppsala University Hospital

Active, not recruiting

Adjuvant Low Dose Aspirin in Colorectal Cancer (ALASCCA)

Colorectal Cancer

Sweden, Denmark, Norway, Finland
National Cancer Centre, Singapore
Novartis

Completed

A Trial of Gefitinib in Combination With BKM120 in Patients With Advanced Non-Small Cell Lung Cancer, With Enrichment for Patients Whose Tumours Harbour Molecular Alterations of PI3K Pathway and Known to Overexpress EGFR (BKM120)

Non-Small Cell Lung Cancer | Solid Tumors

Singapore
Peter MacCallum Cancer Centre, Australia
Novartis Pharmaceuticals

Completed

Phosphatidylinositol 3-kinase (PI3K) Alpha iNhibition In Advanced Breast Cancer (PIKNIC)

Metastatic Breast Cancer

Australia
Zhejiang Cancer Hospital

Completed

Efficacy of Everolimus-containing Chemotherapy in HER2- mBC Patients With PI3K/AKT/mTOR Mutations Study

Breast Cancer | PI3K/AKT/mTOR Pathway Mutation | Everolimus

China
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Metformin Combined With Chemotherapy for Pancreatic Cancer (GEM)

Metastatic Pancreatic Cancer | Locally Advanced Pancreatic Cancer

Netherlands
xjpfW
Cancer Institute and Hospital, Chinese Academy of Medical Sciences; First Hospital... and other collaborators

Completed

The Role of Angiogenesis-related Pathways in the Development of Port Wine Stains

Port Wine Stain
Novartis Pharmaceuticals

Completed

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Metastatic Colorectal Cancer | Gastric Cancer | Advanced Solid Tumors | Metastatic Breast Cancer | Gastroesophageal Junction Cancer | Recurrent Glioblastoma Multiforme | Advanced Pancreatic Adenocarcinoma | Safety | Triple Negative Metastatic Breast Cancer | Dose Escalation | Preliminary Efficacy | Hormone Receptor...

Canada, United Kingdom, Spain, Germany, Italy, Belgium, Australia, United States
Novartis Pharmaceuticals

Terminated

Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer

Metastatic Breast Cancer (MBC) | Inoperable Locally Advanced Breast Cancer

France, Spain
ArQule, Inc. (a wholly owned subsidiary of Merck...

Terminated

Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole

Ovarian Cancer | Endometrial Cancer | Solid Tumors

United States
SCRI Development Innovations, LLC
Novartis

Completed

Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme

Glioblastoma Multiforme

United States
Novartis Pharmaceuticals

Completed

A Phase Ib Dose De-escalation Study With BYL719 in Premenopausal Patients With Locally Advanced or Metastatic Breast Cancer (B-YOND)

Pre-menopausal Breast Cancer | PI3K Pathway Inhibition

Taiwan, Hong Kong, Thailand, Korea, Republic of
Novartis Pharmaceuticals

Completed

BKM120 as Second-line Therapy for Advanced Endometrial Cancer

Advanced Endometrial Cancer

Belgium, France, Italy, Canada, Spain, Australia, Germany, United States, Japan, Brazil, Singapore, Russian Federation, Poland
Novartis Pharmaceuticals

Completed

BKM120 for Patients With PI3K-activated Tumors (SIGNATURE)

PI3K Pathway Activated Tumors

United States
EMD Serono

Completed

First-in-Human Dose Escalation Trial in Subjects With Advanced Malignancies

Solid Tumor

United States
Emory University
Novartis Pharmaceuticals

Completed

A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies

Lung Cancer | Solid Tumors

United States
ArQule, Inc. (a wholly owned subsidiary of Merck...

Completed

Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma

Solid Tumor | Tumor | Malignant Lymphoma

United States
Medical Research Council
Merck Sharp & Dohme LLC; Aarhus University Hospital; NCRI Clinical Studies Groups and other collaborators

Unknown

Evaluation Of The Treatment Effectiveness Of Glioblastoma / Gliosarcoma Through The Suppression Of The PI3K/Akt Pathway In Compared With MK-3475

Glioblastoma

United States, Italy, Belgium, Germany, Poland, Russian Federation, Spain, Switzerland, Ukraine, United Kingdom
Merck Sharp & Dohme LLC

Completed

The Growth Factor Signature (GFS) as an Intermediate Biomarker of Response for Development of PI3K-Pathway Inhibitors in Patients With Breast Cancer (MK-8669-050)

Breast Cancer
Paloma Pharmaceuticals, Inc.

Completed

Phase I Study of Palomid 529 a Dual TORC1/2 Inhibitor of the PI3K/Akt/mTOR Pathway for Advanced Neovascular Age-Related Macular Degeneration (P52901)

Age-Related Macular Degeneration

United States
Novartis Pharmaceuticals

Withdrawn

BEZ235 Trial in Patients With HER2-(Human Epidermal Growth Factor Receptor 2 Negative) /HR+ (Hormonal Receptor Positive) Metastatic Breast Cancer

Metastatic Breast Cancer
Shanghai Changzheng Hospital

Completed

The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway

Colorectal Disease

China
Mayo Clinic

Not yet recruiting

NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Metastatic Cholangiocarcinoma | Refractory Cholangiocarcinoma | Stage III Hilar Cholangiocarcinoma AJCC v8 | Stage IV Hilar Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Advanced Cholangiocarcinoma

United States
Hitit University

Recruiting

Schroth Treatment and Proprioception Pathway

Adolescent Idiopathic Scoliosis

Turkey
University of Alberta

Not yet recruiting

Pharmacist Case Finding and Intervention for Vascular Prevention Trial (PRxOACT)

Cardiovascular Disease | Diabetes | Dyslipidemia | Blood Pressure | Cardiovascular Risk Factors
Assistance Publique Hopitaux De Marseille

Recruiting

Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway (BIOCEPTION)

Lung Cancer | Smoking-related Pathology | Atheroma | Non-progressive Cancer > 5 Years

France
The Cleveland Clinic

Not yet recruiting

Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes (OPUS)

Prenatal Disorder

United States
Mayo Clinic

Not yet recruiting

Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial (DIVINE)

Recurrent Prostate Cancer | Castration-resistant Prostate Cancer | Stage IVB Prostate Cancer AJCC v8 | Recurrent Castration-Sensitive Prostate Carcinoma

United States
University of Alberta
Alberta Innovates Health Solutions

Not yet recruiting

Digital Health Pathway for Children With Medical Complexity Requiring Tracheostomy (DECIDE-T)

Tracheostomy

Canada
Stony Brook University
Massachusetts General Hospital; Mclean Hospital

Recruiting

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Bipolar Disorder | Bipolar Disorder Type 1

United States
University Hospital, Toulouse
Janssen, LP; Ligue contre le cancer, France

Not yet recruiting

Real-life Management of Patients Eligible for CAR-T Cell Therapy (CARAVAGE)

Hemopathy

France
Medical College of Wisconsin

Not yet recruiting

Molecular Analyses to Identify Pathways of Endocrine Resistance Following Short Term Neoadjuvant Endocrine Treatment in Patients With Hormone Receptor-Positive HER2-negative Breast Cancer

Breast Cancer

United States
University of Alabama at Birmingham

Not yet recruiting

Establishment of an Interdisciplinary Functional Neurological Disorder (FND) Treatment Program and Development of a Clinical Care Pathway for FND

Convulsion, Non-Epileptic | Functional Neurological Disorder | Functional Seizure

United States
Tianjin Medical University Cancer Institute and...

Recruiting

Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial

Non-small Cell Lung Cancer | EGFR Activating Mutation | EGFR-TKI Resistant Mutation | Cell Cycle Deregulation

China
Chinese University of Hong Kong

Not yet recruiting

To Evaluate an MRI-based Optimized Prostate Cancer Diagnostic Pathway Powered by Artificial Intelligence

Prostate Cancer

Hong Kong
Institut Jean-Godinot
Université de Reims Champagne-Ardenne

Not yet recruiting

Development of a Questionnaire on Patients' Perception of Their Oncology Care Pathway (Onco-PREMs) (OncoPREMs)

Cancer
University of Michigan
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Not yet recruiting

Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation

Constipation

United States
Karolinska University Hospital

Not yet recruiting

Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome

Critical Illness | Hypophosphatemia | Refeeding Syndrome

Sweden, Czechia, Italy
Elsan

Not yet recruiting

Innovative Care Pathway in Physical Activity and Behavior Change in Coronary Patients Post-cardiac Rehabilitation (APIC)

Individualised Physical Activity Program | Coronary Patient
Pr. Nicolas GIRERD

Recruiting

PAtient Treatment Analysis: Hospital and Wide-ranging Out-of-hospital Care Assessment Yields Insights Into Heart Failure Outcomes (PATHWAY-HF)

Heart Failure

France
University of Alberta
Alberta Health services

Recruiting

Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB)

Staph Aureus Bacteremia

Canada
Fondazione del Piemonte per l'Oncologia

Recruiting

INSIDE: Identification of Genomic Screening Pathways in Cancer Patients With DNA Repair Alterations (INSIDE)

Prostate Cancer

Italy
Ziauddin University

Not yet recruiting

Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial (MROSF)

Oral Submucous Fibrosis

Pakistan
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies (3776)

Noonan Syndrome | Costello Syndrome | RASopathy | Cardio-Facio-Cutaneous Syndrome

Italy
University of Edinburgh

Not yet recruiting

Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology (ORACLE)

Coronary Artery Disease | Angina, Stable
Nested Therapeutics, Inc

Recruiting

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628)

Glioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene Mutation

Australia

Search clinical trials for: PI3K Pathway

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