Search clinical trials for: randomized phase II

Total 53307 results

Second Affiliated Hospital, School of Medicine,...

Recruiting

Randomized Phase II Trial: Chest Wall RT Omission After Prosthetic Reconstruction

Breast Neoplasms

China
Virginia Commonwealth University

Not yet recruiting

CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial (CBT-I in PBT)

Glioblastoma | Astrocytoma | Oligodendroglioma | Meningioma | Primary Brain Tumor | Primary Central Nervous System (CNS) Lymphoma

United States
M.D. Anderson Cancer Center

Recruiting

A Randomized Phase II Basket Trial EXTENDing Efficacy of Systemic Therapy With Local Consolidative Therapy for OligoProgressive Metastatic Disease (EXTEND-OP)

OligoProgressive Metastatic Disease

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

An Phase III Study, Multicenter，Randomized Controlled Trail to Determine the Safety and Efficacy of the Combination of Tislelizumab With Cisplatin and Gemcitabine, With or Without Trilaciclib for Patients With Untreated Unresectable and Metastatic Urothelial Carcinoma.

Bladder Cancer

China
Zhejiang Cancer Hospital

Recruiting

A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherapy Followed by Immunotherapy-Based Systemic Therapy +/- L. Rhamnosus M9 for the First-Line Treatment of Advanced Digestive System Malignancies.

Gastric Cancer | Colorectal Cancer | Pancreatic Adenocarcinoma | Biliary Tract Cancer | Gastroesophageal Junction Adenocarcinoma | Liver Cancer Stage IV

China
Beijing Friendship Hospital
Changhai Hospital; The First Affiliated Hospital of Anhui Medical University; Fudan University and other collaborators

Recruiting

A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer: From a Multicenter Phase II Cohort to a Phase III Randomized Controlled Study

Locally Advanced Rectal Carcinoma

China
The University of Hong Kong-Shenzhen Hospital

Not yet recruiting

iTAPVR Study - Phase II Randomized Study

Advanced Tumors
Biocomposites Ltd
MCRA

Not yet recruiting

A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers. (BLADE OPU2)

Osteomyelitis | Pressure Ulcer, Stage IV
M.D. Anderson Cancer Center
Janssen Scientific Affairs, LLC

Not yet recruiting

PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.

Prostate Cancer | Prostatectomy | Androgen Axis Suppression

United States
Fujian Akeylink Biotechnology Co., Ltd.

Recruiting

A Randomized, Double-blind, Placebo-controlled Phase IIa Clinical Study to Evaluate the Safety and Efficacy of GST-HG131 Tablets in Patients With Chronic Hepatitis B

Chronic Hepatitis B

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Randomized, Open, Controlled, Multicenter Phase III Clinical Study of Fluzoparib in Combination With Apatinib Versus Investigator-Selected Chemotherapy for HRD-Positive/HER2-negative Advanced Breast Cancer

Breast Cancer

China
European Organisation for Research and Treatment...
Northwell Health Cancer Institute

Not yet recruiting

Adjuvant Tebentafusp in High Risk Ocular Melanoma (ATOM)

Uveal Melanoma
Sun Yat-sen University

Recruiting

A Multi-center, Randomized, Double-blind, Phase II/III Clinical Trial of AK104 or Placebo in Combination With Chemotherapy as Second-line or More Lines for Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC)

Recurrent or Metastatic Nasopharyngeal Carcinoma

China
Research Institute for Physical Chemical Problems...
The state institution N. N. Alexandrov National Cancer Centre of Belarus; Unitary...

Not yet recruiting

An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II (ИНТЕЛОН-02)

Gastric Cancer With Peritoneal Dissemination

Belarus
Senhwa Biosciences, Inc.

Not yet recruiting

Phase II, Double Blind, Randomized Trial of CX-4945 in Viral Community Acquired Pneumonia

Community-acquired Pneumonia | Influenza With Pneumonia | SARS-CoV-2 -Associated Pneumonia

Taiwan
JHM BioPharma (Tonghua) Co. , Ltd.

Recruiting

A Phase I/II, Randomized, Double-blind, Placebo, and Active Controlled Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, and Preliminary Efficacy of JHM03 in Subjects With Moderate to Severe Glabellar Lines

Moderate to Severe Glabellar Lines

China
Changchun GeneScience Pharmaceutical Co., Ltd.
West China Hospital

Not yet recruiting

A Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetic Profile of Genakumab Injection in Patients With Connective Tissue Disease-associated Interstitial Lung Disease

Systemic Sclerosis Associated Interstitial Lung Disease | Rheumatoid Arthritis Associated Interstitial Lung Disease (RA-ILD) | Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)

China
M.D. Anderson Cancer Center

Recruiting

Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)

Oropharyngeal Neoplasms | Robotic Surgery and/or Radiotherapy | Lymphoscintigraphy

United States
Zai Lab (Hong Kong), Ltd.

Recruiting

A Phase 3b Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline to Moxifloxacin for Treating Adult Subjects With CABP (public)

Community-acquired Bacterial Pneumonia

China
National Cancer Center, Korea

Recruiting

A Randomized Phase II Study of LAZE rtiNib Alone Versus Lazertinib Plus bevaCizumab for NSCLC With EGFR + & Smoker

Lazertinib

Korea, Republic of
Nanjing Zenshine Pharmaceuticals

Not yet recruiting

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Trial of ZX-7101A Tablets to Evaluate the Efficacy and Safety in the Treatment of Uncomplicated Influenza in Adolescents (ZX-7101A-207)

Respiratory Viral Infection

China
VA Office of Research and Development

Recruiting

Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc

Prostate Cancer

United States
Cancer Institute and Hospital, Chinese Academy...

Recruiting

A Prospective, Open-label, Multicenter, Randomized Controlled Phase III Study of Prophylactic Central Neck Dissection in Low-risk Papillary Thyroid Cancer

Recurrence | Thyroid Cancer

China
University of Texas Southwestern Medical Center

Recruiting

Phase II Randomized Study of Hypofractionated Versus Conventional Radiotherapy (G-FORCE)

Laryngeal Carcinoma

United States
Vivacelle Bio

Not yet recruiting

A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02) (VBI-S-02)

Sepsis | Septic Shock | Hypovolemia
M.D. Anderson Cancer Center

Recruiting

A Phase III Randomized Trial Comparing Stereotactic Body Radiation Therapy (SBRT) vs Conventional Palliative Radiation Therapy for Painful Bone Metastases

Bone Metastases

United States
Yonsei University

Recruiting

A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study) (DOVE)

Uterine Cervical Neoplasms | Ovarian Neoplasms | Endometrial Neoplasms | Vulvar Cancer | Clear Cell Carcinoma | Vagina Neoplasm

Korea, Republic of
Sohag University

Not yet recruiting

Evaluation of the Efficacy of Preoperative Ketamine Nebulization on Postoperative Sore Throat Due to Tracheal Intubation for Adult Patients Under General Anesthesia, A Prospective Randomized Controlled Study

Post Operative Sore Throat
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Technische Universität Dresden; Canadian Critical Care Trials Group and other collaborators

Recruiting

Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock (UC-CISSII)

Pathologic Processes | Infections | Sepsis | Systemic Inflammatory Response Syndrome | Inflammation | Shock | Septic Shock

Canada
VA Office of Research and Development

Not yet recruiting

Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial

Chronic Low Back Pain

United States
European Organisation for Research and Treatment...

Recruiting

Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study (LEGATO)

First Progression of Glioblastoma

Netherlands, Austria, Germany
Centre Francois Baclesse
National Cancer Institute, France

Not yet recruiting

Long-term Cognitive and Functional Impact of Proton-therapy or Modern Fractionated Radiotherapy in Cavernous Sinus Meningioma: An Open-label Randomized 1:1 Phase III Study (COG-PROTON-01)

Cognitive Impairment | Cavernous Sinus Meningioma | Proton-therapy | Photon Radiotherapy

France
Tianjin Medical University Cancer Institute and...

Recruiting

A Multicenter, Randomized, Open, Phase III Trial of ddEC-THPvs Evaluating the Efficacy and Safety of TCHP Neoadjuvant Therapy for HER2-positive Breast Cancer

HER-2 Positive Breast Cancer

China
Peng Liu

Not yet recruiting

The Efficacy and Safety of Nanoparticle Albumin-bound (NAB)-Paclitaxel Plus Cisolation Versus CEP (Cisplatin, Epirubicin,Cyclophosphamide) in Induction Therapy for Thymoma: a Study for a Single-center Prospective Phase II Randomized Controlled Train.

Histological or Cytological Confirmed Stage Ⅲ and Ⅳa Thymoma

China
Qilu Pharmaceutical Co., Ltd.

Not yet recruiting

A Multicenter, Randomized, Double-blind Phase II Trial to Evaluate GM1 Prevention of Peripheral Neuropathy in Patients With Breast Cancer

To Evaluate the Effectiveness of GM1 in the Prevention of Albumin-paclitaxel Therapy Induced Peripheral Neuropathy in Breast Cancer Patients
Sun Yat-sen University
JIANGSU JIBEIER PHARMACEUTICAL CO.,LTD

Not yet recruiting

A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC

Nasopharyngeal Carcinoma | Chemotherapy | Myelosuppression | Leucogen

China
Fondazione IRCCS Istituto Nazionale dei Tumori,...
Federico II University; Humanitas Clinical and Research Center; Istituto Oncologico... and other collaborators

Recruiting

Targeting Triple Negative BREAst Cancer Metabolism With a Combination of Chemoimmunotherapy and a FASTing-like Approach in the Preoperative Setting: the BREAKFAST 2 Trial (BREAKFAST-2)

Breast Cancer | Triple Negative Breast Cancer | Fasting | Dietary Exposure

Italy
David Palma

Recruiting

A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for Patients With Up to 10 Oligometastases and a Synchronous Primary Tumor. (SABR-SYNC)

Metastatic Tumor

Canada
M.D. Anderson Cancer Center

Recruiting

3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

Head and Neck Squamous Cell Carcinoma

United States
Institut de cancérologie Strasbourg Europe
Centre Georges Francois Leclerc

Not yet recruiting

Contribution From PET-DOPA in Glioblastoma Re-irradiation - A Randomized Phase II Study (ReciDOPA)

Glioblastoma

France
National Human Genome Research Institute (NHGRI)

Recruiting

Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

Attention Deficit Hyperactivity Disorder

United States
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Adjuvant Stereotactic Body Radiotherapy (SBRT) for Hepatocellular Carcinoma After Hepatectomy With Narrow Margin: a Prospective, Multi-center, Randomized Controlled, Open-labelled, Phase III Study

Hepatocellular Carcinoma | Hepatectomy | Narrow Margin | Adjuvant Stereotactic Body Radiotherapy

China
Xeolas Pharmaceuticals Limited

Recruiting

A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction (XEOLAS)

Bone Loss, Alveolar

Spain
Drugs for Neglected Diseases
Novartis Pharmaceuticals

Recruiting

A Phase II, Multicentre, Randomized, Two-arm Blinded Study to Assess the Efficacy and Safety of Two LXE408 Regimens for Treatment of Patients With Primary Visceral Leishmaniasis

Primary Visceral Leishmaniasis

India
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics (BELA TRIPP)

Severe Traumatic Brain Injury

Peru, United States, El Salvador, Guatemala, Honduras
EpicentRx, Inc.
Sciclone Pharmaceuticals (China) Co., Ltd.

Recruiting

A Phase 3, Controlled, Open-label, Global Randomized Study of RRx-001 With a Platinum Doublet or a Platinum Doublet in Small Cell Lung Cancer (REPLATINUM)

Carcinoma, Small Cell Lung

United States
Sun Yat-sen University

Recruiting

A Randomized, Double-blind,Phase Ⅲ Study of Liposome Doxorubicin in Desmoid Tumor

Desmoid Tumor

China
Sichuan Cancer Hospital and Research Institute

Recruiting

Nituzumab (Taixinsheng ®） A Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Phase II Clinical Study on the Efficacy and Safety of Combined Induction Chemotherapy for Locally Advanced Nasopharyngeal Carcinomatreatment of Locally Advanced Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

China
Lawson Health Research Institute

Recruiting

Ablative Radiotherapy to Restrain Every Metastasis Safely Treatable (ARREST-2): A Randomized Phase II/III Trial

Metastatic Cancer

Canada
Shanghai Zhimeng Biopharma, Inc.
Tigermed Consulting Co., Ltd

Recruiting

A Study to Evaluate the Efficacy and Safety of ZM-H1505R in Combination With ETV Compared With ETV Monotherapy in Patients With CHB

Hepatitis B, Chronic

China

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