Peripheral Stem Cell Transplantation Followed By Infusion of White Blood Cells in Treating Patients With AIDS-Related Lymphoma

DISEASE CHARACTERISTICS:

• Diagnosis of Hodgkin's disease or non-Hodgkin's lymphoma

  • Failed to achieve a complete remission with initial therapy OR
  • Relapsed after initial therapy
• HIV-1 seropositive by Western Blot
• Measurable or evaluable (e.g., pleural fluid involvement) disease
• No leptomeningeal or parenchymal CNS involvement or active CNS leukemia
• HLA-A, B, or DR antigen matched or 1 antigen mismatched related donor available
• CD4 cell count greater than 100/mm3 (initial 12 patients) OR greater than 50/mm3 (subsequent patients)*
• HIV RNA less than 110,000 copies/mL* NOTE: *Unless not receiving optimal anti-retroviral therapy as defined by current clinical standards

PATIENT CHARACTERISTICS:

Age:

• Physiologic 65 and under

Performance status:

• Karnofsky 70-100%

Life expectancy:

• Estimated disease-free survival less than 1 year

Hematopoietic:

• See Disease Characteristics

Hepatic:

• Bilirubin no greater than 2 mg/dL
• Alkaline phosphatase no greater than 3 times upper limit of normal (ULN)*
• SGOT or SGPT no greater than 3 times ULN*
• Hepatitis B surface antigen negative NOTE: *Unless receiving indinavir

Renal:

• Creatinine no greater than 1.5 mg/dL
• Creatinine clearance at least 50 mL/min

Cardiovascular:

• No symptomatic congestive heart failure
• No angina pectoris
• No uncontrolled hypertension
• LVEF at least 45% by radionuclide ventriculography

Pulmonary:

• No severe chronic obstructive lung disease
• No symptomatic restrictive lung disease
• DLCO greater than 50% predicted

Other:

• No active uncontrolled infection
• No history of cytomegalovirus retinitis or pneumonitis, even if treated
• No other disease that would limit life expectancy
• No symptomatic leukoencephalopathy
• No neuropsychiatric abnormalities that would preclude transplantation
• Human T-cell lymphotrophic virus (HTLV-1) antibody negative
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 3 months after study

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• At least 1 week since prior chemotherapy

Endocrine therapy:

• Not specified

Radiotherapy:

• Not specified

Surgery:

• Not specified

Other:

• No concurrent chronic suppressive therapy