Study of Eye Pressure as a Predictor of Intracranial Pressure in the Acutely Head-Injured Population
Intraocular Pressure as a Predictor of Intracranial Pressure in the Acutely Head-Injured Population
調査の概要
状態
条件
詳細な説明
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in the United States, with an estimated 1.5 million American sustaining a TBI and 50,000 people dying from a TBI each year. While the immediate, or primary, injury causes significant damage, secondary injury is caused by cerebral edema, increased intracranial pressure, and resultant hypoperfusion and ischemia. Elevated intracranial pressure is strongly associated with poor recovery and death; failure to control intracranial pressure is likewise associated with poor outcomes and mortality.
Early detection of elevated ICP allows for the initiation of early therapy. However, patients with significant head injuries are often intubated for airway protection. The sedation required for intubation obscures the ED neurologic exam. Precise measurement of elevated ICP has required invasive monitoring via ventriculostomy. Yet this method is only provided at set institutions with neurosurgical services. Further there are distinct time delays between the trauma occurrence, transportation to a facility with neurosurgical services and placement of ventriculostomies. There is at the forefront, then, to establish non-invasive measures of ICP that are both time efficient and reliable.
Previous studies, including a pilot study conducted at this institution, showed a correlation between intraocular and intracranial pressure. However, this relationship has not been tested in an acute care trauma setting. We propose an observational cohort study of critically injured trauma patients with suspected closed head injury. Patients requiring intubation and mechanical ventilation pose a significant challenge to assess neurologically, as they are almost always sedated and often chemically paralyzed to facilitate airway management. Therefore, it is in this population of intubated trauma patients with suspected head injury that we will evaluate the use of tonometry to predict intracranial pressure from intraocular pressure.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Ohio
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Columbus、Ohio、アメリカ、43210
- The Ohio State University Medical Center
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Patients with suspected acute traumatic head injury
- Intubated prior to arrival in the Emergency Department or in the Emergency Department, including patients transferred from other facilities
Exclusion Criteria:
- Too unstable to allow the investigator access to the head of the bed to perform tonometry.
- Severe ocular or facial trauma such that an intact globe is not accessible
- Known history of glaucoma
- Penetrating head injury
- Patients that undergo operative decompression prior to the placement of an intracranial pressure monitor may be screened in the trauma bay and have an intraocular pressure obtained; however, these patients will not be included in the intraocular / intracranial pressure analysis.
- Known allergy to latex or tetracaine
研究計画
研究はどのように設計されていますか？
デザインの詳細
協力者と研究者
スポンサー
捜査官
- 主任研究者：Brian C Hiestand, MD、The Ohio State University Department of Emergency Medicine
研究記録日
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研究の完了 (実際)
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最終確認日
詳しくは
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