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A Clinical Trial to Evaluate the Efficacy and Safety of Testosterone Gel

2017年9月25日 更新者：Ferring Pharmaceuticals

A Phase 3, Open-label, Non-randomized, Clinical Trial to Evaluate the Efficacy and Safety of FE 999303 (Testosterone Gel) in Adult Hypogonadal Males

This is a Phase 3 clinical trial in adult hypogonadal males with baseline serum testosterone concentrations <300 ng/dL. The purpose of this study is to evaluate the safety and efficacy of testosterone gel (2%) delivered using an applicator.

調査の概要

状態

完了

条件

介入・治療

研究の種類

介入

入学 (実際)

180

段階

  • フェーズ 3

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究場所

  • アメリカ
    • Alabama
      • Huntsville、Alabama、アメリカ
        • Medical Affiliated Research Cente
    • California
      • Newport Beach、California、アメリカ
        • California Professional Research
      • San Diego、California、アメリカ
        • San Diego Sexual Medicine
    • Connecticut
      • Middlebury、Connecticut、アメリカ
        • Connecticut Clinical Research
    • Florida
      • Aventura、Florida、アメリカ
        • South Florida Medical Research
    • Michigan
      • Saint Clair Shores、Michigan、アメリカ
        • Michigan Institute of Urology
    • Nebraska
      • Omaha、Nebraska、アメリカ
        • Quality Clinical Research
    • New Jersey
      • Lawrenceville、New Jersey、アメリカ
        • Premier Urology Associates
    • New York
      • New York、New York、アメリカ
        • University Urology
      • Poughkeepsie、New York、アメリカ
        • Premier Medical Group of the Hudson Valley
    • North Carolina
      • Winston-Salem、North Carolina、アメリカ
        • PMG Research of Wilmington
    • Ohio
      • Cincinnati、Ohio、アメリカ
        • Tristate Urologic Services
    • Rhode Island
      • Warwick、Rhode Island、アメリカ
        • Omega Medical Research
    • South Carolina
      • Mount Pleasant、South Carolina、アメリカ
        • Coastal Carolina Research Center
      • Myrtle Beach、South Carolina、アメリカ
        • Carolina Urologic Research Center
    • Tennessee
      • Nashville、Tennessee、アメリカ
        • Clinical Research Associates
    • Texas
      • Dallas、Texas、アメリカ
        • Urology Clinics of North Texas
  • カナダ
    • Ontario
      • London、Ontario、カナダ
        • St. Joseph's Healthcare
      • North Bay、Ontario、カナダ
        • Private Practice and Clinical Research

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

18年～75年 (大人、高齢者)

健康ボランティアの受け入れ

いいえ

受講資格のある性別

男

説明

Inclusion Criteria:

  1. Males between 18-75 years of age
  2. Two screening serum testosterone values less than 300 ng/dL
  3. One or more symptoms of testosterone deficiency

Exclusion Criteria:

  1. Previous use of the investigational product
  2. Use of any investigational product within 30 days prior to screening and during the study
  3. BMI less than 18 kg/m^2 or more than 35 kg/m^2
  4. Prostatic mass(es)
  5. Generalized skin irritation or skin disease
  6. Lower urinary tract obstruction
  7. Myocardial infarction or cerebrovascular accident in the last 6 months
  8. Unstable angina or congestive heart failure
  9. Thromboembolic disorders
  10. Sleep apnea
  11. Hyperparathyroidism or uncontrolled diabetes
  12. Untreated moderate to severe depression
  13. History of testicular, prostate, or breast cancer
  14. HIV, Hepatitis B, or Hepatitis C positive
  15. PSA more or equal to 3 ng/mL
  16. Use of any medications that could be considered anabolic
  17. Use of estrogens, Gonadotropin Releasing Hormone agonists/antagonists, antiandrogens, or human Growth Hormone
  18. Chronic use of any drug of abuse
  19. Involvement in a sport in which there is a screening for anabolic steroids
  20. Not willing to use adequate contraception during the study
  21. Partner is pregnant and/or breast feeding
  22. Partner has a history of breast, uterine or ovarian cancer

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか？

デザインの詳細

  • 主な目的：処理
  • 割り当て：なし
  • 介入モデル：単一グループの割り当て
  • マスキング：なし（オープンラベル）

武器と介入

参加者グループ / アーム
介入・治療
実験的：Testosterone gel (FE 999303)

Subjects received a starting dose of 46 mg (two actuations) of testosterone gel (2%) daily in the morning. The dose was further titrated (increased or decreased - three actuations [69 mg] or single actuation [23 mg], respectively) based on serum testosterone concentrations.

Testosterone gel was applied using an applicator, to the shoulder/upper arm in a contralateral fashion.
薬：テストステロンジェル (FE 999303)

この研究は何を測定していますか？

主要な結果の測定

結果測定
メジャーの説明
時間枠
The Percentage of Subjects on Day 90 Whose Cavg (0-24) Serum Total Testosterone Levels Are Between 300 and 1050 ng/dL
時間枠：Day 90
The data were presented using descriptive statistics. No statistical analysis was performed.
Day 90

二次結果の測定

結果測定
メジャーの説明
時間枠
The Percentage of Participants on Day 1 Whose Serum Cavg (0-24) Serum Total Testosterone Levels Are Between 300 and 1050 ng/dL
時間枠：Day 1
The data were presented using descriptive statistics. No statistical analysis was performed.
Day 1
Pharmacokinetics of Total Testosterone Measuring Area Under the Concentration-time Curve From the Last Dose and 24 Hours Post-dose (AUCτ)
時間枠：Day 1; Day 90
A validated high pressure liquid chromatography with tandem mass spectrometry detection (LC/MS/MS) method was used to determine the levels of total testosterone.
Day 1; Day 90
Pharmacokinetics of Total Testosterone Measuring Time of Maximum Observed Concentration (Tmax)
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of total testosterone.
Day 1; Day 90
Pharmacokinetics of Total Testosterone Measuring Maximum Concentration Observed (Cmax)
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of total testosterone.
Day 1; Day 90
Pharmacokinetics of Total Testosterone Measuring Average Steady State Concentration (Cave)
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of total testosterone.
Day 1; Day 90
Pharmacokinetics of Total Testosterone Measuring Minimum Concentration Observed (Cmin)
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of total testosterone.
Day 1; Day 90
Pharmacokinetics of Total Testosterone Measuring Time of Minimum Observed Concentration (Tmin)
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of total testosterone.
Day 1; Day 90
Pharmacokinetics of DHT (Dihydrotestosterone) Measuring AUCτ
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of DHT.
Day 1; Day 90
Pharmacokinetics of DHT Measuring Tmax
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of DHT.
Day 1; Day 90
Pharmacokinetics of DHT Measuring Cmax
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of DHT.
Day 1; Day 90
Pharmacokinetics of DHT Measuring Cave
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of DHT.
Day 1; Day 90
Pharmacokinetics of DHT Measuring Cmin
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of DHT.
Day 1; Day 90
Pharmacokinetics of DHT Measuring Tmin
時間枠：Day 1; Day 90
A validated LC/MS/MS method was used to determine the levels of DHT.
Day 1; Day 90
Change From Baseline in the International Index of Erectile Dysfunction (IIEF) Questionnaire
時間枠：Day 91

Data collected from the five domains of sexual functions were summarized by descriptive statistics. The domains are:

  1. Erectile function (6 items, questions 1-5 and 15) (Score range: 1-30)
  2. Orgasmic function (2 items, questions 9-10) (Score range: 0-10)
  3. Sexual desire (2 items, questions 11-12) (Score range: 2-10)
  4. Intercourse satisfaction (3 items, questions 6-8) (Score range: 0-15)
  5. Overall satisfaction (2 items, questions 13-14) (Score range: 2-10)

A score of 0-5 is awarded to questions 1 to 10 and a score of 1-5 is awarded to questions 11 to 15. Total score was calculated by summing up scores of each domain and ranged from 5 to 75. Low score indicates severe dysfunction and a high score indicates no dysfunction in sexual function.
Day 91
Change From Baseline in the Multidimensional Assessment of Fatigue (MAF) Questionnaire
時間枠：Day 91

The MAF contains four sub-domains:

  1. Severity (2 items, questions 1-2) (Score range: 2-20)
  2. Distress (1 item, question 3) (Score range: 1-10)
  3. Degree of interference in activities of daily living (11 items, questions 4-14) (Score range: 11-110)
  4. Timing (2 items, questions 15-16) (Score range: 5-20)

A score of 1-10 is awarded to each of the 14 questions across the 3 domains. The timing domain is categorical and was converted to 1-10 scale by multiplying each score by 2.5. Lower score in each domain indicates improvement in fatigue.

To calculate GFI : Score of question 15 is converted to a 0-10 scale by multiplying each score by 2.5 and then sum questions 1, 2, 3, average of 4-14, and newly scored question 15. A score of zero is assigned to question 2-16, if patient select 'no fatigue' to question 1. Question 16 is not included in GFI calculation. Range of GFI: 1 (no fatigue) to 50 (severe fatigue).

The data were presented using descriptive statistics.
Day 91
Change From Baseline in the SF-12 Health Questionnaire
時間枠：Day 91

Data collected from the SF-12 questionnaire was used to assess improvement in the psychometrically-based physical component summary (PCS) and mental component summary (MCS). Both PCS and MCS contains four sub-domains:

PCS: General Health (1 item), Physical Functioning (2 items), Role-Physical (2 items), Bodily Pain (1 item)

MCS: Role-Emotional (2 items), Mental Health (2 items), Vitality (1 item), Social Functioning (1 item)

The scale scores are calculated by summing responses across scale items and then transforming these raw scores to a 0-100 scale. Computerized scoring algorithms are used to produce norm-based scores for each scale (mean of 50 and standard deviation of 10) as well as the PCS and MCS summary scores. A zero score indicates the lowest level of health measured by the scales and 100 indicates the highest level of health.

The data were presented using descriptive statistics.
Day 91

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

Ferring Pharmaceuticals

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始

2012年7月1日

一次修了 (実際)

2013年4月1日

研究の完了 (実際)

2013年5月1日

試験登録日

最初に提出

2012年8月1日

QC基準を満たした最初の提出物

2012年8月10日

最初の投稿 (見積もり)

2012年8月15日

学習記録の更新

投稿された最後の更新 (実際)

2017年10月26日

QC基準を満たした最後の更新が送信されました

2017年9月25日

最終確認日

2017年9月1日

詳しくは

本研究に関する用語

追加の関連 MeSH 用語

その他の研究ID番号

  • 000023

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