Words Generation in Compulsives Gamblers and Parkinson's Disease Patients (FLUENCE)
Study of Words Generation in Compulsives Gamblers and Healthy Volunteers: Comparison With a Study of Parkinson's Disease Patients
The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.
Thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of Parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.
調査の概要
詳細な説明
The main objective of this study is to evaluate performance during words generation in gamblers and healthy volunteers compare to those of PD patients with and without hyper-dopaminergic behaviors collected during another study.
2 groups of subjects will be recruited for the study: 20 compulsive gamblers and 20 healthy volunteers
Each subject will realize twice each test during 2 sessions with one hour in between :
During the session 1 :
- The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
- The test of Stroop that assesses selective attention
During the session 2:
- The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
- The task of the casino (Iowa Gambling Test)
- The task of landing
- The test of Stroop
We supposed that the performance of compulsive gamblers in words generation test will be higher than those of healthy volunteers, themselves superior to those of PD patients with a hyper-dopaminergic behavior, themselves superior to those of PD patient without hyper-dopaminergic behavior.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Toulouse、フランス、31000
- CHU Toulouse
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
For healthy volunteers :
- Subject from 30 to 75 years old (Male and female)
- Subject with French mother tongue
- Subject who give their informed and signed consent.
- Subject affiliated to a social protection program
For compulsive gamblers :
- Subject from 30 to 75 years old (Male and female)
- Subject with French mother tongue
- Subject with at least 5 criteria of 10 DSM IV diagnostic criteria for pathological gambling
- Subject who give their informed and signed consent.
- Subject affiliated to a social protection program
Exclusion Criteria:
For healthy volunteers and compulsive gamblers :
- Presence of apathy defined as a score greater or equal to 14 on the scale of Starkstein
- Presence of severe depression defined as a score greater or equal to 25 on the scale BDI (Beck Depression Inventory)
- Presence of dementia defined as a score below 25 on the MMSE
- Subject with vision problems making it impossible for the tests
- Pregnant women
- Subject under tutelage, curatelle or law protection
- Subject included in an other clinical study
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：非ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
他の：healthy volunteers
evaluation of word generation and of motivation
|
Each subject will realize twice each test during 2 sessions with one hour in between : During the session 1 :
During the session 2:
|
|
他の：compulsive gamblers
evaluation of word generation and of motivation
|
Each subject will realize twice each test during 2 sessions with one hour in between : During the session 1 :
During the session 2:
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
|
Changement of number of mistake during the words generation test
時間枠：one hour
|
one hour
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二次結果の測定
結果測定 |
時間枠 |
|---|---|
|
changement of number of uncorrected errors during the Stroop test which reflects the incapacity to inhibit the reading and that evaluates attention
時間枠：one hour
|
one hour
|
協力者と研究者
捜査官
- 主任研究者：Christine Brefel, MD、UH Toulouse
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
パーキンソン病の臨床試験
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Adelphi Values LLCBlueprint Medicines Corporation完了肥満細胞性白血病 (MCL) | 攻撃的な全身性肥満細胞症 (ASM) | SM w Assoc Clonal Hema Non-mast Cell Lineage Disease (SM-AHNMD) | くすぶり全身性肥満細胞症 (SSM) | 無痛性全身性肥満細胞症 (ISM) ISM サブグループが完全に募集されましたアメリカ
evaluation of word generation and of motivationの臨床試験
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Giancarlo Natalucciまだ募集していません
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University of LincolnNottinghamshire Healthcare NHS Trust募集