Words Generation in Compulsives Gamblers and Parkinson's Disease Patients (FLUENCE)

Study of Words Generation in Compulsives Gamblers and Healthy Volunteers: Comparison With a Study of Parkinson's Disease Patients

The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.

Thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of Parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.

Study Overview

• Status: Completed
• Conditions: Parkinson Disease
• Intervention / Treatment: Other: evaluation of word generation and of motivation

Detailed Description

The main objective of this study is to evaluate performance during words generation in gamblers and healthy volunteers compare to those of PD patients with and without hyper-dopaminergic behaviors collected during another study.

2 groups of subjects will be recruited for the study: 20 compulsive gamblers and 20 healthy volunteers

Each subject will realize twice each test during 2 sessions with one hour in between :

During the session 1 :

• The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
• The test of Stroop that assesses selective attention

During the session 2:

• The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
• The task of the casino (Iowa Gambling Test)
• The task of landing
• The test of Stroop

We supposed that the performance of compulsive gamblers in words generation test will be higher than those of healthy volunteers, themselves superior to those of PD patients with a hyper-dopaminergic behavior, themselves superior to those of PD patient without hyper-dopaminergic behavior.

• Study Type: Interventional
• Enrollment (Actual): 37
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Toulouse, France, 31000
    • CHU Toulouse

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 30 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

For healthy volunteers :

• Subject from 30 to 75 years old (Male and female)
• Subject with French mother tongue
• Subject who give their informed and signed consent.
• Subject affiliated to a social protection program

For compulsive gamblers :

• Subject from 30 to 75 years old (Male and female)
• Subject with French mother tongue
• Subject with at least 5 criteria of 10 DSM IV diagnostic criteria for pathological gambling
• Subject who give their informed and signed consent.
• Subject affiliated to a social protection program

Exclusion Criteria:

For healthy volunteers and compulsive gamblers :

• Presence of apathy defined as a score greater or equal to 14 on the scale of Starkstein
• Presence of severe depression defined as a score greater or equal to 25 on the scale BDI (Beck Depression Inventory)
• Presence of dementia defined as a score below 25 on the MMSE
• Subject with vision problems making it impossible for the tests
• Pregnant women
• Subject under tutelage, curatelle or law protection
• Subject included in an other clinical study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: healthy volunteers; evaluation of word generation and of motivation	Other: evaluation of word generation and of motivation; Each subject will realize twice each test during 2 sessions with one hour in between : During the session 1 : The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.; The test of Stroop that assesses selective attention During the session 2: The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.; The task of the casino (Iowa Gambling Test); The task of landing; The test of Stroop
Other: compulsive gamblers; evaluation of word generation and of motivation	Other: evaluation of word generation and of motivation; Each subject will realize twice each test during 2 sessions with one hour in between : During the session 1 : The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.; The test of Stroop that assesses selective attention During the session 2: The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.; The task of the casino (Iowa Gambling Test); The task of landing; The test of Stroop

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Changement of number of mistake during the words generation test	one hour

Secondary Outcome Measures

Outcome Measure	Time Frame
changement of number of uncorrected errors during the Stroop test which reflects the incapacity to inhibit the reading and that evaluates attention	one hour

Collaborators and Investigators

• Sponsor: University Hospital, Toulouse
• Investigators: Principal Investigator: Christine Brefel, MD, Uh Toulouse

Study record dates

Study Major Dates

• Study Start: February 1, 2012
• Primary Completion (Actual): April 1, 2014
• Study Completion (Actual): April 1, 2014

Study Registration Dates

• First Submitted: February 20, 2012
• First Submitted That Met QC Criteria: June 24, 2013
• First Posted (Estimate): June 27, 2013

Study Record Updates

• Last Update Posted (Estimate): June 11, 2015
• Last Update Submitted That Met QC Criteria: June 10, 2015
• Last Verified: June 1, 2015

More Information

Terms related to this study

• Keywords: Words generation, compulsive gamblers
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Parkinson Disease
• Other Study ID Numbers: 11 225 02